Enantioselective Synthesis via Allylic Sulfide Anions and Carbohydrate-Derived Chirons (Chemistry)

Information

• NSF Award
• 8700399

Owner

• Hendrix College

• Award Id

  8700399

• Award Effective Date

  5/1/1987 - 38 years ago

• Award Expiration Date

  10/31/1990 - 35 years ago

• Award Amount

  $ 92,663.00

• Award Instrument

  Continuing grant

The investigation objectives are: (1) the optimization of reaction parameters for the condensation of allylic sulfide anions with epoxides and subsequent conversion of the products into E,E-2,4-pentadienols; (2) Michael addition of malonates to an enone derived from D-glucose and subsequent transformations thereof; (3) the preparation of an electrophilic chiron and a nucleophilic chiron from D-arabinose; and (4) the eventual integration of these methodologies into a modular approach to the enantioselective synthesis of 15-oxomaytansinoids. A key element of this study is the training of talented undergraduate students for science, as well as, better preparing them for graduate studies in chemistry. This project will develop new synthetic methods directed at the preparation of very complex alkaloids that are of potential theoretical and medical value.

• Program Officer

  George M. Rubottom

• Min Amd Letter Date

  4/30/1987 - 38 years ago

• Max Amd Letter Date

  4/4/1989 - 36 years ago

• ARRA Amount

• Name

  Hendrix College

• City

  Conway

• State

  AR

• Country

  United States

• Address

  1600 Washington Avenue

• Postal Code

  720323080

• Phone Number

  5014504501

• First Name

  Thomas

• Last Name

  Goodwin

• Email Address

  goodwin@hendrix.edu

• Start Date

  5/1/1987 12:00:00 AM

• Name

  Other Applications NEC

• Code

  99

• Name

  Chemistry

• Code

  12

• Text

  CROSS-DIRECTORATE PROGRAMS

• Code

  9120

• Text

  METHODOLOGY

• Code

  1950

• Text

  RES IN UNDERGRAD INST-RESEARCH

• Code

  9229