Claims
- 1. A compound of the formula: ##STR4## wherein R.sub.1 is an unbranched or branched alkyl group of the formula C.sub.n H.sub.2n+1 where n is an integer from 8 to 19, inclusive; R.sub.2 is selected from the group consisting of hydrogen, methyl, carboxyalkyl, acetyl, succinyl, 1-(sodiumsulfo)loweralkyl, 1-(sodiumsulfo)polyhydroxyalkyl, and 1,3-bis(sodiumsulfo)aralkyl; and R.sub.3 is selected from the group consisting of unsubstituted or substituted aryl selected from the group consisting of phenyl, 3-bromophenyl, 4-fluorophenyl, 2,6-dichlorophenyl, 2,4-difluorophenyl, 3-carbomethoxyphenyl, 4-carboxyphenyl, and 4-carboxamidophenyl, and substituted unbranched or branched (loweralkyl, loweralkenyl, cycloalkyl, or hydroxyloweralkyl) groups consisting of 1-6 carbon atoms and bearing 1-3 substituents selected from the group consisting of carboxy, carboalkoxy, carboxamido, N,N-dialkylcarboxamido, and 2-dimethylaminoethoxycarbonyl; and the pharmaceutically acceptable acid-addition and cationic salts thereof.
- 2. A compound according to claim 1, wherein R.sub.1 is an unbranched or branched alkyl group of the formula C.sub.n H.sub.2n+1 where n is an integer from 8 to 19, inclusive; R.sub.2 is hydrogen; and R.sub.3 is an unsubstituted or substituted phenyl group.
- 3. A compound according to claim 1, wherein R.sub.1 is an unbranched or branched alkyl group of the formula C.sub.n H.sub.2n+1 where n is an integer from 8 to 19, inclusive; R.sub.2 is hydrogen; and R.sub.3 is a substituted unbranched or branched (loweralkyl, loweralkenyl, or hydroxyloweralkyl) group consisting of 1-6 carbon atoms and bearing 1-3 substituents selected from the group consisting of carboxy, carboalkoxy, carboxamido, N,N-dialkylcarboxamido, and 2-dimethylaminoethoxycarbonyl; and the pharmaceutically acceptable acid-addition or cationic salts thereof.
- 4. The compound according to claim 1, carboxymethyl 4-(hexadecylamino)benzoate.
- 5. The compound according to claim 1, carboethoxymethyl 4-(hexadecylamino)benzoate.
- 6. The compound according to claim 1, 3-carboxy-2-hydroxypropyl 4-(hexadecylamino)benzoate.
- 7. The compound according to claim 1, phenyl 4-(hexadecylamino)benzoate.
- 8. The compound according to claim 1, p-chlorophenyl 4-(hexadecylamino)benzoate.
- 9. The compound according to claim 1, p-carboxyphenyl 4-(hexadecylamino)benzoate.
- 10. The method of treating hyperlipidemia and hyperlipoproteinemia and/or altering the lipoprotein pattern in a mammal comprising administering to said mammal an effective lipid-altering amount of a compound in accordance with claim 1.
Parent Case Info
This is a division of application Ser. No. 861,736, filed Dec. 19, 1977, now U.S. Pat. No. 4,196,208.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3868416 |
Albright et al. |
Feb 1975 |
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4182776 |
Albright et al. |
Jan 1980 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
861736 |
Dec 1977 |
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