Claims
- 1. An embolic composition comprising microspheres formed from macromers, wherein the macromers prior to crosslinking have a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups which are olefinically unsaturated groups, wherein the macromers are crosslinked via free-radical polymerization to form a hydrogel.
- 2. The embolic composition of claim 1, wherein the polymeric backbone comprises a polyhydroxy polymer.
- 3. The embolic composition of claim 1, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via the 1,2-diol or 1,3-diol groups.
- 4. The embolic composition of claim 3, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via cyclic acetal linkages.
- 5. The embolic composition of claim 1, wherein the polyhydroxy polymer comprises poly(vinyl alcohol) (PVA) and copolymers thereof.
- 6. The embolic composition of claim 1, wherein the macromers comprise units having the formula: in which R is a linear or branched C1-C8 alkylene or a linear or branched C1-C12 alkane;R1 is hydrogen, a C1-C6 alkyl, or a cycloalkyl; R2 is hydrogen or a C1-C6 alkyl; and R3 is an olefinically unsaturated electron attracting copolymerizable radical having up to 25 carbon atoms.
- 7. The embolic composition of claim 1, wherein the macromers further comprise pendant modifier groups.
- 8. The embolic composition of claim 1, further comprising an active agent.
- 9. The embolic composition of claim 1, wherein the hydrogel is biodegradable.
- 10. The embolic composition of claim 1, further comprising a contrast agent.
- 11. A method for embolization comprising administering the embolic composition of claim 1.
- 12. A method for embolization comprising administering the embolic composition of claim 6.
- 13. An embolic microsphere comprising a hydrogel, wherein the hydrogel is formed from macromers, wherein the macromers prior to crosslinking have a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups which are olefinically unsaturated groups, and wherein the macromers are crosslinked via free-radical polymerization to form the hydrogel.
- 14. The embolic microsphere of claim 13, wherein the polymeric backbone comprise a polyhydroxy polymer.
- 15. The embolic microsphere of claim 13, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via the 1,2-diol or 1,3-diol groups.
- 16. The embolic microsphere of claim 13, wherein the pendant chains bearing crosslinkable groups are attached to the backbone via cyclic acetal linkages.
- 17. The embolic microsphere of claim 13, wherein the polyhydroxy polymer comprises poly(vinyl alcohol) (PVA) and copolymers thereof.
- 18. The embolic microsphere of claim 13, wherein the macromers comprise units having the formula: in which R is a linear or branched C1-C8 alkylene or a linear or branched C1-C12 alkane;R1 is hydrogen, a C1-C6 alkyl, or a cycloalkyl; R2 is hydrogen or a C1-C6 alkyl; and R3 is an olefinically unsaturated electron attracting copolymerizable radical having up to 25 carbon atoms.
- 19. The embolic microsphere of claim 13, wherein the macromers further comprise pendant modifier groups.
RELATED APPLICATIONS
This application claims priority to U.S. Ser. No. 60/188,975, filed on Mar. 13, 2000, and U.S. Ser. No. 60/254,697, filed on Dec. 11, 2000.
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Provisional Applications (2)
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