Claims
- 1. 4"-Epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A or a pharmaceutically-acceptable salt thereof.
- 2. A pharmaceutical composition which comprises an antibacterial amount of the compound of claim 1 and a pharmaceutically-acceptable carrier.
- 3. A method of treating a bacterial infection in a mammal which comprises administering to said mammal an antibacterially effective amount of the compound of claim 1.
- 4. A compound selected from the group consisting of 4"-epi-9a-aza-9a-homoerythromycin A and the 9-deoxo derivative thereof.
- 5. The compound of claim 4 which is 4"-epi-9a-aza-9a-homoerythromycin A.
- 6. The compound of claim 4 which is the 9-deoxo derivative of 4"-epi-9a-aza-9-homoerythromycin A.
- 7. 4"-Epi-erythromycin A oxime.
- 8. A compound selected from the group consisting of 9a-benzyloxycarbonyl-9-deoxo-4"-deoxy-4"-oxo-9a-aza-9a-homoerythromycin A and the 2'-O-(C2-C3)alkanoyl derivative thereof.
- 9. The compound of claim 8 which is 9a-benzyloxycarbonyl-9-deoxo-4"-deoxy-4"-oxo-9-aza-9a-homoerythromycin A.
- 10. The compound of claim 8 which is 2'-O-acetyl-9a-benzyloxycarbonyl-9-deoxo-4"-deoxy-4"-oxo-9-aza-9a-homoerythromycin A.
- 11. A compound selected from the group consisting of 2'-O-acetyl- and 2'-O-propionyl-9-deoxo-9a-benzyloxycarbonyl-9a-aza-9a-homoerythromycin A.
- 12. The compound of claim 11 which is 2'-O-acetyl-9-deoxo-9a-benzyloxycarbonyl-9a-aza-9a-homoerythromycin A.
- 13. A compound selected from the group consisting of 4"-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A 3'-N-oxide and 4"-epi-9-deoxo-9a-hydroxy-9a-aza-9a-homoerythromycin A 3'-N-oxide.
- 14. The 9a-hydroxy-3'-N-oxide of claim 13.
- 15. The 9a-methyl-3'-N-oxide of claim 13.
- 16. A compound selected from the group consisting of 4"-deoxy-4"-oxo-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A and the 2'-O-(C.sub.2 -C.sub.3)alkanoyl derivative thereof.
- 17. The compound of claim 16 which is 4"-deoxy-4"-oxo-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A.
- 18. The compound of claim 16 which is 2'-O-acetyl-4"-deoxy-4"-oxo-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A.
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of co-pending application, Ser. No. 441,979, filed Nov. 15, 1982, now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2094293 |
Sep 1982 |
GBX |
Non-Patent Literature Citations (3)
Entry |
BNA's "Patent, Trademark & Copyright Journal", vol. 29, 11/84. |
Lullmann et al., "CRC Critical Reviews in Toxicology", 11/75, pp. 185-218. |
Massey et al., Tetrahedron Letters, pp. 157-160, 1970. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
441979 |
Nov 1982 |
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