Patent Grant
11751773
The standard of care in caregiver environments includes patient monitoring through spectroscopic analysis using, for example, a pulse oximeter. Devices capable of spectroscopic analysis generally include a light source(s) transmitting optical radiation into or reflecting off a measurement site, such as, body tissue carrying pulsing blood. After attenuation by tissue and fluids of the measurement site, a photodetection device(s) detects the attenuated light and outputs a detector signal(s) responsive to the detected attenuated light. A signal processing device(s) process the detector(s) signal(s) and outputs a measurement indicative of a blood constituent of interest, such as glucose, oxygen, met hemoglobin, total hemoglobin, other physiological parameters, or other data or combinations of data useful in determining a state or trend of wellness of a patient.
In noninvasive devices and methods, a sensor is often adapted to position a finger proximate the light source and light detector. For example, noninvasive sensors often include a clothespin-shaped housing that includes a contoured bed conforming generally to the shape of a finger. The contoured bed positions the finger for measurement and attempts to stabilize it.
Unfortunately, this type of contour cannot be ideal, especially for measuring blood constituents like glucose.
This disclosure describes embodiments of noninvasive methods, devices, and systems for measuring a blood analyte, such as oxygen, carbon monoxide, methemoglobin, total hemoglobin, glucose, proteins, glucose, lipids, a percentage thereof (e.g., saturation) or for measuring many other physiologically relevant patient characteristics. These characteristics can relate, for example, to pulse rate, hydration, trending information and analysis, and the like. In certain embodiments, a noninvasive sensor interfaces with tissue at a measurement site and deforms the tissue in a way that increases signal gain in certain desired wavelengths. In an embodiment, a protrusion can be provided in a finger bed of a noninvasive sensor for a patient's finger. The protrusion can reduce tissue thickness, thereby sometimes increasing signal gain by tens of times or even more. This protrusion can include different sizes and shapes depending on the tissue site and the desired blood analyte to be measured.
In disclosed embodiments, the protrusion is employed in noninvasive sensors to assist in measuring and detecting various analytes. The disclosed noninvasive sensor can also include, among other things, emitters and detectors positioned to produce multi-stream sensor information. The noninvasive senor can have different architectures and can include or be coupled to other components, such as a display device, a network interface, and the like. The protrusion can be employed in any type of noninvasive sensor.
In certain embodiments, a noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.
For purposes of summarizing the disclosure, certain aspects, advantages and novel features of the inventions have been described herein. It is to be understood that not necessarily all such advantages can be achieved in accordance with any particular embodiment of the inventions disclosed herein. Thus, the inventions disclosed herein can be embodied or carried out in a manner that achieves or optimizes one advantage or group of advantages as taught herein without necessarily achieving other advantages as can be taught or suggested herein.
Throughout the drawings, reference numbers can be re-used to indicate correspondence between referenced elements. The drawings are provided to illustrate embodiments of the inventions described herein and not to limit the scope thereof.
The present disclosure generally relates to non-invasive medical devices. In an embodiment, a physiological sensor includes a detector housing that can be coupled to a measurement site, such as a patient's finger. The sensor housing can include a curved bed that can generally conform to the shape of the measurement site. In addition, the curved bed can include a protrusion shaped to increase an amount of light radiation from the measurement site. In an embodiment, the protrusion is used to thin out the measurement site. This allows the light radiation to pass through less tissue, and accordingly is attenuated less. In an embodiment, the protrusion can be used to increase the area from which attenuated light can be measured. In an embodiment, this is done through the use of a lens which collects attenuated light exiting the measurement site and focuses onto one or more detectors. The protrusion can advantageously include plastic, including a hard opaque plastic, such as a black or other colored plastic, helpful in reducing light noise. In an embodiment, such light noise includes light that would otherwise be detected at a photodetector that has not been attenuated by tissue of the measurement site of a patient sufficient to cause the light to adequately included information indicative of one or more physiological parameters of the patient. Such light noise includes light piping.
In an embodiment, the protrusion can be formed from the curved bed, or can be a separate component that is positionable with respect to the bed. In an embodiment, a lens made from any appropriate material is used as the protrusion. The protrusion can be convex in shape. The protrusion can also be sized and shaped to conform the measurement site into a flat or relatively flat surface. The protrusion can also be sized to conform the measurement site into a rounded surface, such as, for example, a concave or convex surface. The protrusion can include a cylindrical or partially cylindrical shape. The protrusion can be sized or shaped differently for different types of patients, such as an adult, child, or infant. The protrusion can also be sized or shaped differently for different measurement sites, including, for example, a finger, toe, hand, foot, ear, forehead, or the like. The protrusion can thus be helpful in any type of noninvasive sensor. The external surface of the protrusion can include one or more openings or windows. The openings can be made from glass to allow attenuated light from a measurement site, such as a finger, to pass through to one or more detectors. Alternatively, some of all of the protrusion can be a lens, such as a partially cylindrical lens.
The sensor can also include a shielding, such as a metal enclosure as described below or embedded within the protrusion to reduce noise. The shielding can be constructed from a conductive material, such as copper, in the form of a metal cage or enclosure, such as a box. The shielding can include a second set of one or more openings or windows. The second set of openings can be made from glass and allow light that has passed through the first set of windows of the external surface of the protrusion to pass through to one or more detectors that can be enclosed, for example, as described below.
In various embodiments, the shielding can include any substantially transparent, conductive material placed in the optical path between an emitter and a detector. The shielding can be constructed from a transparent material, such as glass, plastic, and the like. The shielding can have an electrically conductive material or coating that is at least partially transparent. The electrically conductive coating can be located on one or both sides of the shielding, or within the body of the shielding. In addition, the electrically conductive coating can be uniformly spread over the shielding or may be patterned. Furthermore, the coating can have a uniform or varying thickness to increase or optimize its shielding effect. The shielding can be helpful in virtually any type of noninvasive sensor that employs spectroscopy.
In an embodiment, the sensor can also include a heat sink. In an embodiment, the heat sink can include a shape that is functional in its ability to dissipate excess heat and aesthetically pleasing to the wearer. For example, the heat sink can be configured in a shape that maximizes surface area to allow for greater dissipation of heat. In an embodiment, the heat sink includes a metalicized plastic, such as plastic including carbon and aluminum to allow for improved thermal conductivity and diffusivity. In an embodiment, the heat sink can advantageously be inexpensively molded into desired shapes and configurations for aesthetic and functional purposes. For example, the shape of the heat sink can be a generally curved surface and include one or more fins, undulations, grooves or channels, or combs.
In the present disclosure, a sensor can measure various blood analytes noninvasively using multi-stream spectroscopy. In an embodiment, the multi-stream spectroscopy can employ visible, infrared and near infrared wavelengths. As disclosed herein, the sensor is capable of noninvasively measuring blood analytes or percentages thereof (e.g., saturation) based on various combinations of features and components.
The sensor can include photocommunicative components, such as an emitter, a detector, and other components. The emitter can include a plurality of sets of optical sources that, in an embodiment, are arranged together as a point source. The various optical sources can emit a sequence of optical radiation pulses at different wavelengths towards a measurement site, such as a patient's finger. Detectors can then detect optical radiation from the measurement site. The optical sources and optical radiation detectors can operate at any appropriate wavelength, including, as discussed herein, infrared, near infrared, visible light, and ultraviolet. In addition, the optical sources and optical radiation detectors can operate at any appropriate wavelength, and such modifications to the embodiments desirable to operate at any such wavelength will be apparent to those skilled in the art. In certain embodiments, multiple detectors are employed and arranged in a spatial geometry. This spatial geometry provides a diversity of path lengths among at least some of the detectors and allows for multiple bulk and pulsatile measurements that are robust. Each of the detectors can provide a respective output stream based on the detected optical radiation, or a sum of output streams can be provided from multiple detectors. In some embodiments, the sensor can also include other components, such as one or more heat sinks and one or more thermistors.
The sensor can be coupled to one or more monitors that process and/or display the sensor's output. The monitors can include various components, such as a sensor front end, a signal processor, a display, etc.
The sensor can be integrated with a monitor, for example, into a handheld unit including the sensor, a display and user controls. In other embodiments, the sensor can communicate with one or more processing devices. The communication can be via wire(s), cable(s), flex circuit(s), wireless technologies, or other suitable analog or digital communication methodologies and devices to perform those methodologies. Many of the foregoing arrangements allow the sensor to be attached to the measurement site while the device is attached elsewhere on a patient, such as the patient's arm, or placed at a location near the patient, such as a bed, shelf or table. The sensor or monitor can also provide outputs to a storage device or network interface.
Reference will now be made to the Figures to discuss embodiments of the present disclosure.
The data collection system 100 can be capable of measuring optical radiation from the measurement site. For example, in some embodiments, the data collection system 100 can employ photodiodes defined in terms of area. In an embodiment, the area is from about 1 mm2-5 mm2 (or higher) that are capable of detecting about 100 nanoamps (nA) or less of current resulting from measured light at full scale. In addition to having its ordinary meaning, the phrase “at full scale” can mean light saturation of a photodiode amplifier (not shown). Of course, as would be understood by a person of skill in the art from the present disclosure, various other sizes and types of photodiodes can be used with the embodiments of the present disclosure.
The data collection system 100 can measure a range of approximately about 2 nA to about 100 nA full scale. The data collection system 100 can also include sensor front-ends that are capable of processing and amplifying current from the detector(s) at signal-to-noise ratios (SNRs) of about 100 decibels (dB) or more, such as about 120 dB in order to measure various desired analytes. The data collection system 100 can operate with a lower SNR if less accuracy is desired for an analyte like glucose.
The data collection system 100 can measure analyte concentrations, including glucose, at least in part by detecting light attenuated by a measurement site 102. The measurement site 102 can be any location on a patient's body, such as a finger, foot, ear lobe, or the like. For convenience, this disclosure is described primarily in the context of a finger measurement site 102. However, the features of the embodiments disclosed herein can be used with other measurement sites 102.
In the depicted embodiment, the system 100 includes an optional tissue thickness adjuster or tissue shaper 105, which can include one or more protrusions, bumps, lenses, or other suitable tissue-shaping mechanisms. In certain embodiments, the tissue shaper 105 is a flat or substantially flat surface that can be positioned proximate the measurement site 102 and that can apply sufficient pressure to cause the tissue of the measurement site 102 to be flat or substantially flat. In other embodiments, the tissue shaper 105 is a convex or substantially convex surface with respect to the measurement site 102. Many other configurations of the tissue shaper 105 are possible. Advantageously, in certain embodiments, the tissue shaper 105 reduces thickness of the measurement site 102 while preventing or reducing occlusion at the measurement site 102. Reducing thickness of the cite can advantageously reduce the amount of attenuation of the light because the there is less tissue through which the light must travel. Shaping the tissue in to a convex (or alternatively concave) surface can also provide more surface area from which light can be detected.
The embodiment of the data collection system 100 shown also includes an optional noise shield 103. In an embodiment, the noise shield 103 can be advantageously adapted to reduce electromagnetic noise while increasing the transmittance of light from the measurement site 102 to one or more detectors 106 (described below). For example, the noise shield 103 can advantageously include a conductive coated glass or metal grid electrically communicating with one or more other shields of the sensor 101. In an embodiment where the noise shield 103 includes conductive coated glass, the coating can advantageously include indium tin oxide. In an embodiment, the indium tin oxide includes a surface resistivity ranging from approximately from 30 ohms per square inch to 500 ohms per square inch. In an embodiment, the resistivity is approximately 30, 200, or 500 ohms per square inch. As would be understood by a person of skill in the art from the present disclosure, other resistivities can also be used which are less than 30 ohms or more than 500 ohms. Other conductive materials transparent or substantially transparent to light can be used instead.
In some embodiments, the measurement site 102 is somewhere along a non-dominant arm or a non-dominant hand, e.g., a right-handed person's left arm or left hand. In some patients, the non-dominant arm or hand can have less musculature and higher fat content, which can result in less water content in that tissue of the patient. Tissue having less water content can provide less interference with the particular wavelengths that are absorbed in a useful manner by blood analytes like glucose. Accordingly, in some embodiments, the data collection system 100 can be used on a person's non-dominant hand or arm.
The data collection system 100 can include a sensor 101 (or multiple sensors) that is coupled to a processing device or physiological monitor 109. In an embodiment, the sensor 101 and the monitor 109 are integrated together into a single unit. In another embodiment, the sensor 101 and the monitor 109 are separate from each other and communicate one with another in any suitable manner, such as via a wired or wireless connection. The sensor 101 and monitor 109 can be attachable and detachable from each other for the convenience of the user or caregiver, for ease of storage, sterility issues, or the like. The sensor 101 and the monitor 109 will now be further described.
In the depicted embodiment shown in
In some embodiments, the emitter 104 is used as a point optical source, and thus, the one or more optical sources of the emitter 104 can be located within a close distance to each other, such as within about a 2 mm to about 4 mm. The emitters 104 can be arranged in an array, such as is described in U.S. Publication No. 2006/0211924, filed Sep. 21, 2006, titled “Multiple Wavelength Sensor Emitters,” the disclosure of which is hereby incorporated by reference in its entirety. In particular, the emitters 104 can be arranged at least in part as described in paragraphs [0061] through [0068] of the aforementioned publication, which paragraphs are hereby incorporated specifically by reference. Other relative spatial relationships can be used to arrange the emitters 104.
For analytes like glucose, currently available non-invasive techniques often attempt to employ light near the water absorbance minima at or about 1600 nm. Typically, these devices and methods employ a single wavelength or single band of wavelengths at or about 1600 nm. However, to date, these techniques have been unable to adequately consistently measure analytes like glucose based on spectroscopy.
In contrast, the emitter 104 of the data collection system 100 can emit, in certain embodiments, combinations of optical radiation in various bands of interest. For example, in some embodiments, for analytes like glucose, the emitter 104 can emit optical radiation at three (3) or more wavelengths between about 1600 nm to about 1700 nm. In particular, the emitter 104 can emit optical radiation at or about 1610 nm, about 1640 nm, and about 1665 nm. In some circumstances, the use of three wavelengths within about 1600 nm to about 1700 nm enable sufficient SNRs of about 100 dB, which can result in a measurement accuracy of about 20 mg/DL or better for analytes like glucose.
In other embodiments, the emitter 104 can use two (2) wavelengths within about 1600 nm to about 1700 nm to advantageously enable SNRs of about 85 dB, which can result in a measurement accuracy of about 25-30 mg/DL or better for analytes like glucose. Furthermore, in some embodiments, the emitter 104 can emit light at wavelengths above about 1670 nm. Measurements at these wavelengths can be advantageously used to compensate or confirm the contribution of protein, water, and other non-hemoglobin species exhibited in measurements for analytes like glucose conducted between about 1600 nm and about 1700 nm. Of course, other wavelengths and combinations of wavelengths can be used to measure analytes and/or to distinguish other types of tissue, fluids, tissue properties, fluid properties, combinations of the same or the like.
For example, the emitter 104 can emit optical radiation across other spectra for other analytes. In particular, the emitter 104 can employ light wavelengths to measure various blood analytes or percentages (e.g., saturation) thereof. For example, in one embodiment, the emitter 104 can emit optical radiation in the form of pulses at wavelengths about 905 nm, about 1050 nm, about 1200 nm, about 1300 nm, about 1330 nm, about 1610 nm, about 1640 nm, and about 1665 nm. In another embodiment, the emitter 104 can emit optical radiation ranging from about 860 nm to about 950 nm, about 950 nm to about 1100 nm, about 1100 nm to about 1270 nm, about 1250 nm to about 1350 nm, about 1300 nm to about 1360 nm, and about 1590 nm to about 1700 nm. Of course, the emitter 104 can transmit any of a variety of wavelengths of visible or near-infrared optical radiation.
Due to the different responses of analytes to the different wavelengths, certain embodiments of the data collection system 100 can advantageously use the measurements at these different wavelengths to improve the accuracy of measurements. For example, the measurements of water from visible and infrared light can be used to compensate for water absorbance that is exhibited in the near-infrared wavelengths.
As briefly described above, the emitter 104 can include sets of light-emitting diodes (LEDs) as its optical source. The emitter 104 can use one or more top-emitting LEDs. In particular, in some embodiments, the emitter 104 can include top-emitting LEDs emitting light at about 850 nm to 1350 nm.
The emitter 104 can also use super luminescent LEDs (SLEDs) or side-emitting LEDs. In some embodiments, the emitter 104 can employ SLEDs or side-emitting LEDs to emit optical radiation at about 1600 nm to about 1800 nm. Emitter 104 can use SLEDs or side-emitting LEDs to transmit near infrared optical radiation because these types of sources can transmit at high power or relatively high power, e.g., about 40 mW to about 100 mW. This higher power capability can be useful to compensate or overcome the greater attenuation of these wavelengths of light in tissue and water. For example, the higher power emission can effectively compensate and/or normalize the absorption signal for light in the mentioned wavelengths to be similar in amplitude and/or effect as other wavelengths that can be detected by one or more photodetectors after absorption. Alternatively, the emitter 104 can use other types of sources of optical radiation, such as a laser diode, to emit near-infrared light into the measurement site 102.
In addition, in some embodiments, in order to assist in achieving a comparative balance of desired power output between the LEDs, some of the LEDs in the emitter 104 can have a filter or covering that reduces and/or cleans the optical radiation from particular LEDs or groups of LEDs. For example, since some wavelengths of light can penetrate through tissue relatively well, LEDs, such as some or all of the top-emitting LEDs can use a filter or covering, such as a cap or painted dye. This can be useful in allowing the emitter 104 to use LEDs with a higher output and/or to equalize intensity of LEDs.
The data collection system 100 also includes a driver 111 that drives the emitter 104. The driver 111 can be a circuit or the like that is controlled by the monitor 109. For example, the driver 111 can provide pulses of current to the emitter 104. In an embodiment, the driver 111 drives the emitter 104 in a progressive fashion, such as in an alternating manner. The driver 111 can drive the emitter 104 with a series of pulses of about 1 milliwatt (mW) for some wavelengths that can penetrate tissue relatively well and from about 40 mW to about 100 mW for other wavelengths that tend to be significantly absorbed in tissue. A wide variety of other driving powers and driving methodologies can be used in various embodiments.
The driver 111 can be synchronized with other parts of the sensor 101 and can minimize or reduce jitter in the timing of pulses of optical radiation emitted from the emitter 104. In some embodiments, the driver 111 is capable of driving the emitter 104 to emit optical radiation in a pattern that varies by less than about 10 parts-per-million.
The detectors 106 capture and measure light from the measurement site 102. For example, the detectors 106 can capture and measure light transmitted from the emitter 104 that has been attenuated or reflected from the tissue in the measurement site 102. The detectors 106 can output a detector signal 107 responsive to the light captured or measured. The detectors 106 can be implemented using one or more photodiodes, phototransistors, or the like.
In addition, the detectors 106 can be arranged with a spatial configuration to provide a variation of path lengths among at least some of the detectors 106. That is, some of the detectors 106 can have the substantially, or from the perspective of the processing algorithm, effectively, the same path length from the emitter 104. However, according to an embodiment, at least some of the detectors 106 can have a different path length from the emitter 104 relative to other of the detectors 106. Variations in path lengths can be helpful in allowing the use of a bulk signal stream from the detectors 106.
The front end interface 108 provides an interface that adapts the output of the detectors 106, which is responsive to desired physiological parameters. For example, the front end interface 108 can adapt a signal 107 received from one or more of the detectors 106 into a form that can be processed by the monitor 109, for example, by a signal processor 110 in the monitor 109. The front end interface 108 can have its components assembled in the sensor 101, in the monitor 109, in connecting cabling (if used), combinations of the same, or the like. The location of the front end interface 108 can be chosen based on various factors including space desired for components, desired noise reductions or limits, desired heat reductions or limits, and the like.
The front end interface 108 can be coupled to the detectors 106 and to the signal processor 110 using a bus, wire, electrical or optical cable, flex circuit, or some other form of signal connection. The front end interface 108 can also be at least partially integrated with various components, such as the detectors 106. For example, the front end interface 108 can include one or more integrated circuits that are on the same circuit board as the detectors 106. Other configurations can also be used.
The front end interface 108 can be implemented using one or more amplifiers, such as transimpedance amplifiers, that are coupled to one or more analog to digital converters (ADCs) (which can be in the monitor 109), such as a sigma-delta ADC. A transimpedance-based front end interface 108 can employ single-ended circuitry, differential circuitry, and/or a hybrid configuration. A transimpedance-based front end interface 108 can be useful for its sampling rate capability and freedom in modulation/demodulation algorithms. For example, this type of front end interface 108 can advantageously facilitate the sampling of the ADCs being synchronized with the pulses emitted from the emitter 104.
The ADC or ADCs can provide one or more outputs into multiple channels of digital information for processing by the signal processor 110 of the monitor 109. Each channel can correspond to a signal output from a detector 106.
In some embodiments, a programmable gain amplifier (PGA) can be used in combination with a transimpedance-based front end interface 108. For example, the output of a transimpedance-based front end interface 108 can be output to a PGA that is coupled with an ADC in the monitor 109. A PGA can be useful in order to provide another level of amplification and control of the stream of signals from the detectors 106. Alternatively, the PGA and ADC components can be integrated with the transimpedance-based front end interface 108 in the sensor 101.
In another embodiment, the front end interface 108 can be implemented using switched-capacitor circuits. A switched-capacitor-based front end interface 108 can be useful for, in certain embodiments, its resistor-free design and analog averaging properties. In addition, a switched-capacitor-based front end interface 108 can be useful because it can provide a digital signal to the signal processor 110 in the monitor 109.
As shown in
The signal processor 110 can provide various signals that control the operation of the sensor 101. For example, the signal processor 110 can provide an emitter control signal to the driver 111. This control signal can be useful in order to synchronize, minimize, or reduce jitter in the timing of pulses emitted from the emitter 104. Accordingly, this control signal can be useful in order to cause optical radiation pulses emitted from the emitter 104 to follow a precise timing and consistent pattern. For example, when a transimpedance-based front end interface 108 is used, the control signal from the signal processor 110 can provide synchronization with the ADC in order to avoid aliasing, cross-talk, and the like. As also shown, an optional memory 113 can be included in the front-end interface 108 and/or in the signal processor 110. This memory 113 can serve as a buffer or storage location for the front-end interface 108 and/or the signal processor 110, among other uses.
The user interface 112 can provide an output, e.g., on a display, for presentation to a user of the data collection system 100. The user interface 112 can be implemented as a touch-screen display, an LCD display, an organic LED display, or the like. In addition, the user interface 112 can be manipulated to allow for measurement on the non-dominant side of patient. For example, the user interface 112 can include a flip screen, a screen that can be moved from one side to another on the monitor 109, or can include an ability to reorient its display indicia responsive to user input or device orientation. In alternative embodiments, the data collection system 100 can be provided without a user interface 112 and can simply provide an output signal to a separate display or system.
A storage device 114 and a network interface 116 represent other optional output connections that can be included in the monitor 109. The storage device 114 can include any computer-readable medium, such as a memory device, hard disk storage, EEPROM, flash drive, or the like. The various software and/or firmware applications can be stored in the storage device 114, which can be executed by the signal processor 110 or another processor of the monitor 109. The network interface 116 can be a serial bus port (RS-232/RS-485), a Universal Serial Bus (USB) port, an Ethernet port, a wireless interface (e.g., WiFi such as any 802.1x interface, including an internal wireless card), or other suitable communication device(s) that allows the monitor 109 to communicate and share data with other devices. The monitor 109 can also include various other components not shown, such as a microprocessor, graphics processor, or controller to output the user interface 112, to control data communications, to compute data trending, or to perform other operations.
Although not shown in the depicted embodiment, the data collection system 100 can include various other components or can be configured in different ways. For example, the sensor 101 can have both the emitter 104 and detectors 106 on the same side of the measurement site 102 and use reflectance to measure analytes. The data collection system 100 can also include a sensor that measures the power of light emitted from the emitter 104.
Referring specifically to
The sensor 201a can be constructed of white material used for reflective purposes (such as white silicone or plastic), which can increase usable signal at the detector 106 by forcing light back into the sensor 201a. Pads in the emitter shell 204a and the detector shell 206a can contain separated windows to prevent or reduce mixing of light signals, for example, from distinct quadrants on a patient's finger. In addition, these pads can be made of a relatively soft material, such as a gel or foam, in order to conform to the shape, for example, of a patient's finger. The emitter shell 204a and the detector shell 206a can also include absorbing black or grey material portions to prevent or reduce ambient light from entering into the sensor 201a.
In some embodiments, some or all portions of the emitter shell 204a and/or detector shell 206a can be detachable and/or disposable. For example, some or all portions of the shells 204a and 206a can be removable pieces. The removability of the shells 204a and 206a can be useful for sanitary purposes or for sizing the sensor 201a to different patients. The monitor 209a can include a fitting, slot, magnet, or other connecting mechanism to allow the sensor 201c to be removably attached to the monitor 209a.
The monitoring device 200a also includes optional control buttons 208a and a display 210a that can allow the user to control the operation of the device. For example, a user can operate the control buttons 208a to view one or more measurements of various analytes, such as glucose. In addition, the user can operate the control buttons 208a to view other forms of information, such as graphs, histograms, measurement data, trend measurement data, parameter combination views, wellness indications, and the like. Many parameters, trends, alarms and parameter displays could be output to the display 210a, such as those that are commercially available through a wide variety of noninvasive monitoring devices from Masimo® Corporation of Irvine, Calif.
Furthermore, the controls 208a and/or display 210a can provide functionality for the user to manipulate settings of the monitoring device 200a, such as alarm settings, emitter settings, detector settings, and the like. The monitoring device 200a can employ any of a variety of user interface designs, such as frames, menus, touch-screens, and any type of button.
The cable 212 connecting the sensor 201b and the monitor 209b can be implemented using one or more wires, optical fiber, flex circuits, or the like. In some embodiments, the cable 212 can employ twisted pairs of conductors in order to minimize or reduce cross-talk of data transmitted from the sensor 201b to the monitor 209b. Various lengths of the cable 212 can be employed to allow for separation between the sensor 201b and the monitor 209b. The cable 212 can be fitted with a connector (male or female) on either end of the cable 212 so that the sensor 201b and the monitor 209b can be connected and disconnected from each other. Alternatively, the sensor 201b and the monitor 209b can be coupled together via a wireless communication link, such as an infrared link, radio frequency channel, or any other wireless communication protocol and channel.
The monitor 209b can be attached to the patient. For example, the monitor 209b can include a belt clip or straps (see, e.g.,
The monitor 209b can also include other components, such as a speaker, power button, removable storage or memory (e.g., a flash card slot), an AC power port, and one or more network interfaces, such as a universal serial bus interface or an Ethernet port. For example, the monitor 209b can include a display 210b that can indicate a measurement for glucose, for example, in mg/dL. Other analytes and forms of display can also appear on the monitor 209b.
In addition, although a single sensor 201b with a single monitor 209b is shown, different combinations of sensors and device pairings can be implemented. For example, multiple sensors can be provided for a plurality of differing patient types or measurement sites or even patient fingers.
Referring to
In an embodiment, the pivot point 303a advantageously includes a pivot capable of adjusting the relationship between the emitter and detector shells 304a, 306a to effectively level the sections when applied to a tissue site. In another embodiment, the sensor 301a includes some or all features of the finger clip described in U.S. Publication No. 2006/0211924, incorporated above, such as a spring that causes finger clip forces to be distributed along the finger. Paragraphs [0096] through [0105], which describe this feature, are hereby specifically incorporated by reference.
The emitter shell 304a can position and house various emitter components of the sensor 301a. It can be constructed of reflective material (e.g., white silicone or plastic) and/or can be metallic or include metalicized plastic (e.g., including carbon and aluminum) to possibly serve as a heat sink. The emitter shell 304a can also include absorbing opaque material, such as, for example, black or grey colored material, at various areas, such as on one or more flaps 307a, to reduce ambient light entering the sensor 301a.
The detector shell 306a can position and house one or more detector portions of the sensor 301a. The detector shell 306a can be constructed of reflective material, such as white silicone or plastic. As noted, such materials can increase the usable signal at a detector by forcing light back into the tissue and measurement site (see
Referring to
Finger bed 310 can also include an embodiment of a tissue thickness adjuster or protrusion 305. The protrusion 305 includes a measurement site contact area 370 (see
Referring specifically to
The windows 320, 321, 322, and 323 can also include shielding, such as an embedded grid of wiring or a conductive glass coating, to reduce noise from ambient light or other electromagnetic noise. The windows 320, 321, 322, and 323 can be made from materials, such as plastic or glass. In some embodiments, the windows 320, 321, 322, and 323 can be constructed from conductive glass, such as indium tin oxide (ITO) coated glass. Conductive glass can be useful because its shielding is transparent, and thus allows for a larger aperture versus a window with an embedded grid of wiring. In addition, in certain embodiments, the conductive glass does not need openings in its shielding (since it is transparent), which enhances its shielding performance. For example, some embodiments that employ the conductive glass can attain up to an about 40% to about 50% greater signal than non-conductive glass with a shielding grid. In addition, in some embodiments, conductive glass can be useful for shielding noise from a greater variety of directions than non-conductive glass with a shielding grid.
Turning to
In an embodiment, the photodetectors can be positioned within or directly beneath the protrusion 305 (see
In an embodiment, the protrusion 305 can include a pliant material, including soft plastic or rubber, which can somewhat conform to the shape of a measurement site. Pliant materials can improve patient comfort and tactility by conforming the measurement site contact area 370 to the measurement site. Additionally, pliant materials can minimize or reduce noise, such as ambient light. Alternatively, the protrusion 305 can be made from a rigid material, such as hard plastic or metal.
Rigid materials can improve measurement accuracy of a blood analyte by conforming the measurement site to the contact area 370. The contact area 370 can be an ideal shape for improving accuracy or reducing noise. Selecting a material for the protrusion 305 can include consideration of materials that do not significantly alter blood flow at the measurement site. The protrusion 305 and the contact area 370 can include a combination of materials with various characteristics.
The contact area 370 serves as a contact surface for the measurement site. For example, in some embodiments, the contact area 370 can be shaped for contact with a patient's finger. Accordingly, the contact area 370 can be sized and shaped for different sizes of fingers. The contact area 370 can be constructed of different materials for reflective purposes as well as for the comfort of the patient. For example, the contact area 370 can be constructed from materials having various hardness and textures, such as plastic, gel, foam, and the like.
The formulas and analysis that follow with respect to
Referring to
According to the Beer Lambert law, a transmittance of light (I) can be expressed as follows: I=Io*e−m*b*c, where Io is the initial power of light being transmitted, m is the path length traveled by the light, and the component “b*c” corresponds to the bulk absorption of the light at a specific wavelength of light. For light at about 1600 nm to about 1700 nm, for example, the bulk absorption component is generally around 0.7 mm−1. Assuming a typical finger thickness of about 12 mm and a mean path length of 20 mm due to tissue scattering, then I=Io*e(−20*0.7).
In an embodiment where the protrusion 305 is a convex bump, the thickness of the finger can be reduced to 10 mm (from 12 mm) for some fingers and the effective light mean path is reduced to about 16.6 mm from 20 mm (see box 510). This results in a new transmittance, I1=Io*e(−16.6*0.7). A curve for a typical finger (having a mean path length of 20 mm) across various wavelengths is shown in the plot 500 of
The contribution of a the protrusion 305 to increased SNR cannot have been previously recognized by persons having ordinary skill in the art at least in part because currently available devices can have been concerned primarily with conforming to the measurement site for patient comfort. In addition, for light in the visible range and infrared range, or in other words, at the wavelengths of many previous devices, the bulk absorption of light component in the finger is generally much lower at around 0.1 mm−1. Therefore, the same change in thickness increases intensity by, for example, e(−16.6*0.1)/e(−20*0.1), which results in about a 1.5 times increase. In currently available devices, such an impact cannot have been significant enough to warrant overriding other considerations, such as patient comfort. It should be noted, however, that the various protrusion 305 designs disclosed herein can increase SNR while also preserving patient comfort.
Turning again to
In some embodiments, the heat sink 350a includes metalicized plastic. The metalicized plastic can include aluminum and carbon, for example. The material can allow for improved thermal conductivity and diffusivity, which can increase commercial viability of the heat sink. In some embodiments, the material selected to construct the heat sink 350a can include a thermally conductive liquid crystalline polymer, such as CoolPoly® D5506, commercially available from Cool Polymers®, Inc. of Warwick, R.I. Such a material can be selected for its electrically non-conductive and dielectric properties so as, for example, to aid in electrical shielding. In an embodiment, the heat sink 350a provides improved heat transfer properties when the sensor 301a is active for short intervals of less than a full day's use. In an embodiment, the heat sink 350a can advantageously provide improved heat transfers in about three (3) to about four (4) minute intervals, for example, although a heat sink 350a can be selected that performs effectively in shorter or longer intervals.
Moreover, the heat sink 350a can have different shapes and configurations for aesthetic as well as for functional purposes. In an embodiment, the heat sink is configured to maximize heat dissipation, for example, by maximizing surface area. In an embodiment, the heat sink 350a is molded into a generally curved surface and includes one or more fins, undulations, grooves, or channels. The example heat sink 350a shown includes fins 351a (see
An alternative shape of a sensor 301b and heat sink 350b is shown in
However, the shape of the sensor 301b is different in this embodiment. In particular, the heat sink 350b includes comb protrusions 351b. The comb protrusions 351b are exposed to the air in a similar manner to the fins 351a of the heat sink 350a, thereby facilitating efficient cooling of the sensor 301b.
As shown, the detector shell 306b includes detectors 316. The detectors 316 can have a predetermined spacing 340 from each other, or a spatial relationship among one another that results in a spatial configuration. This spatial configuration can purposefully create a variation of path lengths among detectors 316 and the emitter discussed above.
In the depicted embodiment, the detector shell 316 can hold multiple (e.g., two, three, four, etc.) photodiode arrays that are arranged in a two-dimensional grid pattern. Multiple photodiode arrays can also be useful to detect light piping (e.g., light that bypasses measurement site 102). In the detector shell 316, walls can be provided to separate the individual photodiode arrays to prevent or reduce mixing of light signals from distinct quadrants. In addition, the detector shell 316 can be covered by windows of transparent material, such as glass, plastic, or the like, to allow maximum or increased transmission of power light captured. In various embodiments, the transparent materials used can also be partially transparent or translucent or can otherwise pass some or all of the optical radiation passing through them. As noted, this window can include some shielding in the form of an embedded grid of wiring, or a conductive layer or coating.
As further illustrated by
In addition to these features, the sensor 301f includes a flex circuit cover 360, which can be made of plastic or another suitable material. The flex circuit cover 360 can cover and thereby protect a flex circuit (not shown) that extends from the emitter shell 304f to the detector shell 306f. An example of such a flex circuit is illustrated in U.S. Publication No. 2006/0211924, incorporated above (see
The protrusion 405 can have dimensions that are suitable for a measurement site such as a patient's finger. As shown, the protrusion 405 can have a length 400, a width 410, and a height 430. The length 400 can be from about 9 to about 11 millimeters, e.g., about 10 millimeters. The width 410 can be from about 7 to about 9 millimeters, e.g., about 8 millimeters. The height 430 can be from about 0.5 millimeters to about 3 millimeters, e.g., about 2 millimeters. In an embodiment, the dimensions 400, 410, and 430 can be selected such that the measurement site contact area 470 includes an area of about 80 square millimeters, although larger and smaller areas can be used for different sized tissue for an adult, an adolescent, or infant, or for other considerations.
The measurement site contact area 470 can also include differently shaped surfaces that conform the measurement site into different shapes. For example, the measurement site contact area 470 can be generally curved and/or convex with respect to the measurement site. The measurement site contact area 470 can be other shapes that reduce or even minimize air between the protrusion 405 and or the measurement site. Additionally, the surface pattern of the measurement site contact area 470 can vary from smooth to bumpy, e.g., to provide varying levels of grip.
In
Advantageously, in certain embodiments, placing the partially cylindrical protrusion 605 over the photodiodes in any of the sensors described above adds multiple benefits to any of the sensors described above. In one embodiment, the partially cylindrical protrusion 605 penetrates into the tissue and reduces the pathlength of the light traveling in the tissue, similar to the protrusions described above.
The partially cylindrical protrusion 605 can also collect light from a large surface and focus down the light to a smaller area. As a result, in certain embodiments, signal strength per area of the photodiode can be increased. The partially cylindrical protrusion 605 can therefore facilitate a lower cost sensor because, in certain embodiments, less photodiode area can be used to obtain the same signal strength. Less photodiode area can be realized by using smaller photodiodes or fewer photodiodes (see, e.g.,
The dimensions of the partially cylindrical protrusion 605 can vary based on, for instance, a number of photodiodes used with the sensor. Referring to
Referring to
In certain embodiments, the focal length (f) for the partially
cylindrical protrusion 605 can be expressed as: where R is the radius of curvature of the partial cylinder 608 and n is the index of refraction of the material used. In certain embodiments, the radius of curvature can be between about 1.5 mm and about 2 mm. In another embodiment, the partially cylindrical protrusion 605 can include a material, such as nBK7 glass, with an index of refraction of around 1.5 at 1300 nm, which can provide focal lengths of between about 3 mm and about 4 mm.
A partially cylindrical protrusion 605 having a material with a higher index of refraction such as nSF11 glass (e.g., n=1.75 at 1300 nm) can provide a shorter focal length and possibly a smaller photodiode chip, but can also cause higher reflections due to the index of refraction mismatch with air. Many types of glass or plastic can be used with index of refraction values ranging from, for example, about 1.4 to about 1.9. The index of refraction of the material of the protrusion 605 can be chosen to improve or optimize the light focusing properties of the protrusion 605. A plastic partially cylindrical protrusion 605 could provide the cheapest option in high volumes but can also have some undesired light absorption peaks at wavelengths higher than 1500 nm. Other focal lengths and materials having different indices of refraction can be used for the partially cylindrical protrusion 605.
Placing a photodiode at a given distance below the partially cylindrical protrusion 605 can facilitate capturing some or all of the light traveling perpendicular to the lens within the active area of the photodiode (see
The example of finger bed 310f shown also includes the protrusion 605b, which includes the features of the protrusion 605 described above. In addition, the protrusion 605b also includes chamfered edges 607 on each end to provide a more comfortable surface for a finger to slide across (see also
The protrusion 605b also includes a measurement site contact area 670 that can contact body tissue of a measurement site. The protrusion 605b can be removed from or integrated with the finger bed 310f. Interchangeable, differently shaped protrusions 605b can also be provided, which can correspond to different finger shapes, characteristics, opacity, sizes, or the like.
For example, referring specifically to
During operation, a finger 102 can be placed on the tissue bed 710a and optical radiation can be emitted from the LEDs 104. Light can then be attenuated as it passes through or is reflected from the tissue of the finger 102. The attenuated light can then pass through the opening 703a in the tissue bed 710a. Based on the received light, the detectors 106 can provide a detector signal 107, for example, to the front end interface 108 (see
In the depicted embodiment, the conductive glass 730 is provided in the opening 703. The conductive glass 730 can thus not only permit light from the finger to pass to the detectors 106, but it can also supplement the shielding of the detectors 106 from noise. The conductive glass 730 can include a stack or set of layers. In
In an embodiment, the conductive glass 730a can be coated with a conductive, transparent or partially transparent material, such as a thin film of indium tin oxide (ITO). To supplement electrical shielding effects of a shielding enclosure 790a, the conductive glass 730a can be electrically coupled to the shielding enclosure 790a. The conductive glass 730a can be electrically coupled to the shielding 704a based on direct contact or via other connection devices, such as a wire or another component.
The shielding enclosure 790a can be provided to encompass the detectors 106 to reduce or prevent noise. For example, the shielding enclosure 790a can be constructed from a conductive material, such as copper, in the form of a metal cage. The shielding or enclosure a can include an opaque material to not only reduce electrical noise, but also ambient optical noise.
Referring to
A shielding enclosure 790b is also provided, which can have all the features of the shielding enclosure 790a. The shielding enclosure 790b is smaller than the shielding enclosure 790a; however, a variety of sizes can be selected for the shielding enclosures 790.
Although the conductive material 733 is shown spread over the surface of the glass layer 731, the conductive material 733 can be patterned or provided on selected portions of the glass layer 731. Furthermore, the conductive material 733 can have uniform or varying thickness depending on a desired transmission of light, a desired shielding effect, and other considerations.
In
In
Other configurations and patterns for the conductive material can be used in certain embodiments, such as, for example, a conductive coating lining periphery edges, a conductive coating outlaid in a pattern including a grid or other pattern, a speckled conductive coating, coating outlaid in lines in either direction or diagonally, varied thicknesses from the center out or from the periphery in, or other suitable patterns or coatings that balance the shielding properties with transparency considerations.
A line 915 on the graph 900 illustrates example light transmission of a window made from plain glass. As shown, the light transmission percentage of varying wavelengths of light is approximately 90% for a window made from plain glass. A line 920 on the graph 900 demonstrates an example light transmission percentage for an embodiment in which a window is made from glass having an ITO coating with a surface resistivity of 500 ohms per square inch. A line 925 on the graph 900 shows an example light transmission for an embodiment in which a window is made from glass that includes a coating of ITO oxide with a surface resistivity of 200 ohms per square inch. A line 930 on the graph 900 shows an example light transmission for an embodiment in which a window is made from glass that includes a coating of ITO oxide with a surface resistivity of 30 ohms per square inch.
The light transmission percentage for a window with currently available embedded wiring can have a light transmission percentage of approximately 70%. This lower percentage of light transmission can be due to the opacity of the wiring employed in a currently available window with wiring. Accordingly, certain embodiments of glass coatings described herein can employ, for example, ITO coatings with different surface resistivity depending on the desired light transmission, wavelengths of light used for measurement, desired shielding effect, and other criteria.
In
The thermistor 1120 can be provided to compensate for temperature variations. For example, the thermistor 1120 can be provided to allow for wavelength centroid and power drift of LEDs 1102 and 1104 due to heating. In addition, other thermistors (not shown) can be employed, for example, to measure a temperature of a measurement site. Such a temperature can be helpful in correcting for wavelength drift due to changes in water absorption, which can be temperature dependent, thereby providing more accurate data useful in detecting blood analytes like glucose.
The driver 1105 can provide pulses of current to the emitter 1104. In an embodiment, the driver 1105 drives the emitter 1104 in a progressive fashion, for example, in an alternating manner based on a control signal from, for example, a processor (e.g., the processor 110). For example, the driver 1105 can drive the emitter 1104 with a series of pulses to about 1 milliwatt (mW) for visible light to light at about 1300 nm and from about 40 mW to about 100 mW for light at about 1600 nm to about 1700 nm. However, a wide number of driving powers and driving methodologies can be used. The driver 1105 can be synchronized with other parts of the sensor and can minimize or reduce any jitter in the timing of pulses of optical radiation emitted from the emitter 1104. In some embodiments, the driver 1105 is capable of driving the emitter 1104 to emit an optical radiation in a pattern that varies by less than about 10 parts-per-million; however other amounts of variation can be used.
The submount 1106 provides a support structure in certain embodiments for aligning the top-emitting LEDs 1102 and the side-emitting LEDs 1104 so that their optical radiation is transmitted generally towards the measurement site. In some embodiments, the submount 1106 is also constructed of aluminum nitride (AlN) or beryllium oxide (BEO) for heat dissipation, although other materials or combinations of materials suitable for the submount 1106 can be used.
The detectors include photodiode detectors 1-4 that are arranged in a grid pattern on the submount 1200 to capture light at different quadrants from the measurement site. As noted, other patterns of photodiodes, such as a linear row, or logarithmic row, can also be employed in certain embodiments.
In response to the pulse sequence 1300, detectors 1 to n (n being an integer) in a detector 1306 capture optical radiation from the measurement site 1302 and provide respective streams of output signals. Each signal from one of detectors 1-n can be considered a stream having respective time slots corresponding to the optical pulses from emitter sets 1-n in the emitter 1304. Although n emitters and n detectors are shown, the number of emitters and detectors need not be the same in certain implementations.
A front end interface 1308 can accept these multiple streams from detectors 1-n and deliver one or more signals or composite signal(s) back to the signal processor 1310. A stream from the detectors 1-n can thus include measured light intensities corresponding to the light pulses emitted from the emitter 1304.
The signal processor 1310 can then perform various calculations to measure the amount of glucose and other analytes based on these multiple streams of signals. In order to help explain how the signal processor 1310 can measure analytes like glucose, a primer on the spectroscopy employed in these embodiments will now be provided.
Spectroscopy is premised upon the Beer-Lambert law. According to this law, the properties of a material, e.g., glucose present in a measurement site, can be deterministically calculated from the absorption of light traveling through the material. Specifically, there is a logarithmic relation between the transmission of light through a material and the concentration of a substance and also between the transmission and the length of the path traveled by the light. As noted, this relation is known as the Beer-Lambert law.
The Beer-Lambert law is usually written as:
Absorbance A=m*b*c, where:
m is the wavelength-dependent molar absorptivity coefficient (usually expressed in units of M−1 cm−1);
b is the mean path length; and
c is the analyte concentration (e.g., the desired parameter).
In spectroscopy, instruments attempt to obtain the analyte concentration (c) by relating absorbance (A) to transmittance (T). Transmittance is a proportional value defined as:
T=I/Io, where:
I is the light intensity measured by the instrument from the measurement site; and
Io is the initial light intensity from the emitter.
Absorbance (A) can be equated to the transmittance (T) by the equation:
A=−log T
Therefore, substituting equations from above:
A=−log(I/Io)
In view of this relationship, spectroscopy thus relies on a proportional-based calculation of −log(I/Io) and solving for analyte concentration (c).
Typically, in order to simplify the calculations, spectroscopy will use detectors that are at the same location in order to keep the path length (b) a fixed, known constant. In addition, spectroscopy will employ various mechanisms to definitively know the transmission power (Io), such as a photodiode located at the light source. This architecture can be viewed as a single channel or single stream sensor, because the detectors are at a single location.
However, this scheme can encounter several difficulties in measuring analytes, such as glucose. This can be due to the high overlap of absorption of light by water at the wavelengths relevant to glucose as well as other factors, such as high self-noise of the components.
Embodiments of the present disclosure can employ a different approach that in part allows for the measurement of analytes like glucose. Some embodiments can employ a bulk, non-pulsatile measurement in order to confirm or validate a pulsatile measurement. In addition, both the non-pulsatile and pulsatile measurements can employ, among other things, the multi-stream operation described above in order to attain sufficient SNR. In particular, a single light source having multiple emitters can be used to transmit light to multiple detectors having a spatial configuration.
A single light source having multiple emitters can allow for a range of wavelengths of light to be used. For example, visible, infrared, and near infrared wavelengths can be employed. Varying powers of light intensity for different wavelengths can also be employed.
Secondly, the use of multiple-detectors in a spatial configuration allow for a bulk measurement to confirm or validate that the sensor is positioned correctly. This is because the multiple locations of the spatial configuration can provide, for example, topology information that indicates where the sensor has been positioned. Currently available sensors do not provide such information. For example, if the bulk measurement is within a predetermined range of values, then this can indicate that the sensor is positioned correctly in order to perform pulsatile measurements for analytes like glucose. If the bulk measurement is outside of a certain range or is an unexpected value, then this can indicate that the sensor should be adjusted, or that the pulsatile measurements can be processed differently to compensate, such as using a different calibration curve or adjusting a calibration curve. This feature and others allow the embodiments to achieve noise cancellation and noise reduction, which can be several times greater in magnitude that what is achievable by currently available technology.
In order to help illustrate aspects of the multi-stream measurement approach, the following example derivation is provided. Transmittance (T) can be expressed as:
T=e−m*b*c
In terms of light intensity, this equation can also be rewritten as:
I/Io=e−m*b*c
Or, at a detector, the measured light (I) can be expressed as:
I=Io*e−m*b*c
As noted, in the present disclosure, multiple detectors (1 to n) can be employed, which results in I1 . . . In streams of measurements. Assuming each of these detectors have their own path lengths, b1 . . . bn, from the light source, the measured light intensities can be expressed as:
In=Ioe−m*b
The measured light intensities at any two different detectors can be referenced to each other. For example:
I1/In=(Io*e−mb
As can be seen, the terms, Io, cancel out and, based on exponent algebra, the equation can be rewritten as:
I1/In=e−m(b
From this equation, the analyte concentration (c) can now be derived from bulk signals I1 . . . In and knowing the respective mean path lengths b1 and bn. This scheme also allows for the cancelling out of Io, and thus, noise generated by the emitter 1304 can be cancelled out or reduced. In addition, since the scheme employs a mean path length difference, any changes in mean path length and topological variations from patient to patient are easily accounted. Furthermore, this bulk-measurement scheme can be extended across multiple wavelengths. This flexibility and other features allow embodiments of the present disclosure to measure blood analytes like glucose.
For example, as noted, the non-pulsatile, bulk measurements can be combined with pulsatile measurements to more accurately measure analytes like glucose. In particular, the non-pulsatile, bulk measurement can be used to confirm or validate the amount of glucose, protein, etc. in the pulsatile measurements taken at the tissue at the measurement site(s) 1302. The pulsatile measurements can be used to measure the amount of glucose, hemoglobin, or the like that is present in the blood. Accordingly, these different measurements can be combined to thus determine analytes like blood glucose.
To illustrate, in some sensors that do not include the partially cylindrical protrusion 605, sixteen detectors can be used, including four rows of four detectors each. Multiple rows of detectors can be used to measure certain analytes, such as glucose or total hemoglobin, among others. Multiple rows of detectors can also be used to detect light piping (e.g., light that bypasses the measurement site). However, using more detectors in a sensor can add cost, complexity, and noise to the sensor.
Applying the partially cylindrical protrusion 605 to such a sensor, however, could reduce the number of detectors or rows of detectors used while still receiving the substantially same amount of light, due to the focusing properties of the protrusion 605 (see
In other embodiments, using the partially cylindrical protrusion 605 can allow the number of detector rows to be reduced to one or three rows of four detectors. The number of detectors in each row can also be reduced. Alternatively, the number of rows might not be reduced but the size of the detectors can be reduced. Many other configurations of detector rows and sizes can also be provided.
Light, represented by rays 1420, is emitted from the emitters onto the protrusion 605. These light rays 1420 can be attenuated by body tissue (not shown). When the light rays 1420 enter the protrusion 605, the protrusion 605 acts as a lens to refract the rays into rays 1422. This refraction is caused in certain embodiments by the partially cylindrical shape of the protrusion 605. The refraction causes the rays 1422 to be focused or substantially focused on the one or more detectors 1410b. Since the light is focused on a smaller area, a sensor including the protrusion 605 can include fewer detectors to capture the same amount of light compared with other sensors.
The detector submount 1400c is shown positioned under the protrusion 605b in a detector subassembly 1450 illustrated in
The cylindrical housing 1430 can be made of metal, plastic, or another suitable material. The transparent cover 1432 can be fabricated from glass or plastic, among other materials. The cylindrical housing 1430 can be attached to the submount 1400c at the same time or substantially the same time as the detectors 1410c to reduce manufacturing costs. A shape other than a cylinder can be selected for the housing 1430 in various embodiments.
In certain embodiments, the cylindrical housing 1430 (and transparent cover 1432) forms an airtight or substantially airtight or hermetic seal with the submount 1400c. As a result, the cylindrical housing 1430 can protect the detectors 1410c and conductors 1412c from fluids and vapors that can cause corrosion. Advantageously, in certain embodiments, the cylindrical housing 1430 can protect the detectors 1410c and conductors 1412c more effectively than currently-available resin epoxies, which are sometimes applied to solder joints between conductors and detectors.
In embodiments where the cylindrical housing 1430 is at least partially made of metal, the cylindrical housing 1430 can provide noise shielding for the detectors 1410c. For example, the cylindrical housing 1430 can be soldered to a ground connection or ground plane on the submount 1400c, which allows the cylindrical housing 1430 to reduce noise. In another embodiment, the transparent cover 1432 can include a conductive material or conductive layer, such as conductive glass or plastic. The transparent cover 1432 can include any of the features of the noise shields 790 described above.
The protrusion 605b includes the chamfered edges 607 described above with respect to
A noise shield 1403 is disposed above the shielding enclosure 1490. The noise shield 1403, in the depicted embodiment, includes a window 1492a corresponding to the window 1492a. Each of the windows 1492a, 1492b can include glass, plastic, or can be an opening without glass or plastic. In some embodiments, the windows 1492a, 1492b may be selected to have different sizes or shapes from each other.
The noise shield 1403 can include any of the features of the conductive glass described above. In the depicted embodiment, the noise shield 1403 extends about three-quarters of the length of the detector shell 306f. In other embodiments, the noise shield 1403 could be smaller or larger. The noise shield 1403 could, for instance, merely cover the detectors 1410c, the submount 1400c, or a portion thereof. The noise shield 1403 also includes a stop 1413 for positioning a measurement site within the sensor 301f. Advantageously, in certain embodiments, the noise shield 1403 can reduce noise caused by light piping.
A thermistor 1470 is also shown. The thermistor 1470 is attached to the submount 1400c and protrudes above the noise shield 1403. As described above, the thermistor 1470 can be employed to measure a temperature of a measurement site. Such a temperature can be helpful in correcting for wavelength drift due to changes in water absorption, which can be temperature dependent, thereby providing more accurate data useful in detecting blood analytes like glucose.
In the depicted embodiment, the detectors 1410c are not enclosed in the cylindrical housing 1430. In an alternative embodiment, the cylindrical housing 1430 encloses the detectors 1410c and is disposed under the noise shield 1403. In another embodiment, the cylindrical housing 1430 encloses the detectors 1410c and the noise shield 1403 is not used. If both the cylindrical housing 1403 and the noise shield 1403 are used, either or both can have noise shielding features.
In addition to these features, emitters 1404 are depicted in the emitter shell 304f. The emitters 1404 are disposed on a submount 1401, which is connected to a circuit board 1419. The emitters 1404 are also enclosed within a cylindrical housing 1480. The cylindrical housing 1480 can include all of the features of the cylindrical housing 1430 described above. For example, the cylindrical housing 1480 can be made of metal, can be connected to a ground plane of the submount 1401 to provide noise shielding, and can include a transparent cover 1482.
The cylindrical housing 1480 can also protect the emitters 1404 from fluids and vapors that can cause corrosion. Moreover, the cylindrical housing 1480 can provide a gap between the emitters 1404 and the measurement site (not shown), which can allow light from the emitters 1404 to even out or average out before reaching the measurement site.
The heat sink 350f, in addition to including the fins 351f, includes a protuberance 352f that extends down from the fins 351f and contacts the submount 1401. The protuberance 352f can be connected to the submount 1401, for example, with thermal paste or the like. The protuberance 352f can sink heat from the emitters 1404 and dissipate the heat via the fins 351f.
The sensor portions 1500A, 1500B shown include LED emitters 1504; however, for ease of illustration, the detectors have been omitted. The sensor portions 1500A, 1500B shown can be included, for example, in any of the emitter shells described above.
The LEDs 1504 of the sensor portions 1500A, 1500B are connected to a substrate or submount 1502. The submount 1502 can be used in place of any of the submounts described above. The submount 1502 can be a non-electrically conducting material made of any of a variety of materials, such as ceramic, glass, or the like. A cable 1512 is attached to the submount 1502 and includes electrical wiring 1514, such as twisted wires and the like, for communicating with the LEDs 1504. The cable 1512 can correspond to the cables 212 described above.
Although not shown, the cable 1512 can also include electrical connections to a detector. Only a portion of the cable 1512 is shown for clarity. The depicted embodiment of the cable 1512 includes an outer jacket 1510 and a conductive shield 1506 disposed within the outer jacket 1510. The conductive shield 1506 can be a ground shield or the like that is made of a metal such as braided copper or aluminum. The conductive shield 1506 or a portion of the conductive shield 1506 can be electrically connected to the submount 1502 and can reduce noise in the signal generated by the sensor 1500A, 1500B by reducing RF coupling with the wires 1514. In alternative embodiments, the cable 1512 does not have a conductive shield. For example, the cable 1512 could be a twisted pair cable or the like, with one wire of the twisted pair used as a heat sink.
Referring specifically to
Referring to
The cable 1512 includes the outer jacket 1510 and the conductive shield 1506. The conductive shield 1506 is soldered to the submount 1502, and the solder joint 1561 is shown. In some embodiments, a larger solder joint 1561 can assist with removing heat more rapidly from the emitters 1504. Various connections 1563 between the submount 1502 and a circuit board 1519 are shown. In addition, a cylindrical housing 1580, corresponding to the cylindrical housing 1480 of
In the depicted embodiment, the conductive shield 1506 of the cable 1512 is soldered to the heat sink layer 1530 instead of the submount 1502. The solder joint 1565 is shown. In some embodiments, a larger solder joint 1565 can assist with removing heat more rapidly from the emitters 1504. Various connections 1563 between the submount 1502 and a circuit board 1519 are shown. In addition, the cylindrical housing 1580 is shown protruding through the circuit board 1519. The emitters 1504 are enclosed in the cylindrical housing 1580.
Advantageously, in certain embodiments, using a daughter board 1587 to connect to the circuit board 1519 can enable connections to be made more easily to the circuit board 1519. In addition, using separate boards can be easier to manufacture than a single circuit board 1519 with all connections soldered to the circuit board 1519.
The sensors 1600 include an adult/pediatric sensor 1610 for finger placement and a disposable infant/neonate sensor 1602 configured for toe, foot or hand placement. Each sensor 1600 has a tape end 1610 and an opposite connector end 1620 electrically and mechanically interconnected via a flexible coupling 1630. The tape end 1610 attaches an emitter and detector to a tissue site. Although not shown, the tape end 1610 can also include any of the protrusion, shielding, and/or heat sink features described above. The emitter illuminates the tissue site and the detector generates a sensor signal responsive to the light after tissue absorption, such as absorption by pulsatile arterial blood flow within the tissue site.
The sensor signal is communicated via the flexible coupling 1630 to the connector end 1620. The connector end 1620 can mate with a cable (not shown) that communicates the sensor signal to a monitor (not shown), such as any of the cables or monitors shown above with respect to
A spring 1787 attaches to a detector shell 1706 via pins 1783, 1785, which hold the emitter and detector shells 1704, 1706 together. A support structure 1791 attaches to the detector shell 1706, which provides support for a shielding enclosure 1790. A noise shield 1713 attaches to the shielding enclosure 1790. A detector submount 1700 is disposed inside the shielding enclosure 1790. A finger bed 1710 attaches to the noise shield 1703. A partially cylindrical protrusion 1705 is disposed in the finger bed 1710. Moreover, a flex circuit cover 1706 attaches to the pins 1783, 1785. Although not shown, a flex circuit can also be provided that connects the circuit board 1719 with the submount 1700 (or a circuit board to which the submount 1700 is connected).
Conditional language used herein, such as, among others, “can,” “could,” “might,” “may,” “e.g.,” and the like, unless specifically stated otherwise, or otherwise understood within the context as used, is generally intended to convey that certain embodiments include, while other embodiments do not include, certain features, elements and/or states. Thus, such conditional language is not generally intended to imply that features, elements and/or states are in any way required for one or more embodiments or that one or more embodiments necessarily include logic for deciding, with or without author input or prompting, whether these features, elements and/or states are included or are to be performed in any particular embodiment.
While certain embodiments of the inventions disclosed herein have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the inventions disclosed herein. Indeed, the novel methods and systems described herein can be embodied in a variety of other forms; furthermore, various omissions, substitutions and changes in the form of the methods and systems described herein can be made without departing from the spirit of the inventions disclosed herein. The claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of certain of the inventions disclosed herein.
This application is a continuation of U.S. patent application Ser. No. 15/660,743, filed Jul. 26, 2017, which is a continuation of U.S. patent application Ser. No. 14/069,974, filed Nov. 1, 2013, which is a continuation of U.S. patent application Ser. No. 12/497,528, filed Jul. 2, 2009 (“the '528 application”), which claims the benefit of priority under 35 U.S.C. § 119(e) of the following U.S. Provisional Patent Applications: App. No.Filing DateTitleAttorney Docket61/086,060Aug. 4, 2008Multi-Stream Data Collection System ForCERCA.002PRNon-Invasive Measurement of Glucoseand Other Analytes61/086,108Aug. 4, 2008Multi-Stream Sensor Front Ends forCERCA.003PRNoninvasive Measurement of Glucoseand Other Analytes61/086,063Aug. 4, 2008Multi-Stream Detector For NoninvasiveCERCA.004PRMeasurement Of Glucose And OtherAnalytes61/086,057Aug. 4, 2008Multi-Stream Emitter For NoninvasiveCERCA.005PRMeasurement Of Glucose And OtherAnalytes61/078,228Jul. 3, 2008Noise Shielding For A Non-InvasiveCERCA.006PRDevice61/078,207Jul. 3, 2008Contoured Protrusion for ImprovingCERCA.007PRSpectroscopic Measurement of BloodConstituents61/091,732Aug. 25, 2008Sensor For Improving Measurement OfCERCA.011PRBlood Constituents The '528 application also claims the benefit of priority under 35 U.S.C. § 120 as a continuation-in-part of the following U.S. Design Patent Applications: App. No.Filing DateTitleAttorney Docket29/323,409Aug. 25, 2008Patient MonitoringCERCA.009DASensor The foregoing applications are hereby incorporated by reference in their entirety.
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| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,588,553, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01536, dated Jun. 1, 2021, in 72 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01536, dated Aug. 24, 2021, 39 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,588,553, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01536, dated Aug. 24, 2021, in 47 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01536, dated Oct. 5, 2021, 38 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01536, dated Feb. 23, 2022, 78 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01536, dated Apr. 12, 2022, 84 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Aug. 31, 2020, in 114 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,588,553, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Aug. 31, 2020, in 181 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Jun. 4, 2021, in 76 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,588,553, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Jun. 3, 2021, in 81 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Aug. 27, 2021, 40 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,588,553, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Aug. 27, 2021, in 42 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Oct. 8, 2021, 37 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Feb. 23, 2022, 82 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,588,553, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01537, dated Apr. 12, 2022, 88 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,292,628, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Sep. 2, 2020, in 107 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,292,628, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Sep. 2, 2020, in 133 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,292,628, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Jul. 9, 2021, in 77 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,292,628, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Jul. 9, 2021, in 81 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,292,628, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Oct. 1, 2021, 42 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,292,628, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Sep. 29, 2021, in 41 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,292,628, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Nov. 12, 2021, 33 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,292,628, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Apr. 11, 2022, 92 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,292,628, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01521, dated Apr. 12, 2022, 98 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Sep. 2, 2020, in 108 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Sep. 2, 2020, in 151 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Jun. 8, 2021, in 82 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,588,554, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Jun. 8, 2021, in 80 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Aug. 31, 2021, 40 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Aug. 30, 2021, in 38 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Oct. 12, 2021, 40 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Feb. 23, 2022, 70 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01538, dated Apr. 12, 2022, 76 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Sep. 2, 2020, in 111 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Sep. 2, 2020, in 170 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Jun. 11, 2021, in 88 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,588,554, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Jun. 11, 2021, in 89 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Sep. 3, 2021, 40 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,588,554, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Sep. 2, 2021, in 36 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Oct. 15, 2021, 38 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Feb. 23, 2022, 86 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,588,554, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01539, dated Apr. 12, 2022, 92 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,624,564, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Sep. 30, 2020, in 117 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,624,564, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Sep. 30, 2020, in 159 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,624,564, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Aug. 4, 2021, in 67 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,624,564, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Aug. 4, 2021, in 72 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,624,564, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Oct. 27, 2021, 43 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,624,564, Ex. 1050, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Oct. 27, 2021, in 43 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,624,564, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Dec. 8, 2021, 34 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,624,564, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated May 2, 2022, 75 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,624,564, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01713, dated Jun. 28, 2022, 81 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Sep. 30, 2020, in 113 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Sep. 30, 2020, in 122 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Jul. 23, 2021, in 80 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,631,765, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Jul. 23, 2021, in 82 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Oct. 29, 2021, 42 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Oct. 29, 2021, in 45 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Dec. 10, 2021, 37 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Apr. 6, 2022, 77 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01714, dated Apr. 12, 2022, 83 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Sep. 30, 2020, in 114 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Sep. 30, 2020, in 117 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Jul. 27, 2021, in 84 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,631,765, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Jul. 27, 2021, in 88 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Nov. 9, 2021, 44 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,631,765, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Nov. 7, 2021, in 45 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Dec. 17, 2021, 35 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Apr. 6, 2022, 84 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,631,765, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01715, dated Apr. 12, 2022, 90 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,702,194, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Sep. 30, 2020, in 100 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,702,194, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Sep. 30, 2020, in 109 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,702,194, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Aug. 6, 2021, in 94 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,702,194, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Aug. 5, 2021, in 89 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,702,194, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Nov. 1, 2021, 41 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,702,194, Ex. 1060, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Nov. 1, 2021, in 42 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,702,194, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Dec. 13, 2021, 36 pages. |
| Patent Owner's Corrected Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,702,194, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Jan. 6, 2022, 36 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,702,194, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Apr. 28, 2022, 82 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,702,194, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01716, dated Jun. 28, 2022, 88 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,702,195, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Sep. 30, 2020, in 105 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,702,195, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Sep. 30, 2020, in 108 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,702,195, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Aug. 10, 2021, in 88 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,702,195, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Aug. 10, 2021, in 89 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,702,195, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Nov. 8, 2021, 42 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,702,195, Ex. 1060, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Nov. 7, 2021, in 41 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,702,195, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Dec. 20, 2021, 36 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,702,195, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Apr. 28, 2022, 75 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,702,195, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01733, dated Jun. 28, 2022, 81 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,709,366, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Sep. 30, 2020, in 104 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,709,366, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Sep. 30, 2020, in 110 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,709,366, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Aug. 12, 2021, in 89 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,709,366, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Aug. 12, 2021, in 86 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,709,366, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Nov. 12, 2021, 40 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,709,366, Ex. 1060, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Nov. 10, 2021, in 40 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,702,366, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Dec. 22, 2021, 35 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,709,366, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated May 4, 2022, 77 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,709,366, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2020-01737, dated Jun. 28, 2022, 83 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,299,708, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Nov. 20, 2020, in 107 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,299,708, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Nov. 20, 2020, in 136 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,299,708, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Aug. 27, 2021, in 67 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,299,708, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Aug. 27, 2021, in 76 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,299,708, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Nov. 19, 2021, 33 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,299,708, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Nov. 19, 2021, in 29 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,299,708, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Jan. 3, 2022, 28 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,299,708, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Jun. 1, 2022, 85 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,299,708, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00193, dated Jul. 27, 2022, 91 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,376,190, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Nov. 20, 2020, in 109 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,376,190, Ex. 1003, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Nov. 20, 2020, in 139 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,376,190, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Sep. 2, 2021, in 72 pages. |
| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,376,190, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Sep. 2, 2021, in 81 pages. |
| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,376,190, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Nov. 29, 2021, 34 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of US Patent No. B191, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Nov. 27, 2021, in 30 pages. |
| Patent Owner's Sur-Reply to Reply for Inter Partes Review of U.S. Pat. No. 10,376,190, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Jan. 12, 2022, 29 pages. |
| Final Written Decision for Inter Partes Review of U.S. Pat. No. 10,376,190, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated May 25, 2022, 79 pages. |
| Patent Owner's Notice of Appeal to the U.S. Court of Appeals for the Federal Circuit for Inter Partes Review of U.S. Pat. No. 10,376,190, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00195, dated Jul. 27, 2022, 85 pages. |
| Petition for Inter Partes Review of U.S. Pat. No. 10,258,266, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00208, dated Nov. 20, 2020, in 80 pages. |
| Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,258,266, Ex. 1003,Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00208, dated Nov. 20, 2020, in 96 pages. |
| Patent Owner Response for Inter Partes Review of U.S. Pat. No. 10,258,266, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00208, dated Sep. 8, 2021, in 69 pages. |
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| Petitioner's Reply to Patent Owner Response's to Petition for Inter Partes Review of U.S. Pat. No. 10,258,266, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00208, dated Dec. 3, 2021, 35 pages. |
| Second Declaration of Thomas W. Kenny, Ph.D., in support of Petition for Inter Partes Review of U.S. Pat. No. 10,258,266, Ex. 1047, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00208, dated Dec. 2, 2021, in 32 pages. |
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| Declaration of Vijay K. Madisetti, Ph.D., in support of Patent Owner for Inter Partes Review of U.S. Pat. No. 10,376,191, Ex. 2004, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2021-00209, dated Sep. 14, 2021, in 78 pages. |
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| Sep.16, 2020 Public Order Regarding Masimo's Motion for Preliminary Injunction, Masimo Corporation and Cercacor Laboratories, Inc. v. Apple Inc., Case No. SACV 20-00048, 14 pages. |
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| Jun. 6, 2022 through Jun. 10, 2022 Masimo Corp. et al. v. Apple Inc., Public Hearing Transcript, ITC Inv. No. 337-TA-1276, pp. 670. |
| Jan. 10, 2023 Notice of Final Initial Determination on Violation of Section 337, Inv. No. 337-TA-1276, pp. 2. |
| Jan. 10, 2023 Final Initial Determination on Violation of Section 337, Inv. No 337-TA-1276, pp. 342. [Submitted in 10 parts]. |
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| Reply Brief of Appellant Masimo Corporation, Appeal from the Patent Trial and Appeal Board Case Nos. IPR2020-01520 (U.S. Pat. No. 10,258,265), IPR2020-01521 (U.S. Pat. No. 10,292,628), IPR2020-01536 (U.S. Pat. No. 10,588,553), IPR2020-01537 (U.S. Pat. No. 10,588,553), IPR2020- 01538 (U.S. Pat. No. 10,588,554), IPR2020-01539 (U.S. Pat. No. 10,588,554), IPR2020-01714 (U.S. Pat. No. 10,631,765), IPR2020-01715 (U.S. Pat. No. 10,631,765), Federal Circuit Case Nos. 2022- 1631, 2022-1632, 2022-1633, 2022-1634, 2022-1635, 2022-1636, 2022-1637, 2022-1638, Masimo Corporation v. Apple Inc., Nov. 9, 2022, 44 pages. |
| Brief of Appellant Masimo Corporation, Appeal from the Patent Trial and Appeal Board Case Nos. IPR2020-01713 (U.S. Pat. No. 10,624,564), IPR2020-01716 (U.S. Pat. No. 10,702,194), IPR2020- 01733 (U.S. Pat. No. 10,702,195), and IPR2020-01737 (U.S. Pat. No. 10,709,366), Federal Circuit Case Nos. 22-1972, 22-1973, 22-1975, 22-1976, Masimo Corporation v. Apple Inc., Dec. 12, 2022, 73 pages. |
| Apple's Response Brief, Appeal from the Patent Trial and Appeal Board Case Nos. IPR2020-01713 (U.S. Pat. No. 10,624,564), IPR2020-01716 (U.S. Pat. No. 10,702,194), IPR2020-01733 (U.S. Pat. No. 10,702,195), and IPR2020-01737 (U.S. Pat. No. 10,709,366), Federal Circuit Case Nos. 22-1972, 22-1973, 22-1975, 22-1976, Masimo Corporation v. Apple Inc., Feb. 21, 2023, 61 pages. |
| Brief of Appellant Masimo Corporation, Appeal from the Patent Trial and Appeal Board Case Nos. IPR2021-00193 (U.S. Pat. No. 10,299,708), IPR2021-00195 (U.S. Pat. No. 10,376,190), IPR2021- 00208 (U.S. Pat. No. 10,258,266), and IPR2021-00209 (U.S. Pat. No. 10,376,191), Federal Circuit Case Nos. 22-2069, 22-2070, 22-2071, and 22-2072, Masimo Corporation v. Apple Inc., Dec. 29, 2022, 64 pages. |
| Apple Inc.'s Response Brief, Appeal from the Patent Trial and Appeal Board Case Nos. IPR2021-00193 (U.S. Pat. No. 10,299,708), IPR2021-00195 (U.S. Pat. No. 10,376,190), IPR2021-00208 (U.S. Pat. No. 10,258,266), and IPR2021-00209 (U.S. Pat. No. 10,376,191), Federal Circuit Case Nos. 22-2069, 22-2070, 22-2071, and 22-2072, Masimo Corporation v. Apple Inc., Feb. 21, 2023, 63 pages. |
| Declaration of R. James Duckworth, Ph.D., Inter Partes Review of U.S. Pat. No. 10,912,501, Ex. 2002, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01271, dated Oct. 26, 2022, in 134 pages. |
| Patent Owners Preliminary Response, Inter Partes Review of U.S. Pat. No. 10,912,501, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01271, dated Oct. 26, 2022, in 79 pages. |
| Decision Denying Institution of Inter Partes Review 35 U.S.C. § 314, Inter Partes Review of U.S. Pat. No. 10,912,501, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01271, dated Jan. 24, 2023, in 21 pages. |
| Petitioner's Request for Rehearing Pursuant to 37 C.F.R § 42.7, Inter Partes Review of U.S. Pat. No. 10,912,501, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01271, dated Feb. 23, 2023, in 19 pages. |
| Petitioner's Request for Rehearing Pursuant to 37 C.F.R § 42.7, Inter Partes Review of U.S. Pat. No. 10,912,501, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01271, dated Feb. 23, 2023, in 20 pages. |
| Declaration of R. James Duckworth, Ph.D., Inter Partes Review of U.S. Pat. No. 10,912,501, Ex. 2002, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01272, dated Oct. 26, 2022, in 134 pages. |
| Patent Owners Preliminary Response, Inter Partes Review of U.S. Pat. No. 10,912,501, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01272, dated Oct. 26, 2022, in 86 pages. |
| Decision Denying Institution of Inter Partes Review 35 U.S.C. § 314, Inter Partes Review of U.S. Pat. No. 10,912,501, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01272, dated Jan. 24, 2023, in 21 pages. |
| Petitioner's Request for Rehearing Pursuant to 37 C.F.R § 42.7, Inter Partes Review of U.S. Pat. No. 10,912,501, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01272, dated Feb. 23, 2023, in 19 pages. |
| Declaration of R. James Duckworth, Ph.D., Inter Partes Review of U.S. Pat. No. 10,912,501, Ex. 2002, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01273, dated Nov. 3, 2022, in 151 pages. |
| Patent Owners Preliminary Response, Inter Partes Review of U.S. Pat. No. 10,912,502, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01273, dated Nov. 4, 2022, in 85 pages. |
| Decision Denying Institution of Inter Partes Review 35 U.S.C. § 314, Inter Partes Review of U.S. Pat. No. 10,912,502, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01273, dated Jan. 24, 2023, in 24 pages. |
| Petitioner's Request for Rehearing Pursuant to 37 C.F.R § 42.7, Inter Partes Review of U.S. Pat. No. 10,912,502, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01273, dated Feb. 23, 2023, in 19 pages. |
| Declaration of R. James Duckworth, Ph.D., Inter Partes Review of U.S. Pat. No. 10,912,501, Ex. 2002, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01274, dated Nov. 3, 2022, in 151 pages. |
| Patent Owners Preliminary Response, Inter Partes Review of U.S. Pat. No. 10,912,502, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01274, dated Nov. 4, 2022, in 86 pages. |
| Decision Denying Institution of Inter Partes Review 35 U.S.C. § 314, Inter Partes Review of U.S. Pat. No. 10,912,502, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01274, dated Jan. 24, 2023, in 21 pages. |
| Petitioner's Request for Rehearing Pursuant to 37 C.F.R § 42.7, Inter Partes Review of U.S. Pat. No. 10,912,502, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01274, dated Feb. 23, 2023, in 19 pages. |
| Declaration of R. James Duckworth, Ph.D., Inter Partes Review of U.S. Pat. No. 10,945,648, Ex. 2002, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01275, dated Nov. 3, 2022, in 152 pages. |
| Patent Owners Preliminary Response, Inter Partes Review of U.S. Pat. No. 10,945,648, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01275, dated Nov. 4, 2022, in 84 pages. |
| Decision Denying Institution of Inter Partes Review 35 U.S.C. § 314, Inter Partes Review of U.S. Pat. No. 10,945,648, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01275, dated Jan. 30, 2023, in 34 pages. |
| Petitioner's Request for Rehearing Pursuant to 37 C.F.R § 42.7, Inter Partes Review of U.S. Pat. No. 10,945,648 Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01275, dated Mar. 1, 2023, in 19 pages. |
| Declaration of R. James Duckworth, Ph.D., Inter Partes Review of U.S. Pat. No. 10,945,648, Ex. 2002, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01276, dated Nov. 3, 2022, in 152 pages. |
| Patent Owners Preliminary Response, Inter Partes Review of U.S. Pat. No. 10,945,648, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01276, dated Nov. 4, 2022, in 86 pages. |
| Decision Denying Institution of Inter Partes Review 35 U.S.C. § 314, Inter Partes Review of U.S. Pat. No. 10,945,648, Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01276, dated Jan. 30, 2023, in 27 pages. |
| Petitioner's Request for Rehearing Pursuant to 37 C.F.R § 42.7, Inter Partes Review of U.S. Pat. No. 10,945,648 Apple Inc. v. Masimo Corporation, Inter Partes Review No. IPR2022-01276, dated Mar. 1, 2023, in 18 pages. |
| Number | Date | Country | |
|---|---|---|---|
| 20200196882 A1 | Jun 2020 | US |
| Number | Date | Country | |
|---|---|---|---|
| 61091732 | Aug 2008 | US | |
| 61086057 | Aug 2008 | US | |
| 61086060 | Aug 2008 | US | |
| 61086108 | Aug 2008 | US | |
| 61086063 | Aug 2008 | US | |
| 61078207 | Jul 2008 | US | |
| 61078228 | Jul 2008 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 15660743 | Jul 2017 | US |
| Child | 16805605 | US | |
| Parent | 14069974 | Nov 2013 | US |
| Child | 15660743 | US | |
| Parent | 12497528 | Jul 2009 | US |
| Child | 14069974 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 29323409 | Aug 2008 | US |
| Child | 12497528 | US | |
| Parent | 29323408 | Aug 2008 | US |
| Child | 29323409 | US |
