Ohloff, G. et al., “Structural and Configurational Dependence of the Sensory Process in Steroids,” Helvetica Chimica Acta., vol. 66, No. 1, pp. 192-217, XP002069805, Basel CH. |
Signoret, J. P. et al., “Utilization of various synthetic odorous products to facilitate detection of heats in sow”,Ann. Zootech. (1975), 24(4), 639-43, XP002121379, p. 641, compounds L2292, L2268, L2253 and 6628 WO. (Abstract only). |
Booth, W. D. et al., “The isolation, purification and some properties of pheromaxein, the pheromonal steroid-binding protein, in porcine submaxillary glands and saliva,” J. Endocrinol. (1988), 118(1), 47-57 2 Plates, XP002121381, p. 54, Table 2. |
Romer, J. et al., “Androsta-4, 16-Diene-3,6-Dione: An unknown member among the smelling androst-16-enes,” Steroids, Structure, Function, And Regulation, vol. 51, No. 5/06, May 1, 1988, pp. 577-581, XP000027980 ISSN: 0039-128X, p. 579, paragraph 3. |
W. Johns: “Synthesis of 3-Methoxy-17-acetyl-18-nor-estr-1,3,5(10), 16-tetraene,” Journal of Organic Chemistry, vol. 28, No. 7, Jul. 1963, pp. 1856-1861, XP002121382 American Chemical Society, Easton, US ISSN: 0022-3263, p. 1857, compounds 7 and 8. |
Hussain et al., “Administering natural female sex hormones,” Pharmaceuticals, vol. 96, p. 421, 1982, CA 96: 187314. |
Monti-Bloch et al., “Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium,” J. Steroid Biochem. amd Molec. Biol., vol. 39, No. 4B, pp. 573-582, 1991. |
Bird et al., “Estimation of the odorous steroid, 5-alpha-androst-16-en-3-one, in human saliva,” CA: 99(1):64581s, 1983. |
Chakravarti et al., Relation between plasma hormone profiles, symptoms, and response to estrogen treatment in women approaching the menopause, CA 91-124649f, 1979. |
Lauber et al., “Estradiol induction of proenkephalin messenger RNA in hypothalamus: dose-response and relation to reproductive behavior in the female rat,” CA 113:165668p. 1990. |
Perry et al., “Pig courtship behavior, pheromonal property of androsterone steroids in male submaxillary secretion,” CA 94: 45007q. 1980. |
Thomson et al., “Sexual behavior, seminal pH and accessory sex glad weights in geldings administered testosterone and (or) estradiol-17.beta,” CA 94:77415n, 1980. |
Agosta, W.C., “Chemical Communication (The Language of Pheromones),” Scientific American Library, New York, Chapter 6, pp. 130-140, 1992. |
Beauchamp et al., “The pheromone concept in mammalian chemical communications: A Critique,” Mammalian Offaction Reproductive Processes, and Behavior, Doty, RLL, Ed., Academic Press, New York, pp. 143-160, 1976. |
Brooksbank et al., “Fate of Androsta-4, 15-dien-3-one and the origin of 3a-hydroxy-5a-androst-16-ene in man,” J. Endocr., vol. 52, pp. 239-251, 1972. |
Claus et al., “The boar-pheromone steroid identified in vegetables,” Experimentia, vol. 25, pp. 1674-1675, 1979. |
Claus et al., “Occurrence of 5a-androst-16-en-3-one, a boar pheromone, in man and its relationship to testosterone,” J. Endocr., vol. 68, pp. 483-484, 1976 (abstract). |
Foreman et al., “Preclinical studies on quinelorane, a potent and highly selective Dx-Dopamineric agonist,” J. Pharmacology and Experimental Therapeutics, vol. 250, No. 1, pp. 227-235, 1989. |
Garcia Velasco et al., “The Incidence of the vomeronasal organ in 1000 human subjects and its possible clinical significance,” J. Steroid Biochem. and Molec. Biol., vol. 39, No. 4B, pp. 561-563, 1991. |
Gower et al., “The significance of odorous steroids in axillary odour,” Perfumery: The Psychology and Biology of Fragrance, Van Toller et al., Eds., Chapman and Hall, London, pp. 47-75, 1988. |
Johnson et al., “Clinical and histological evidence for the presence of the vomeronasal (Jacobson's) organ in adult humans,” J. Otolaryngology, vol. 14, No. 2, pp. 71-79, 1985. |
Kirk-Smith et al., “Human social attitudes affected by androstenol,” Research Communications in Psychology, Psychiatry, and Behavior, vol. 3, No. 4, pp. 379-384, 1978. |
Kwan et al., “15-androstenes, putative pheromones in human semen,” Med. Sci. Res., vol. 15, pp. 1443-1444, 1987. |
Melrose et al., “Androgen-steroids associated with boar odour as an aid to the detection of oestrus in pig artificial insemination,” Br. Vet. J., vol. 127, pp. 497-502, 1971. |
Moran et al., “The vomeronasal (Jacobson's) organ in man: UItrastructure and frequency of occurrence,” J. Steroid Biochem. and Molec. Biol., vol. 29, No. 4B, pp. 545-522, 1991. |
Muller-Schwarze et al., “Chemical Signals (Vertebrates and Aquatic Invertebrates),” Plenum Press, New York 1980. |
Parott, R. F., “Homotypical sexual behavior in gonadectomized female and male rats treated with 5a-19-Hydroxytestosterone: Comparison with related androgens,” Hormones & Behavior, vol. 7, pp. 207-215, 1976. |
Phoenix, C. H., “Sexual behavior of castrated male rhesus monkeys treated with 19-Hydroxytesterone,” Physiological & Behavior, vol. 8, pp. 356-362, 1977. |
Reed et al., “Androgen steroids as an aid to the detection of oestrus in pig artificial insemination,” Br. Vet. J., vol. 130, pp. 61-65, 1974. |
Stensaas et al., “Ultrastructure of the human vomeronasal organ,” J. Steroid Bioche., and Molec. Biol., vol. 39, No. 4B, pp. 553-560, 1991. |
Michael et al., “Pheromones in the communication of sexual status in primates,” Nature, vol. 218, pp. 746-749, 1968. |
Physicians Desk Reference, 31st Ed., pp. 598-599, Premarin, 1977. |
The Merck Index, 11th Ed., “Estrone” No. 3660, 1989. |
Phoenix, C. H., “Induction of sexual behavior in ovariectomized rhesus females with 19-Hydroxytestosterone,” Hormones & Behavior, vol. 8, pp. 356-362, 1977. |
“Olfaction in Human with special reference to odorous 16-androstenes: their occurrence, perception and possible social, psychological and sexual impact,” Chemical Abstract, vol. 118, No. 25, 1992, see abstract No. 247775p, J. Endocrin., 137(2), 167-168. |
Phoenix, C. H., “Sexual behavior of castrated male rhesus monkeys treated with 19-Hydroxytestosterone,” Physiology & Behavior, vol. 16, pp. 305-310, 1976. |
CA 68: 3116. |
CA 97: 168926. |
CA 112: 173065. |
CA 89: 189785, Hainut et al., 1978. |
CA 94: 59948, Breuer et al., 1980. |
CA 99: 38694, Ohloff et al., 1983. |
CA 90: 157006, Conine et al., 1975. |
CA 53: 18985, RN 102471-98-7, 101863-76-7, 1967. |
CA 97: 154109, RN 83059-92-1, 1967. |
CA 79: 105459, RN 50394-23-5, 1967. |
CA 87: 102517, RN 63779-91-9, 1967. |
CA 80: 15104, RN 50865-75-3, 50704-61-5, 1967. |
CA 79: 115762, RN 50686-66-3, 1967. |
CA 76: 72701, RN 35456-74-7, 1967. |
CA 90: 121877, RN 69283-69-8, 1967. |
CAOLD, RN 103212-27-7, 1967. |
RN 93998-04-0, 1967. |
CA 70: 97046 Bascoul et al. 1969. |
Ca 62: 789 Nakamura et al. 1965. |
Arunachalam, T. et al., “Iodoestrogens, syntheses, and interaction with uterine receptors” Journal of Biological Chemistry, vol. 254, No. 13, Jul. 10, 1979, pp. 5900-5905, XP002089938, ISSN: 0021-9258, p. 5903, column 2, paragraph 3. |
M. A. Kraevskaya et al., “Molecular Mechanism of Olefaction: Binding of Boar Sex Pheremone 5. alpha.-Androst-16-en-3-one and Its Analogs by Cystosolic Fraction of Porcine Olefactory Epithelium” SENSORNYE SISTEMY (English Translation-Plenum Publishing Corp), vol. 1, No. 2, 1987, pp. 99-107, XP002124893, p. 103, compound XIII, p. 105; figure 3. |
H. Takagi et al., “Synthesis and mechanism of hydrolysis of estrogen 6-sulfates: model compounds for demonstrating the carinogenesis of estrogen” Steroids: Structure, Function, and Regulation, vol. 56, No. 4, 1991, pp. 173-179, XPOO2121386, Elsevier Science Publishers, New York, NY., US, ISSN: 0039-128X, p. 176, compounds 2, 3, 5-7, 9, 10. |
M. Pons et al., “Structural requirements for maximal inhibitory allosteric effect of estrogens and estrogen analogs on glutamate dehydrogenase” Eur. J. Biochem., vol. 84, No. 1, 1978, pp. 257-266, XP002121388, p. 259; table 3; p. 265, column 1, paragraph 2. |
J. P. Dusza et al., “Steroid Conjugates IV. The Preparation of Steroid Sulfates with Triethylamine-Sulfur Trioxide” Steroids, vol. 12, No. 1, Jul. 1968, pp. 49-61, XP002121390, Elsevier Science Publishers, New York, NY, US, p. 59, compound XIX. |
O. N. Minailova et al., “Silylsteroids VIII. Synthesis of 1.alpha.-(trimethylsilyl)-19-nortestosterone and its Analogs by the Reductive Silylation of Estradiol Ethers” Journal of General Chemistry USSR, vol. 53, No. 3, Mar. 1983, pp. 539-550, XP002121391, Consultant Bureau, New York, US, p. 545, compound la and lf. |
J. R. Bull et al., “Hydroxylation of delta-4 steroids by Osmium Tetroxide; Stereochemistry and Substituent Effects” Journal of Chemical Society, Perkin Transactions1, No. 7, 1977, pp. 724-730, SP002121394, Chemical Society, Letchworth, GB, ISSN: 0300-922X, p. 726, compounds 22 and 24. |
A. M. Ponomarev et al., Journal of Organic Chemistry of The USSR (Zhurnal Organischeskoi KHIMII), vol. 7, 1971, pp. 1477-1479, XP002121397, Consultants Bureau, New York, US, p. 1478, compound V. |
A. N. Cherkasov et al., Journal of Organic Chemistry of The USSR (ZHURNAL ORGANICHESKOI KHIMII), vol. 7, 1971, pp. 955-961, XP002121398, Consultant Bureau, New York, US, p. 956, compounds Va and VIa. |