Evaluation and Disruption of Tau - GSK3? Vicious Cycle

Information

  • Research Project
  • 10398663
  • ApplicationId
    10398663
  • Core Project Number
    F32AG062039
  • Full Project Number
    3F32AG062039-03S1
  • Serial Number
    062039
  • FOA Number
    PA-20-272
  • Sub Project Id
  • Project Start Date
    9/1/2019 - 4 years ago
  • Project End Date
    8/31/2022 - a year ago
  • Program Officer Name
    YANG, AUSTIN JYAN-YU
  • Budget Start Date
    9/1/2021 - 2 years ago
  • Budget End Date
    8/31/2022 - a year ago
  • Fiscal Year
    2021
  • Support Year
    03
  • Suffix
    S1
  • Award Notice Date
    8/3/2021 - 2 years ago

Evaluation and Disruption of Tau - GSK3? Vicious Cycle

Project Summary/Abstract Our goal is to advance our understanding and ability to treat Alzheimer's disease. Our lab discovered that tau reduction can prevent A?-induced activation of GSK3?, a kinase that is activated by many AD-relevant pathomechanisms and has been implicated in the hyperphosphorylation of tau. We will determine which of these mechanisms activate GSK3? in a tau-dependent manner and whether the activation involves direct interactions between tau and GSK3?. To prevent tau-dependent GSK3? activation, we propose to reduce overall tau levels. Tau reduction can prevent cognitive decline and neurodegeneration in mouse models of AD. We found that blocking the rho-associated protein kinase (ROCK) pathway reduces tau levels in primary cells and in adult mouse brain. To further explore this therapeutic strategy, we will use a new ROCK inhibitor that has high potency and good brain penetration in mouse models.

IC Name
NATIONAL INSTITUTE ON AGING
  • Activity
    F32
  • Administering IC
    AG
  • Application Type
    3
  • Direct Cost Amount
    2500
  • Indirect Cost Amount
  • Total Cost
    2500
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    866
  • Ed Inst. Type
  • Funding ICs
    NIA:2500\
  • Funding Mechanism
    TRAINING, INDIVIDUAL
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    J. DAVID GLADSTONE INSTITUTES
  • Organization Department
  • Organization DUNS
    099992430
  • Organization City
    SAN FRANCISCO
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    941582261
  • Organization District
    UNITED STATES