Claims
- 1. An endoparasiticidal gel composition which comprises: about 1.0% to 3.5% wt/wt of moxidectin; about 10.0% to 15.0% wt/wt of praziquantel; about 4.0% to 24.0% wt/wt of benzyl alcohol; about 1.0% to 34.0% wt/wt of ethanol; about 2.0% to 15.0% wt/wt of colloidal silicon dioxide; about 1.0% to 20.0% wt/wt of a surfactant; and about 35.0% to 61.0% wt/wt of an oil.
- 2. The composition according to claim 1 wherein the oil is propylene glycol dicaprylate/dicaprate or dicaprylic/dicapric triglyceride.
- 3. The composition according to claim 1 wherein moxidectin is present at about 1.5% to 2.5% wt/wt.
- 4. The composition according to claim 1 wherein praziquantel is present at about 12.0% to 13.0% wt/wt.
- 5. The composition according to claim 1 wherein benzyl alcohol is present at about 18.0% to 22.0% wt/wt.
- 6. The composition according to claim 1 wherein ethanol is present at about 5.0% to 7.5% wt/wt.
- 7. The composition according to claim 5 wherein the surfactant is present at about 3.0% to 6.0%.
- 8. The composition according to claim 7 wherein the surfactant comprises a polyoxyethylene sorbitan ester.
- 9. The composition according to claim 8 wherein ethanol is present at about 5.0% to 7.5% wt/wt.
- 10. The composition according to claim 9 wherein the oil is propylene glycol dicaprylate/dicaprate.
- 11. The composition according to claim 10 wherein moxidectin is present at about 1.9% to 2.0% wt/wt and praziquantel is present at about 12.0% to 12.5% wt/wt.
- 12. A method for the treatment and control of endoparasiticidal infection and infestation in a homeothermic animal which comprises orally administering to said animal a composition according to claim 1.
- 13. The method according to claim 12 wherein said animal is an equid.
- 14. The method according to claim 13 wherein said composition is administered to provide said equid with moxidectin in an amount of about 0.3 mg/kg to 0.5 mg/kg of moxidectin per body weight.
- 15. The method according to claim 14 wherein the amount of moxidectin is about 0.4 mg/kg of moxidectin per body weight.
- 16. The method according to claim 15 wherein the amount of praziquantel is about 2.5 mg/kg of praziquantel per body weight.
- 17. The method according to claim 13 wherein said composition is administered to provide said equid with praziquantel in an amount of about 2.0 mg/kg to 3.0 mg/kg of praziquantel per body weight.
- 18. A method for the preparation of a composition according to claim 1 which comprises the following steps:
a) dissolving a thickener in a mixture of benzyl alcohol and ethanol to form a solution A; b) mixing an oil with praziquantel to form a suspension B; c) admixing solution A with suspension B at temperatures≦50° C. until a solution C which is homogenous at room temperature is obtained; d) admixing surfactant and optionally butylated hydroxytoluene with solution C to form solution D; and, e) sequentially admixing moxidectin and colloidal silicon dioxide to solution D to form gel E.
- 19. The method of claim 18 further comprising the step:
f) mixing gel E under a vacuum to form a clear yellow endoparasiticidal gel composition that is essentially free of air.
- 20. The method according to claim 18 wherein the oil is propylene glycol dicaprylate/dicaprate and the thickener is ethyl cellulose.
- 21. The method according to claim 20 wherein the surfactant comprises a polyoxyethylene sorbitan ester.
- 22. The method according to claim 21 wherein said ester is polysorbate 80.
BACKGROUND OF THE INVENTION
[0001] This application claims priority from copending provisional application serial No. 60/315,104, filed on Aug. 27, 2001, the entire disclosure of which is hereby incorporated by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60315104 |
Aug 2001 |
US |