Claims
- 1. The method of inhibiting lentivirus in a host infected with said lentivirus comprising administering to said host a lentiviral inhibitory effective amount of a compound selected from the group consisting of:
- (A) ##STR101## wherein: FA is a fatty acid moiety of the formula C.sub.1 -C.sub.3 alkyl O(CH.sub.2).sub.8-12 ;
- f is zero or one;
- X is selected from the group consisting of OH, O-alkyl having from one to six carbon atoms, and N(R.sub.1)R in which R and R.sub.1 are independently H or alkyl having from one to six carbon atoms or arylalkyl having from one to eight carbon atoms;
- D is selected from the group consisting of H, C.sub.1 -C.sub.3 alkyl, C.sub.6 -C.sub.9 aryl, C.sub.1 -C.sub.3 alk C.sub.6 -C.sub.9 aryl;
- E is selected from the group consisting of H, C.sub.1 -C.sub.3 alkyl, C.sub.6 -C.sub.9 aryl, C.sub.1 -C.sub.3 alk C.sub.6 -C.sub.9 aryl, OH or halo mono substituted C.sub.1 -C.sub.3 alk C.sub.6 -C.sub.9 aryl, hydroxy C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy C.sub.1 -C.sub.3 alkyl, C.sub.6 -C.sub.9 aryl C.sub.1 -C.sub.3 alkoxy C.sub.1 -C.sub.3 alkyl, thio C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkylthio C.sub.1 -C.sub.3 alkyl, C.sub.6 -C.sub.9 aryl C.sub.1 -C.sub.3 alkylthio C.sub.1 -C.sub.3 alkyl, imdazolyl and indolyl;
- (B) ##STR102## wherein: FA is a heteroatom-containing fatty acid moiety selected from the group consisting of CH.sub.3 O(CH.sub.2).sub.11 -and CH.sub.3 (CH.sub.2).sub.9 O(CH.sub.2).sub.2 -;
- X is selected from the group consisting of amido, monoalkyl-amido, dialkyl-amido, monoaryl-amido, monoaryl-amido substituted with OH or halogen, diaryl-amido, and diaryl-amido substituted with OH or halogen;
- and in which the number of carbon atoms in alkyl are from one to eight and the number of carbon atoms in aryl is six;
- (C) FA-X
- wherein:
- FA is a heteroatom-containing fatty acid moiety selected from the group consisting of CH.sub.3 O(CH.sub.2).sub.11 -- and CH.sub.3 (CH.sub.2).sub.9 O(CH.sub.2).sub.2 --;
- X is selected from the group consisting of cyano, tetrazole, N-alkyltetrazole and N-arylalkyltetrazole;
- and in which the number of carbon atoms in alkyl is from one to eight, and the number of carbon atoms in aryl is six;
- (D)
- CH.sub.3 (CH.sub.2).sub.9 O(CH.sub.2).sub.2 --X
- wherein X is selected from the group consisting of
- CONEt.sub.2,
- CONHCH.sub.2 Ph,
- CO--NHCH.sub.2 CO.sub.2 C.sub.2 H.sub.5,
- CO--D--C.sub.6 H.sub.5 CH.sub.2 CH(NH)CO.sub.2 C.sub.2 H.sub.5 and
- CO--L--C.sub.6 H.sub.5 CH.sub.2 CH(NH)CO.sub.2 C.sub.2 H.sub.5 ;
- (E)
- (CH.sub.3 O(CH.sub.2).sub.7 --X--(CH.sub.2).sub.3 --Y wherein X is CH.sub.2 or O, and Y is COCH.sub.3 or CH.sub.2 OH.
- 2. The method of claim 1 in which the lentivirus is HIV.
- 3. A pharmaceutical composition comprising a compound of formulae (A),(B),(C), or (E) of claim 1 in a lentiviral effective amount admixed with a pharmaceutically acceptable diluent or carrier.
CROSS-REFERENCE TO RELATED APPLICATION
This is division of application Ser. No. 09/049,237, filed Mar. 27, 1998, now U.S. Pat. No. 5,859,052, which is a continuation-in-part of application Ser. No. 08/743,100, filed Nov. 4, 1996, now U.S. Pat. No. 5,744,631, which is a continuation of application Ser. No. 08/410,450, filed Mar. 24, 1995, now U.S. Pat. No. 5,599,947, which is a continuation-in-part of application Ser. No. 08/004,370, filed Jan. 14, 1993, now abandoned.
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Divisions (1)
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Number |
Date |
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Parent |
049237 |
Mar 1998 |
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Continuations (1)
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Number |
Date |
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Parent |
410450 |
Mar 1995 |
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Continuation in Parts (2)
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Number |
Date |
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Parent |
743100 |
Nov 1996 |
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Parent |
004370 |
Jan 1993 |
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