Claims
- 1. A process for preparing a compound of the formula:
- 2. A process according to claim 1, wherein the hydrolytic enzyme is lipase.
- 3. A process according to claim 1, wherein the hydrolytic enzyme is esterase.
- 4. A process according to claim 1, wherein the hydrolytic enzyme is liver acetone powder.
- 5. A process according to claim 1, wherein the hydrolytic enzyme is lipase from Porcine pancreas, cholesterol esterase from Pseudomonas Fluorscens and cholesterol esterase from Porcine pancreas.
- 6. A process according to claim 2, wherein the lipase is GC-4, PS30, AY30, PGE, AK, N, L-10, AP-12, FAP-15, R-10, G, MAP10, SAM II, lipase from Pseudomonas fluorescens, lipase from Candida cylindracea, Lip-300, lipase from Chromobacterium viscosum, lipase from Mucor miehei, lipase from Pancreatic, lipase from Pseudomonas fluorescens, lipase from Rhizopus niveus, PPL, type II, lipase from Wheat germ, lipase from Rhizopus arrhizus, lipase from Mucor javanicus, lipase from Pseudomonas cepacia, lipase from Cadia lipolytica, lipase from Penicillium roqueforti, lipoprotein lipase ca #70-6571-01, lipase from Porcine pancreas, and lipoprotein lipase ca #70-1481-01.
- 7. A process according to claim 3, wherein the esterase is PLE-A, immobilized, hog liver, esterase from Hog pancreas, Porcine liver E-3128, cholesterin-esterase, cholesterol esterase from Pseudomonas fluorescens, cholesterol esterase from Porcine pancreas, cholesterol esterase from Bovine pancreas, cholesterol esterase from Pseudonomas fluorescens, cholesterol esterase from Porcine liver, cholesterol esterase from Rabbit liver, cholinesterase, cholinesterase from Electric eel, cholinesterase, choloylglycine hydrolase, esterase from Thermoanaerobium brockii, esterase from Bacillus sp and esterase from Mucor miehi.
- 8. A process according to claim 4, wherein the liver acetone powder is cat I-1256, dog I7379, eel I-1266, horse I9627, calf I7876, guinea pig I1631, mouse I8254, goat I2635, chicken I8001, sheep I0132, pigeon I8376, seal I7627, rattlesnake I9885, trout I5131, turtle I-0757, rat I1380, lungfish I7377, salmon I7502, eel (electrophorus electricus) I8380 and lemon shark I1130.
- 9. A process according to claim 1, wherein the hydrolytic enzyme is immobilized on a solid support.
- 10. A process according to claim 1, wherein the hydrolytic enzyme is a cross-linked enzyme.
- 11. A process according to claim 1, wherein the lipase is in pure crystalline form.
- 12. A process according to claim 1, wherein the aqueous buffer solution is a phosphate, citric acid or boronic acid solution.
- 13. A process according to claim 1, wherein the aqueous buffer solution has a pH between a pH of about 6 to a pH of about 8.
- 14. A process according to claim 1, for preparing a compound of the formula
- 15. A process for preparing a compound of the formula:
- 16. A process according to claim 15, wherein the aqueous buffer solution is a phosphate, citric acid or boronic acid solution.
- 17. A process according to claim 15, wherein the lipase from Mucor miehei.
- 18. A process according to claim 15, wherein the base is sodium methoxy, sodium hydroxide, lithium hydroxide or potassium hydroxide.
- 19. A process according to claim 15, wherein the polar protic solvent is methanol, ethanol or water.
- 20. A process according to claim 15, wherein the lipase is immobilized on a solid support.
- 21. A process according to claim 15, wherein the lipase is a cross-linked enzyme.
- 22. A process according to claim 15, wherein the lipase is in pure crystalline form.
- 23. A process according to claim 15, for preparing a compound of the formula
- 24. A process for preparing a compound of the formula:
- 25. A process according to claim 24, wherein the hydrolytic enzyme is a lipase.
- 26. A process according to claim 24, wherein the lipase is GC-4, PS30, AY30, PGE, AK, N, L-10, AP-12, FAP-15, R-10, G, MAP10, SAM II, lipase from Pseudomonas fluorescens, lipase from Candida cylindracea, Lip-300, lipase from Chromobacterium viscosum, lipase from Mucor miehei, lipase from Pancreatic, lipase from Pseudomonas fluorescens, lipase from Rhizopus niveus, PPL, type II, lipase from Wheat germ, lipase from Rhizopus arrhizus, lipase from Mucor javanicus, lipase from Pseudomonas cepacia, lipase from Cadia lipolytica, lipase from Penicillium roqueforti, lipoprotein lipase ca #70-6571-01, lipase from Porcine pancreas, and lipoprotein lipase ca #70-1481-01.
- 27. A process according to claim 24, wherein the acetylating agent is ethyl acetate, vinyl acetate, chloroacetate or trifluoroacetate.
- 28. A process according to claim 24, wherein the base is sodium methoxy, sodium hydroxide, lithium hydroxide or potassium hydroxide.
- 29. A process according to claim 24, wherein the polar protic solvent is methanol, ethanol or water.
- 30. A process according to claim 24, wherein the lipase is immobilized on a solid support.
- 31. A process according to claim 24, wherein the lipase is a cross-linked enzyme.
- 32. A process according to claim 24, wherein the lipase is in pure crystalline form.
- 33. A process according to claim 24, for preparing a compound of the formula
- 34. A process for preparing a compound of the formula:
- 35. A process according to claim 34, wherein the lipase is Mucor miehei.
- 36. A process according to claim 34, wherein the lipase is immobilized on a solid support.
- 37. A process according to claim 34, wherein the lipase is a cross-linked enzyme.
- 38. A process according to claim 34, wherein the lipase is in pure crystalline form.
- 39. A process according to claim 34, wherein the hydrolytic enzyme is lipase from Porcine pancreas, cholesterol esterase from Pseudomonas fluorscens and cholesterol esterase from Porcine pancreas.
- 40. A process according to claim 34, for preparing a compound of the formula
Parent Case Info
[0001] This non-provisional application is based upon and claims priority from provisional patent application number 60/202,418, filed May 8, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
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60202418 |
May 2000 |
US |