Claims
- 1. A compound according to Formula (I): wherein,R1 is selected from the group consisting of H, C1-10 alkyl, C1-3 arylalkyl C1-3 heteroarylalkyl aryl, heteroaryl, C1-3alkyl-C3-6cycloalkyl, and C3-6cycloalkyl; R2 is selected from the group consisting of H, O(CH2)maryl, O(CH2)mheteroaryl, N(R5)(CH2)maryl, N(R5)(CH2)m heteroaryl, N(R6)COaryl, N(R6)COheteroaryl, N(R6)SO2aryl and N(R6)SO2heteroaryl; provided that R2 is H when R3 is selected from the group consisting of O(CH2)maryl, O(CH2)mheteroaryl, N(R5)(CH2)m aryl, N(R5)(CH2)m heteroaryl, N(R6)COaryl, N(R6)COheteroaryl, N(R6)SO2aryl and N(R6)SO2heteroaryl; R3 is selected from the group consisting of H, halogen, OCH3, CH3, O(CH2)maryl, O(CH2)mheteroaryl, N(R5)(CH2)m aryl, N(R5)(CH2)m heteroaryl, N(R6)COaryl, N(R6)COheteroaryl, N(R6)SO2aryl and N(R6)SO2heteroaryl; provided that R3 is selected from the group consisting of O(CH2)maryl, O(CH2)mheteroaryl, N(R5)(CH2)m aryl, N(R5)(CH2)m heteroaryl, N(R6)COaryl, N(R6)COheteroaryl, N(R6)SO2aryl and N(R6)SO2heteroaryl when R2 and R4 are H; R4 is selected from the group consisting of H, halogen, OCH3, and CH3; R5 is selected from the group consisting of H, C1-10 alkyl, C1-3 alkyl-aryl, C1-3 alkyl-heteroaryl CO(C1-8)alkyl, and COaryl and COheteroaryl; R6 is selected from the group consisting of H, C1-10 alkyl, C1-3alkyl-aryl and C1-3alkyl-heteroaryl; and m is an integer from 0-3; or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt complex thereof.
- 2. A compound according to claim 1 selected from the group consisting of:(E)-2′-(6-Chloropiperonyl)-3-(2,6-dichlorobenzyloxy)cinnamic acid; (E)-2′-(6-Chloropiperonyl)-4-(2,6-dichlorobenzyloxy)cinnamic acid; (E)-2′-(6-Chloropiperonyl)-4-(3,5-dichlorophenoxy)cinnamic acid; (E)-2′-(6-Chloropiperonyl)-4-(2,5-dichloroanilino)cinnamic acid; and (E)-2′-(6-Chloropiperonyl)-4-(3,5-dichlorophenyl)cinnamic acid.
- 3. A method of treating bacterial infections by administering to a patient in need thereof an effective amount of a compound of Formula (I) according to claim 1.
- 4. A method of treatment according to claim 3 wherein the compound of Formula (I) is selected from the group consisting of:(E)-2′-(6-Chloropiperonyl)-3-(2,6-dichlorobenzyloxy)cinnamic acid; (E)-2′-(6-Chloropiperonyl)-4-(2,6-dichlorobenzyloxy)cinnamic acid; (E)-2′-(6-Chloropiperonyl)-4-(3,5-dichlorophenoxy)cinnamic acid; (E)-2′-(6-Chloropiperonyl)-4-(2,5-dichloroanilino)cinnamic acid; and (E)-2′-(6-Chloropiperonyl)-4-(3,5-dichlorophenyl)cinnamic acid.
Parent Case Info
This application calims the benefit of Provisional application Ser. No. 60/150,212, filed Aug. 23, 1999.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/US00/23019 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO01/14363 |
3/1/2001 |
WO |
A |
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5547983 |
Charpentier |
Aug 1996 |
A |
5814657 |
Burk et al. |
Sep 1998 |
A |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/150212 |
Aug 1999 |
US |