Claims
- 1. A method of enhancing cellular immunity in a mammal which consists essentially of administering an immunologically effective amount of a carbohydrate antigenic determinant-bearing antigen, said antigen being a synthetic conjugate of a synthetic carbohydrate antigenic determinant and a non-tumor associated immunogenic carrier not naturally associated with said determinant, said mammal subsequently exhibiting a cellular immune response elicited by said antigen and specific to the carbohydrate antigenic determinant of said antigen, said response being mediated by the DTH-effector cells of said mammal, said cells having a CD5 positive, CD8 negative phenotype.
- 2. The method of claim 1 in which the immunity is immunity to tumors and the carbohydrate antigen is tumor-associated.
- 3. The method of claim 1 in which the determinant is the Tn determinant.
- 4. The method of claim 1 in which the determinant is the T determinant.
- 5. The method of claim 2 in which the amount of carbohydrate antigen is selected so that the cellular immune response predominates over the humoral immune response.
- 6. The method of claim 2 in which the carbohydrate antigen is a glycoprotein.
- 7. The method of claim 1 in which the mammal is a human being.
- 8. The method of claim 1 in which the carbohydrate determinant is associated with adenocarcinomas.
- 9. The method of claim 1 in which the carrier is a protein.
- 10. The method of claim 1 in which the conjugate is a glycoprotein.
Parent Case Info
This application is a continuation of Ser. No. 07/883,234, filed May 7, 1992, now abandoned, which is a continuation of Ser. No.07/524,310 filed on May 17, 1990, now abandoned, which is a division of Ser. No. 7/222,390, filed on Jul. 21, 1988, now Pat. No. 4,971,795, which is a continuation of Ser. No. 06/883,266, filed on Jul. 8, 1986 which is now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4180627 |
Klesius et al. |
Dec 1979 |
|
4690915 |
Rosenberg |
Sep 1987 |
|
4971795 |
Longenecker et al. |
Nov 1990 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2106935 |
Apr 1983 |
GBX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
222390 |
Jul 1988 |
|
Continuations (3)
|
Number |
Date |
Country |
Parent |
883234 |
May 1992 |
|
Parent |
524310 |
May 1990 |
|
Parent |
883266 |
Jul 1986 |
|