Claims
- 1. A wound dressing comprising fibrinogen, fibrin, or both and at least one procoagulant.
- 2. The wound dressing of claim 1, wherein the fibrinogen is human.
- 3. The wound dressing of claim 1, wherein the fibrin is human.
- 4. The wound dressing of claim 1, wherein the fibrinogen is in an amount of about 4.3 to about 6.7 mg/cm3.
- 5. The wound dressing of claim 1, further comprising collagen.
- 6. The wound dressing of claim 1, further comprising thrombin.
- 7. The wound dressing of claim 1, wherein the procoagulant is propyl gallate in a therapeutic amount.
- 8. The wound dressing of claim 1, further comprising at least one pharmaceutical.
- 9. The wound dressing of claim 8, wherein the pharmaceutical is an analgesic, an anti-inflammatory agent, or an antibacterial.
- 10. The wound dressing of claim 1, further comprising a biological agent.
- 11. The wound dressing of claim 1, further comprising a bio-absorbable component or a bio-absorbable matrix.
- 12. The wound dressing of claim 11, wherein the bio-absorbable component or the bio-absorbable matrix comprises collagen.
- 13. A method of treating a wound comprising applying to the wound a wound dressing comprising fibrinogen, fibrin, or both and at least one procoagulant.
- 14. A method of increasing an amount of or rate of coagulation of blood from a wound comprising applying to the wound a wound dressing comprising fibrinogen, fibrin, or both and at least one procoagulant.
- 15. A method of increasing an amount of or rate of clot formation over a wound comprising applying to the wound a wound dressing comprising fibrinogen, fibrin, or both and at least one procoagulant.
- 16. A method of increasing blood platelet counts in a subject comprising administering to the subject fibrinogen, fibrin, or both and at least one procoagulant.
- 17. The method of claim 16, wherein a therapeutic amount of the procoagulant is administered.
- 18. The method of claim 16, wherein the fibrinogen, fibrin, or both and the procoagulant are administered to the subject in the form of a wound dressing.
- 19. A method of activating a coagulation system of a subject comprising administering to the subject fibrinogen, fibrin, or both and at least one procoagulant.
- 20. A method of studying arterial bleeding comprising scoring an arterial wall of a subject with a dermal punch and removing the scored tissue with a scissors.
- 21. The method of claim 20, wherein the subject is a pig.
- 22. The wound dressing of claim 1, wherein the procoagulant is lyophilized to a substrate.
- 23. The wound dressing of claim 1, wherein the fibrinogen, fibrin, or both and the procoagulant are lyophilized together.
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT
[0001] This invention was made by employees of the United States Army. The government has rights in the invention.
Provisional Applications (1)
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Number |
Date |
Country |
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60307355 |
Jul 2001 |
US |