Claims
- 1. An ethanolamine derivative selected from the group consisting of a compound of the formula: ##STR31## wherein A is alkylene of from 2 to 6 carbon atoms, wherein R.sup.1 is hydrogen or alkyl, alkenyl, halogenoalkyl or cycloalkyl each of up to 6 carbon atoms, or aryl of the formula: ##STR32## wherein R.sup.2, R.sup.3, R.sup.12 and R.sup.13, which may be the same or different, each is hydrogen, halogen, nitro, amino or cyano, or alkyl alkenyl, alkoxy, alkenyloxy, hydroxyalkyl, alkanoyl, acylamino or alkanesulphonamido each of up to 6 carbon atoms, wherein R.sup.4 is hydrogen, hydroxy or carbamoyl, wherein R.sup.5 is hydrogen or alkyl of up to 6 carbon atoms, wherein X is carbonyl and wherein Y is imino (--NH--); and an acid addition salt thereof.
- 2. An ethanolamine derivative as claimed in claim 1 wherein A is ethylene, 1-methylethylene or 1,1-dimethylethylene, wherein R.sup.1 is alkyl or cycloalkyl each of up to 6 carbon atoms and wherein R.sup.2 and R.sup.3 are both hydrogen, or an acid-addition salt thereof.
- 3. An ethanolamine derivative as claimed in claim 1 wherein A is ethylene, 1-methylethylene or 1,1-dimethylethylene, wherein R.sup.1 is phenyl, chlorophenyl or methoxyphenyl, wherein R.sup.2 and R.sup.3 are both hydrogen and or an acid-addition salt thereof.
- 4. An acid-addition salt as claimed in claim 1 which is a hydrochloride, hydrobromide, phosphate, sulphate, oxalate, lactate, tartrate, acetate, salicylate, citrate, benzoate, .beta.-naphthoate, adipate or 1,1-methylene-bis-(2-hydroxy-3-naphthoate), or a salt derived from a sulphonated polystyrene resin.
- 5. A pharmaceutical composition having .beta.-adrenergic blocking activity comprising as active ingredient an effective amount of at least one alkanolamine or an acid-addition salt thereof, claimed in claim 1, in association with a pharmaceutically-acceptable diluent or carrier therefor.
- 6. A method for the treatment angina pectoris and cardiac arrythmias and hypertension in warm-blooded animals which comprises administering to said animals an effective amount of at least one compound claimed in claim 1.
- 7. A method for producing coronary .beta.-adrenergic blockade in warm-blooded animals in need of such blockade which comprises administering to said animals an effective amount of at least one compound claimed in claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
29679/73 |
Jun 1973 |
GBX |
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Parent Case Info
This is a division, of application Ser. No. 645,300, filed Dec. 29, 1975, now U.S. Pat. No. 4,034,112 which is a division of application Ser. No. 479,174, filed June 13, 1974, now U.S. Pat. No. 3,944,611.
US Referenced Citations (4)
Divisions (2)
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Number |
Date |
Country |
Parent |
645300 |
Dec 1975 |
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Parent |
479174 |
Jun 1974 |
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