Claims
- 1. A medicinal kit which consists of:
- (1) a first container means containing a fat emulsion; and
- (2) a second container means containing a pharmaceutical substance; and either
- (a) at least one solvent selected from the group consisting of liquid polyalkylene glycols, liquid alkylethanolamines, and liquid polyhydric alcohols; or
- (b) at least one excipient selected from the group consisting of a saccharide and an amino acid,
- wherein the pharmaceutical substance is at least one member selected from the group consisting of steroids, carcinostatics, prostaglandins, fat-soluble vitamins, anti-inflammatories, caridiotonics, antiarrhythmics, vasodilators, and calcium antagonists whereby the contents of said first container means and of said second container means are mixed upon use to form a resulting composition.
- 2. The medicinal kit according to claim 1, wherein the fat emulsion is composed of:
- (a) 0.1-50 w/v % of an oil component;
- (b) 1-50 part by weight of an emulsifier per 100 parts by weight of the oil component; and
- (c) water.
- 3. The medicinal kit of claim 2, wherein the oil component is at least one member selected from the group consisting of soybean oil, cotton seed oil, safflower oil, corn oil, sesame oil, olive oil, medium chain fatty acid triglycerides, eicosapentanoic acid, and triacetin.
- 4. The medicinal kit of claim 2, wherein the emulsifier is at least one member selected from the group consisting of phospholipids, lecithin, hydrogenated lecithin, and nonionic surface active agents.
- 5. The medicinal kit according to claim 1 or claim 2, wherein the fat emulsion includes fat particles having an average particle size of 1 .mu.m or less.
- 6. The medicinal kit according to claim 1, wherein the fat emulsion consists of fat emulsion particles whose surfaces are modified.
- 7. The medicinal kit according to claim 1, wherein the amount of component (2) is less than 10 parts by weight or volume per 100 parts by weight or volume of the fat emulsion.
- 8. The medicinal kit according to claim 1, wherein the liquid polyalkylene glycol is polyethylene glycol having an average molecular weight of 800 or less.
- 9. The medicinal kit according to claim 1, wherein the polyhydric alcohol is propylene glycol.
- 10. A method for preparation of a pharmaceutical composition comprising the step of admixing:
- (1) a fat emulsion, and
- (2) a composition comprising a pharmaceutical substance; and either
- (a) at least one solvent selected from the group consisting of liquid polyalkylene glycols, liquid alkylethanolamines and liquid polyhydric alcohols; or
- (b) at least one excipient selected from the group consisting of a saccharide and an amino acid, wherein the pharmaceutical substance is at least one member selected from the group consisting of steroids, carcinostatics, prostaglandins, fat-soluble vitamins, anti-inflammatories, caridiotonics, antiarrhythmics, vasodilators, and calcium antagonists.
Priority Claims (2)
Number |
Date |
Country |
Kind |
62-222130 |
Sep 1987 |
JPX |
|
62-222131 |
Sep 1987 |
JPX |
|
Parent Case Info
This is a Continuation of application Ser. No. 07/378,519, filed May 4, 1989 now abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP88/00889 |
9/5/1988 |
|
|
5/4/1989 |
5/4/1989 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO89/02265 |
3/23/1989 |
|
|
US Referenced Citations (8)
Foreign Referenced Citations (3)
Number |
Date |
Country |
2441761 |
Mar 1976 |
DEX |
2112759 |
Jun 1972 |
FRX |
2300574 |
Oct 1976 |
FRX |
Non-Patent Literature Citations (4)
Entry |
Fortner et al, Am. J. Hosp. Pharm., 32:582-584 (1975). |
El-Sayed et al, Int'l. J. Pharmaceutics, 13:303-312 (1983). |
Chemical Abstracts, 101:375 (1984) Huang, L et al. |
Physicians Desk Reference (Ed: Carrie. Henwood) pub. by Edward Barnhart (1990) 44th Edition pp. 502-2455. |
Continuations (1)
|
Number |
Date |
Country |
Parent |
378519 |
May 1989 |
|