Claims
- 1. A delivery device for delivering a substance which comprises a water impermeable hollow female body (6) having a neck portion and containing the substance (12) to be delivered, together with an expandable material (10) whose volume expands rapidly in contact with an aqueous medium in order to positively expel the substance from the female body, the expandable material being present in a lower layer within the female body and the substance to be delivered being present in a upper layer closer to the neck portion of the female body; and a water-swellable male member (2) engaged with the neck portion (4) of the hollow female body which swells so as to disengage the hollow female body upon exposure of the device to the aqueous medium and thereby allows the aqueous medium to come into contact with the expandable material (10) within the hollow female body.
- 2. A device according to claim 1 wherein the expandible material is a solid material whose volume increases due to absorption of water from the aqueous environment.
- 3. A device according to claim 2 wherein the solid expandible material is in particulate form.
- 4. A device according to claim 3 wherein the solid expandable material has a particle size in range the range 50 to 500 microns.
- 5. A device according to claim 1 wherein the expandable material is a hydrogel.
- 6. A device according to claim 5 wherein on absorption of water the hydrogel particles swell into a porous network having channels therein which continue to allow access of said aqueous medium thereto.
- 7. A device according to claim 5 wherein the hydrogel is a polyurethane prepared from a polyethylene glycol, a C.sub.6 -C.sub.10 alkanetriol and a diisocyanate.
- 8. A device according to claim 7 wherein the polyurethane is prepared from a polyethylene glycol having a number average molecular weight of 4000 to 12,000, hexanetriol and dicyclohexylmethane-4,4-diisocyanate.
- 9. A device according to claim 6 wherein the hydrogel is comprised of coated particles.
- 10. A device according to claim 9 wherein the particles are covered with a coating material selected from the group consisting of: monosaccharides, polysaccharides, sugars, starches and celluloses.
- 11. A device according to claim 10 wherein the coating materials comprises 0.5 to 20 wt % of the coated particle.
- 12. A device according to claim 1 wherein the expandible material is a pharmaceutical disintegrant.
- 13. A device according to claim 12 wherein the disintegrant is selected from the group consisting of starches, celluloses and polyvinylpyrrolidone.
- 14. A device according to claim 13 wherein the disintegrant is a low-substituted 2-hydroxypropyl ether cellulose.
- 15. A device according to claim 1 wherein the substance is substantially completely expelled from the body in 0.5 to 5 mins.
- 16. A device according to claim 1 wherein the male member is a plug, and the plug is formed of a water swellable material.
- 17. A device according to claim 16 wherein the plug is formed of a hydrogel.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9326267 |
Dec 1993 |
GBX |
|
Parent Case Info
This application is a 371 of PCT/GB94/02793 filed Dec. 22, 1994.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/GB94/02793 |
12/22/1994 |
|
|
9/20/1996 |
9/20/1996 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO95/17172 |
6/29/1995 |
|
|
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5342624 |
Mc Neill et al. |
Aug 1994 |
|