Claims
- 1. A compound of the formula (I) ##STR73## and pharmaceutically acceptable salt thereof; (1) wherein R.sub.1 is (i) ##STR74## (ii) ##STR75## wherein R.sub.6 is hydrogen, lower alkyl, aryl, aralkyl, or cycloalkyl of from three to ten carbons having three to seven ring carbons; R.sub.7 is H, lower alkyl, or acyl, and R.sub.8 is H or lower alkyl or (iii) as defined together with R.sub.2 below;
- (2) R.sub.2 is hydrogen, lower alkyl, or taken together with R.sub.1 is ##STR76## wherein L.sub.1 is H.sub.2 or oxygen; and R.sub.7 is independently as defined above;
- (3) R.sub.5 and R.sub.11 are independently H, fluoro, chloro, bromo, trifluoromethyl, lower alkyl, CN, hydroxy, lower alkoxy, --S(O).sub.n -lower alkyl wherein n is an integer or 0 through 2, NO.sub.2, or NR.sub.9 R.sub.10 wherein R.sub.9 or R.sub.10 are independently hydrogen, lower alkyl, or acyl; and R.sub.3 and R.sub.4 are fluoro, chloro, bromo, trifluoromethyl, or lower alkyl; with a proviso that when R.sub.1 is ##STR77## then R.sub.3 and R.sub.4 cannot both be lower alkyl when R.sub.5 is hydrogen, and when R.sub.1 is ##STR78## wherein R.sub.7 is hydrogen or lower alkyl and one of R.sub.3 or R.sub.4 is lower alkyl then R.sub.5 cannot be meta-nitro, meta-difluoromethyl, or meta-trifluoromethyl when R.sub.11 is H, Br, Cl, or nitro.
- 2. A compound of claim 1 wherein R.sub.11 is hydrogen or lower alkyl.
- 3. A compound of claim 1 which is 2-[(2,6-dichloro-3-methylphenyl)amino]-N-hydroxybenzamide.
- 4. A compound of claim 1 which is 2-[(2,6-dichloro-3-methylphenyl)amino].TM.N-methoxybenzamide.
- 5. A compound of claim 1 which is 2-[(2,6-dichloro-3-methylphenyl)amino-N-hydroxy-N-methylbenzamide.
- 6. A compound of claim 1 which is 2-[(2,6-dichloro-3-methylphenyl)amino]-N-hydroxy-N-phenylmethylbenzamide.
- 7. A compound of claim 1 which is 2-[(2,6-dichloro-3-methylpheny)amino]-N-hydroxy-N-(1-methylethylbenzamide.
- 8. A compound of claim 1 which is 2-[(2,6-dichlorophenyl)amino]-N-hydroxybenzamide.
- 9. A compound of claim 1 which is N-hydroxy-N-methyl-2[(2,6-dichlorophenyl)amino]benzamide.
- 10. A compound of claim 1 which is 1-(2,6-dichloro-3-methylphenyl)-2,3-dihydro-3-hydroxy-4(1H)-quinazolinone or the monosodium salt thereof.
- 11. A compound of claim 1 which is 1-(2,6-dichlorophenyl)-2,3-dihydro-3-hydroxy-4(1H)-quinazolinone.
- 12. A compound of claim 1 which is 1-(2,6-dichloro-3-methylphenyl)-3-methoxy-4(1H)-quinazolinone.
- 13. A compound of claim 1 which is 1-(2,6-dichloro-3-methylphenyl)-3-hydroxy-2,4-(1H,3H)-quinazolinedione.
- 14. A compound of claim 1 which is 1-(2,6-dichloro-3-methylphenyl)-3-methoxy-2,4-(1H,3H)-quinazolinedione.
- 15. A compound of claim 1 which is 1-(2,6-dichloro-3-methylphenyl)-1H-indole-2,3-dione-3-oxime.
- 16. A compound of claim 1 which is 2-[(2,6-dichloro-3-methylphenyl)amino]-.alpha.-(hydroxylimino)benzene acetic acid.
- 17. A pharmaceutical composition for inhibiting 5-lipoxygenase or cyclooxygenase which comprises an amount effective for inhibiting 5-lipoxygenase or cyclooxygenase of a compound as claimed in claim 16, together with a pharmaceutically acceptable carrier.
Parent Case Info
This application is a continuation-in-part of U.S. application Ser. No. 134,725, filed Dec. 18, 1987, which is a continuation-in-part of U.S. application Ser. No. 113,789, filed Oct. 27, 1987, both now abandoned.
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Name |
Date |
Kind |
4029815 |
Sherlock |
Jun 1977 |
|
4906667 |
Varma |
Mar 1990 |
|
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EPX |
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Non-Patent Literature Citations (3)
Entry |
Wolf and Kohn; Liebigs Ann. Chem. 1975, 1245-1251 "Cyclisierungsreaktionen von am Aminostickstoff Substituierten o-Aminobenzhydroxamsaure-O-methylestern". |
James B. Summers, et al., "Hydroxamic Acid Inhibitors of 5-Lipoxygenase" J. Med. Chem 1987, 30, 574-580. |
Summers, et al. "In Vivo Characterization of Hydroxamic Acid Inhibitors of 5-Lipoxygenase" Sep. 1987, (Abstract). |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
134725 |
Dec 1987 |
|
Parent |
113789 |
Oct 1987 |
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