This application is the U.S. National Phase under 35. U.S.C. § 371 of International Application PCT/KR2019/010558, filed Aug. 20, 2019, which claims priority to Korean Patent Application No. 10-2018-006819, filed Aug. 20, 2018, and Korean Patent Application No. 10-2019-0101608, filed Aug. 20, 2019. The disclosure of each of the above-described applications is hereby incorporated by reference in its entirety.
The present disclosure relates to an electroosmotic pump, and more particularly, to an electroosmotic pump using a fluid.
Diabetes is a disease based on metabolic abnormalities that occur due to insufficient insulin which is one of the hormones secreted from the pancreas. A diabetic may use a method of injecting insulin into the body as one of active treatment methods. An insulin injection device may be used to inject insulin into the body to be suitable for a change in the blood sugar of the patient.
A mechanism for driving a drug injection device, e.g., an insulin injection device, may include driving members such as various kinds of motors or pumps. The present disclosure relates to a driving member and provides a pump capable of performing a fine pumping operation by using a fluid. However, the above technical features are exemplary, and the scope of the disclosure is not limited thereto.
According to an embodiment of the present disclosure, an electroosmotic pump includes: a housing including a shaft hole; a membrane disposed between a first space arranged in a direction away from the shaft hole and a second space adjacent to the shaft hole; a first electrode body and a second electrode body arranged at opposite sides based on the membrane; a shaft extending to an outside of the housing through the shaft hole; and a first fluid included in an internal space of the housing.
The shaft may reciprocate in a first direction from the first space to the second space and in a second direction opposite to the first direction.
According to the embodiment, a volume of the first fluid may be less than a volume of the internal space.
According to the embodiment, the first fluid may be in the first space and the second space, and a volume of the first fluid in the first space may be less than a volume of the first space.
According to the embodiment, the first space may include a first sub-space occupied by the first fluid and a second sub-space, and the reciprocation of the shaft may be changed according to a ratio of the volume of the second sub-space with respect to the first space.
According to the embodiment, the electroosmotic pump may further include a second fluid in the second sub-space.
The first fluid may be a liquid and the second fluid may be a gas.
According to another embodiment of the present disclosure, an electroosmotic pump includes: a housing including a shaft hole in a side thereof; a shaft extending to an outside of the housing through the shaft hole; a membrane arranged in an internal space that is defined by an inner surface of the housing and the shaft; a first electrode body arranged at a first side of the membrane; a second electrode body arranged at a second side of the membrane, wherein the second side is opposite to the first side; and a fluid included in the internal space.
According to the embodiment, the internal space may include a first space and a second space at opposite sides of the membrane, the fluid may include a first fluid in the first space, and a volume of the first fluid in the first space may be less than a volume of the first space.
According to another embodiment of the present disclosure, an electroosmotic pump includes: a housing including a shaft hole; a membrane arranged between a first space disposed in a direction away from the shaft hole and a second space adjacent to the shaft hole; a first electrode body and a second electrode body arranged at opposite sides of the membrane; a shaft extending to an outside of the housing through the shaft hole; a deformation portion communicating with a side of the housing, in which the first space is formed, including a third space connecting to the first space, and being deformable; and a first fluid included in an internal space of the housing.
According to the embodiment, the electroosmotic pump may further include a second fluid in the first space and the third space, wherein the first fluid may be a liquid and the second fluid may be a gas.
Other aspects, features and advantages of the disclosure will become better understood through the accompanying drawings, the claims and the detailed description.
According to one or more embodiments, a reciprocating movement of a shaft may be finely controlled by using a pressure of a fluid.
Also, forward or backward movement of a shaft may be accurately controlled due to an elastic deformation of a deformation portion.
However, the above effects are exemplary and the scope of the present disclosure is not limited thereto.
As the present disclosure allows for various changes and numerous embodiments, particular embodiments will be illustrated in the drawings and described in detail in the written description. The attached drawings for illustrating one or more embodiments are referred to in order to gain a sufficient understanding, the merits thereof, and the objectives accomplished by the implementation. However, the embodiments may have different forms and should not be construed as being limited to the descriptions set forth herein.
The embodiments will be described below in more detail with reference to the accompanying drawings. Those components that are the same or are in correspondence are rendered the same reference numeral regardless of the figure number, and redundant explanations are omitted.
While such terms as “first,” “second,” etc., may be used to describe various components, such components are not be limited to the above terms. The above terms are used only to distinguish one component from another.
An expression used in the singular encompasses the expression of the plural, unless it has a clearly different meaning in the context.
In the present specification, it is to be understood that the terms “including,” “having,” and “comprising” are intended to indicate the existence of the feature or components disclosed in the specification, and are not intended to preclude the possibility that one or more other features or components may exist or may be added.
Sizes of components in the drawings may be exaggerated for convenience of explanation. In other words, since sizes and thicknesses of components in the drawings are arbitrarily illustrated for convenience of explanation, the following embodiments are not limited thereto.
In the embodiments below, it will be understood when areas or elements are referred to as being “connected,” they may be directly connected or an intervening portion may be present between areas or elements.
Referring to
A first portion 121 of the shaft 120 is in the housing 110, and a second portion 122 of the shaft 120 extends to the outside of the housing 110 after passing through the shaft hole 112H as described above. The shaft 120 may reciprocate in an up-and-down direction (Z-direction) in
The second portion 122 of the shaft 120 has a diameter R2 that is less than the diameter R3 of the shaft hole 112H, and in order to prevent the second portion 122 from falling out of the shaft hole 112H, the second portion 122 may be coupled to a movement controller 130 that is provided outside the housing 110.
A sealing material 125 may be disposed on a side surface of the first portion 121 of the shaft 120. The internal space of the housing 110, e.g., a space defined by an inner surface of the housing 110 and an inner surface of the shaft 120, is a sealed space, and there is a fluid in the internal space and the sealing material 125 may prevent leakage of the fluid through a gap between the housing 110 and the shaft 120. In
According to an embodiment, as shown in
A membrane 140 may be disposed in the internal space of the housing 110, e.g., the internal space corresponding to the main body 111. The internal space includes a first space S1 and a second space S2 that are at opposite sides of the membrane 140. In
The membrane 140 may have a porous structure through which the fluid and ions may pass. The membrane 140 may include, for example, a frit-type membrane that is fabricated by sintering spherical silica with heat. For example, the spherical silica used to form the membrane may have a diameter of about 20 nm to about 500 nm, for example, a diameter of about 30 nm to about 300 nm, and in particular, a diameter of about 40 nm to about 200 nm. When the diameter of the spherical silica satisfies the above range, a pressure caused by a first fluid passing through the membrane 140, that is, a sufficient pressure to move the shaft 120, may be generated.
In the above embodiment, the membrane 140 includes the spherical silica, but the membrane 140 is not limited thereto. In another embodiment, a kind of the material included in the membrane 40 is not particularly limited, provided that the material may cause an electrokinetic phenomenon due to zeta potential, for example, porous silica or porous alumina.
The membrane 140 may have a thickness of about 20 μm to about 10 mm, for example, about 300 μm to about 5 mm, and in particular, about 1000 μm to about 4 mm.
A first electrode body 150 and a second electrode body 160 are respectively arranged on opposite sides of the membrane 140. The first electrode body 150 may include a first porous plate 151 and a first electrode strip 152 arranged on a first side of the membrane 140. The second electrode body 160 may include a second porous plate 161 and a second electrode strip 162 arranged on a second side of the membrane 140.
The first and second porous plates 151 and 161 may be arranged to be respectively in contact with opposite main surfaces of the membrane 140. The first and second porous plates 151 and 161 may effectively move the fluid and ions through the porous structures. The first and second porous plates 151 and 161 may each have a structure in which an electrochemical reaction material is formed on a porous base layer. The electrochemical reaction material may be electrodeposited or coated on the porous base layer by a method, for example, electroless plating, vacuum deposition, coating, sol-gel processing, etc.
The porous base layer may include an insulator. For example, the porous base layer may include one or more selected from a non-conductive ceramic material, a non-conductive polymer resin, a non-conductive glass material, and a combination thereof.
The non-conductive ceramic material may include, but is not limited to, one or more selected from the group consisting of rock wool, gypsum, ceramics, cement, and a combination thereof, and in particular, one or more selected from the group consisting of rock wool, gypsum, and a combination thereof.
The non-conductive polymer resin may include, but is not limited to, one or more selected from the group consisting of: for example, synthetic fiber selected from the group consisting of polypropylene, polyethylene terephthalate, polyacrylonitrile, and a combination thereof; natural fiber selected from the group consisting of wool, cotton, and a combination thereof; a sponge; an organism, e.g., a porous material derived from a bone of an organism; and a combination thereof.
The non-conductive glass may include, but is not limited to, one or more selected from the group consisting of glass wool, glass frit, porous glass, and a combination thereof.
The porous base layer may have a pore size of about 0.1 μm to about 500 for example, about 5 μm to about 300 μm, and in particular, about 10 μm to about 200 μm. When the pore size of the porous support satisfies the above range, the fluid and ions may be effectively moved, to thereby improve stability, lifespan property, and efficiency of the pump 100.
The electrochemical reaction material may include a material that may generate a pair of reactions in which an oxidizing electrode and a reducing electrode exchange positive ions, e.g., hydrogen ions, during electrode reactions of the first and second electrode bodies 150 and 160, and at the same time, may constitute a reversible electrochemical reaction. The electrochemical reaction material may include one or more selected from the group consisting of, for example, silver/silver oxide, silver/silver chloride, MnO (OH), polyaniline, polypyrrole, polythiophene, polythionine, quinone-based polymer, and a combination thereof.
The first and second strips 152 and 162 may be arranged at edges of the first and second porous plates 151 and 161, and may be connected to first and second terminals 153 and 163 on the outside of the housing 110. The first and second strips 152 and 162 may include a conductive material such as silver, copper, etc.
The fluid included in the internal space of the housing 110 may include a first fluid and a second fluid having different phases from each other. The first fluid may include a liquid such as water, and the second fluid may include a gas such as air. The first fluid in the internal space does not entirely fill the internal space. That is, a volume of the internal space is greater than a volume of the first fluid in the internal space. In the internal space, the second fluid exists in the region where there is no water.
Sealing materials 170 are arranged at opposite sides of a structure including the membrane 140, the first electrode body 150, and the second electrode body 160. Each of the sealing materials 170 may have a loop shape having an area corresponding to the edge of the structure. The fluid, e.g., the first fluid, moves from the first space S1 to the second space S2 or in the reverse direction along a thickness direction of the membrane 140 so as to pass through the membrane 140, and the sealing material 170 blocks a gap between the inner surface of the housing 110 and the above structure to prevent the liquid from moving to the gap.
The fluid may enter the internal space through an injection port 180 as shown in
Hereinafter, the behavior of the fluid and movement of the shaft according to the behavior will be described with reference to
Referring to
In an embodiment, an example in which the silver/silver oxide is used as the electrochemical reaction material and the first fluid is a solution including water will be described.
As shown in
Cations (Mn+, e.g., hydrogen ions) generated according to the oxidation reaction in the first electrode body 150 move toward the second electrode body 160 through the membrane 140 due to a voltage difference, and at this time, water (H2O) moves together with the cations and a certain pressure may be generated.
After that, as shown in
Referring to
For example, the first fluid exists in each of the first and second spaces S1 and S2, and the first fluid and the second fluid coexist in the first space S1, while the volume of the first fluid in the first space S1 may be less than a volume of the first space S1. The first fluid also exists in the second space S2, but the second fluid does not exist in the second space S2, unlike in the first space S1. Hereinafter, for convenience of description, in the first space S1, a space in which the first fluid, that is, the liquid, exists is referred to as a first sub-space SS1 and a space in which the second fluid, that is, the gas, exists is referred to as a second sub-space SS2. The first sub-space SS1 and the second sub-space SS2 may constitute the first space S1. For example, in the first space S1, a remaining space except for the first sub-space SS1 may be the second sub-space SS2.
In the state of
On the contrary, when the power supply unit 200 changes the polarity of the voltage and supplies the voltage to the first and second electrode bodies 150 and 160 in the state of
When the power supply unit 200 alternately changes the polarity of the voltage supplied to the first and second electrode bodies 150 and 160, the shaft 120 moves in the first direction and then moves in the reverse direction, that is, in the second direction, and then, moves back in the first direction, that is, may reciprocate.
The reciprocating movement of the shaft 120 may be described as a change according to a ratio of the volume of the space in which the second fluid exists, that is, the volume of the second sub-space SS2, with respect to the first space S1.
When a ratio of the volume of the second sub-space SS2 with respect to the volume of the first space S1 (ratio=VSS2/VS1) in a state before the power supply unit 200 applies the voltage to the first and second electrode bodies 150 and 160, that is, a state before driving the pump 100, is referred to as “A”, the ratio increases to “B” during a forward stroke of the shaft 120, that is, when the shaft 120 moves in the first direction (A<B, A is greater than 0 and B is less than 1).
In a backward stroke, in the second direction, of the shaft 120 that has proceeded, the above ratio decreases from B to A, but the ratio is not less than A. When the ratio is less than A during the backward stroke, the shaft 120 enters the inside of the housing 110 further, or the encapsulation of the internal space of the housing 110 that is the sealed space is released, and thus, leakage of the fluid, etc. may occur.
The pump 100 described above with reference to
When the shaft 120 moves forward or backward, the second fluid (e.g., air) in the second sub-space SS2 may be slightly compressed or slightly expanded. A certain force may be stored in the second fluid according to the compression or expansion of the second fluid, and the force may be applied to the piston 120. An accurate control on the forward and backward strokes of the piston 120 may affect an injection dose of a drug in a drug injection device in which the pump 100 is used. Therefore, the forward and backward strokes of the piston 120 may be designed taking the above-described force into account. Alternatively, in order to accurately control the forward and backward strokes of the piston 120, the force stored in the second fluid may be removed. For example, as shown in
The main body 111 may include a first sub-main body 111A and a second sub-main body 111B. The first sub-main body 111A and the second sub-main body 111B are coupled to each other with the membranes 140 therebetween, and this structure may be also applied to the embodiment described above with reference to
The main body 111 may include the hole 111H. The hole 111H is located opposite to the second sub-main body 111B that accommodates the shaft 120, with the membrane 140 in the center therebetween. For example, the hole 111H may be formed in the first sub-main body 111A.
The hole 111H may be covered by the breathable film 190. Therefore, the second sub-space SS2 may not be spatially connected to the outer space due to the breathable film 190. The breathable film 190 may be formed at a location corresponding to the center of the first space S1. In
The breathable film 190 is a film that blocks the liquid and transmits the gas, and thus the first fluid (e.g., water) of the pump 100 does not pass through the breathable film 190. For example, the breathable film 190 may include, for example, Tyvek® from Dupont, Inc. On the contrary, the second fluid in the pump 100 or the external air may pass through the breathable film 190, and in this case, the force generated when the piston 120 moves forward and backward may be prevented from being stored in the second fluid.
Hereinafter, a structure, operating principles, and effects of the pump 100 according to another embodiment will be described below.
Referring to
Referring to
Referring to
In the state of
Here, the first fluid (e.g., H2O) in the first space S1 is moved with the cations in the first direction (−Z direction in
Referring to
Referring to
The main body 111, in particular, the hole 111H is formed in the first sub-main body 111A, and the hole 111H is located opposite to the second sub-main body 111B that accommodates the shaft 120, with the membrane 140 in the center therebetween.
Referring to
Referring to
The elastic portion 192 may deform according to an internal pressure of the internal space of the deformation portion 191, in particular, the internal pressure of the third space S3. Referring to
The elastic portion 192 may have an elastic recovery force in a direction in which the elastic portion 192 is convex toward the outer direction (upper direction in
When the first fluid (e.g., H2O) in the first space S1 moves to the second space S2, a ratio of the volume of the first sub-space SS1 with respect to the volume of the first space S1 is reduced, whereas a ratio occupied by the second sub-space SS2 in the first space S1 increases.
On the contrary, referring to
Referring to
In detail, as the elastic portion 192 is deformed from a concave shape to a convex shape toward the outer direction of the deformation portion 191, the volume of the third space S3 increases and the shaft 120 may be easily moved and easily compressed.
In addition, when the first space S1 and the third space S3 are compressed, the deformation portion 191, in particular, the elastic portion 192, has the elastic recovery force in a direction of being convex, and thus, the compression may be more easily performed.
In addition, when a gas is generated as the reaction shown in
As described above, referring to
In detail, the deformation portion 191 may be coupled to a side of the housing 110 (upper side in
The hole 111H is formed in one surface (upper surface in
Referring to
Referring to
When the reaction shown in
Referring to
In addition, the fixing member 193 may block leakage of the second fluid including the air from the third space S3, that is, the internal space of the deformation portion 191, to the outside.
The fixing member 195 is in close contact with an outer circumferential surface of the deformation portion 191 and may be installed on the housing 110.
Referring to
The inner circumferential surface of the deformation portion 191 is in close contact with the sealing wall 111W and the outer circumferential surface of the deformation portion 191 is in close contact with the fixing member 195 due to the sealing wall 111W, and thus, leakage of the fluid accommodated in the third space S3 to the outside may be prevented.
Referring to
The breathable film 195 is a film that blocks the liquid and transmits the gas, and thus the first fluid (e.g., water) of the pump 100 does not pass through the breathable film 190.
However, the second fluid in the pump 100 or the external air may pass through the breathable film 195, and in this case, the second fluid or the external air flows into the third space S3 that is the internal space of the deformation portion 191, and the force generated during the forward and backward movements of the shaft 120 may be prevented from being stored in the second fluid.
The pump 100 according to another embodiment of the present disclosure has the same structure, the same operating principles, and same effects as those of the pump 100 according to the embodiments of
Referring to
As such, when the first fluid moves between the third space S3 and the first space S1 in
In addition, the diameter HD1 of the hole 111H in the pump 100 according to another embodiment of the present disclosure may be equal to a diameter of the sealing wall 111W, and then, the first fluid may sufficiently fluid between the third space S3 and the first space S1.
The diameter HD1 or HD2 of the hole 111H according to one or more embodiments may be variously set.
The pump 100 according to one or more embodiments of the present disclosure described above with reference to
While the disclosure has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope as defined by the following claims. Therefore, the scope sought to be protected of the disclosure shall be defined by the appended claims.
According to the present disclosure, an electroosmotic pump is provided. Also, one or more embodiments of the present disclosure may be applied to an insulin injection device that is industrially used for injecting insulin into a human body to be suitable for a change in the blood sugar of a patient.
Number | Date | Country | Kind |
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10-2018-0096819 | Aug 2018 | KR | national |
10-2019-0101608 | Aug 2019 | KR | national |
Filing Document | Filing Date | Country | Kind |
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PCT/KR2019/010558 | 8/20/2019 | WO |
Publishing Document | Publishing Date | Country | Kind |
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WO2020/040519 | 2/27/2020 | WO | A |
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Entry |
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International Search Report and Written Opinion mailed Nov. 26, 2019 in International Application No. PCT/KR2019/010558 in 8 pages. (including English translation of the ISR). |
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Number | Date | Country | |
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20210196884 A1 | Jul 2021 | US |