Claims
- 1. A method of removing aggregates and other impurities from a biological sample, comprising:adjusting the pH of the sample to 0.2 logs lower than the isoelectric point of the biological sample; passing the biological sample through a means for ion exchange which is charged so as to bind the aggregates in the biological sample.
- 2. The method of claim 1 wherein the means for ion exchange is an anion exchanger matrix.
- 3. The method of claim 1 wherein the biological sample includes a biopharmaceutical product.
- 4. The method of claim 3 wherein the biopharmaceutical product is a monoclonal antibody.
- 5. The method of claim 1 wherein impurities are removed by the means for ion exchange.
Parent Case Info
This application claims the benefit of U.S. provisional application Ser. No. 60/061,842 filed Oct. 14, 1997, the content of which is incorporated herein by reference.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5110913 |
Coan et al. |
May 1992 |
|
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/061842 |
Oct 1997 |
US |