EVALUATION OF 'CHEMOPREVENTIVE AGENTS BY IN VITRO SCREEN

Information

• Research Project
• 6346791

• ApplicationId

  6346791

• Core Project Number

  N01CN005103

• Full Project Number

  N01CN005103-000

• Serial Number

  5103

• FOA Number

• Sub Project Id

• Project Start Date

  8/1/2000 - 24 years ago

• Project End Date

  7/31/2002 - 22 years ago

• Program Officer Name

• Budget Start Date

  8/1/2000 - 24 years ago

• Budget End Date

  7/31/2002 - 22 years ago

• Fiscal Year

  2000

• Support Year

• Suffix

• Award Notice Date

  -

Organizations

• ALION SCIENCE AND TECHNOLOGY CORP

The efficacy chemopreventive agents to inhibit angiogenesis will be tested in the chorioallantoic membrane (CAM) assay, wherein the inhibition of new vessel formation is computed by the intrafocal microvessel density (IFMD) and by the circumfocal microvessel number (CFMN). The system compares 3 types of angiogenesis evoking cells, including human glioblastoma MF, human tumor cells with defined genetic elements, and syrian hamster embryo cells transduced with v-Ha-ras and v-myc as a positive control. Additional endpoints include VEGF, Integrins, and apoptosis induction of vascular endothelial cells.

IC Name

• Activity

  N01

• Administering IC

  CN

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  480564

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  399

• Ed Inst. Type

• Funding ICs

  NCI:480564\

• Funding Mechanism

• Study Section

• Study Section Name

• Organization Name

  ALION SCIENCE AND TECHNOLOGY CORP

• Organization Department

• Organization DUNS

  119162332

• Organization City

  DURHAM

• Organization State

  NC

• Organization Country

  UNITED STATES

• Organization Zip Code

  27713

• Organization District

  UNITED STATES