Electrophoretic Nano-HA Coating for Improved Adhesion

Information

  • Research Project
  • 6947210
  • ApplicationId
    6947210
  • Core Project Number
    R44AR047278
  • Full Project Number
    5R44AR047278-04
  • Serial Number
    47278
  • FOA Number
    PA-02-25
  • Sub Project Id
  • Project Start Date
    9/15/2000 - 24 years ago
  • Project End Date
    8/31/2006 - 18 years ago
  • Program Officer Name
    QUATRANO, LOUIS A
  • Budget Start Date
    9/1/2005 - 19 years ago
  • Budget End Date
    8/31/2006 - 18 years ago
  • Fiscal Year
    2005
  • Support Year
    4
  • Suffix
  • Award Notice Date
    8/11/2005 - 19 years ago
Organizations

Electrophoretic Nano-HA Coating for Improved Adhesion

DESCRIPTION (provided by applicant): This proposed phase II program is expected to produce prototype hydroxyapatite ("HA") coated bone implants with significantly extended lifetime, fabricated using a room temperature electrophoretic deposition process. Novel HA nanocoatings with significantly increased adhesion strength and corrosion resistance under simulated body fluid in-vitro have been demonstrated in the Phase I work. The proposed Phase II program emphasizes developing prototype implant devices to rapidly commercialize this Phase I nanotechnology. The benefits of exceptional coating to substrate bond strength enable expansion of the HA nanocoatings market to hips, knees, and dental applications. Achieving 100% crystallinity and density at the HA substrate interface with electrophoretic deposited HA nanocoatings assures no degradation during implant service. Functionally graded HA nanocoatings can be generated at the HA tissue interface, thus promoting optimal bioactivity. The Phase II specific aims include scale up of the experimental HA bath nanocoating composition to pilot-scale production of prototype medical implants; demonstration of the HA nanoparticles coating on prototype medical implants, such as hip, knee, and dental implants; and demonstration of superior performance of the coated prototype devices with extended lifetime in-vivo, using an animal model. Phase II participants include Spire Corporation and the University of Texas at San Antonio.

IC Name
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
  • Activity
    R44
  • Administering IC
    AR
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    356910
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    846
  • Ed Inst. Type
  • Funding ICs
    NIAMS:356910\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    INFRAMAT CORPORATION
  • Organization Department
  • Organization DUNS
  • Organization City
    FARMINGTON
  • Organization State
    CT
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    060322597
  • Organization District
    UNITED STATES