Claims
- 1. A compound which is:
- (1RS, 2SR, 3RS)-3-(2-Carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylene-dioxyphenyl)-5-(prop-1-yloxy)-indane-2-carboxylic acid or a pharmaceutically acceptable salt thereof.
- 2. A compound which is:
- (+)(1S, 2R, 3S)-3-(2-Carboxymethoxy-4-methoxyphenyl!-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid; or a pharmaceutically acceptable salt thereof.
- 3. A compound of claim 2 which is:
- (+)(1S, 2R, 3S)-3-(2-Carboxymethoxy-4-methoxyphenyl!-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid disodium salt.
- 4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 5. A method of antagonizing endothelin receptors which comprises administering to a subject in need thereof, an effective amount of a compound of claim 1.
- 6. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier.
- 7. A method of antagonizing endothelin receptors which comprises administering to a subject in need thereof, an effective amount to antagonize endothelin receptors of a compound of claim 2.
- 8. A method of treatment of diseases caused by an excess of endothelin comprising administering to a subject in need thereof, an effective amount of an endothelin receptor antagonist of claim 2.
- 9. A method of treating hypertension, renal failure or cerebrovascular disease which comprises administering to a subject in need thereof, an effective amount of a compound of claim 2.
- 10. A method for the prophylaxis and treatment of radiocontrast induced renal failure which comprises administering to a subject in need thereof, an effective amount of a compound of claim 2.
- 11. A method of treatment of congestive heart failure which comprises administering to a subject in need thereof, an effective amount of a compound of claim 2.
- 12. A method of treatment of migraine which comprises administering to a subject in need thereof, an effective amount of a compound of claim 2.
- 13. A method of preventing or treating restenosis which comprises administering to a subject in need thereof, an effective amount of a compound of claim 2.
- 14. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier.
- 15. A method of antagonizing endothelin receptors which comprises administering to a subject in need thereof, an effective amount of a compound of claim 3.
Parent Case Info
This is a continuation of application Ser. No. 08/336,444, filed Nov. 9, 1994 which is a continuation-in-part of PCT/US94/04603 filed Apr. 26, 1994 which is a continuation-in-part of Ser. No. 08/066,818, filed on Apr. 27, 1993, now abandoned which is a continuation-in-part of PCT/US92/09427 filed on Oct. 29, 1992, which is a continuation-in-part of Ser. No. 07/854,195 filed on Mar. 20, 1992, now abandoned, which is a continuation-in-part of Ser. No. 07/787,870 filed on Nov. 5, 1991, now abandoned.
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3642785 |
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Feb 1972 |
|
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Foreign Referenced Citations (1)
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Continuations (1)
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Number |
Date |
Country |
Parent |
336444 |
Nov 1994 |
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Continuation in Parts (3)
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Number |
Date |
Country |
Parent |
66818 |
Apr 1993 |
|
Parent |
854195 |
Mar 1992 |
|
Parent |
787870 |
Nov 1991 |
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