Claims
- 1. A compound of formula (I). ##STR26## wherein Ar represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the groups C.sub.1-6 alkyl, nitro, --(CH.sub.2).sub.q R, [where R is hydroxy, C.sub.1-6 alkoxy, --NR.sup.3 R.sup.4 (where R.sup.3 and R.sup.4 each represents a hydrogen atom, or a C.sub.1-4 alkyl group, or --NR.sup.3 R.sup.4 forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring one or more atoms selected from --O-- or --S-- or a group --NH-- or --N(CH.sub.3)--), --NR.sup.5 COR.sup.6 (where R.sup.5 represents a hydrogen atom or a C.sub.1-4 alkyl group, and R.sup.6 represents a hydrogen atom or a C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl or --NR.sup.3 R.sup.4 group), --NR.sup.5 SO.sub.2 R.sup.7 (where R.sup.7 represents a C.sub.1-4 alkyl, phenyl or --NR.sup.3 R.sup.4 group), -- COR.sup.8 (where R.sup.8 represents hydroxy, C.sub.1-4 alkoxy or --NR.sup.3 R.sup.4), --SR.sup.9 (where R.sup.9 is a hydrogen atom, or a C.sub.1-4 alkyl or phenyl group), --SOR.sup.9, --SO.sub.2 R.sup.9, or --CN, and q represents an integer from 0 to 3], or --O(CH.sub.2).sub.t R.sup.10 [where R.sup.10 represents a hydroxy or C.sub.1--4 alkoxy group, and t is an integer 2 or 3], or Ar is a phenyl group substituted by an alkylenedioxy group of formula --O(CH.sub.2).sub.p O--, where p represents an integer 1 or 2;
- R.sup.1 and R.sup.2 each represents a hydrogen atom or a C.sub.1-3 alkyl group with the proviso that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 4;
- X represents a bond or a C.sub.1-7 alkylene, C.sub.2-7 alkenylene or C.sub.2-7 alkynylene chain and
- Y represents a bond or a C.sub.1-6 alkylene, C.sub.2-6 alkenylene or C.sub.2-6 alkynylene chain with the proviso that the sum total of carbon atoms in X and Y is 2-10;
- Q represents the group ##STR27## [where Q.sup.1 represents the group --CH.sub.2 R.sup.23 (where R.sup.23 represents C.sub.1-3 alkoxy, methanesulphonyl or cyano), or the group --CH.sub.2 NHR.sup.11 (where R.sup.11 represents R.sup.12 CO--, R.sup.12 NHCO--, R.sup.12 R.sup.13 NSO.sub.2 -- or R.sup.14 SO.sub.2 --, where R.sup.12 and R.sup.13 each represent a hydrogen atom or a C.sub.1-3 alkyl group, and R.sup.14 represents a C.sub.1-3 alkyl group), or the group --NR.sup.15 R.sup.16 (where R.sup.15 represents a hydrogen atom or a C.sub.1-4 alkyl group, and R.sup.16 represents a hydrogen atom or a C.sub.1-4 alkyl group or, when R.sup.15 is a hydrogen atom, R.sup.16 also represents a C.sub.1-4 alkoxycarbonyl group)], or Q represents the group ##STR28## or Q represents a phenyl group substituted by a hydroxy group and optionally also by a halogen atom;
- or a physiologically acceptable salt or solvate thereof.
- 2. A compound according to claim 1 in which the sum total of carbon atoms in the chains X and Y is 5, 6 or 7.
- 3. A compound according to claim 1 in which X represents --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 --, and Y represents --CH.sub.2 --, --(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.3 --.
- 4. A compound according to claim 1 in which R.sup.1 is a hydrogen atom and R.sup.2 is a hydrogen atom or a methyl group.
- 5. A compound according to claim 1 in which
- Q represents the group ##STR29## and Q.sup.1 represents: methoxymethyl; --CH.sub.2 NHR.sup.11 where R.sup.11 is HCO--, CH.sub.3 CO--, NH.sub.2 CO--, NH.sub.2 SO.sub.2 -- or CH.sub.3 SO.sub.2 --; or --NR.sup.15 R.sup.16 where R.sup.15 represents a hydrogen atom and R.sup.16 represents a methyl group.
- 6. A compound according to claim 1 in which Q represents ##STR30##
- 7. A compound according to claim 1 in which Ar is a phenyl group or a phenyl group substituted by chlorine, bromine, iodine, fluorine, methyl, ethyl, methoxy, ethoxy, --(CH.sub.2).sub.q R , --NO.sub.2, --O(CH.sub.2).sub.2 OH, --O(CH.sub.2).sub.3 OH, --O(CH.sub.2).sub.2 OCH.sub.3, or --O(CH.sub.2).sub.2 OCH.sub.2 CH.sub.3.
- 8. A compound according to claim 1 in which Ar is phenyl, or phenyl substituted by a halogen atom, or by a group selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, a 5-7 membered heterocyclic amino group, --SR.sup.9 (where R.sup.9 is C.sub.1-4 alkyl), --CONR.sup.3 R.sup.4 (where R.sup.3 and R.sup.4 represent C.sub.1-4 alkyl), --NHSO.sub.2 R.sup.7 (where R.sup.7 is C.sub.1-4 alkyl), or --(CH.sub.2).sub.q NHCOR.sup.6 (where q is zero or 1, and R.sup.6 is C.sub.1-4 alkyl), or Ar represents phenyl substituted by methoxy and hydroxy.
- 9. A pharmaceutical composition which comprises an effective amount of at least one compound of general formula (I) as defined in claim 1 or a physiologically acceptable salt of solvate thereof, together with a physiologically acceptable carrier or diluent.
Priority Claims (5)
Number |
Date |
Country |
Kind |
8525478 |
Oct 1985 |
GBX |
|
8525479 |
Oct 1985 |
GBX |
|
8525480 |
Oct 1985 |
GBX |
|
8525481 |
Oct 1985 |
GBX |
|
8525485 |
Oct 1985 |
GBX |
|
Parent Case Info
This is a continuation of co-pending application Ser. No. 919,123 filed on Oct. 15, 1986.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
3818101 |
Baile et al. |
Jun 1974 |
|
4072760 |
Hedegaard |
Feb 1978 |
|
4317930 |
Hirose et al. |
Mar 1982 |
|
4379166 |
Neustadt et al. |
Apr 1983 |
|
4730008 |
Skidmore et al. |
Mar 1988 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
1214012 |
Nov 1970 |
GBX |
1367668 |
Sep 1974 |
GBX |
2140800A |
Dec 1984 |
GBX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
919123 |
Oct 1986 |
|