Claims
- 1. An external anti-inflammatory and analgesic plaster preparation comprising a salt of diclofenac, 2[(2,6-dichlorophenyl)amino]benzene-acetic acid and a cyclic organic base as an active ingredient, said cyclic organic base comprising hydroxyethylpyrrolidine or hydroxyethylpiperidine, a pH adjuster and optionally, pharmaceutically acceptable thickening agents, humectants, fillers, preservatives and cross-linking agents, wherein a pH value of said preparation is adjusted to a range of 7.3 to 9.0.
- 2. The external plaster preparation of claim 1 wherein the pH value of the preparation is within a range of 7.5 to 8.5.
- 3. A process for producing an external anti-inflammatory and analgesic plaster preparation, comprising subjecting a composition comprising a salt of diclofenac, 2[2,6-dichlorophenyl)amino]benzene-acetic acid with a cyclic organic base as an active ingredient, said cyclic organic base comprising hydroxyethylpyrrolidine or hydroxyethylpiperidine, a pH adjuster and optionally, pharmaceutically acceptable thickening agents, humectants, fillers, preservatives and cross-linking agents to the steps of incorporating each ingredient, dissolving or dispersing a part or all of the ingredients in water, and kneading one ingredient with other ingredients while adjusting and maintaining a pH of the composition at a range of 7.3 to 9.0 during the step of preparation and then, spreading the resulting product over a support.
- 4. An external anti-inflammatory and analgesic plaster comprising:
- a preparation containing a salt of diclofenac, 2[(2,6-dichlorophenyl)amino]benzene-acetic acid with a cyclic organic base as an active ingredient, said cyclic organic base comprising hydroxyethylpyrrolidine or hydroxyethylpiperidine; a pH adjuster; pharmaceutically acceptable ingredients comprising a thickening agent; a humectant; a filler, a preservative and a cross-linking agent, wherein a pH value of the said preparation is adjusted to a range of 7.3 to 9.0; and
- a support on which said preparation is spread.
Priority Claims (1)
Number |
Date |
Country |
Kind |
5-119246 |
Apr 1993 |
JPX |
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Parent Case Info
This is a continuation of application Ser. No. 08/226,875, filed Apr. 13, 1994, now abandoned.
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Continuations (1)
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Number |
Date |
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Parent |
226875 |
Apr 1994 |
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