Evaluation of molecular mechanisms of treatment response in late-life depression

Information

• Research Project
• 9816774

• ApplicationId

  9816774

• Core Project Number

  R01MH118311

• Full Project Number

  1R01MH118311-01A1

• Serial Number

  118311

• FOA Number

  PA-17-088

• Sub Project Id

• Project Start Date

  7/1/2019 - 5 years ago

• Project End Date

  3/31/2023 - a year ago

• Program Officer Name

  EVANS, JOVIER D

• Budget Start Date

  7/1/2019 - 5 years ago

• Budget End Date

  3/31/2020 - 4 years ago

• Fiscal Year

  2019

• Support Year

  01

• Suffix

  A1

• Award Notice Date

  6/26/2019 - 5 years ago

Organizations

• CENTRE FOR ADDICTION AND MENTAL HEALTH

PROJECT SUMMARY DESCRIPTION: Over the past decades, antidepressants and psychotherapy have been the first-line treatments for LLD. Despite being safe and well-tolerated, a large number of patients do not achieve full and persistent remission after initial treatment. About 50% of patients with LLD do not respond after two antidepressant trials, meeting the consensus definition of treatment resistance (TR-LLD). The persistence of chronic and elevated depressive symptoms in older adults has significant clinical and public health implications. This has been correlated to poor general health, reduced quality of life, and a higher risk of mortality when compared to those with sustained remission after treatment. Despite the

IC Name

• Activity

  R01

• Administering IC

  MH

• Application Type

  1

• Direct Cost Amount

  482982

• Indirect Cost Amount

  35343

• Total Cost

  518325

• Sub Project Total Cost

• ARRA Funded

  False

• CFDA Code

  242

• Ed Inst. Type

• Funding ICs

  NIMH:518325\

• Funding Mechanism

  Non-SBIR/STTR RPGs

• Study Section

  MESH

• Study Section Name

  Biobehavioral Mechanisms of Emotion, Stress and Health Study Section

• Organization Name

  CENTRE FOR ADDICTION AND MENTAL HEALTH

• Organization Department

• Organization DUNS

  207855271

• Organization City

  TORONTO

• Organization State

  ON

• Organization Country

  CANADA

• Organization Zip Code

  M5S2S1

• Organization District

  CANADA