Claims
- 1. A consumable film adapted to adhere to and dissolve in the oral cavity of a warm-blooded animal including humans, comprising a modified starch and a pharmaceutically active agent.
- 2. The consumable film of claim 1 wherein the modified starch is selected from the group consisting of a mechanically modified starch, a chemically modified starch, a thermally modified starch and combinations thereof.
- 3. The consumable film of claim 1 wherein the modified starch is selected from a chemically modified starch.
- 4. The consumable film of claim 1 wherein the modified starch is selected from the group consisting of modified corn starches, modified tapioca starches, acid hydrolyzed corn starches, acid hydrolyzed potato starches, enzyme hydrolyzed corn starches, enzyme hydrolyzed potato starches, hypochlorite-oxidized starches, acid-thinned starches, ethylated starches, cross-bonded starches, hydroxypropylated tapioca starches, hydroxypropylated corn starches, pregelatinized modified starches and combinations thereof.
- 5. The consumable film of claim 1 wherein the modified starch is selected from the group consisting of a pregelatinized modified corn starch, a pregelatinized modified tapioca starch and combinations thereof.
- 6. The consumable film of claim 1 wherein the modified starch is a pregelatinized modified starch.
- 7. The consumable film of claim 1 wherein the modified starch is present in the amount of from about 1% to 90% by weight based on the total weight of the consumable film.
- 8. The consumable film of claim 1 wherein the pharmaceutically active agent is selected from the group consisting of benzonatate, caramiphen edisylate, menthol, dextromethorphan hydrobromide, chlophedianol hydrochloride and combinations thereof.
- 9. The consumable film of claim 1 wherein the pharmaceutically active agent is selected from the group consisting of pseudoephedrine hydrochloride, phenylepherine hydrochloride, phenylpropanolamine, pseudoephedrine sulfate and combinations thereof.
- 10. The consumable film of claim 1 wherein the pharmaceutically active agent is selected from the group consisting of brompheniramine maleate, chlorpheniramine maleate, carbinoxamine maleate, clemastine fumarate, dexchlorpheniramine maleate, diphenylhydramine hydrochloride, azatadine maleate, diphenhydramine citrate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, doxylamine succinate, promethazine hydrochloride, pyrilamine maleate, tripelennamine citrate, triprolidine hydrochloride, acrivastine, loratadine, brompheniramine, dexbropheniramine, fexofenadine, cetirizine and combinations thereof.
- 11. The consumable film of claim 1 wherein the pharmaceutically active agent is selected from the group consisting of famotidine, ranitidine and combinations thereof.
- 12. The consumable film of claim 1 wherein the pharmaceutically active agent is selected from the group consisting of aspirin, acetaminophen, ibuprofen, ketoprofen, diflunisal, fenoprofen calcium, naproxen, tolmetin sodium, indomethacin, flurbiprofen sodium, celecoxib, valdecoxib, rofecoxib and mixtures thereof.
- 13. The consumable film of claim 1 further comprising at least one water soluble polymer; wherein the at least one water soluble polymer is selected from the group consisting of pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, tragacanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymers, carboxyvinyl polymers, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, pectin, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate, casein and combinations thereof.
- 14. The consumable film of claim 1, wherein said film is in the form of a single layer.
- 15. A method for delivering and enhancing the retention of a pharmaceutically active agent to the oral cavity of a warm-blooded animal including humans, comprising orally administering the consumable film of claim 1 to said warm-blooded animal.
PRIORITY INFORMATION
[0001] This application claims priority to U.S. provisional application No. 60/467,339, filed May 2, 2003.
Provisional Applications (1)
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Number |
Date |
Country |
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60467339 |
May 2003 |
US |