Claims
- 1. A compound selected from the group consisting of:
- Pib-Gly-3[2-(2-methylindol-3-yl)ethyl].beta.-alanine, and
- Pib-Gly-3(R)-[2-(indol-3-yl)ethyl].beta.-alanine.
- 2. A composition for inhibiting the binding of fibrinogen to blood platelets in a mammal, comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 3. A composition for inhibiting the aggregation of blood platelets in a mammal, comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 4. A composition for preventing thrombus or embolus formation in a mammal, comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 5. a composition for treating thrombus or embolus formation in a mammal, comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 6. A method for inhibiting the binding of fibrinogen to blood platelets in a mammal, comprising administering to the mammal a composition of claim 3.
- 7. A method for inhibiting the aggregation of blood platelets in a mammal, comprising administering to the mammal the composition of claim 3.
- 8. A method for preventing thrombus or embolus formation in a mammal, comprising administering to the mammal the composition of claim 4.
- 9. A method for treating thrombus or embolus formation in a mammal, comprising administering to the mammal the composition of claim 5.
CROSS REFERENCE
This is a continuation-in-part application of U.S. Ser. No. 07/750,646, filed Aug. 30, 1991, now abandoned, which is a continuation-in-part of U.S. Ser. No. 07/650,389, filed on Feb. 1, 1991, now abandoned, which is a continuation-in-part application of U.S. Ser. No. 07/589,145 filed on Sep. 27, 1990, now abandoned.
US Referenced Citations (8)
Foreign Referenced Citations (7)
Number |
Date |
Country |
352249 |
Jan 1990 |
EPX |
372486 |
Jun 1990 |
EPX |
381033 |
Aug 1990 |
EPX |
384362 |
Aug 1990 |
EPX |
405537 |
Jan 1991 |
EPX |
449079A |
Oct 1992 |
EPX |
2207922 |
Feb 1989 |
GBX |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
750646 |
Aug 1991 |
|
Parent |
650389 |
Feb 1991 |
|
Parent |
589145 |
Sep 1990 |
|