Claims
- 1. A pharmaceutical composition adapted for transdermal delivery of a therapeutically effective amount of a natural or synthetic opioid to the systemic circulation of a mammal consisting essentially of an aqueous suspension containing:
- a therapeutically effective amount of a natural or synthetic opioid or a pharmaceutically acceptable salt thereof;
- an effective amount of a saturated or unsaturated fatty acid of 8-18 carbon atoms or a C.sub.1 -C.sub.4 alkyl ester thereof, and a pharmaceutically acceptable excipient.
- 2. A composition according to claim, 1 wherein the opioid is morphine, oxymorphone, fentanyl, meperidine, propoxyphen, or oxycodone; a natural or synthetic narcotic antagonist such as nalmefene, naloxone, naltrexone, nalbuphine, butorphanol, buprenorphine or pentazocine; or a pharmaceutically acceptable salt thereof.
- 3. A composition according to claim 2, wherein the opioid is oxymorphone.
- 4. A composition according to claim 1, wherein the fatty acid is linoleic or oleic.
- 5. A composition according to claim 1, wherein the aqueous suspension contains up to 0.1-10% by weight of opioid.
- 6. A composition according to claim 1, wherein the aqueous suspension contains from about 1 to about 30% by weight of a saturated or unsaturated fatty acid of 8-18 carbon atoms or a C.sub.1 -C.sub.4 alkyl ester thereof.
- 7. A composition according to claim 6, wherein the aqueous suspension contains from about 1 to about 20% by weight of linoleic or oleic acid or a C.sub.1 -C.sub.4 alkyl ester thereof.
- 8. A composition according to claim 6, wherein the aqueous system contains about 1 to about 30% by weight of linoleic acid.
- 9. A composition according to claim 6, wherein the aqueous system contains about 10 to about 20% by weight of linoleic acid.
- 10. A method for the transdermal delivery of a therapeutically effective amount of a natural or synthetic opioid to the systemic circulation of a mammal which comprises administering to said mammal in an aqueous suspension;
- a therapeutically effective amount of a natural or synthetic opioid or a pharmaceutically acceptable salt thereof;
- an effective amount of a saturated or unsaturated fatty acid of C.sub.8 -C.sub.18 carbon atoms or a C.sub.1 -C.sub.4 alkyl ester thereof, and a pharmaceutically acceptable excipient.
Parent Case Info
This is a continuation of Ser. No. 056,520, filed June 1, 1987, now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0171742 |
Feb 1986 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Chem. Abst 104 (1986)-213272 T and 107(1987)-212096 P. |
Continuations (1)
|
Number |
Date |
Country |
Parent |
056520 |
Jun 1987 |
|