Claims
- 1. A method of treating a disorder selected from dementia, mania or nicotine dependence in a patient in need thereof comprising administering to the patient a tablet comprising as an active ingredient a therapeutically effective amount of galanthamine hydrobromide (1:1) and a pharmaceutically acceptable carrier, wherein said carrier comprises a spray-dried mixture of lactose monohydrate and microcrystalline cellulose (75:25) as a diluent, and an insoluble or poorly soluble cross-linked polymer disintegrant.
- 2. The method of claim 1 wherein the disorder is dementia.
- 3. The method of claim 2 wherein the disorder is Alzheimer's dementia.
- 4. The method of claim 1 wherein the disorder is mania.
- 5. The method of claim 1 wherein the disorder is nicotine dependence.
- 6. A fast-dissolving galanthamine hydrobromide (1:1) tablet made by (i) dry blending the active ingredient, an insoluble or poorly soluble cross-linked polymer disintegrant and an optional glidant with a diluent comprising a spray-dried mixture of lactose monohydrate and microcrystalline cellulose (75:25); (ii) optionally mixing a lubricant with the mixture obtained in step (i); (iii) compressing the mixture obtained in step (i) or in step (ii) in the dry state into a tablet; and (iv) optionally film-coating the tablet obtained in step (iii).
Priority Claims (1)
Number |
Date |
Country |
Kind |
96201676 |
Jun 1996 |
EP |
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation application of U.S. Ser. No. 09/202,187, U.S. Pat. No. 6,099,863 filed Dec. 9, 1998, which is a National Stage application under 35 U.S.C. §371 of PCT/EP97/02986 filed Jun. 6, 1997, which claims priority from EP 96.201.676.2, filed Jun. 14, 1996.
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Continuations (1)
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Number |
Date |
Country |
Parent |
09/202187 |
|
US |
Child |
09/585122 |
|
US |