Claims
- 1. A method for modulating an immune response in a subject in need thereof comprising irradiating said subject with light after administration of a compound of the formula or their 1,4-diene isomers or the metallated and/or labeled and/or conjugated forms thereofwherein each R1 is independently alkyl (1-6C); each n is independently an integer of 0-6; and R2 is vinyl or a derivative thereof.
- 2. The method of claim 1 wherein in said compound, R2 is vinyl, —CHOR′, —CHO, —COOR′, —CH(OR′)CH3, —CH(OR′)CH2OR′, —CH(SR′)CH3, —CH(NR′)2CH3, —CH(CN)CH3, —CH(COOR′)CH3, —CH(OOCR′)CH3, —CH(NR′COR′)CH3, —CH(CONR′2)CH3, —CH(halo)CH3, or —CH(halo)CH2(halo) wherein R′ is H, or a hydrocarbon radical (1-6C) optionally substituted with a heteroatom substituent.
- 3. The method of claim 1 wherein in said compound, R2 is an organic group of less than 12C resulting from derivatization of a vinyl substituent.
- 4. The method of claim 1 wherein in said compound, R2 is a group containing 1-3 tetrapyrrole nuclei.
- 5. The method of claim 1 wherein said compound is in a metallated form.
- 6. The method of claim 1 wherein said compound is in conjugated form.
- 7. The method of claim 1 wherein said compound is labeled.
- 8. The method of claim 1 wherein said compound does not contain a metal ion.
- 9. The method of claim 1 wherein in said compound, R2 is vinyl.
- 10. The method of claim 1 wherein in said compound, each R1 is methyl.
- 11. The method of claim 1 wherein in said compound, both n are 2.
- 12. The method of claim 1 wherein in said compound, R2 is vinyl and both R1 are methyl.
- 13. The method of claim 1 wherein said compound is of formulas 1-4.
- 14. The method of claim 13 wherein in said compound, R2 is vinyl, —CHOR′, —CHO, —COOR′, —CH(OR′)CH3, —CH(OR′)CH2OR′, —CH(SR′)CH3, —CH(NR′)2CH3, —CH(CN)CH3, —CH(COOR′)CH3, —CH(OOCR′)CH3, —CH(NR′COR′)CH3, —CH(CONR′2)CH3, —CH(halo)CH3, or —CH(halo)CH2(halo) wherein R′ is H, or a hydrocarbon radical (1-6C) optionally substituted with a heteroatom substituent.
- 15. The method of claim 13 wherein in said compound, R2 is an organic group of less than 12C resulting from derivatization of a vinyl substituent.
- 16. The method of claim 13 wherein in said compound, R2 is vinyl.
- 17. The method of claim 13 wherein in said compound, each R1 is methyl.
- 18. The method of claim 13 wherein in said compound, both n are 2.
- 19. The method of claim 18 wherein in said compound, R2 is vinyl and both R1 are methyl.
- 20. The method of claim 12 wherein said compound is A-EA6 or B-EA6 or the metallated and/or labeled and/or conjugated forms thereof.
- 21. The method of claim 20 wherein said compound is in a metallated form.
- 22. The method of claim 20 wherein said compound is in conjugated form.
- 23. The method of claim 20 wherein said compound is labeled.
- 24. The method of claim 20 wherein said compound does not contain a metal ion.
- 25. The method of claim 1 wherein said modulation of an immune response is prevention of said immune response.
- 26. The method of claim 1 wherein said subject has an autoimmune disease.
- 27. The method of claim 1 wherein said subject has arthritis.
Parent Case Info
This is a continuation of allowed U.S. patent application Ser. No. 09/313,106, filed May 17, 1999, now U.S. Pat. No. 6,153,637 which is a continuation of U.S. patent application Ser. No. 09/088,524, filed Jun. 1, 1998, now U.S. Pat. No. 5,929,105, which is a continuation-in-part of U.S. Ser. No. 08/852,494 filed 7 May 1997, the contents of which are incorporated herein by reference.
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352 076 |
Jan 1990 |
EP |
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WO |
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Continuations (2)
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Number |
Date |
Country |
Parent |
09/313106 |
May 1999 |
US |
Child |
09/588206 |
|
US |
Parent |
09/088524 |
Jun 1998 |
US |
Child |
09/313106 |
|
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
08/852494 |
May 1997 |
US |
Child |
09/088524 |
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US |