Claims
- 1. An enteric film which comprises
- (a) hydroxypropylmethylcellulose phthalate exhibiting a viscosity of about 136 to 204 centistokes as 10% methanol/dichloromethane (1 : 1 by weight) solution at 20.degree. C.,
- (b) polyethylene glycol presenting solid state at ambient temperature and
- (c) shellac, the ratios of (b) and (c) to (a) being 0.1 to 20 weight percent and 5 to 40 weight percent, respectively.
- 2. An enteric film according to claim 1, wherein the contents of methoxyl, hydroxypropoxyl, and carboxybenzoyl groups in the hydroxypropylmethylcellulose phthalate are 18.0 to 22 percent, 5.0 to 9.0 percent and 27 to 35.0 percent, respectively, and the mean degree of polymerization of hydroxypropylmethylcellulose phthalate is about 240; and the polyethylene glycol presents solid state at 15 to 25.degree. C. and has mean molecular weight of 1,200 to 25, 000.
- 3. An enteric film according to claim 1, wherein the polyethylene glycol is polyethylene glycol 1500, 4000, 6,000 or 20,000.
- 4. A process for preparing an enteric film, which comprises spraying on a material a mixed solution of (a) hydroxypropylmethylcellulose phthalate exhibiting a viscosity of about 136 to 204 centistokes as 10% methanol/dichloromethane (1 : 1 by weight) solution at 20.degree. C., (b) polyethylene glycol presenting solid state at ambient temperature and (c) shellac, respective ratios of (b) and (c) to (a) being 0.1 to 20 weight percent and 5 to 40 weight percent; and then drying the solution.
- 5. A process according to claim 4, wherein the contents of methoxyl, hydroxypropoxyl and carboxybenzoyl groups in the hydroxypropylmethylcellulose phthalate are 18.0 to 22 percent, 5.0 to 9.0 percent and 27.0 to 35.0 percent, respectively, and the mean degree of polymerization of the hydroxypropylmethylcellulose phthalate is about 240; and the polyethylene glycol presents solid state at 15 to 25.degree. C. and has mean molecular weight of 1,200 to 2,5000.
- 6. A process according to claim 4, wherein the polyethylene glycol is polyethylene glycol 1500, 4000, 6,000 or 20,000.
- 7. A process according to claim 4, wherein the material is powder, fine granules, granules, pills, tablets or capsules.
- 8. A process according to claim 4, wherein the solution is prepared by employing a mixture of acetone and ethanol or ethanol and water as a solvent.
- 9. A process according to claim 4, wherein the solution is prepared by mixing a solution of the hydroxypropylmethylcellulose phthalate in acetone and a solution of the polyethylene glycol and the shellac in ethanol.
- 10. A process according to claim 9, wherein the concentration of the hydroxypropylmethylcellulose phthalate in acetone is 3 to 15 weight percent, the concentration of the polyethylene glycol in ethanol is 0.1 to 5 weight percent, and the concentration of the shellac in ethanol is 1 to 10 weight percent.
- 11. An enteric film according to claim 2, wherein the molecular weight of the polyethylene glycol is 2,000 to 10,000.
- 12. An enteric film according to claim 2, wherein the molecular weight of the polyethylene glycol is 7,000 to 9,500.
- 13. A process according to claim 5, wherein the molecular weight of the polyethylene glycol is 2,000 to 10,000.
- 14. A process according to claim 5, wherein the molecular weight of the polyethylene glycol is 7,000 to 9,500.
- 15. A process according to claim 8, wherein the solution additionally contains isopropanol or normal propanol.
- 16. A process according to claim 10, wherein the concentration of hydroxypropylmethylcellulose phthalate in acetone is 6 to 10 weight percent, the concentration of polyethylene glycol in ethanol is 0.5 to 1.5 weight percent and the concentration of shellac in ethanol is 3 to 6 weight percent.
- 17. An enteric film comprising an admixture of:
- (a) hydroxypropylmethylcellulose phthalate exhibiting a viscosity of about 136 to 204 centistokes as a 10% methanol/dichloromethane (1:1 by weight) solution at 20.degree. C.,
- (b) polyethylene glycol which is solid at ambient temperature, and
- (c) shellac,
- wherein the ratios of (b) and (c) to (a) are 0.1 to 20 weight percent and 5to 40 weight percent, respectively.
Priority Claims (1)
Number |
Date |
Country |
Kind |
63-243542 |
Sep 1988 |
JPX |
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Parent Case Info
This application is a continuation-in-part of Ser. No. 412,439, filed Sep. 26, 1989, now abandoned.
US Referenced Citations (11)
Non-Patent Literature Citations (2)
Entry |
Japanese Pharmacopeia, 11th Rev. Ed. "Hydroxy propylmethylcellulose phthalate 200731," Chemical Abstract 111:120929s Enteric-Coating Soft Gelatin Capsules Containing Hydroxypropyl Methyl Cellulose & Polyethylene Glycol. |
Catalog of HP-MCP, Shin-Etsu Chemical Company, Ltd., Tokyo, Japan (1985). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
412439 |
Sep 1989 |
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