Claims
- 1. A method for administering a dosage of at least one active agent to a subject, comprising:
(i) applying to a skin surface of the subject, an amount of a formulation including a film-forming polymer and the active agent selected from one or more of a pharmaceutical agent, a wound healing agent and a cosmetic agent, (ii) allowing the formulation to dry on the skin to form a peelable, water-removable agent-releasing film of a thickness between 0.03 and 0.1 mm. containing the active agent; and (iii) administering the dosage of the active agent to the subject from the formulation and then from the film.
- 2. A method according to claim 1 wherein the dosage of active agent is administered by percutaneous absorption, first from the formulation and then from the film.
- 3. A method according to claim 1, wherein the formulation is administered from a container selected from the group consisting of: an aerosol can, an atomizer, a jar having an apical manual pump, a rollette and a tube container.
- 4. A method according to claim 3, wherein the formulation is administered in a controlled dosage.
- 5. A method according to claim 1, wherein the pharmaceutical agent is an agent selected from the group consisting of: an anti-inflammatory, a local anesthetic, a xanthine derivative, an antihistaminic, an antifungal, an antimicrobial, an antibiotic, a cardiovascular, a hormone, an erectile dysfunction treatment, a vasodilator, an antirheumatoid, a chemotherapy, an adrenergic agonist or an adrenergic antagonist.
- 6. A method according to claim 1, wherein one or more cosmetic agents are selected from the group consisting of: anti-irritant, anti-oxidant, skin conditioning, anti-blotching, anti-aging, anti-cellulite, skin firming, eye contour, slimming, sooth, sunburn, skin lifting, anti-elastase, anti-collagenase, free radical scavenger, seboregulator, hydrative, vitamin, mineral, a-hydroxy acid, and anti-hyperpigmentation agents.
- 7. A method according to claim 1 wherein the film is at least translucent.
- 8. A method according to claim 7 wherein the film is transparent.
- 9. A method according to claim 1 wherein the film is between 0.03 and 0.1 mm in thickness.
- 10. A formulation, comprising: an aqueous mixture including a first polyvinyl alcohol having a viscosity in the range of from 38 to 55 cPs, a second polyvinyl alcohol having a viscosity in the range of from 13 to 27 cPs and at least one active agent selected from a pharmaceutical agent, a wound healing agent and a cosmetic agent, the mixture forming a composition, the composition when dried forming an agent releasing, water removable, peelable film when applied to a skin surface.
- 11. A formulation according to claim 10, wherein the composition is in the form of a gel.
- 12. A formulation according to claim 10, wherein the first polyvinyl alcohol and second polyvinyl alcohol are present at about 6 to 8% and 4 to 5%, respectively, on a wet weight basis with respect to the total composition.
- 13. A formulation according to claim 10, wherein the ratio of first polyvinyl alcohol to second polyvinyl alcohol is about 3:2.
- 14. A formulation according to claim 10 wherein the film is at least translucent.
- 15. A formulation according to claim 14 wherein the film is transparent.
- 16. A formulation according to claim 10 wherein the film is between 0.01 and 0.25 mm thick.
- 17. A formulation according to claim 10 wherein the film is 0.03 to 0.1 mm thick.
- 18. A method for administering a dosage of at least one active agent to a site on a subject, comprising:
(i) providing a formulation, the formulation including a first polyvinyl alcohol having a viscosity in the range of from 38 to 55 cPs, a second polyvinyl alcohol having a viscosity in the range of from 13 to 27 cPs, water and at least one active agent selected from one or more of a pharmaceutical agent, a wound healing agent and a cosmetic agent; (ii) releasing from a container, a quantity of the formulation onto skin of the subject so as to form a quick-drying, agent releasing, water removable, peelable film containing the active agent; and (iii) administering the agent to the subject from the film.
- 19. A method according to claim 18, wherein the first polyvinyl alcohol and the second polyvinyl alcohol, each present at about 1 to 10%, on a wet weight basis with respect to the total composition.
- 20. A method according to claim 18, wherein the first polyvinyl alcohol and the second polyvinyl alcohol are present at about 6 to 8% and 4 to 5%, respectively, on a wet weight basis with respect to the total composition.
- 21. A method according to claim 18, wherein at least one agent is selected from the group consisting of: an anti-inflammatory, a local anesthetic, a xanthine derivative, an antihistaminic, an antifungal, an antimicrobial, an antibiotic, a cardiovascular, a hormone, an erectile dysfunction treatment, a vasodilator, an antirheumatoid, a chemotherapy, an adrenergic agonist, an adrenergic antagonist, an anti-irritant, an anti-oxidant, a skin conditioning, an anti-blotching, an anti-aging, an anti-cellulite, a skin firming, a eye contour, a slimming, a sunburn soothing, a skin lifting, an anti-elastase, an anti-collagenase, a free radical scavenger, a seboregulator, a hydrative, a vitamin, a mineral, an a-hydroxy acid, and an anti-hyperpigmentation agents.
- 22. A method according to claim 18 wherein the film is at least translucent.
- 23. A method according to claim 22 wherein the film is transparent.
- 24. A method according to claim 18 wherein the film is between 0.01 and 0.25 mm thick.
- 25. A method according to claim 18 wherein the film is between 0.03 and 0.1 mm thick.
- 26. A method according to claim 18 wherein administering includes percutaneous absorption of the agent.
- 27. A method for administering a dosage of at least one active agent to a subject, comprising:
(i) applying to a skin surface of the subject, an amount of a formulation containing water, a film-forming polymer and the active agent selected from one or more of a pharmaceutical agent, a wound healing agent and a cosmetic agent but not containing methacrylate adhesive; (ii) allowing the formulation to dry on the skin to form a peelable, water-removable agent-releasing film containing the active agent; and (iii) administering the dosage of the active agent to the subject from the wet formulation and then from the film.
- 28. A method according to claim 27 wherein the film forming polymer is at least one polyvinyl alcohol.
- 29. A method according to claim 27 wherein the film is at least translucent.
- 30. A method according to claim 29 wherein the film is transparent.
- 31. A method according to claim 27 wherein the film is between 0.01 and 0.25 mm thick.
- 32. A method according to claim 27 wherein the film is between 0.03 and 0.1 mm thick.
- 33. A method according to claim 27 wherein administering is performed by percutaneous absorption of the active agent.
- 34. An active agent delivery system comprising:
a peelable agent-releasing film dried on the skin of a subject so as to be at least translucent, the film administering a dosage of active agent contained in the film into the subject through percutaneous absorption.
- 35. The active agent delivery system of claim 34 wherein the film has a thickness between 0.01 to 0.25 mm.
- 36. The active agent delivery system of claim 34 wherein the film has a thickness between 0.03 and 0.1 mm.
- 37. The active agent delivery system of claim 34 wherein the active agent is a pharmaceutical agent.
- 38. The active agent delivery system of claim 34 wherein the active agent is a wound healing agent.
- 39. The active agent delivery system of claim 34 wherein the film is made from a first polyvinyl alcohol having a viscosity in the range of from 38 to 55 cPs and a second polyvinyl alcohol having a viscosity in the range of from 13 to 27 cPs.
- 40. The active agent delivery system of claim 34 wherein the film is transparent.
- 41. A method for delivering an active agent to the skin of a subject, comprising:
combining a polymer mixture, an active ingredient, and a solvents mixture to form a composition wherein the polymer in the composition consists of one or more polyvinyl alcohols; and applying the composition to the skin of the subject for delivery of the active ingredient to the skin.
- 42. A method according to claim 41, wherein the step of applying the composition comprises spraying from a container.
- 43. A method according to claim 41, wherein the step of applying the composition comprises pressing from a tube.
- 44. A method according to claim 41, wherein the step of applying the composition comprises spreading from a rollette.
- 45. A method according to claim 41, wherein the step of applying the composition comprises pumping from ajar with an apical manual pump.
- 46. A method according to claim 41, further comprising removing air bubbles from the composition under conditions of ambient temperature and pressure.
- 47. A method according to claim 46 wherein removing the air bubbles comprises placing the composition under conditions of reduced atmospheric pressure.
- 48. A method according to claim 41 wherein the one or more polyvinyl alcohols include a first polyvinyl alcohol having a viscosity in the range of from 38 to 55 cPs and a second polyvinyl alcohol having a viscosity of from 13 to 27 cPs.
- 49. A method according to claim 41 further comprising allowing the composition to dry to form a peelable, water removable agent releasing film.
- 50. A method according to claim 49 wherein the film is between 0.01 and 0.25 mm thick.
- 51. A method according to claim 49 wherein the film is 0.03 to 0.1 mm.
- 52. A method according to claim 49 wherein the film is at least translucent.
- 53. A method according to claim 52 wherein the film is transparent.
Priority Claims (1)
Number |
Date |
Country |
Kind |
1. 09/537,318 |
Mar 2000 |
US |
|
RELATED APPLICATION
[0001] This application is a continuation in part of U.S. patent application Ser. No. 09/537,318, filed Mar. 29, 2000 which claims the benefit of Provisional Application No. 60/149,751, filed in the United States Patent and Trademark Office on Aug. 19, 1999, the full disclosures of which are both hereby incorporated by reference herein.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60149751 |
Aug 1999 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09537318 |
Mar 2000 |
US |
Child |
10408845 |
Apr 2003 |
US |