Claims
- 1. A compound of the formula ##STR18## wherein R.sub.1 is C.sub.1-3 alkyl.
- 2. The compound according to claim 1 having the formula ##STR19##
- 3. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier, said effective amount being an amount sufficient to inhibit cholesterol biosynthesis in a mammal.
- 4. A method of inhibiting cholesterol biosynthesis comprising administering to a mammal in need of such treatment an effective amount of a compound according to claim 1, said effective amount being an amount effective for inhibiting cholesterol biosynthesis.
- 5. A method of treating atherosclerosis comprising administering to a mammal in need of such treatment an effective amount of a compound according to claim 1, said effective amount being an amount effective for the treatment of atherosclerosis.
Parent Case Info
This application is a division of application Ser. No. 06/831,394, filed Feb. 19, 1986 and now U.S. Pat. No. 4,686,237, which is a continuation of application Ser. No. 06/633,809, filed July 24, 1984 and now abandoned.
US Referenced Citations (17)
Foreign Referenced Citations (3)
Number |
Date |
Country |
895445 |
Apr 1983 |
BEX |
38061 |
Oct 1981 |
EPX |
68038 |
Jan 1983 |
EPX |
Non-Patent Literature Citations (5)
Entry |
Sankyo--Derwent Abstract 20213, 1/27/81. |
Hoffman et al., J. Med. Chem. 29, 159-169 (1986). |
Stokker et al., J. Med. Chem 28, 347-358 (1985). |
Stokker et al., J. Med. Chem. 29, 170-181 (1986). |
Sato et al., Chem. Pharm. Bull. 28, 1509-1525 (1980). |
Divisions (1)
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Number |
Date |
Country |
Parent |
831394 |
Feb 1986 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
633809 |
Jul 1984 |
|