Patent Grant
10485753
The present disclosure generally relates to pharmaceutical compositions that provide extended release of active ingredients and have abuse deterrent properties.
In 2008 it was reported that non-medical use of pain relievers among the population aged 12 or older in the United States was second highest in prevalence among illicit drugs, after marijuana. Abuse of prescription pharmaceutical products follows the increasing availability of opioid dosage forms due to the more aggressive treatment of chronic pain in the populace. The increasing number of abusers, increasing availability, and the destructive/addictive potential of opiates make prescription pharmaceutical abuse a matter of public health concern.
Several routes of administration are commonly attempted by abusers. For example, the pharmaceutical dosage form may be chewed, or it may be crushed or pulverized into a powder and administered intranasally (i.e., snorted). Alternatively, the intact or tampered pharmaceutical dosage form may be dissolved in a suitable solvent and administered parenterally (i.e., injected intravenously), or the intact or tampered dosage form may be smoked.
To deter misuse and/or abuse of pharmaceutical dosage forms with extended drug release, multiple strategies have been employed. First, a chemical approach has been utilized to include an opioid antagonist in opioid pharmaceutical dosage forms. The opioid antagonist, which is not orally active, will substantially block the analgesic effects of the opioid when one attempts to abuse the tampered dosage form via snorting or injecting. Second, aversive agents and/or bitter agents have been added to pharmaceutical formulations to prevent abuse of the active pharmaceutical ingredient. This approach, however, could cause adverse effects in the patient population due to the properties associated with these agents. Third, a safer alternative is to incorporate excipients that provide a physical barrier in which abuse of the API is deterred. In one case, this is accomplished by incorporating the API into a polymeric matrix tablet containing high molecular weight gel forming polymers such as polyethylene oxide. The polymeric matrix tablet has increased hardness and retains a plastic-like nature after curing at a temperature above the softening temperature of the polyethylene oxide. The resultant tablet dosage form is difficult to crush or chew and forms a viscous gel when the dosage form comes into contact with a suitable solvent. However, because polyethylene oxide forms oxidative peroxide radicals when heated, APIs susceptible to oxidative degradation should be incorporated into such dosage forms with care. Alternately, the conditions for curing the dosage form with an API sensitive to oxidation must be tightly controlled, sometimes limiting the tamper resistant properties thereof. Similarly, thermolabile APIs cannot be incorporated into these cured dosage forms.
To impart abuse deterrent properties to pharmaceutical dosage forms comprising polymers, the polymers generally need to be plasticized. Typically, polymers are plasticized by plasticizers using either of two commonly used methods that thoroughly incorporate the plasticizers into the polymers. The most common method is hot melt extrusion. In this process, polymers and plasticizers are intimately mixed under heat and pressure and then extruded out of small orifices. Recent strides in this technique have resulted in acceptable material throughput for large scale manufacturing. A less common method for incorporating a plasticizer into a polymer involves dissolving the polymer and the plasticizer in a suitable co-solvent and then spray drying the mixture. This method has a very low material throughput and also has the significant technical issue of the plasticized polymers sticking to the spray drier. However, in both of these methods, the resultant plasticized polymer mass can be a sticky, non-flowable material that poses additional processing problems in milling, blending, and compressing with conventional manufacturing equipment.
Thus, there is a need for pharmaceutical dosage forms comprised of polymers that provide extended release of the API and are resistant to abuse and/or misuse. Additionally, there is a need for the easy manufacture of a plasticized polymer mass into a dosage form utilizing conventional processing equipment.
The present disclosure provides a tamper resistant, extended release comprising at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer. The pharmaceutical composition disclosed herein provides extended release of the API and has abuse deterrent properties.
A further aspect of the present disclosure provides a process for preparing a solid dosage form. The process comprises: (a) forming a mixture comprising at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the mixture is a powder, a granulate, or a solid dosage unit; (b) humidifying the mixture of (a) to form a humidified powder, a humidified granulate, or a humidified solid dosage unit; (c) optionally forming the humidified powder or the humidified granulate into a treated solid dosage unit; (d) optionally coating the humidified solid dosage unit of (b) or the treated solid dosage unit of (c) to form a coated solid dosage unit; and (e) heating the humidified solid dosage unit of (b), the treated solid dosage unit of (c), or the coated solid dosage unit of (d) to form the solid dosage form.
Other aspects and iterations of the disclosure are described in more detail below.
The present disclosure provides solid dosage pharmaceutical compositions that provide extended release of an active pharmaceutical ingredient and have abuse deterrent properties. Also provided are methods for making the extended release, abuse deterrent pharmaceutical compositions. The pharmaceutical compositions disclosed herein comprise at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer. Applicants of the present invention discovered that the hydrophilic polymers can be plasticized with deliquescent plasticizer by humidification of the composition comprising the polymers. Under a humid environment, the deliquescent plasticizer absorbs moisture from the atmosphere to become a liquid, thereby allowing the plasticizer to effectively plasticize the hydrophilic polymers. The humidified composition is then heated to remove excess moisture and to cure the hydrophilic polymers. The resultant composition has sufficient hardness and resiliency such that it resists being crushed or ground into fine particles.
(I) Pharmaceutical Composition
One aspect of the present disclosure provides extended release, abuse deterrent pharmaceutical compositions. Detailed below are the components of the composition, dosage forms of the composition, release characteristics of the composition, and abuse deterrent properties of the composition.
The pharmaceutical composition disclosed herein comprises at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer. The combination of hydrophilic plastomers and optional hydrophilic elastomer, when suitably plasticized by the deliquescent plasticizer and heat-treated, creates a functional abuse deterrent composition.
(i) Hydrophilic Plastomer
The pharmaceutical composition comprises at least one hydrophilic plastomer. The term “hydrophilic” refers to a substance with affinity for water that readily absorbs and/or dissolves in water, and the term “plastomer” refers to a hard, rigid polymeric substance. More specifically, a hydrophilic plastomer refers to any polymeric substance that imparts hardness to a solid dosage form matrix when plasticized and/or cured.
The hydrophilic plastomer may be water soluble, water swellable, thermoplastic, or any combination thereof, and the hydrophilic plastomer may be natural, semi-synthetic, or synthetic. Non-limiting examples of suitable hydrophilic plastomers include cellulose ethers (such as, e.g., hydroxypropyl cellulose (HPC), methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose (HPMC), carboxymethyl cellulose, and the like); polyalkylene oxides (such as, e.g., polyethylene oxide (PEO), polypropylene oxide, and copolymers thereof); polyalkylene glycols (such as, e.g., polyethylene glycol, polypropylene glycol, and copolymers thereof); polyolefinic alcohols (such as, e.g., polyvinyl alcohol); polyvinyl lactams (such as, e.g., polyvinylpyrrolidone); polyvinyl alcohol/polyvinylpyrrolidone copolymers; polycarboxylic acids; polysaccharides (such as, e.g., celluloses, dextrans, gums derived from microbes or plants, starches, pectins, chitin, chitosan, and the like); polypeptides (such as, e.g., gelatin, albumin, polylysine, soy protein, and so forth); and combinations or copolymers of any of the foregoing. In exemplary embodiments, the hydrophilic plastomer may be hydroxypropyl cellulose, hydroxypropylmethyl cellulose, polyethylene oxide, or combinations thereof.
The hydrophilic plastomer may have a molecular weight ranging from about 20,000 daltons (Da) to about 2,000,000 Da. In various embodiments, the molecular weight of the hydrophilic plastomer may range from about 20,000 Da to about 100,000 Da, from about 100,000 Da to about 400,000 Da, from about 400,000 Da to about 1,000,000 Da, or from about 1,000,000 Da to about 2,000,000 Da. In one exemplary embodiment, the hydrophilic plastomer may have a molecular weight ranging from about 100,000 Da to about 200,000 Da. In another exemplary embodiment, the hydrophilic plastomer may have a molecular weight ranging from about 800,000 Da to about 900,000 Da.
The amount of hydrophilic plastomer present in the pharmaceutical composition can and will vary depending upon the identity of the hydrophilic plastomer, as well as the identity and/or amount of the other components utilized in the pharmaceutical composition. In general, the amount of hydrophilic plastomer present in the pharmaceutical composition may range from about 10% to about 90% by weight of the composition. In various embodiments, the amount of the hydrophilic plastomer present in the pharmaceutical composition may range from about 10% to about 20%, from about 20% to about 30%, from about 30% to about 40%, from about 40% to about 50%, or from about 50% to about 60%, from about 60% to about 70%, from about 70% to about 80%, or from about 80% to about 90% by weight of the pharmaceutical composition. In exemplary embodiments, the amount of the hydrophilic plastomer present may range from 30% to about 80% by weight of the pharmaceutical composition.
(ii) Hydrophilic Elastomer
The pharmaceutical composition disclosed herein may comprise at least one hydrophilic elastomer. The term “elastomer” refers to a substance with viscoelasticity, generally having a low Young's modulus (i.e., low rigidity) and a high strain yield (i.e., high deformability). The inclusion of a hydrophilic elastomer in the composition may counter the brittleness of the hydrophilic plastomer(s).
The hydrophilic elastomer may be water soluble and/or water swellable; and the elastomer may be natural, semi-synthetic, or synthetic. As will be appreciated by those skilled in the art, the molecular size of the elastomer can and will vary depending upon the identity of the elastomer. Suitable hydrophilic elastomers include, without limit, polyacrylates, polymethacrylates, combinations thereof, or copolymers thereof. Non-limiting examples of suitable polyacrylates include carbomers, which are homopolymers of acrylic acid crosslinked with a polyalcohol allyl ether (e.g., allyl ether pentaerythritol, allyl ether of sucrose, allyl ether of propylene), and polycarbophil, which is a homopolymer of acrylic acid crosslinked with divinyl glycol. Suitable hydrophilic methacrylate polymers include, but are not limited to, polyhydroxyethyl methacrylate, copolymers of methyl methacrylate and ethyl acrylate, and the like. In one embodiment, the hydrophilic elastomer may be a carbomer.
The amount of hydrophilic elastomer present in the pharmaceutical composition can and will vary depending upon the identity of the hydrophilic elastomer, as well as the identity and/or the amount of the hydrophilic plastomer(s) present in the pharmaceutical composition. In embodiments in which the hydrophilic elastomer is present, the amount of hydrophilic elastomer present in the pharmaceutical composition may range from about 0.5% to about 40% by weight of the composition. In various embodiments, the amount of hydrophilic elastomer present in the pharmaceutical composition may range from about 0.5% to about 2%, from about 2% to about 5%, from about 5% to about 10%, or from about 10% to about 20%, or from about 20% to about 40% by weight of the pharmaceutical composition. In exemplary embodiments, the pharmaceutical composition comprises the hydrophilic elastomer at an amount ranging from about 0.5% to about 10% by weight of the composition. In other embodiments, the hydrophilic elastomer is not present.
(iii) Deliquescent Plasticizer
The pharmaceutical composition disclosed herein also comprises at least one deliquescent plasticizer. In general, plasticizers increase the plasticity or fluidity of a material. A “deliquescent plasticizer” refers to a compound that is able to absorb moisture from the air such that it forms a saturated solution. Deliquescence occurs when the partial vapor pressure of the deliquescent plasticizer is less than the partial pressure of water vapor in the air. As a consequence, the deliquescent plasticizer liquefies and its mobility increases. Thus, in the pharmaceutical composition disclosed herein, humidification of a mixture comprising the hydrophilic plastomer, the hydrophilic elastomer, and the deliquescent plasticizer allows the deliquescent plasticizer to become liquid such that it can incorporate into the hydrophilic plastomer and the hydrophilic elastomer, thereby plasticizing the hydrophilic plastomer and the hydrophilic elastomer.
The deliquescent plasticizer may be an organic acid, a sugar alcohol, a co-processed mixture of an organic acid and/or a sugar alcohol and a liquid plasticizer, or combinations thereof. Non-limiting examples of suitable organic acids include citric acid, glutaric acid, malic acid, tartaric acid, and the like. In one embodiment, the organic acid may be citric acid. Suitable sugar alcohols include, without limit, sorbitol, xylitol, maltitol, and the like. In another embodiment, the sugar alcohol may be sorbitol. In general, the organic acid and the sugar alcohol are in solid forms. Non-limiting examples of suitable liquid plasticizers include glycerol (glycerin), polyethylene glycols (e.g., PEG 300, PEG 400, PEG 600, PEG 1000, etc.), triethyl citrate, tributyl citrate, acetyl triethyl citrate, triacetin (i.e., glycerol triacetal), dibutyl sebacate, diethyl phthalate, dibutyl phthalate, and combinations thereof. In one embodiment, the co-processed mixture may comprise sorbitol and PEG. In another embodiment, the co-processed mixture may comprise sorbitol and glycerol.
A co-processed mixture of an organic acid and/or a sugar alcohol and a liquid plasticizer may be prepared by contacting a solid form of the organic acid and/or the sugar alcohol with the liquid plasticizer. In general, the liquid plasticizer contacts the surface of the solid form of the organic acid and/or the sugar alcohol. The ratio of the liquid plasticizer to the organic acid and/or the sugar alcohol can and will vary. For example, the ratio of the liquid plasticizer to the organic acid and/or the sugar alcohol may be about 1:99, about 5:95, about 10:90, about 15:85, about 20:80, about 25:75, about 30:70, about 40:60, or any ratio there between. In some embodiments, the liquid plasticizer may be mixed with a suitable solvent. A suitable solvent is a solvent in which the liquid plasticizer dissolves, but the solid organic acid and/or sugar alcohol does not dissolve. Non-limiting examples of suitable solvents include alcohols, such as methanol, ethanol, isopropanol, propanol, and the like. In an embodiment in which the liquid plasticizer is glycerol, the solvent may be isopropanol. Contact between the liquid plasticizer and the solid form of the organic acid and/or the sugar alcohol may be performed in a fluid bed coater, a low shear planetary mixer, or any other suitable device known in the art.
In exemplary embodiments, the deliquescent plasticizer may be citric acid, a combination of citric acid and sorbitol, or a combination of citric acid and a co-processed mixture of sorbitol and glycerol.
In embodiments in which the deliquescent plasticizer comprises an organic acid, the amount of organic acid present in the pharmaceutical composition may range from about 1% to about 20% by weight of the pharmaceutical composition. In various iterations, the amount of organic acid present in the pharmaceutical composition may range from about 1% to about 5%, from about 5% to about 10%, from about 10% to about 15%, or from about 15% to about 20% by weight of the pharmaceutical composition.
In embodiments in which the deliquescent plasticizer comprises a sugar alcohol, the amount of sugar alcohol present in the pharmaceutical composition may range from about 1% to about 15% by weight of the pharmaceutical composition. In certain iterations, the amount of sugar alcohol present in the pharmaceutical composition may range from about 1% to about 5%, from about 5% to about 10%, or from about 10% to about 15% by weight of the pharmaceutical composition.
In embodiments in which the deliquescent plasticizer comprises a co-processed blend of a sugar alcohol and a liquid plasticizer, the amount of the co-processed blend present in the pharmaceutical composition may range from about 5% to about 25% by weight of the pharmaceutical composition. In some iterations, the amount of the co-processed blend present in the pharmaceutical composition may range from about 5% to about 10%, from about 10% to about 15%, from about 15% to about 20%, or from about 20% to about 25% by weight of the pharmaceutical composition.
The total amount of deliquescent plasticizer present in the pharmaceutical composition can and will vary depending upon the identities and/or amounts of the hydrophilic plastomers and elastomers present in the pharmaceutical composition. In general, the total amount of the deliquescent plasticizer present in the composition may range from about 2% to about 50% by weight of the pharmaceutical composition. In some embodiments, the total amount of the deliquescent plasticizer present may range from about 5% to about 40% by weight of the pharmaceutical composition. In other embodiments, the total amount of the deliquescent plasticizer present may range from about 10% to about 30% by weight of the pharmaceutical composition. In various embodiments, the total amount of the deliquescent plasticizer present in the pharmaceutical composition may range from about 5% to about 10%, from about 10% to about 15%, from about 15% to about 20%, from about 20% to about 25%, from about 25% to about 30%, from about 30% to about 40%, or from about 40% to about 50% by weight of the pharmaceutical composition. In exemplary embodiments, the total amount of the deliquescent plasticizer present may range from about 10% to about 30% by weight of the pharmaceutical composition.
(iv) Optional Modifying Agents
The pharmaceutical composition disclosed herein may optionally include one or more modifying agents that improve the abuse deterrent properties, add additional abuse deterrent features, and/or facilitate preparation (e.g., manufacturability) of the pharmaceutical composition. The modifying agent may be a hydrophilic gelling polymer, a clay mineral, a super-disintegrant, an alkalizing agent, a lubricant, or combinations thereof.
Hydrophilic gelling polymer. The optional modifying agent may be a hydrophilic gelling polymer. Hydrophilic gelling polymers, which are well known in the art, form viscous mixtures or gels when in contact with a suitable solvent. Inclusion of a gelling polymer may increase the gelling rate kinetics and/or overall gel viscosity when the pharmaceutical composition disclosed herein is in contact with a small volume of a suitable solvent. As a consequence, the resultant viscous mixture is difficult to draw into a syringe, thereby making it difficult or impossible to inject. Thus, the presence of the hydrophilic gelling polymer may provide another tampering deterrent feature to the pharmaceutical composition. Non-limiting examples of hydrophilic polymers are presented above in sections (I)(a)(i)-(ii). In one embodiment, the hydrophilic gelling polymer may be a cellulose ether. For example, the hydrophilic gelling polymer may be hydroxypropylmethyl cellulose (HPMC). In exemplary embodiments, the hydrophilic gelling polymer may be hydroxypropylmethyl cellulose having a molecular weight of about 150,000 Da.
In embodiments in which the hydrophilic gelling polymer is included in the pharmaceutical composition, the amount the hydrophilic gelling polymer may range from about 0.1% to about 40% by weight of the pharmaceutical composition. In certain embodiments, the amount the hydrophilic gelling polymer may range from about 0.1% to about 5%, from about 5% to about 10%, from about 10% to about 20%, or from about 20% to about 40% by weight of the pharmaceutical composition. In exemplary embodiments in which the hydrophilic gelling polymer is included, the amount of the hydrophilic gelling polymer included in the pharmaceutical composition may range from about 5% to about 20% by weight of the pharmaceutical composition.
Clay mineral. The optional modifying agent may be a clay mineral. As used herein, a “clay mineral” refers to a hydrated aluminum phyllosilicate or a hydrated magnesium silicate. In general, clay minerals comprise small insoluble particles. The clay mineral may be absorbent and/or adsorbent. Inclusion of a clay mineral may not only increase the tensile strength of the pharmaceutical composition, but the clay mineral also may adsorb the API when the pharmaceutical composition is in contact with a small volume of a suitable solvent. Additionally, the clay mineral may provide a visual deterrent to tampering with the pharmaceutical composition because the small clay particles form a cloudy suspension when in contact with a small volume of a suitable solvent.
Non-limiting examples of suitable clay minerals include talc, bentonites (such as sodium bentonite or calcium bentonite), kaolinites, nontronites, montmorillonites, pyrophyllites, saponites, sauconites, vermiculites, and combinations thereof. In a preferred embodiment, the clay mineral may be sodium bentonite. In embodiments in which the clay mineral is present in the pharmaceutical composition, the amount of the clay mineral may range from about 0.1% to about 5% by weight of the pharmaceutical composition. In various embodiments, the amount of the clay mineral may range from about 0.1% to about 0.3%, from about 0.3% to about 1%, or from about 1% to about 5% by weight of the pharmaceutical composition.
Super-disintegrant. The optional modifying agent may be a super-disintegrant. A super-disintegrant may facilitate the gelling kinetics of the pharmaceutical composition when it is in contact with a small volume of a suitable solvent, without affecting the extended release properties of the pharmaceutical composition. Non-limiting examples of suitable super-disintegrants include crospovidone, croscarmellose sodium, colloidal silicon dioxide, sodium starch glycolate, and low substituted hydroxypropyl cellulose. In one embodiment, the super-disintegrant may be crospovidone.
In embodiments in which the pharmaceutical composition includes a super-disintegrant, the amount of the super-disintegrant may range from about 0.1% to about 10% by weight of the pharmaceutical composition. In certain embodiments, the amount of the super-disintegrant may range from about 0.1% to about 0.3%, from about 0.3% to about 1%, from about 1% to about 3%, or from about 3% to about 10% by weight of the pharmaceutical composition. In exemplary embodiments, the amount of super-disintegrant included in the pharmaceutical composition may range from about 0.25% to about 3% by weight of the pharmaceutical composition.
Alkalizing agent. The optional modifying agent may be an alkalizing agent. Inclusion of an alkalizing agent may facilitate the gelling kinetics of the hydrophilic elastomer when the pharmaceutical composition is in contact with a small volume of a suitable solvent. Thus, the presence of the alkalizing agent may provide additional abuse deterrent features to the pharmaceutical composition. Non-limiting examples of suitable alkalizing agents include di- and tri-basic phosphate salts (e.g., sodium or potassium phosphate dibasic, or sodium or potassium phosphate tribasic), bicarbonate salts (e.g., sodium or potassium bicarbonate), carbonate salts (e.g., sodium or potassium carbonate), and combinations thereof. In exemplary embodiments, the alkalizing agent may be potassium phosphate dibasic.
In embodiments in which the alkalizing agent is included in the pharmaceutical compositions, the amount of the alkalizing agent may range from about 0.1% to about 3% by weight of the pharmaceutical composition. In various embodiments, the amount of the alkalizing agent may range from about 0.1% to about 0.3%, from about 0.3% to about 1%, or from about 1% to about 3% by weight of the pharmaceutical composition.
Lubricant. The optional modifying agent may be a lubricant, which facilitates preparation of solid dosage forms of the pharmaceutical composition. Non-limiting examples of suitable lubricants include magnesium stearate, calcium stearate, zinc stearate, colloidal silicon dioxide, hydrogenated vegetable oils, sterotex, polyoxyethylene monostearate, polyethylene glycol, sodium stearyl fumarate, sodium benzoate, sodium lauryl sulfate, magnesium lauryl sulfate, and light mineral oil. In exemplary embodiments, the lubricant may be magnesium stearate or colloidal silicon dioxide.
In embodiments in which the lubricant is included in the pharmaceutical composition, the amount of the lubricant may range from about 0.1% to about 3% by weight of the pharmaceutical composition. In various embodiments, the amount of the lubricant may range from about 0.1% to about 0.3%, from about 0.3% to about 1%, or from about 1% to about 3% by weight of the pharmaceutical composition. In exemplary embodiments, the amount of the lubricant may be about 1% by weight of the pharmaceutical composition.
(v) API
The pharmaceutical composition disclosed also comprises at least one API or salt thereof. Suitable APIs include, without limit, opioid analgesic agents (e.g., adulmine, alfentanil, allocryptopine, allylprodine, alphaprodine, anileridine, aporphine, benzylmorphine, berberine, bicuculine, bicucine, bezitramide, buprenorphine, bulbocaprine, butorphanol, clonitazene, codeine, desomorphine, dextromoramide, dezocine, diampromide, diamorphone, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene, fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levorphanol, levophenacylmorphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metopon, morphine, myrophine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, nalbuphene, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, propheptazine, promedol, properidine, propoxyphene, sufentanil, tapentadol, tilidine, and tramadol); non-opioid analgesic agents (e.g., acetylsalicylic acid, acetaminophen, paracetamol, ibuprofen, ketoprofen, indomethacin, diflunisol, naproxen, ketorolac, dichlophenac, tolmetin, sulindac, phenacetin, piroxicam, and mefamanic acid); anti-inflammatory agents (e.g., glucocorticoids such as alclometasone, fluocinonide, methylprednisolone, triamcinolone and dexamethasone; non-steroidal anti-inflammatory agents such as celecoxib, deracoxib, ketoprofen, lumiracoxib, meloxicam, parecoxib, rofecoxib, and valdecoxib); antitussive agents (e.g., dextromethorphan, codeine, hydrocodone, caramiphen, carbetapentane, and dextromethorphan); antipyretic agents (e.g., acetylsalicylic acid and acetaminophen); antibiotic agents (e.g., aminoglycosides such as, amikacin, gentamicin, kanamycin, neomycin, netilmicin, streptomycin, and tobramycin; carbecephem such as loracarbef; carbapenems such as certapenem, imipenem, and meropenem; cephalosporins such as cefadroxil cefazolin, cephalexin, cefaclor, cefamandole, cephalexin, cefoxitin, cefprozil, cefuroxime, cefixime, cefdinir, cefditoren, cefoperazone, cefotaxime, cefpodoxime, ceftazidime, ceftibuten, ceftizoxime, and ceftriaxone; macrolides such as azithromycin, clarithromycin, dirithromycin, erythromycin, and troleandomycin; monobactam; penicillins such as amoxicillin, ampicillin, carbenicillin, cloxacillin, dicloxacillin, nafcillin, oxacillin, penicillin G, penicillin V, piperacillin, and ticarcillin; polypeptides such as bacitracin, colistin, and polymyxin B; quinolones such as ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, and trovafloxacin; sulfonamides such as mafenide, sulfacetamide, sulfamethizole, sulfasalazine, sulfisoxazole, and trimethoprim-sulfamethoxazole; tetracyclines such as demeclocycline, doxycycline, minocycline, and oxytetracycline); antimicrobial agents (e.g., ketoconazole, amoxicillin, cephalexin, miconazole, econazole, acyclovir, and nelfinavir); antiviral agents (e.g., acyclovir, gangciclovir, oseltamivir, and relenza); steroids (e.g., estradiol, testosterone, cortisol, aldosterone, prednisone, and cortisone); amphetamine stimulant agents (e.g., amphetamine and amphetamine-like drugs); non-amphetamine stimulant agents (e.g., methylphenidate, nicotine, and caffeine); laxative agents (e.g., bisacodyl, casanthranol, senna, and castor oil); anti-nausea agents (e.g., dolasetron, granisetron, ondansetron, tropisetron, meclizine, and cyclizine); anorexic agents (e.g., fenfluramine, dexfenfluramine, mazindol, phentermine, and aminorex); antihistaminic agents (e.g., phencarol, cetirizine, cinnarizine, ethamidindole, azatadine, brompheniramine, hydroxyzine, and chlorpheniramine); antiasthmatic agents (e.g., zileuton, montelukast, omalizumab, fluticasone, and zafirlukast); antidiuretic agents (e.g., desmopressin, vasopressin, and lypressin); antimigraine agents (e.g., naratriptan, frovatriptan, eletriptan, dihydroergotamine, zolmitriptan, almotriptan, and sumatriptan); antispasmodic agents (e.g., dicyclomine, hyoscyamine, and peppermint oil); antidiabetic agents (e.g., methformin, acarbose, miglitol, pioglitazone, rosiglitazone, nateglinide, repaglinide, mitiglinide, saxagliptin, sitagliptine, vildagliptin, acetohexamide, chlorpropamide, gliclazide, glimepiride, glipizide, glyburide, tolazamide, and tolbutamide); respiratory agents (e.g., albuterol, ephedrine, metaproterenol, and terbutaline); sympathomimetic agents (e.g., pseudoephedrine, phenylephrine, phenylpropanolamine, epinephrine, norepinephrine, dopamine, and ephedrine); H2 blocking agents (e.g., cimetidine, famotidine, nizatidine, and ranitidine); antihyperlipidemic agents (e.g., clofibrate, cholestyramine, colestipol, fluvastatin, atorvastatin, genfibrozil, lovastatin, niacin, pravastatin, fenofibrate, colesevelam, and simvastatin); antihypercholesterol agents (e.g., lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, cholestyramine, colestipol, colesevelam, nicotinic acid, gemfibrozil, and ezetimibe); cardiotonic agents (e.g., digitalis, ubidecarenone, and dopamine); vasodilating agents (e.g., nitroglycerin, captopril, dihydralazine, diltiazem, and isosorbide dinitrate); vasoconstricting agents (e.g., dihydroergotoxine and dihydroergotamine); anticoagulants (e.g., warfarin, heparin, and Factor Xa inhibitors); sedative agents (e.g., amobarbital, pentobarbital, secobarbital, clomethiazole, diphenhydramine hydrochloride, and alprazolam); hypnotic agents (e.g., zaleplon, zolpidem, eszopiclone, zopiclone, chloral hydrate, and clomethiazole); anticonvulsant agents (e.g., lamitrogene, oxycarbamezine, phenytoin, mephenytoin, ethosuximide, methsuccimide, carbamazepine, valproic acid, gabapentin, topiramate, felbamate, and phenobarbital); muscle relaxing agents (e.g., baclofen, carisoprodol, chlorzoxazone, cyclobenzaprine, dantrolene sodium, metaxalone, orphenadrine, pancuronium bromide, and tizanidine); antipsychotic agents (e.g., phenothiazine, chlorpromazine, fluphenazine, perphenazine, prochlorperazine, thioridazine, trifluoperazine, haloperidol, droperidol, pimozide, clozapine, olanzapine, risperidone, quetiapine, ziprasidone, melperone, and paliperidone); antianxiolitic agents (e.g., lorazepam, alprazolam, clonazepam, diazepam, buspirone, meprobamate, and flunitrazepam); antihyperactive agents (e.g., methylphenidate, amphetamine, and dextroamphetamine); antihypertensive agents (e.g., alpha-methyldopa, chlortalidone, reserpine, syrosingopine, rescinnamine, prazosin, phentolamine, felodipine, propanolol, pindolol, labetalol, clonidine, captopril, enalapril, and lisonopril); anti-neoplasia agents (e.g., taxol, actinomycin, bleomycin A2, mitomycin C, daunorubicin, doxorubicin, epirubicin, idarubicin, and mitoxantrone); soporific agents (e.g., zolpidem tartrate, eszopiclone, ramelteon, and zaleplon); tranquilizer agents (e.g., alprazolam, clonazepam, diazepam, flunitrazepam, lorazepam, triazolam, chlorpromazine, fluphenazine, haloperidol, loxapine succinate, perphenazine, prochlorperazine, thiothixene, and trifluoperazine); decongestant agents (e.g., ephedrine, phenylephrine, naphazoline, and tetrahydrozoline); beta blockers (e.g., levobunolol, pindolol, timolol maleate, bisoprolol, carvedilol, and butoxamine); alpha blockers (e.g., doxazosin, prazosin, phenoxybenzamine, phentolamine, tamsulosin, alfuzosin, and terazosin); non-steroidal hormones (e.g., corticotropin, vasopressin, oxytocin, insulin, oxendolone, thyroid hormone, and adrenal hormone); erectile disfunction improvement agents; herbal agents (e.g., glycyrrhiza, aloe, garlic, nigella sativa, rauwolfia, St John's wort, and valerian); enzymes (e.g., lipase, protease, amylase, lactase, lysozyme, and urokinase); humoral agents (e.g., prostaglandins, natural and synthetic, for example, PGE1, PGE2alpha, PGF2alpha, and the PGE1 analog misoprostol); psychic energizers (e.g., 3-(2-aminopropy)indole and 3-(2-aminobutyl)indole); nutritional agents; essential fatty acids; non-essential fatty acids; vitamins; minerals; and combinations thereof.
Any of the above-mentioned APIs may be incorporated in the pharmaceutical composition described herein in any suitable form, such as, for example, as a pharmaceutically acceptable salt, uncharged or charged molecule, molecular complex, solvate or hydrate, prodrug, and, if relevant, isomer, enantiomer, racemic mixture, and/or mixtures thereof. Furthermore, the API may be in any of its crystalline, semi-crystalline, amorphous, or polymorphous forms.
In one embodiment, the API present in the pharmaceutical composition may have a potential for abuse. For example, the API may be an opioid analgesic agent, a stimulant agent, a sedative agent, a hypnotic agent, an antianxiolitic agent, or a muscle relaxing agent.
In another embodiment, the API present in the pharmaceutical composition may be a combination of an opioid analgesic and a non-opioid analgesic. Suitable opioid and non-opioid analgesics are listed above.
In exemplary embodiments, the API in the pharmaceutical composition may be an opioid analgesic. Exemplary opioid analgesics include oxycodone, oxymorphone, hydrocodone, hydromorphone, codeine, and morphine. In an exemplary embodiment, the API may be oxycodone hydrochloride. In another exemplary embodiment, the API may be oxymorphone hydrochloride.
The amount of API in the pharmaceutical composition can and will vary depending upon the active agent. In embodiments in which the API is an opioid analgesic, the amount of opioid in the pharmaceutical composition may range from about 2 mg to about 160 mg. In various embodiments, the amount of opioid in the pharmaceutical composition may range from about 2 mg to about 10 mg, from about 10 mg to about 40 mg, from about 40 mg to about 80 mg, or from about 80 mg to about 160 mg. In certain embodiments, the amount of opioid in the pharmaceutical composition may be about 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 17.5 mg, 20 mg, 22.5 mg, 25 mg, 27.5 mg, 30 mg, 32.5 mg, 35 mg, 37.5 mg, 40 mg, 45 mg, 50 mg, 60 mg, 70 mg, 80 mg, 100 mg, 120 mg, 140 mg, or 160 mg.
In embodiments in which the opioid is oxycodone hydrochloride, the total amount of oxycodone hydrochloride present in the pharmaceutical composition may range from about 2 mg to about 80 mg. In certain embodiments, the amount of oxycodone hydrochloride present in the pharmaceutical composition may range from about 2 mg to about 10 mg, from about 10 mg to about 30 mg, or from about 30 mg to about 80 mg. In preferred embodiments, the amount of oxycodone hydrochloride present in the pharmaceutical composition may be about 5 mg, about 10 mg, about 15 mg, about 20 mg, about 30 mg, about 40 mg, about 60 mg, or about 80 mg.
In embodiments in which the opioid is oxymorphone hydrochloride, the total amount of oxymorphone hydrochloride present in the pharmaceutical composition may range from about 2 mg to about 80 mg. In certain embodiments, the amount of oxymorphone hydrochloride present in the pharmaceutical composition may range from about 2 mg to about 10 mg, from about 10 mg to about 30 mg, or from about 30 mg to about 80 mg. In preferred embodiments, the amount of oxymorphone hydrochloride present in the pharmaceutical composition may be about 5 mg, about 10 mg, about 20 mg, about 30 mg, or about 40 mg.
(vi) Optional Excipients
In various embodiments, the pharmaceutical composition disclosed herein may further comprise at least one additional pharmaceutically acceptable excipient. Non-limiting examples of suitable excipients include binders, fillers, diluents, antioxidants, chelating agents, flavoring agents, coloring agents, taste masking agents, and combinations thereof.
In one embodiment, the excipient may be a binder. Suitable binders include, but are not limited to, starches, pregelatinized starches, gelatin, polyvinylpyrrolidone, cellulose, methyl cellulose, sodium carboxymethyl cellulose, ethyl cellulose, polyacrylamides, polyvinyloxoazolidone, polyvinylalcohols, C12-C18 fatty acid alcohol, polyethylene glycol, polyols, saccharides, oligosaccharides, polypeptides, peptides, and combinations thereof.
In another embodiment, the excipient may be a filler. Suitable fillers include carbohydrates, inorganic compounds, and polyvinylpyrrolidone. For example, the filler may be calcium sulfate, calcium phosphate, calcium silicate, microcrystalline cellulose, starch, modified starches, lactose, sucrose, mannitol, sorbitol, or combinations thereof.
In another embodiment, the excipient may include a diluent. Non-limiting examples of diluents suitable for use include pharmaceutically acceptable saccharides such as sucrose, dextrose, lactose, microcrystalline cellulose, fructose, xylitol, and sorbitol; polyhydric alcohols; starches; pre-manufactured direct compression diluents; and mixtures of any of the foregoing.
In yet another embodiment, the excipient may be an antioxidant. Suitable antioxidants include, without limit, ascorbyl palmitate, butylated hydroxyanisole, a mixture of 2 and 3 tertiary-butyl-4-hydroxyanisole, butylated hydroxytoluene, sodium isoascorbate, dihydroguaretic acid, potassium sorbate, sodium bisulfate, sodium metabisulfate, sorbic acid, potassium ascorbate, vitamin E, 4-chloro-2,6-ditertiarybutylphenol, alphatocopherol, and propylgallate.
In an alternate embodiment, the excipient may be a chelating agent. Non-limiting examples of suitable chelating agents include ethylenediamine tetracetic acid (EDTA) and its salts, N-(hydroxy-ethyl)ethylenediaminetriacetic acid, nitrilotriacetic acid (NIA), ethylene-bis(oxyethylene-nitrilo)tetraacetic acid, 1,4,7,10-tetraazacyclodo-decane-N,N′,N″,N′″-tetraacetic acid, 1,4,7,10-tetraaza-cyclododecane-N,N′,N″-triacetic acid, 1,4,7-tris(carboxymethyl)-10-(2′-hydroxypropyl)-1,4,7,10-tetraazocyclodecane, 1,4,7-triazacyclonane-N,N′,N″-triacetic acid, 1,4,8,11-tetraazacyclotetra-decane-N,N′,N″,N′″-tetraacetic acid; diethylenetriamine-pentaacetic acid (DTPA), ethylenedicysteine, bis(aminoethanethiol)carboxylic acid, triethylenetetraamine-hexaacetic acid, and 1,2-diaminocyclohexane-N,N,N′,N′-tetraacetic acid.
In a further embodiment, the excipient may be a flavoring agent. Flavoring agents may be chosen from synthetic flavor oils and flavoring aromatics and/or natural oils, extracts from plants, leaves, flowers, fruits, and combinations thereof.
In still another embodiment, the excipient may be a coloring agent. Suitable color additives include food, drug and cosmetic colors (FD&C), drug and cosmetic colors (D&C), or external drug and cosmetic colors (Ext. D&C).
In yet another embodiment, the excipient may be a taste-masking agent. Taste-masking materials include cellulose ethers; polyethylene glycols; polyvinyl alcohol; polyvinyl alcohol and polyethylene glycol copolymers; monoglycerides or triglycerides; acrylic polymers; mixtures of acrylic polymers with cellulose ethers; cellulose acetate phthalate; and combinations thereof.
The amount of excipient or excipients included in the pharmaceutical composition can and will vary depending upon the identity and amounts of the components of the pharmaceutical composition as detailed above.
(vii) Optional Film Coating
In some embodiments, the pharmaceutical composition may further comprise an optional film coating. Typically, the film coating comprises at least one water-soluble polymer, and the film coating does not affect the extended release or abuse deterrent properties of the pharmaceutical composition. The film coating may provide moisture protection, enhanced appearance, increased mechanical integrity, improved swallowability, improved taste, and/or masking of odors.
Film coatings are well known in the art, e.g., some are commercially available, e.g., under the tradename OPADRY®. Typically, a film coating comprises at least one water-soluble polymer and at least one plasticizer. Non-limiting examples of suitable polymers include hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylethyl cellulose, ethyl cellulose, methyl cellulose, cellulose acetate phthalate, microcrystalline cellulose and carrageenan, acrylic polymers, polyvinyl alcohol, anionic and cationic polymers of methacrylic acid, copolymers of methacrylates, copolymers of acrylates and methacrylates, copolymers of ethacrylate and methyl methacrylate, polyvinylacetate phthalate, and shellac. Examples of suitable plasticizers include, without limit, triethyl citrate (TEC), acetyltriethyl citrate (ATEC), acetyl tri-n-butyl citrate (ATBC), dibutyl sebacate, diethyl phthalate, and triacetin. The film coating may optionally comprise additional agents such as a coloring agent, a filler, a flavoring agent, a taste-masking agent, a surfactant, an anti-tacking agent, and/or an anti-foaming agent. Suitable examples of these agents are well known in the art and/or are detailed above.
The physical form of the pharmaceutical composition disclosed herein can and will vary. In general, the pharmaceutical composition is a solid dosage form. The solid dosage form may be one of various solid dosage units. Non-limiting examples of suitable solid dosage units include tablets, compacts, pellets, caplets, pills, and capsules. Such dosage units may be prepared using conventional methods known to those in the field of pharmaceutical formulation and described in the pertinent texts, e.g., in Gennaro, A. R., editor. “Remington: The Science & Practice of Pharmacy”, 21st ed., Williams & Williams, and in the “Physician's Desk Reference”, 2006, Thomson Healthcare. In general, the solid dosage form is formulated for oral administration.
In exemplary embodiments, the solid dosage unit may be a tablet. Non-limiting types of tablets include coated tablets, uncoated tablets, compressed tablets, compacted tablets, molded tablets, layered tablets, bilayer tablets, extruded tablets, multiparticle tablets, monolithic tablets, and matrix tablets. In exemplary embodiments, the pharmaceutical composition may be a solid dosage form comprising a tablet.
In embodiments in which the solid dosage form is a tablet, the tablet generally has a friability of no greater than about 1.0%. In certain embodiments, the tablet may have a friability of less than about 1.0%, less than about 0.5%, less than about 0.3%, less than about 0.2%, less than about 0.1%, less than about 0.05%, or less than about 0.01%. In exemplary embodiments, the tablet has a friability of zero.
The solid dosage pharmaceutical composition disclosed herein is formulated such that the API in the composition is released over an extended period of time. For example, the total amount of API in the pharmaceutical composition may be released over a period of about 6 hours, over a period of about 12 hours, over a period of about 18 hours, or over a period of about 24 hours. In exemplary embodiments, the total amount of the API in the pharmaceutical composition may be released within about 8 hours to about 12 hours.
The in vitro dissolution of the API from the solid dosage pharmaceutical composition disclosed herein may be measured using an approved USP procedure. For example, dissolution may be measured using an USP approved Type 2 paddle apparatus, at a paddle speed of 50 rpm or 100 rpm, and a constant temperature of 37±0.5° C. The dissolution test may be performed in the presence of 500 mL, 900 mL, or 1,000 mL of a suitable dissolution medium (e.g., having a pH from 1.0 to 6.8). Non-limiting examples of suitable dissolution media include water, phosphate buffer (pH 6.8), acetate buffer (pH 4.5), and 0.1 N HCl.
In various embodiments, the in vitro release of the API from the pharmaceutical composition is such that no more than about 50%, 60%, 70%, 80%, 90% or 95% of the API is released within about 6 hours. In additional embodiments, no more than about 80% of the API is released within about 6 hours. In still another embodiment, no more than about 50%, 60%, 70%, 80%, 90% or 95% of the API is released within about 8 hours.
The solid dosage pharmaceutical compositions disclosed herein also have abuse deterrent features. The combination of the plasticized hydrophilic plastomers and plasticized hydrophilic elastomers imparts sufficient mechanical integrity (i.e., strength, hardness, elasticity, etc.) to the composition such that it is resistant to crushing, grinding, cutting, or pulverizing to form a powder comprising small particles. Additionally, the composition comprises gelling polymers such that the composition forms a viscous mixture or gel when in contact with a small volume of a suitable solvent.
The mechanical integrity of the solid dosage pharmaceutical composition may be assessed by measuring the particle size distribution after crushing, grinding, or pulverizing the composition in a suitable apparatus for a specified period of time. The composition may be crushed, ground, or pulverized in a pill crusher, a tablet grinder, a ball mill, a co-mill, a high-shear mill, a coffee grinder, a blender, a hammer, or another apparatus to reduce particle size. In various embodiments in which the composition is subjected to 12 minutes of grinding or milling to form particles, more than 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95% of the particles may have an average diameter of at least about 250 microns. In further embodiments, in which the composition is subjected to 12 minutes of grinding or milling to form particles, more than 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95% of the particles may have an average diameter of at least about 500 microns. Because the pharmaceutical composition disclosed herein is resistant to forming a fine powder, it deters abuse by inhalation.
Alternatively, the mechanical integrity of the pharmaceutical composition may be accessed by measuring the breaking point or the breaking strength of the solid dosage composition. The breaking strength refers to the amount of applied force needed to compromise the integrity of the solid dosage form. The breaking point may be determined from a force profile of the composition. The force profile is a plot of force versus compression distance in which changes in the thickness of the solid dosage form are plotted as a function of increasing force applied to the solid dosage form (Haslam et al., Int. J. Pharmaceut., 1998, 173:233-242). The force profile may be generated using a Texture Analyzer model TA.XT. Plus (Texture Technologies Corp.), an Instron Universal Tester (Instron Engineering Corp.), or other suitable instrument. Force is applied diametrically to the solid dosage form and the compression distance is recorded. The breaking point exhibits itself as the point in the force profile plot at which the ascending line plateaus or descends in response to the application of increasing force (see
Another method to determine the breaking point (or breaking strength) utilizes conventional hardness testers well known in the art. Appropriate models include, without limitation, Dr. Schleuniger® model 8M (Pharmatron Inc.), Varian model VK200 (Varian Medical Systems Inc.), or Sotax HT1 (Sotax Corp.). In this analysis, when the integrity of the dosage form is compromised, the instrument will stop compressing and report the force delivered to the dosage form at the breaking strength. In general, the pharmaceutical composition disclosed herein has a breaking strength of less than about 500 Newtons (N). In various embodiments, the breaking strength of the pharmaceutical composition is less than about 400 N, less than about 350 N, less than about 300 N, less than about 250 N, or less than about 200 N. As additional force is applied beyond the breaking point, the composition continues to flatten or deform, which is indicative of plastic deformation.
An additional abuse deterrent property is that the pharmaceutical composition, whether whole, flattened, or broken into large particles, forms a viscous mixture or gel when in contact with a small volume of a suitable solvent. The volume of the suitable solvent may range from about 1 mL to about 10 mL. For example, the volume may be about 2 mL, about 3 mL, about 4 mL about 5 mL, about 6 mL, about 7 mL, about 8 mL, about 9 mL, or about 10 mL. Suitable solvents include water, alcohols such as ethanol, acids such as acetic acid, fruit juice, and mixtures of any of the foregoing. The resultant gel has a high viscosity that prevents separation of the active ingredient from the viscous gel, provides a visual deterrence to injection abuse, and inhibits the gelled mixture from being drawn through an injection syringe needle. Consequently, the pharmaceutical compositions disclosed herein provide deterrence to abuse by extraction of the API and consequent injection of the extracted mixture.
In one exemplary embodiment, the hydrophilic plastomer comprises hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and polyethylene oxide, and is present in an amount ranging from about 50% to about 80% by weight of the composition; the optional hydrophilic elastomer is present and is a carbomer present in an amount ranging from about 0.5% to about 10% by weight of the composition; the deliquescent plasticizer comprises citric acid and sorbitol, and is present in an amount ranging from about 10% to about 30% by weight of the composition; the optional lubricant is magnesium stearate; the API is chosen from oxycodone, oxymorphone, hydrocodone, hydromorphone, codeine, and morphine; and the composition is a solid dosage form.
(II) Process for Preparing Solid Dosage Pharmaceutical Compositions
Another aspect of the disclosure encompasses a process for preparing a solid dosage form of the pharmaceutical composition disclosed herein. The process comprises: (a) forming a mixture comprising at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the mixture is a powder, a granulate, or a solid dosage unit; (b) humidifying the mixture of (a) to form a humidified powder, a humidified granulate, or a humidified solid dosage unit; (c) optionally forming the humidified powder or the humidified granulate into a treated solid dosage unit; (d) optionally coating the humidified solid dosage unit of (b) or the treated solid dosage unit of (c) to form a coated solid dosage unit; and (e) heating the humidified solid dosage unit of (b), the treated solid dosage unit of (c), or the coated solid dosage unit of (d) to form the solid dosage form.
(a) Forming the Mixture
The first step of the process comprises forming a mixture comprising at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, which are detailed above in sections (I)(a)(i)-(iii), respectively. In some embodiments, the mixture may further comprise at least one API and/or at least one modifying agent, as detailed above in sections (i)(a)(v) and (iv), respectively.
The mixture may be a powder, a granulate, or a solid dosage unit. As mentioned above in section (I)(b), suitable solid dosage units include tablets, compacts, pellets, caplets, pills, and capsules. In some embodiments, the components of the mixture may be blended, mixed, roller compacted, milled, and/or granulated, thereby forming a blend or a granulate. All these procedures are well known in the art. In other embodiments, the blend or granulate may be formed into a solid dosage unit using techniques well known in the art.
(b) Humidifying the Mixture
The process further comprises humidifying the mixture of (a) to form a humidified powder, a humidified granulate, or a humidified solid dosage unit. During this step of the process, the partial pressure of the water vapor in the atmosphere exceeds the partial water vapor pressure of the deliquescent plasticizer such that the deliquescent plasticizer absorbs moisture from the atmosphere and forms a saturated solution. As a consequence, the mobility of the plasticizer increases such that it can incorporate into the hydrophilic plastomer and elastomer, thereby plasticizing the hydrophilic plastomer and elastomer. As detailed below in Example 5, the humidification step increases the mechanical integrity of the solid dosage form, and consequently increases the abuse deterrence of the solid dosage form of the pharmaceutical composition.
The temperature and relative humidity at which the humidification step occurs can and will vary depending mainly upon the identity of the deliquescent plasticizer. Each deliquescent plasticizer deliquesces at a particular level or range of relative humidity. For example, citric acid deliquesces at about 75% relative humidity at 25° C., and sorbitol deliquesces from about 69% to about 91% relative humidity at 25° C.
In various embodiments, the humidification step may occur at a relative humidity that ranges from about 40% to about 100% at 25° C. In some embodiments, the relative humidity may range from about 40% to about 50% at 25° C., from about 50% to about 60% at 25° C., from about 60% to about 70% at 25° C., from about 70% to about 80% at 25° C., from about 80% to about 90% at 25° C., or from about 90% to about 100% at 25° C. In exemplary embodiments, the relative humidity during the humidification step may range from about 65% to about 85% at 25° C.
The temperature of the humidification step also may vary. In general, the humidification step may occur at a temperature ranging from about 5° C. to about 90° C. In certain embodiments, the temperature of the humidification step may range from about 5° C. to about 15° C., from about 15° C. to about 30° C., from about 30° C. to about 60° C., or from about 60° C. to about 90° C. In exemplary embodiments, the temperature of the humidification step may range from about 30° C. to about 50° C.
The duration of the humidification step can and will vary depending upon the components of the pharmaceutical composition and the humidification conditions. In general, the duration of the humidification step may range from several minutes to several hours. For example, the duration of the humidification step may range from about 10 minutes to about 1 hour, from about 1 hour to about 2 hours, or from about 2 hours to about 5 hours. In one exemplary embodiment, the duration of the humidification step may be about 2 hours.
The powder, granulate, or solid dosage form may be humidified in a pan coater unit, an oven, a humidifier, a humidification chamber, a V-blender, or other suitable apparatus known in the art.
The humidified solid dosage unit may be dried prior to the optional coating step (d). The temperature of the drying step may vary. In general, the drying step may occur at a temperature ranging from about 5° C. to about 90° C. In certain embodiments, the temperature of the optional drying step may range from about 5° C. to about 15° C., from about 15° C. to about 30° C., from about 30° C. to about 60° C., or from about 60° C. to about 90° C. In exemplary embodiments, the temperature of the drying step may range from about 30° C. to about 50° C. Optional use of nitrogen or vacuum assisted drying techniques will lower the temperature and time requirements needed to effect drying and is assumed to be included in the body of this work as obvious to someone versed in the art.
The duration of the drying step can and will vary depending upon the components of the pharmaceutical composition and the humidification conditions. In general, the duration of the drying step may range from several minutes to several hours. For example, the duration of the drying step may range from about 10 minutes to about 1 hour, from about 1 hour to about 2 hours, or from about 2 hours to about 5 hours. In one exemplary embodiment, the duration of the humidification step may be about 2 hours
(c) Optionally Forming a Solid Dosage Unit
In embodiments in which the mixture from step (a) comprises a powder or a granulate, the humidified powder or the humidified granulate formed during step (b) may be optionally mixed with at least one API and/or at least one modifying agent and formed into a treated solid dosage unit using procedures well known in the art.
(d) Optionally Coating the Solid Dosage Unit
The process further comprises an optional step in which the humidified solid dosage unit from step (b) or the treated solid dosage unit from step (c) is coated with a film coating to form a coated solid dosage form. Examples of suitable film coatings are detailed above in section (I)(a)(vii). The optional coating step prevents agglomeration or sticking among individual solid dosage forms and sticking between the solid dosage forms and the equipment. The film coating may be spray coated onto the solid dosage form. The spray coating system by be a bottom spray coating system, a top spray coating system, a tangential spray coating system, a pan coating system, or another suitable coating system.
(e) Heating the Solid Dosage Unit
The final step of the process comprises heating the humidified solid dosage unit from step (b), the treated solid dosage unit from step (c), or the coated solid dosage unit from step (d) to form the solid dosage form. This heating step essentially cures the hydrophilic plastomer in the solid dosage unit matrix that has a softening temperature below the selected temperature. The heating step may also remove excess moisture from the dosage unit retained from the humidification step. The solid dosage form prepared by the process disclosed herein has sufficient mechanical integrity such that it is resistant to crushing, cutting, milling, pulverizing, or other means of tampering.
In general, the heating step occurs at a temperature greater than about 50° C. For example, the humidified or treated solid dosage units may be heated to a temperature greater than about 50° C., greater than about 60° C., greater than about 70° C., greater than about 80° C., greater than about 90° C., or greater than about 100° C. In exemplary embodiments, the temperature of the heating step may range from about 60° C. to about 90° C.
The duration of the heating step can and will vary depending upon the components of the pharmaceutical composition. The duration of the heating step may range from about 10 minutes to about 10 hours. In general, the higher the temperature, the shorter the duration of time. For example, the solid dosage unit may be heated to a temperature of about 80° C. for about 3 hours, or the solid dosage unit may be heated to a temperature of about 90° C. for about 1 hour.
(f) Iterations of the Process
Persons skilled in the art will appreciate that different components of the pharmaceutical composition may be introduced at various points during the process for preparing a solid dosage form of the pharmaceutical composition. Table A lists non-limiting examples of various iterations of the process.
Definitions
Compounds useful in the compositions and methods include those described herein in any of their pharmaceutically acceptable forms, including isomers such as diastereomers and enantiomers, salts, solvates, and polymorphs, as well as racemic mixtures and pure isomers of the compounds described herein, where applicable.
When introducing elements of the present invention or the preferred embodiments(s) thereof, the articles “a”, “an”, “the” and “said” are intended to mean that there are one or more of the elements. The terms “comprising”, “including” and “having” are intended to be inclusive and mean that there may be additional elements other than the listed elements.
The term “about,” particularly in reference to a given quantity, is meant to encompass deviations of plus or minus five percent.
The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples represent techniques discovered by the inventors to function well in the practice of the invention. Those of skill in the art should, however, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments that are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention, therefore all matter set forth is to be interpreted as illustrative and not in a limiting sense.
A first prototype of the disclosed extended release (ER), abuse deterrent formulation (ADF) was prepared in which the plasticizer comprised a combination of citric acid and a co-processed mixture of sorbitol and glycerol. The co-processed plasticizer (90% sorbitol/10% glycerol) was prepared by spraying a solution of 30% glycerol/70% isopropyl alcohol onto sorbitol powder using a suitable fluid bed coating unit or low shear planetary mixer. A mixture comprising high molecular weight hydroxypropyl cellulose (25-35% w/w), carbomer (2-4% w/w), citric acid (1-10% w/w), co-processed sorbitol/glycerol (10-20% w/w) was roller compacted to an appropriate ribbon thickness. The ribbons were milled to an appropriate particle size, which were then dry blended with hydroxypropylmethyl cellulose (1-10% w/w), polyethylene oxide (15-25% w/w), and oxycodone hydrochloride (40 mg). The blend was lubricated with Mg stearate (1% w/w), and the lubricated blend was compacted into tablets using an automated press. The tablets were humidified in a pan coater with clean steam for 2 hours at 45° C. and between 65% to 99% relative humidity, cured in the pan coater at 80° C. for 3 hours, and then coated with a non-functional appearance coating.
A second prototype of the extended release, abuse deterrent formulation was prepared in which the plasticizer comprised a combination of citric acid and sorbitol. A mixture comprising high molecular weight hydroxypropyl cellulose (25-35% w/w), carbomer (2-4% w/w), citric acid (5-15% w/w), sorbitol (1-10% w/w) was roller compacted to the appropriate ribbon thickness. The ribbons were milled to the appropriate particle size, which were then dry blended with hydroxypropylmethyl cellulose (1-10% w/w), polyethylene oxide (15-25% w/w), and oxycodone hydrochloride (40 mg). The blend was lubricated with Mg stearate (1% w/w), and the lubricated blend was compacted into tablets using an automated press. The tablets were humidified in a pan coater with clean steam for 2 hours at 45° C. and between 65% to 99% relative humidity, cured in the pan coater at 80° C. for 3 hours, and then coated with a non-functional appearance coating.
The in vitro dissolution of oxycodone from prototypes #1 and #2 was measured in 900 mL phosphate buffer (pH 6.8) or 0.1 N HCl using an USP type 2 paddle apparatus with a paddle speed of 50 rpm and a constant temperature of 37° C. In some instances, the tablets (n=3) were placed in sinkers to prevent flotation. Samples were removed at various time points from 0.5 to 12 hr and analyzed by HPLC for oxycodone hydrochloride.
The abuse deterrence properties of prototypes #1 and #2 were compared to those of the reference ER, ADF oxycodone formulation and the reference ER, non-ADF oxycodone formulation. For this, each tablet was flattened in a hardness tester, the flattened tablet was twisted to form a “butterfly,” and the butterflied tablet was then milled in an IKA 10A mill at 1 minute intervals for up to 15 minutes total. At relevant time points, the milled tablet was analyzed for particle size distribution using a Sonic Sifter with a screen mesh size of 35 mesh (500 microns), 60 mesh (250 microns), and 120 mesh (125 microns).
Table 2 presents the percent of particles retained on each screen or passed through the 120 mesh screen for each sample after 12 minutes of milling. For both prototypes #1 and #2, more than 80% of the particles had an average diameter of greater than 500 microns, whereas for both of the reference formulations less than 10% of the particles had an average diameter of greater than 500 microns.
The humidification step is a transformative event in the preparation of the formulations disclosed herein. In this step, the deliquescent plasticizers adsorb water to the point of forming a saturated solution (all or in part) and increase in mobility. This allows for sufficient plasticization of the target polymers while in the blend, granulate, or tablet state. To investigate the effect of humidification, the physical properties of prototypes #1 and #2 were examined after being prepared: 1) with no humidification and curing steps; 2) with a curing step but no humidification step; and 3) with both humidification and curing steps. The physical properties of each tablet was measured by flattening the tablet in a hardness tester, measuring the thickness of the flattened tablet, butterflying the flattened tablet, and milling the butterflied tablet as described above in Example 4.
As shown in Table 3, the hardness of the tablets increased from less than about 25 kp (250N) to greater than about 85 kp (850N) when humidification was incorporated into the manufacturing process.
The combination of plasticized hydrophilic plastomers and elastomers in the pharmaceutical composition disclosed herein provides abuse deterrent properties. As demonstrated above in Examples 4 and 5, when properly plasticized, the prototypic formulation has sufficient hardness and tensile strength such that it is resistant to crushing, grinding, cutting, or pulverizing to form a powder comprising small particles. Additionally, the formulation comprises gelling polymers such that it forms a viscous mixture or gel when in contact with a small volume of a suitable solvent.
To measure syringeability, ground tablets were hydrated in 5 mL of water while stirring for 1 minute, 3 minutes, or 5 minutes. A 1 mL syringe with a 27 gauge needle connected to an appropriate instrument to measure force (Texture Analyzer) was used to pull the sample up into the syringe barrel. The amount of solution aspirated into the needle was recorded and then analyzed via HPLC to determine the oxycodone HCl content. The results for the prototypic formulation, the reference ER, ADF oxycodone formulation, and the reference ER, non-ADF oxycodone formulation are shown in Table 4. Very little oxycodone was detected in the mixtures derived from the prototype formulation.
Another method for testing the injectabilty of a pharmaceutical composition is to determine the amount of freely soluble drug present in small volumes regardless of polymer entrapment. In this test, whole tablets, or tablets cut into 16 pieces were hydrated with 2 mL, 5 mL or 10 mL of water and the mixture was stirred for 5 min, 10 min, or 30 min. The solution was then back loaded into a syringe stuffed with ˜225 mg of cotton at the syringe tip and expelled to simulate common filtering methods. The expelled solution (regardless of viscosity) was analyzed for oxycodone content. The results for the prototypic formulation, the reference ER, ADF oxycodone formulation, and the reference ER, non-ADF oxycodone formulation are shown in Tables 5, 6, and 7.
A third prototype of the disclosed formulation was prepared. A mixture comprising high molecular weight hydroxypropyl cellulose (15-25% w/w), hydroxypropylmethyl cellulose (5-15% w/w), oxycodone hydrochloride (10-80 mg), and Mg stearate (0.1-0.4% w/w) was roller compacted to the appropriate ribbon thickness. The ribbons were milled to the appropriate particle size, which were then dry blended with carbomer (1-4% w/w), polyethylene oxide (20-50% w/w), citric acid (5-15% w/w), and sorbitol (1-10% w/w). The blend was lubricated with Mg stearate (total of 1% w/w in overall formulation), and the lubricated blend was compacted into tablets (250 mg) using an automated press. The tablets were humidified in a pan coater with clean steam for 2 hours at 30-50° C. and between 65% to 99% relative humidity, dried at 20-60° C. for 2 hours, coated, and cured in a pan coater at 80° C. for 3 hours.
The breaking point of the tablets prepared in Example 7 was determined using a Texture Analyzer model TA.XT. Plus (Texture Technologies Corp.). Force was applied diametrically to each tablet and the compression distance was recorded. As shown in
A prototype of the disclosed formulation was prepared using oxymorphone HCl as the active pharmaceutical ingredient and tested for abuse deterrence. A mixture comprising high molecular weight hydroxypropyl cellulose (15-25% w/w), hydroxypropylmethyl cellulose (5-15% w/w) and oxymorphone hydrochloride (5-40 mg), and Mg stearate (0.1-0.4% w/w) was roller compacted to the appropriate ribbon thickness. The ribbons were milled to the appropriate particle size, which were then dry blended with carbomer (1-4% w/w), polyethylene oxide (20-50% w/w), citric acid (5-15% w/w), and sorbitol (1-10% w/w). The blend was lubricated with Mg stearate (total of 1% w/w in overall formulation), and the lubricated blend was compacted into tablets using an automated press. The tablets were humidified in a pan coater with clean steam for 2 hours at 30-50° C. and between 65% to 99% relative humidity, dried at 20-60° C. for 2 hours, coated, and cured at 80° C. for 3 hours.
This application is a continuation of U.S. application Ser. No. 13/939,357, filed Jul. 11, 2013, which claims priority to U.S. Provisional Application No. 61/670,751, filed Jul. 12, 2012, and U.S. Provisional Application No. 61/790,463, filed Mar. 15, 2013, the disclosure of each is hereby incorporated by reference in its entirety.
| Number | Name | Date | Kind |
|---|---|---|---|
| 4070494 | Hoffmeister et al. | Jan 1978 | A |
| 4753801 | Oren et al. | Jun 1988 | A |
| 5266331 | Oshlack et al. | Nov 1993 | A |
| 5460826 | Merrill et al. | Oct 1995 | A |
| 5472712 | Oshlack et al. | Dec 1995 | A |
| 5508042 | Oshlack et al. | Apr 1996 | A |
| 5549912 | Oshlack et al. | Aug 1996 | A |
| 5578709 | Woiszwillo | Nov 1996 | A |
| 5656295 | Oshlack et al. | Aug 1997 | A |
| 5700478 | Biegajski et al. | Dec 1997 | A |
| 5709883 | Drizen et al. | Jan 1998 | A |
| 5843347 | Nguyen et al. | Dec 1998 | A |
| 5885616 | Hsiao et al. | Mar 1999 | A |
| 5958458 | Norling et al. | Sep 1999 | A |
| 5968551 | Oshlack et al. | Oct 1999 | A |
| 6066339 | Stark et al. | May 2000 | A |
| 6072100 | Mooney et al. | Jun 2000 | A |
| 6090925 | Woiszwillo et al. | Jul 2000 | A |
| 6103261 | Chasin et al. | Aug 2000 | A |
| 6106862 | Chen et al. | Aug 2000 | A |
| 6143322 | Sackler et al. | Nov 2000 | A |
| 6143353 | Oshlack et al. | Nov 2000 | A |
| 6177102 | Chen et al. | Jan 2001 | B1 |
| 6245357 | Edgren et al. | Jun 2001 | B1 |
| 6251430 | Zhang et al. | Jun 2001 | B1 |
| 6268053 | Woiszwillo et al. | Jul 2001 | B1 |
| 6309668 | Bastin et al. | Oct 2001 | B1 |
| 6316031 | Oshlack et al. | Nov 2001 | B1 |
| 6335033 | Oshlack et al. | Jan 2002 | B2 |
| 6340471 | Kershman et al. | Jan 2002 | B1 |
| 6342250 | Masters | Jan 2002 | B1 |
| 6372254 | Ting et al. | Apr 2002 | B1 |
| 6387404 | Oshlack et al. | May 2002 | B2 |
| 6436438 | Momberger et al. | Aug 2002 | B1 |
| 6458387 | Scott et al. | Oct 2002 | B1 |
| 6488963 | McGinity et al. | Dec 2002 | B1 |
| 6500459 | Chhabra et al. | Dec 2002 | B1 |
| 6541025 | Kershman et al. | Apr 2003 | B1 |
| 6572885 | Oshlack et al. | Jun 2003 | B2 |
| 6673369 | Rampal et al. | Jan 2004 | B2 |
| 6685964 | Bartholomaeus et al. | Feb 2004 | B1 |
| 6706281 | Oshlack et al. | Mar 2004 | B2 |
| 6730321 | Ting et al. | May 2004 | B2 |
| 6733783 | Oshlack et al. | May 2004 | B2 |
| 6893661 | Odidi et al. | May 2005 | B1 |
| 6902742 | Devane et al. | Jun 2005 | B2 |
| 6905709 | Oshlack et al. | Jun 2005 | B2 |
| 6916485 | Aiache et al. | Jul 2005 | B2 |
| 6923988 | Patel et al. | Aug 2005 | B2 |
| 6939538 | Prescott et al. | Sep 2005 | B2 |
| 6960357 | Chopra | Nov 2005 | B2 |
| 6962717 | Huber et al. | Nov 2005 | B1 |
| 6974591 | Kendrup et al. | Dec 2005 | B2 |
| 7070806 | Oshlack et al. | Jul 2006 | B2 |
| 7129248 | Chapman et al. | Oct 2006 | B2 |
| 7201920 | Kumar et al. | Apr 2007 | B2 |
| 7316821 | Oshlack et al. | Jan 2008 | B2 |
| 7338668 | Lynenskhold et al. | Mar 2008 | B2 |
| 7476402 | Kumar et al. | Jan 2009 | B2 |
| 7510726 | Kumar et al. | Mar 2009 | B2 |
| 7510727 | Oshlack et al. | Mar 2009 | B2 |
| 7514100 | Oshlack et al. | Apr 2009 | B2 |
| 7572463 | Bartholomaeus et al. | Aug 2009 | B2 |
| 7674798 | Chapman et al. | Mar 2010 | B2 |
| 7674799 | Chapman et al. | Mar 2010 | B2 |
| 7674800 | Chapman et al. | Mar 2010 | B2 |
| 7682633 | Matthews et al. | Mar 2010 | B2 |
| 7683072 | Chapman et al. | Mar 2010 | B2 |
| 7691873 | Duncalf et al. | Apr 2010 | B2 |
| 7776314 | Bartholomaus et al. | Aug 2010 | B2 |
| 7815934 | Boehm | Oct 2010 | B2 |
| 7842307 | Oshlack et al. | Nov 2010 | B2 |
| 7842309 | Oshlack et al. | Nov 2010 | B2 |
| 7842311 | Oshlack et al. | Nov 2010 | B2 |
| 7851482 | Dung et al. | Dec 2010 | B2 |
| 7879362 | Castan et al. | Feb 2011 | B2 |
| 7906143 | Odidi et al. | Mar 2011 | B1 |
| 7981439 | Kumar et al. | Jul 2011 | B2 |
| 8017150 | Yang et al. | Sep 2011 | B2 |
| 8075872 | Arkenau-Maric et al. | Dec 2011 | B2 |
| 8101630 | Kumar et al. | Jan 2012 | B2 |
| 8110226 | Li | Feb 2012 | B2 |
| 8114383 | Bartholomaus et al. | Feb 2012 | B2 |
| 8114384 | Arkenau et al. | Feb 2012 | B2 |
| 8142811 | Oshlack et al. | Mar 2012 | B2 |
| 8173152 | Crowley et al. | May 2012 | B2 |
| 8192722 | Arkenau-Maric et al. | Jun 2012 | B2 |
| 8202542 | Mehta et al. | Jun 2012 | B1 |
| 8236351 | Oshlack et al. | Aug 2012 | B2 |
| 8298577 | Moe | Oct 2012 | B2 |
| 8309060 | Bartholomaus et al. | Nov 2012 | B2 |
| 8309122 | Kao et al. | Nov 2012 | B2 |
| 8323889 | Arkenau-Maric et al. | Dec 2012 | B2 |
| 8329216 | Kao et al. | Dec 2012 | B2 |
| 8337888 | Wright et al. | Dec 2012 | B2 |
| 8357399 | Oshlack et al. | Jan 2013 | B2 |
| 8361499 | Oshlack et al. | Jan 2013 | B2 |
| 8372432 | Han et al. | Feb 2013 | B2 |
| 8377453 | Han et al. | Feb 2013 | B2 |
| 8377994 | Gray et al. | Feb 2013 | B2 |
| 8383152 | Jans et al. | Feb 2013 | B2 |
| 8389007 | Wright et al. | Mar 2013 | B2 |
| 8394408 | Han et al. | Mar 2013 | B2 |
| 8399414 | Harada et al. | Mar 2013 | B2 |
| 8415401 | Yum et al. | Apr 2013 | B2 |
| 8445023 | Guimberteau et al. | May 2013 | B2 |
| 8465776 | Hoarau | Jun 2013 | B2 |
| 8486448 | Rahmouni et al. | Jul 2013 | B2 |
| 8486449 | Rahmouni et al. | Jul 2013 | B2 |
| 8501160 | Cailly-Dufestel et al. | Aug 2013 | B2 |
| 20010008639 | Oshlack et al. | Jul 2001 | A1 |
| 20020058050 | Sackler et al. | May 2002 | A1 |
| 20020192287 | Mooney et al. | Dec 2002 | A1 |
| 20030091635 | Baichwal et al. | May 2003 | A1 |
| 20030118641 | Maloney et al. | Jun 2003 | A1 |
| 20030129234 | Baichwal et al. | Jul 2003 | A1 |
| 20030157167 | Kao et al. | Aug 2003 | A1 |
| 20030211157 | Simon | Nov 2003 | A1 |
| 20040052843 | Lerner et al. | Mar 2004 | A1 |
| 20040062812 | Maloney | Apr 2004 | A1 |
| 20040131552 | Boehm | Jul 2004 | A1 |
| 20040241234 | Vilkov | Dec 2004 | A1 |
| 20050142203 | Heinicke | Jun 2005 | A1 |
| 20050163856 | Maloney et al. | Jul 2005 | A1 |
| 20050186139 | Bartholomaus et al. | Aug 2005 | A1 |
| 20050191244 | Bartholomaus et al. | Sep 2005 | A1 |
| 20050196459 | Castan et al. | Sep 2005 | A1 |
| 20050214223 | Bartholomaeus et al. | Sep 2005 | A1 |
| 20050226929 | Xie et al. | Oct 2005 | A1 |
| 20050236741 | Arkenau et al. | Oct 2005 | A1 |
| 20050245557 | Schoenhard et al. | Nov 2005 | A1 |
| 20050266078 | Jorda et al. | Dec 2005 | A1 |
| 20060002860 | Bartholomaus et al. | Jan 2006 | A1 |
| 20060110327 | Emigh et al. | May 2006 | A1 |
| 20060153918 | Lerner et al. | Jul 2006 | A1 |
| 20060165791 | Oshlack et al. | Jul 2006 | A1 |
| 20060193782 | Bartholomaus et al. | Aug 2006 | A1 |
| 20060233879 | Lerner et al. | Oct 2006 | A1 |
| 20060233880 | Lerner et al. | Oct 2006 | A1 |
| 20060263429 | Feng | Nov 2006 | A1 |
| 20060275367 | Chungi | Dec 2006 | A1 |
| 20070003616 | Arkenau-Maric et al. | Jan 2007 | A1 |
| 20070048228 | Arkenau-Maric et al. | Mar 2007 | A1 |
| 20070098792 | Kao et al. | May 2007 | A1 |
| 20070098793 | Kao et al. | May 2007 | A1 |
| 20070140975 | Baichwal et al. | Jun 2007 | A1 |
| 20070183980 | Arkenau-Maric et al. | Aug 2007 | A1 |
| 20070190142 | Breitenbach et al. | Aug 2007 | A1 |
| 20070212414 | Baichwal et al. | Sep 2007 | A1 |
| 20070224129 | Guimberteau et al. | Sep 2007 | A1 |
| 20070231268 | Emigh et al. | Oct 2007 | A1 |
| 20070243245 | Heinicke | Oct 2007 | A1 |
| 20070275065 | Oshlack et al. | Nov 2007 | A1 |
| 20070281016 | Kao et al. | Dec 2007 | A1 |
| 20070281017 | Kao et al. | Dec 2007 | A1 |
| 20070298103 | Hayes | Dec 2007 | A1 |
| 20080008659 | Guimberteau et al. | Jan 2008 | A1 |
| 20080014257 | He et al. | Jan 2008 | A1 |
| 20080020039 | Parikh et al. | Jan 2008 | A1 |
| 20080031949 | Hamed et al. | Feb 2008 | A1 |
| 20080057129 | Lerner et al. | Mar 2008 | A1 |
| 20080069871 | Vaughn | Mar 2008 | A1 |
| 20080075770 | Vaughn et al. | Mar 2008 | A1 |
| 20080085304 | Baichwal et al. | Apr 2008 | A1 |
| 20080102121 | Devane et al. | May 2008 | A1 |
| 20080152595 | Emigh et al. | Jun 2008 | A1 |
| 20080187579 | Bhat et al. | Aug 2008 | A1 |
| 20080193540 | Soula et al. | Aug 2008 | A1 |
| 20080247959 | Bartholomaus et al. | Oct 2008 | A1 |
| 20080248113 | Bartholomaus et al. | Oct 2008 | A1 |
| 20080260844 | Soula et al. | Oct 2008 | A1 |
| 20080311187 | Ashworth et al. | Dec 2008 | A1 |
| 20080311197 | Arkenau-Maric et al. | Dec 2008 | A1 |
| 20080317854 | Arkenau et al. | Dec 2008 | A1 |
| 20090005408 | Arkenau-Maric et al. | Jan 2009 | A1 |
| 20090053310 | Pilgaonkar et al. | Feb 2009 | A1 |
| 20090068269 | Oshlack et al. | Mar 2009 | A1 |
| 20090081290 | McKenna et al. | Mar 2009 | A1 |
| 20090098200 | Temtsin Krayz et al. | Apr 2009 | A1 |
| 20090124650 | Ahdieh | May 2009 | A1 |
| 20090175937 | Rahmouni et al. | Jul 2009 | A1 |
| 20090192183 | Kao et al. | Jul 2009 | A1 |
| 20090238873 | Chattaraj et al. | Sep 2009 | A1 |
| 20090317355 | Roth et al. | Dec 2009 | A1 |
| 20100015223 | Cailly-Dufestel et al. | Jan 2010 | A1 |
| 20100080829 | Dulieu et al. | Apr 2010 | A1 |
| 20100092570 | Oshlack et al. | Apr 2010 | A1 |
| 20100099696 | Soscia et al. | Apr 2010 | A1 |
| 20100120723 | Akbarieh et al. | May 2010 | A1 |
| 20100151028 | Ashworth et al. | Jun 2010 | A1 |
| 20100168148 | Wright et al. | Jul 2010 | A1 |
| 20100209495 | Li et al. | Aug 2010 | A1 |
| 20100221322 | Bartholomaus et al. | Sep 2010 | A1 |
| 20100260833 | Bartholomaus et al. | Oct 2010 | A1 |
| 20110002985 | Shah | Jan 2011 | A1 |
| 20110020444 | Kao et al. | Jan 2011 | A1 |
| 20110020451 | Bartholomaus et al. | Jan 2011 | A1 |
| 20110033537 | Gervais et al. | Feb 2011 | A1 |
| 20110038930 | Barnscheid et al. | Feb 2011 | A1 |
| 20110054038 | Glozman | Mar 2011 | A1 |
| 20110077238 | Leech et al. | Mar 2011 | A1 |
| 20110091488 | Halliday et al. | Apr 2011 | A1 |
| 20110091537 | Castan et al. | Apr 2011 | A1 |
| 20110123613 | Bhat et al. | May 2011 | A1 |
| 20110142943 | Rariy et al. | Jun 2011 | A1 |
| 20110150970 | Shah et al. | Jun 2011 | A1 |
| 20110150971 | Shah et al. | Jun 2011 | A1 |
| 20110150991 | Shah et al. | Jun 2011 | A1 |
| 20110159089 | Shah et al. | Jun 2011 | A1 |
| 20110159090 | Shah et al. | Jun 2011 | A1 |
| 20110200681 | Habib et al. | Aug 2011 | A1 |
| 20110230510 | Oshlack et al. | Sep 2011 | A1 |
| 20110301129 | Berner et al. | Dec 2011 | A1 |
| 20110311631 | Baer et al. | Dec 2011 | A1 |
| 20120034171 | Arkenau-Maric et al. | Feb 2012 | A1 |
| 20120059065 | Barnscheid et al. | Mar 2012 | A1 |
| 20120065220 | Barnscheid et al. | Mar 2012 | A1 |
| 20120083506 | Herry et al. | Apr 2012 | A1 |
| 20120101118 | Fleischer et al. | Apr 2012 | A1 |
| 20120128848 | Yang et al. | May 2012 | A1 |
| 20120135071 | Bartholomaus et al. | May 2012 | A1 |
| 20120135075 | Mohammad | May 2012 | A1 |
| 20120136021 | Barnscheid et al. | May 2012 | A1 |
| 20120141583 | Mannion et al. | Jun 2012 | A1 |
| 20120148672 | Mehta et al. | Jun 2012 | A1 |
| 20120156277 | Shah et al. | Jun 2012 | A1 |
| 20120164209 | Shah et al. | Jun 2012 | A1 |
| 20120164220 | Huang | Jun 2012 | A1 |
| 20120165361 | Cruz et al. | Jun 2012 | A1 |
| 20120202838 | Ghosh et al. | Aug 2012 | A1 |
| 20120207825 | Roy et al. | Aug 2012 | A1 |
| 20120214777 | Crowley et al. | Aug 2012 | A1 |
| 20120231075 | Kao et al. | Sep 2012 | A1 |
| 20120251637 | Bartholomaus et al. | Oct 2012 | A1 |
| 20120252832 | Caruso et al. | Oct 2012 | A1 |
| 20120252845 | Engqvist | Oct 2012 | A1 |
| 20120301546 | Hassan | Nov 2012 | A1 |
| 20120308654 | Bartholomaus et al. | Dec 2012 | A1 |
| 20120321674 | Vachon et al. | Dec 2012 | A1 |
| 20120321716 | Vachon et al. | Dec 2012 | A1 |
| 20120328707 | Hermann | Dec 2012 | A1 |
| 20130005977 | Chapman et al. | Jan 2013 | A1 |
| 20130011543 | Oshlack et al. | Jan 2013 | A1 |
| 20130012533 | Oshlack et al. | Jan 2013 | A1 |
| 20130022646 | Rudnic et al. | Jan 2013 | A1 |
| 20130028955 | Tolia | Jan 2013 | A1 |
| 20130028970 | Schwier et al. | Jan 2013 | A1 |
| 20130039932 | Park et al. | Feb 2013 | A1 |
| 20130059010 | Herry et al. | Mar 2013 | A1 |
| 20130129825 | Billoet | May 2013 | A1 |
| 20130129826 | Gei ler | May 2013 | A1 |
| 20130171075 | Arkenau-Maric et al. | Jul 2013 | A1 |
| 20130171257 | Kumar et al. | Jul 2013 | A1 |
| 20130195935 | Bartholomaus et al. | Aug 2013 | A1 |
| 20130217716 | Wright et al. | Aug 2013 | A1 |
| 20130225625 | Barnscheid et al. | Aug 2013 | A1 |
| 20130225697 | Barnscheid et al. | Aug 2013 | A1 |
| 20130280176 | Diezi et al. | Oct 2013 | A1 |
| 20130280177 | Raman et al. | Oct 2013 | A1 |
| 20140017310 | Gower et al. | Jan 2014 | A1 |
| Number | Date | Country |
|---|---|---|
| 2 123 274 | Nov 2009 | EP |
| 8-291051 | Nov 1996 | JP |
| 2007009806 | Jan 2007 | WO |
| 2008011595 | Jan 2008 | WO |
| 2008086804 | Jul 2008 | WO |
| 2011013082 | Feb 2011 | WO |
| 2011068723 | Jun 2011 | WO |
| 2011079074 | Jun 2011 | WO |
| 2011090724 | Jul 2011 | WO |
| 2011090725 | Jul 2011 | WO |
| 2011106076 | Sep 2011 | WO |
| 2012028317 | Mar 2012 | WO |
| 2012028318 | Mar 2012 | WO |
| 2012028319 | Mar 2012 | WO |
| 2012061779 | May 2012 | WO |
| 2012076907 | Jun 2012 | WO |
| 2012080833 | Jun 2012 | WO |
| 2012085656 | Jun 2012 | WO |
| 2012085657 | Jun 2012 | WO |
| 2012112952 | Aug 2012 | WO |
| 2012162492 | Nov 2012 | WO |
| 2013000578 | Jan 2013 | WO |
| 2013003845 | Jan 2013 | WO |
| 2013017234 | Feb 2013 | WO |
| 2013018050 | Feb 2013 | WO |
| 2013022924 | Feb 2013 | WO |
| 2013057570 | Apr 2013 | WO |
| 2013158810 | Oct 2013 | WO |
| 2013158814 | Oct 2013 | WO |
| 2014011830 | Jan 2014 | WO |
| Entry |
|---|
| Office Action from related U.S. Appl. No. 13/939,357, dated Mar. 18, 2016; 16 pgs. |
| Office Action from related U.S. Appl. No. 13/939,357, dated Aug. 25, 2016; 14 pgs. |
| Office Action from related European Patent Application No. 13 739 584.4, dated Jan. 18, 2018; 3 pgs. |
| Beer et al., “Impact of slow-release oral morphine on drug abusing habits in Austria”, Neuropsychiatrie, Dustri Verlag, Deisenhofen, DE, Jan. 1, 2010, pp. 108-117, vol. 24, No. 2. |
| International Search Report and Written Opinion from related International Application No. PCT/US2013/050005, dated Aug. 19, 2013; 11 pgs. |
| Office Action from related Canadian Patent Application No. 2,877,774, dated Feb. 24, 2016; 4 pgs. |
| Office Action from related Japanese Patent Application No. 2015-521793, dated Mar. 7, 2016; 11 pgs. |
| Office Action from related Japanese Patent Application No. 2015-521793, dated Jul. 12, 2016; 5 pgs. |
| Office Action from related European Patent Application No. 13 739 584.4, dated Feb. 3, 2017; 4 pgs. |
| International Search Report and Written Opinion from related International Patent Application No. PCT/US2013/03756, dated Jun. 24, 2013; 9 pgs. |
| International Search Report and Written Opinion from related International Patent Application No. PCT/US2013/037046, dated Jul. 3, 2013; 12 pgs. |
| Office Action from related Israeli Patent Application No. 236648, dated Sep. 17, 2017; 3 pgs. |
| Office Action from related U.S. Appl. No. 13/939,357, dated Oct. 7, 2015; 13 pgs. |
| Number | Date | Country | |
|---|---|---|---|
| 20170143699 A1 | May 2017 | US |
| Number | Date | Country | |
|---|---|---|---|
| 61670751 | Jul 2012 | US | |
| 61790463 | Mar 2013 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 13939357 | Jul 2013 | US |
| Child | 15420386 | US |
