The present invention generally relates to a device and method for treating dilated cardiomyopathy of a heart. The present invention more particularly relates to a device and method for reshaping the mitral valve annulus.
The human heart generally includes four valves. Of these valves, a most critical one is known as the mitral valve. The mitral valve is located in the left atrial ventricular opening between the left atrium and left ventricle. The mitral valve is intended to prevent regurgitation of blood from the left ventricle into the left atrium when the left ventricle contracts. In preventing blood regurgitation the mitral valve must be able to withstand considerable back pressure as the left ventricle contracts.
The valve cusps of the mitral valve are anchored to muscular wall of the heart by delicate but strong fibrous cords in order to support the cusps during left ventricular contraction. In a healthy mitral valve, the geometry of the mitral valve ensures that the cusps overlie each other to preclude regurgitation of the blood during left ventricular contraction.
The normal functioning of the mitral valve in preventing regurgitation can be impaired by dilated cardiomyopathy caused by disease or certain natural defects. For example, certain diseases may cause dilation of the mitral valve annulus. This can result in deformation of the mitral valve geometry to cause ineffective closure of the mitral valve during left ventricular contraction. Such ineffective closure results in leakage through the mitral valve and regurgitation. Diseases such as bacterial inflammations of the heart or heart failure can cause the aforementioned distortion or dilation of the mitral valve annulus. Needless to say, mitral valve regurgitation must not go uncorrected.
One method of repairing a mitral valve having impaired function is to completely replace the valve. This method has been found to be particularly suitable for replacing a mitral valve when one of the cusps has been severely damaged or deformed. While the replacement of the entire valve eliminates the immediate problem associated with a dilated mitral valve annulus, presently available prosthetic heart valves do not possess the same durability as natural heart valves.
Various other surgical procedures have been developed to correct the deformation of the mitral valve annulus and thus retain the intact natural heart valve function. These surgical techniques involve repairing the shape of the dilated or deformed valve annulus. Such techniques, generally known as annuloplasty, require surgically restricting the valve annulus to minimize dilation. Here, a prosthesis is typically sutured about the base of the valve leaflets to reshape the valve annulus and restrict the movement of the valve annulus during the opening and closing of the mitral valve.
Many different types of prostheses have been developed for use in such surgery. In general, prostheses are annular or partially annular shaped members which fit about the base of the valve annulus. The annular or partially annular shaped members may be formed from a rigid material, such as a metal, or from a flexible material.
While the prior art methods mentioned above have been able to achieve some success in treating mitral regurgitation, they have not been without problems and potential adverse consequences. For example, these procedures require open heart surgery. Such procedures are expensive, are extremely invasive requiring considerable recovery time, and pose the concomitant mortality risks associated with such procedures. Moreover, such open heart procedures are particularly stressful on patients with a comprised cardiac condition. Given these factors, such procedures are often reserved as a last resort and hence are employed late in the mitral regurgitation progression. Further, the effectiveness of such procedures is difficult to assess during the procedure and may not be known until a much later time. Hence, the ability to make adjustments to or changes in the prostheses to obtain optimum effectiveness is extremely limited. Later corrections, if made at all, require still another open heart surgery.
An improved therapy to treat mitral regurgitation without resorting to open heart surgery has recently been proposed. This is rendered possible by the realization that the coronary sinus of a heart is near to and at least partially encircles the mitral valve annulus and then extends into a venous system including the great cardiac vein. As used herein, the term “coronary sinus” is meant to refer to not only the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein. The therapy contemplates the use of a device introduced into the coronary sinus to reshape and advantageously affect the geometry of the mitral valve annulus.
The device includes a resilient member having a cross sectional dimension for being received within the coronary sinus of the heart and a longitudinal dimension having an unstressed arched configuration when placed in the coronary sinus. The device partially encircles and exerts an inward pressure on the mitral valve. The inward pressure constricts the mitral valve annulus, or at least a portion of it, to essentially restore the mitral valve geometry. This promotes effective valve sealing action and eliminates mitral regurgitation.
The device may be implanted in the coronary sinus using only percutaneous techniques similar to the techniques used to implant cardiac leads such as pacemaker leads. One proposed system for implanting the device includes an elongated introducer configured for being releasably coupled to the device. The introducer is preferably flexible to permit it to advance the device into the heart and into the coronary sinus through the coronary sinus ostium. To promote guidance, an elongated sheath is first advanced into the coronary sinus. Then, the device and introducer are moved through a lumen of the sheath until the device is in position within the coronary sinus. Because the device is formed of resilient material, it conforms to the curvatures of the lumen as it is advanced through the sheath. The sheath is then partially retracted to permit the device to assume its unstressed arched configuration. Once the device is properly positioned, the introducer is then decoupled from the device and retracted through the sheath. The procedure is then completed by the retraction of the sheath. As a result, the device is left within the coronary sinus to exert the inward pressure on the mitral valve to restore mitral valve geometry.
The foregoing therapy has many advantages over the traditional open heart surgery approach. Since the device, system and method may be employed in a comparatively noninvasive procedure, mitral valve regurgitation may be treated at an early stage in the mitral regurgitation progression. Further, the device may be placed with relative ease by any minimally invasive cardiologist. Still further, since the heart remains completely intact throughout the procedure, the effectiveness of the procedure may be readily determined. Moreover, should adjustments be deemed desirable, such adjustments may be made during the procedure and before the patient is sent to recovery.
Another approach to treat mitral regurgitation with a device in the coronary sinus is based upon the observation that the application of a localized force against a discrete portion of the mitral valve annulus can terminate mitral regurgitation. This suggests that mitral valve dilation may be localized and nonuniform. Hence, the device applies a force to one or more discrete portions of the atrial wall of the coronary sinus to provide localized mitral valve annulus reshaping instead of generalized reshaping of the mitral valve annulus. Such localized therapy would have all the benefits of the generalized therapy. In addition, a localized therapy device may be easier to implant and adjust.
A still further approach to treat mitral regurgitation from the coronary sinus of the heart contemplates a device having a first anchor configured to be positioned within and fixed to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a cable fixed to the first anchor and extending proximally from the first anchor within the heart, a second anchor configured to be positioned in and fixed in the heart proximal to the first anchor and arranged to slidingly receive the cable, and a lock that locks the cable on the second anchor. When the first and second anchors are fixed within the heart, the cable may be drawn proximally and locked on the second anchor. The geometry of the mitral valve is thereby affected. This approach provides flexibility in that the second anchor may be positioned and fixed in the coronary sinus or alternatively, the second anchor may be positioned and fixed in the right atrium. This approach further allows adjustments in the cable tension after implant. The present invention provides a still further alternative for treating mitral regurgitation with a device placed in the coronary sinus adjacent to the mitral valve annulus.
The present invention provides a device that affects mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, and a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart. The device further includes a connecting member having a fixed length permanently attached to the first and second anchors. As a result, when the first and second anchors are within the heart with the first anchor anchored in the coronary sinus, the second anchor may be displaced proximally to affect the geometry of the mitral valve annulus and released to maintain the effect on the mitral valve geometry. The second anchor may be configured, when deployed, to anchor against distal movement but be moveable proximally to permit the second anchor to be displaced proximally within the coronary sinus.
The first anchor and the second anchor are preferably self-deploying upon release in the coronary sinus or may be deployable after placement. Further, the connecting member, in being of fixed length, has a maximum extended length and as such may be a rigid member, have an initial arcuate configuration, include a spring, having a maximum length or be flexible but not stretchable.
The present invention further provides a device for affecting mitral valve annulus geometry of a heart. The device includes first anchor means for anchoring in the coronary sinus of the heart adjacent the mitral valve annulus, and second anchor means for being deployed within the heart proximal to the first anchor means and adjacent the mitral valve annulus, and connecting means having a fixed length and permanently connecting the first anchor means to the second anchor means. As a result, when the first and second anchor means are within the heart with the first anchor means anchored in the coronary sinus, the second anchor means may be displaced proximally for cooperating with the first anchor means and the connecting means for affecting the geometry of the mitral valve annulus and released for maintaining the effect on the mitral valve geometry.
The invention further provides a system that affects mitral valve annulus geometry of a heart. The system includes a mitral valve device including a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart, and a connecting member having a fixed length permanently attached to the first and second anchors.
The system further includes a catheter having a distal end, a proximal end and a lumen that receives the device, the catheter being guidable into the coronary sinus adjacent to the mitral valve annulus and deploying the first and second anchors of the device within the coronary sinus adjacent to the mitral valve annulus, and a tether releasably coupled to the second anchor and extending proximally through the lumen and out of the catheter proximal end. As a result, when the first anchor is deployed by the catheter in the coronary sinus, the second anchor may be displaced proximally by proximally pulling on the tether to affect the geometry of the mitral valve annulus and thereafter released for deployment to maintain the effect on the mitral valve geometry.
The present invention further provides a method of affecting mitral valve annulus geometry in a heart. The method includes the steps of fixing a first anchor within the coronary sinus of the heart adjacent to the mitral valve annulus, positioning a second anchor within the coronary sinus adjacent to the mitral valve annulus and proximal to the first anchor, fixing a fixed length connecting member between the first anchor and the second anchor, displacing the second anchor proximally to affect the geometry of the mitral valve annulus, and releasing the second anchor from further proximal displacement to maintain the effect on the mitral valve geometry.
The present invention further provides a device that affects mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart, and a connecting member attached between the first and second anchors. At least one of the first and second anchors anchoring against movement in a first direction and being moveable in a second direction opposite the first direction.
The at least one anchor may be the first anchor wherein the first direction is a proximal direction and wherein the second direction is a distal direction. The at least one anchor may be the second anchor wherein the first direction is a distal direction and wherein the second direction is a proximal direction. In a preferred embodiment, the first anchor anchors against movement in a proximal direction and is moveable in a distal direction and the second anchor anchors against movement in the distal direction and is moveable in the proximal direction.
The invention still further provides a device that affects mitral valve annulus geometry of a heart and which permits a cardiac lead to be implanted in the left side of the heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart, a second anchor configured to be positioned within the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart, and a connecting member attached between the first and second anchors. The first anchor is configured to occupy less than all of the coronary sinus to permit a cardiac lead to be passed by the first anchor.
The first anchor may include a loop through which the cardiac lead may be passed. The second anchor may be positionable within the coronary sinus and be configured to occupy less than all of the coronary sinus to permit the cardiac lead to be passed by the second anchor. The second anchor may also include a loop through which the cardiac lead may be passed.
The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further aspects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like reference numerals identify identical elements, and wherein:
Referring now to
The mitral valve 12 includes an anterior cusp 16, a posterior cusp 18 and an annulus 20. The annulus encircles the cusps 16 and 18 and maintains their spacing to provide a complete closure during a left ventricular contraction. As is well known, the coronary sinus 14 partially encircles the mitral valve 12 adjacent to the mitral valve annulus 20. As is also known, the coronary sinus is part of the venous system of the heart and extends along the AV groove between the left atrium and the left ventricle. This places the coronary sinus essentially within the same plane as the mitral valve annulus making the coronary sinus available for placement of the mitral valve therapy device of the present invention therein.
The first anchor 32 is located at the distal end of the device 30. The anchor 32 is hook-shaped so as to be self-deployable when released in the coronary sinus 14. More specifically, the device 30 may be formed of most any biocompatible material such as stainless steel, Nitinol, a nickel/titanium alloy of the type well known in the art having shape memory or plastic. The hook-shaped configuration of the anchor 32 thus expands when released to wedge against the inner wall of the coronary sinus 14 for anchoring or fixing the anchor 32 against at least proximal movement. The anchor 32 may however allow distal movement. Preferably, the anchor 32 is positioned just proximally to the crossover point 19 of the coronary sinus 14 and a circumflex artery 17.
The connecting member 34, by being formed of Nitinol, is relatively rigid and is predisposed to have an arcuate configuration to generally correspond to the shape of the mitral valve annulus 20. The connecting member 34 is of a fixed length and is permanently attached to the first and second anchors 32 and 36. Here it will be noted that the second anchor is positioned within the coronary sinus just distal to the ostium 21 of the coronary sinus 14. The second anchor 36 may have a similar hook-shaped configuration and is also preferably self-expanding to be self-deployable. The hook-shape of the anchor 36 anchors or fixes the anchor 36 against distal movement but permits the anchor to be pulled proximally. This is a particularly significant aspect of the device 30 because it permits the device to be adjusted after the anchors 32 and 36 are first deployed.
When the device 30 is deployed as shown in
The connecting member 34 may be provided with a covering (not shown). The covering may preferably be formed of a compressible material to serve to cushion the forces of the connecting member applied against the inner wall of the coronary sinus 14.
As will be noted in
As shown in
As may now be further seen in
In accordance with the present invention, the device 30 may be deployed in a slightly different manner as described above. Here, the first anchor 32 may be deployed as described above and the second anchor 36 left in the catheter 52 as it is moved proximally. When the second anchor 36 reaches a desired position, the catheter 52 may then be pulled back to release and deploy the second anchor 36. As a result, in accordance with this alternative embodiment, the second anchor, when deployed, may anchor against both distal and proximal movement.
The first and second anchors 72 and 76 are again configured so that when they are released, they self-expand, to wedge against the inner wall of the coronary sinus 14. Again, the first anchor resists proximal movement and the second anchor 76 resists distal movement. In all other respects, the device 70 may be identical to and deployed in the same manner as the device 30.
Implantable cardiac stimulation devices are well known in the art. Such devices may include, for example, implantable cardiac pacemakers and defibrillators. The devices are generally implanted in a pectoral region of the chest beneath the skin of a patient within what is known as a subcutaneous pocket. The implantable devices generally function in association with one or more electrode carrying leads which are implanted within the heart. The electrodes are usually positioned within the right side of the heart, either within the right ventricle or right atrium, or both, for making electrical contact with their respective heart chamber. Conductors within the leads and a proximal connector carried by the leads couple the electrodes to the device to enable the device to sense cardiac electrical activity and deliver the desired therapy.
Traditionally, therapy delivery had been limited to the venous, or right side of the heart. The reason for this is that implanted electrodes can cause blood clot formation in some patients. If a blood clot were released arterially from the left heart, as for example the left ventricle, it could pass directly to the brain potentially resulting in a paralyzing or fatal stroke. However, a blood clot released from the right heart, as from the right ventricle, would pass into the lungs where the filtering action of the lungs would prevent a fatal or debilitating embolism in the brain.
Recently, new lead structures and methods have been proposed and even practiced for delivering cardiac rhythm management therapy to the left heart. These lead structures and methods avoid direct electrode placement within the left atrium and left ventricle of the heart by lead implantation within the coronary sinus of the heart. As previously mentioned, the phrase “coronary sinus” refers to not only the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein.
It has been demonstrated that electrodes placed in the coronary sinus region of the heart may be used for left atrial pacing, left ventricular pacing, or cardioversion and defibrillation. These advancements enable implantable cardiac stimulation devices to address the needs of a patient population with left ventricular dysfunction and/or congestive heart failure which would benefit from left heart side pacing, either alone or in conjunction with right heart side pacing (bi-chamber pacing), and/or defibrillation.
Even though the device of the present invention is implantable in the coronary sinus of the heart, it is configured in accordance with further aspects of the present invention to permit a cardiac lead to pass through the coronary sinus for functioning as described above. To that end, and as best seen in
More specifically, the anchors 32 and 36 take the form of loops 33 and 35 respectively which are then bent backwards on the device to form the previously referred to hook-shapes for self-deployment. The loops 33 and 35 thus permit the cardiac lead 80 to be passed therethrough for implant in the left heart. This is particularly desirable because many patients suffering from mitral regurgitation may also be candidates for left heart cardiac rhythm management therapy.
While particular embodiments of the present invention have been shown and described, modifications may be made, and it is therefore intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention as defined by the appended claims.
This application is a divisional of application Ser. No. 11/132,788, filed May 18, 2005, now abandoned; which is a continuation of application Ser. No. 10/066,426, filed Jan. 30, 2002, now U.S. Pat. No. 6,976,995. These applications are incorporated by reference in their entirety as if fully set forth herein.
Number | Name | Date | Kind |
---|---|---|---|
3620212 | Fannon, Jr. et al. | Nov 1971 | A |
3786806 | Johnson et al. | Jan 1974 | A |
3890977 | Wilson | Jun 1975 | A |
3974526 | Dardik et al. | Aug 1976 | A |
3995623 | Blake et al. | Dec 1976 | A |
4055861 | Carpentier et al. | Nov 1977 | A |
4164046 | Cooley | Aug 1979 | A |
4485816 | Krumme | Dec 1984 | A |
4550870 | Krumme et al. | Nov 1985 | A |
4588395 | Lemelson | May 1986 | A |
4830023 | de Toledo et al. | May 1989 | A |
5061277 | Carpentier et al. | Oct 1991 | A |
5099838 | Bardy | Mar 1992 | A |
5104404 | Wolff | Apr 1992 | A |
5197978 | Hess | Mar 1993 | A |
5250071 | Palermo | Oct 1993 | A |
5261916 | Engelson | Nov 1993 | A |
5265601 | Mehra | Nov 1993 | A |
5344426 | Lau et al. | Sep 1994 | A |
5350420 | Cosgrove et al. | Sep 1994 | A |
5411549 | Peters | May 1995 | A |
5433727 | Sideris | Jul 1995 | A |
5441515 | Khosravi et al. | Aug 1995 | A |
5449373 | Pinchasik et al. | Sep 1995 | A |
5454365 | Bonutti | Oct 1995 | A |
5458615 | Klemm et al. | Oct 1995 | A |
5474557 | Mai | Dec 1995 | A |
5507295 | Skidmore | Apr 1996 | A |
5507802 | Imran | Apr 1996 | A |
5514161 | Limousin | May 1996 | A |
5554177 | Kieval et al. | Sep 1996 | A |
5562698 | Parker | Oct 1996 | A |
5575818 | Pinchuk | Nov 1996 | A |
5584867 | Limousin et al. | Dec 1996 | A |
5601600 | Ton | Feb 1997 | A |
5617854 | Munsif | Apr 1997 | A |
5662703 | Yurek et al. | Sep 1997 | A |
5676671 | Inoue | Oct 1997 | A |
5733325 | Robinson et al. | Mar 1998 | A |
5733328 | Fordenbacher | Mar 1998 | A |
5741297 | Simon | Apr 1998 | A |
5752969 | Cunci et al. | May 1998 | A |
5800519 | Sandock | Sep 1998 | A |
5824071 | Nelson et al. | Oct 1998 | A |
5836882 | Frazin | Nov 1998 | A |
5871501 | Leschinsky et al. | Feb 1999 | A |
5891193 | Robinson et al. | Apr 1999 | A |
5895391 | Farnholtz | Apr 1999 | A |
5899882 | Waksman et al. | May 1999 | A |
5908404 | Elliot | Jun 1999 | A |
5928258 | Khan et al. | Jul 1999 | A |
5935161 | Robinson et al. | Aug 1999 | A |
5954761 | Machek et al. | Sep 1999 | A |
5961545 | Lentz et al. | Oct 1999 | A |
5978705 | KenKnight et al. | Nov 1999 | A |
5984944 | Forber | Nov 1999 | A |
6007519 | Rosselli | Dec 1999 | A |
6015402 | Sahota | Jan 2000 | A |
6022371 | Killion | Feb 2000 | A |
6027517 | Crocker et al. | Feb 2000 | A |
6045497 | Schweich, Jr. et al. | Apr 2000 | A |
6053900 | Brown et al. | Apr 2000 | A |
6056775 | Borghi et al. | May 2000 | A |
6077295 | Limon et al. | Jun 2000 | A |
6077297 | Robinson et al. | Jun 2000 | A |
6080182 | Shaw et al. | Jun 2000 | A |
6086611 | Duffy et al. | Jul 2000 | A |
6096064 | Routh | Aug 2000 | A |
6099549 | Bosma et al. | Aug 2000 | A |
6099552 | Adams | Aug 2000 | A |
6129755 | Mathis et al. | Oct 2000 | A |
6162168 | Schweich, Jr. et al. | Dec 2000 | A |
6171320 | Monassevitch | Jan 2001 | B1 |
6183512 | Howanec et al. | Feb 2001 | B1 |
6190406 | Duerig et al. | Feb 2001 | B1 |
6200336 | Pavcnik et al. | Mar 2001 | B1 |
6210432 | Solem et al. | Apr 2001 | B1 |
6228098 | Kayan et al. | May 2001 | B1 |
6241757 | An et al. | Jun 2001 | B1 |
6254628 | Wallace et al. | Jul 2001 | B1 |
6267783 | Letendre et al. | Jul 2001 | B1 |
6275730 | KenKnight et al. | Aug 2001 | B1 |
6306141 | Jervis | Oct 2001 | B1 |
6312446 | Huebsch et al. | Nov 2001 | B1 |
6334864 | Amplatz et al. | Jan 2002 | B1 |
6342067 | Mathis et al. | Jan 2002 | B1 |
6345198 | Mouchawar et al. | Feb 2002 | B1 |
6352553 | van der Burg et al. | Mar 2002 | B1 |
6352561 | Leopold et al. | Mar 2002 | B1 |
6358195 | Green et al. | Mar 2002 | B1 |
6368345 | Dehdashtian et al. | Apr 2002 | B1 |
6395017 | Dwyer et al. | May 2002 | B1 |
6402781 | Langberg et al. | Jun 2002 | B1 |
6419696 | Ortiz et al. | Jul 2002 | B1 |
6442427 | Boute et al. | Aug 2002 | B1 |
6464720 | Boatman et al. | Oct 2002 | B2 |
6478776 | Rosenman et al. | Nov 2002 | B1 |
6503271 | Duerig et al. | Jan 2003 | B2 |
6537314 | Langberg et al. | Mar 2003 | B2 |
6556873 | Smits | Apr 2003 | B1 |
6562067 | Mathis | May 2003 | B2 |
6569198 | Wilson et al. | May 2003 | B1 |
6589208 | Ewers et al. | Jul 2003 | B2 |
6599314 | Mathis et al. | Jul 2003 | B2 |
6602288 | Cosgrove et al. | Aug 2003 | B1 |
6602289 | Colvin et al. | Aug 2003 | B1 |
6623521 | Steinke et al. | Sep 2003 | B2 |
6626899 | Houser et al. | Sep 2003 | B2 |
6629534 | Dell et al. | Oct 2003 | B1 |
6629994 | Gomez et al. | Oct 2003 | B2 |
6643546 | Mathis et al. | Nov 2003 | B2 |
6648881 | KenKnight et al. | Nov 2003 | B2 |
6652538 | Kayan et al. | Nov 2003 | B2 |
6656221 | Taylor et al. | Dec 2003 | B2 |
6676702 | Mathis | Jan 2004 | B2 |
6689164 | Seguin | Feb 2004 | B1 |
6709425 | Gambale et al. | Mar 2004 | B2 |
6716158 | Raman et al. | Apr 2004 | B2 |
6718985 | Hlavka et al. | Apr 2004 | B2 |
6721598 | Helland et al. | Apr 2004 | B1 |
6723038 | Schroeder et al. | Apr 2004 | B1 |
6733521 | Chobotov et al. | May 2004 | B2 |
6743219 | Dwyer et al. | Jun 2004 | B1 |
6764510 | Vidlund et al. | Jul 2004 | B2 |
6773446 | Dwyer et al. | Aug 2004 | B1 |
6776784 | Ginn | Aug 2004 | B2 |
6790231 | Liddicoat et al. | Sep 2004 | B2 |
6793673 | Kowalsky et al. | Sep 2004 | B2 |
6797001 | Mathis et al. | Sep 2004 | B2 |
6800090 | Alferness et al. | Oct 2004 | B2 |
6805128 | Pless et al. | Oct 2004 | B1 |
6810882 | Langberg et al. | Nov 2004 | B2 |
6821297 | Snyders | Nov 2004 | B2 |
6824562 | Mathis et al. | Nov 2004 | B2 |
6881220 | Edwin et al. | Apr 2005 | B2 |
6890353 | Cohn et al. | May 2005 | B2 |
6899734 | Castro et al. | May 2005 | B2 |
6908478 | Alferness et al. | Jun 2005 | B2 |
6926690 | Renati | Aug 2005 | B2 |
6935404 | Duerig et al. | Aug 2005 | B2 |
6949122 | Adams et al. | Sep 2005 | B2 |
6955689 | Ryan et al. | Oct 2005 | B2 |
6960229 | Mathis et al. | Nov 2005 | B2 |
6964683 | Kowalsky et al. | Nov 2005 | B2 |
6966926 | Mathis | Nov 2005 | B2 |
6976995 | Mathis et al. | Dec 2005 | B2 |
7152605 | Khairkhahan et al. | Dec 2006 | B2 |
7175653 | Gaber | Feb 2007 | B2 |
20010018611 | Solem et al. | Aug 2001 | A1 |
20010041899 | Foster | Nov 2001 | A1 |
20010044568 | Langberg et al. | Nov 2001 | A1 |
20010049558 | Liddicoat et al. | Dec 2001 | A1 |
20020016628 | Langberg et al. | Feb 2002 | A1 |
20020042621 | Liddicoat et al. | Apr 2002 | A1 |
20020042651 | Liddicoat et al. | Apr 2002 | A1 |
20020049468 | Streeter et al. | Apr 2002 | A1 |
20020055774 | Liddicoat | May 2002 | A1 |
20020065554 | Streeter | May 2002 | A1 |
20020087173 | Alferness et al. | Jul 2002 | A1 |
20020095167 | Liddicoat et al. | Jul 2002 | A1 |
20020138044 | Streeter et al. | Sep 2002 | A1 |
20020151961 | Lashinski et al. | Oct 2002 | A1 |
20020156526 | Hlavka et al. | Oct 2002 | A1 |
20020161377 | Rabkin et al. | Oct 2002 | A1 |
20020183837 | Streeter et al. | Dec 2002 | A1 |
20020183838 | Liddicoat et al. | Dec 2002 | A1 |
20020183841 | Cohn et al. | Dec 2002 | A1 |
20020188170 | Santamore et al. | Dec 2002 | A1 |
20030018358 | Saadat | Jan 2003 | A1 |
20030040771 | Hyodoh et al. | Feb 2003 | A1 |
20030069636 | Solem et al. | Apr 2003 | A1 |
20030078465 | Pai et al. | Apr 2003 | A1 |
20030078654 | Taylor et al. | Apr 2003 | A1 |
20030083613 | Schaer | May 2003 | A1 |
20030088305 | Van Schie et al. | May 2003 | A1 |
20030130730 | Cohn et al. | Jul 2003 | A1 |
20030171776 | Adams et al. | Sep 2003 | A1 |
20030236569 | Mathis et al. | Dec 2003 | A1 |
20040010305 | Alferness et al. | Jan 2004 | A1 |
20040019377 | Taylor et al. | Jan 2004 | A1 |
20040039443 | Solem et al. | Feb 2004 | A1 |
20040102840 | Solem et al. | May 2004 | A1 |
20040111095 | Gordon et al. | Jun 2004 | A1 |
20040133240 | Adams et al. | Jul 2004 | A1 |
20040153147 | Mathis | Aug 2004 | A1 |
20040158321 | Reuter et al. | Aug 2004 | A1 |
20040176840 | Langberg | Sep 2004 | A1 |
20040193260 | Alferness et al. | Sep 2004 | A1 |
20040220654 | Mathis et al. | Nov 2004 | A1 |
20040220657 | Nieminen et al. | Nov 2004 | A1 |
20040249452 | Adams et al. | Dec 2004 | A1 |
20040260342 | Vargas et al. | Dec 2004 | A1 |
20050004667 | Swinford et al. | Jan 2005 | A1 |
20050010240 | Mathis et al. | Jan 2005 | A1 |
20050021121 | Reuter et al. | Jan 2005 | A1 |
20050027351 | Reuter et al. | Feb 2005 | A1 |
20050027353 | Alferness et al. | Feb 2005 | A1 |
20050033419 | Alferness et al. | Feb 2005 | A1 |
20050038507 | Alferness et al. | Feb 2005 | A1 |
20050060030 | Lashinski et al. | Mar 2005 | A1 |
20050065598 | Mathis et al. | Mar 2005 | A1 |
20050096666 | Gordon et al. | May 2005 | A1 |
20050096740 | Langberg et al. | May 2005 | A1 |
20050119673 | Gordon et al. | Jun 2005 | A1 |
20050137449 | Nieminen et al. | Jun 2005 | A1 |
20050137450 | Aronson et al. | Jun 2005 | A1 |
20050137451 | Gordon et al. | Jun 2005 | A1 |
20050137685 | Nieminen et al. | Jun 2005 | A1 |
20050149179 | Mathis et al. | Jul 2005 | A1 |
20050149180 | Mathis et al. | Jul 2005 | A1 |
20050149182 | Alferness et al. | Jul 2005 | A1 |
20050187619 | Mathis et al. | Aug 2005 | A1 |
20050197692 | Pai et al. | Sep 2005 | A1 |
20050197693 | Pai et al. | Sep 2005 | A1 |
20050197694 | Pai et al. | Sep 2005 | A1 |
20050209690 | Mathis et al. | Sep 2005 | A1 |
20050216077 | Mathis et al. | Sep 2005 | A1 |
20050261704 | Mathis | Nov 2005 | A1 |
20050272969 | Alferness et al. | Dec 2005 | A1 |
20060020335 | Kowalsky et al. | Jan 2006 | A1 |
20060030882 | Adams et al. | Feb 2006 | A1 |
20060041305 | Lauterjung | Feb 2006 | A1 |
20060116758 | Swinford et al. | Jun 2006 | A1 |
20060142854 | Alferness et al. | Jun 2006 | A1 |
20060161169 | Nieminen et al. | Jul 2006 | A1 |
20060167544 | Nieminen et al. | Jul 2006 | A1 |
20060173536 | Mathis et al. | Aug 2006 | A1 |
20060191121 | Gordon | Aug 2006 | A1 |
20060271174 | Nieminen et al. | Nov 2006 | A1 |
20060276891 | Nieminen et al. | Dec 2006 | A1 |
20070055293 | Alferness et al. | Mar 2007 | A1 |
20070066879 | Mathis et al. | Mar 2007 | A1 |
20070135912 | Mathis | Jun 2007 | A1 |
20070239270 | Mathis et al. | Oct 2007 | A1 |
20110308367 | Hayner et al. | Dec 2011 | A1 |
20120123532 | Mathis | May 2012 | A1 |
20120197389 | Alferness et al. | Aug 2012 | A1 |
20150173901 | Nieminen et al. | Jun 2015 | A1 |
Number | Date | Country |
---|---|---|
0893133 | Jan 1999 | EP |
0903110 | Mar 1999 | EP |
0968688 | Jan 2000 | EP |
1050274 | Nov 2000 | EP |
1095634 | May 2001 | EP |
1177779 | Feb 2002 | EP |
2181670 | May 2010 | EP |
0741604 | Dec 1955 | GB |
2754067 | Mar 1998 | JP |
2000-308652 | Nov 2000 | JP |
2001-503291 | Mar 2001 | JP |
2003-503101 | Jan 2003 | JP |
2003-521310 | Jul 2003 | JP |
WO 9856435 | Dec 1998 | WO |
WO 0044313 | Aug 2000 | WO |
WO 0060995 | Oct 2000 | WO |
WO 0074603 | Dec 2000 | WO |
WO 0100111 | Jan 2001 | WO |
WO 0119292 | Mar 2001 | WO |
WO 0150985 | Jul 2001 | WO |
WO 0154618 | Aug 2001 | WO |
WO 0187180 | Nov 2001 | WO |
WO 0200099 | Jan 2002 | WO |
WO 0201999 | Jan 2002 | WO |
WO 0205888 | Jan 2002 | WO |
WO 0219951 | Mar 2002 | WO |
WO 0234118 | May 2002 | WO |
WO 0247539 | Jun 2002 | WO |
WO 02053206 | Jul 2002 | WO |
WO 02060352 | Aug 2002 | WO |
WO 02062263 | Aug 2002 | WO |
WO 02062270 | Aug 2002 | WO |
WO 02062408 | Aug 2002 | WO |
WO 02076284 | Oct 2002 | WO |
WO 02078576 | Oct 2002 | WO |
WO 02096275 | Dec 2002 | WO |
WO 03015611 | Feb 2003 | WO |
WO 03037171 | May 2003 | WO |
WO 03049647 | Jun 2003 | WO |
WO 03049648 | Jun 2003 | WO |
WO 03055417 | Jul 2003 | WO |
WO 03059198 | Jul 2003 | WO |
WO 03063735 | Aug 2003 | WO |
Entry |
---|
Reuter et al.; U.S. Appl. No. 12/642,525 entitled “Adjustable Height Focal Tissue Deflector,” filed Dec. 18, 2009. |
Alferness et al.; U.S. Appl. No. 12/719,758 entitled “Device and Method for Modifying the Shape of a Body Organ,” filed Mar. 8, 2010. |
Pijls et al.; Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses; The New England J. of Med.; vol. 334; No. 26; pp. 1703-1708; Jun. 27, 1996. |
Yamanouchi, et al.; Activation Mapping from the coronary sinus may be limited by anatomic variations; vol. 21 pp. 2522-2526; Nov. 1998. |
Nieminen et al; U.S. Appl. No. 12/060,781 entitled “Tissue shaping device,” filed Apr. 1, 2008. |
Hayner et al.; U.S. Appl. No. 12/189,527 entitled “Catheter cutting tool,” filed Aug. 11, 2008. |
El-Maasarany et al.; The coronary sinus conduit function: Anatomical study (relationship to adjacent structures); http://europace.oxfordjournals.org/cge/content/full/7/5/475. |
Mathis et al., U.S. Appl. No. 11/782,490 entitled “Device and method for modifying the shape of a body organ, ” filed Jul. 24, 2007. |
Mathis et al., U.S. Appl. No. 11/782,508, entitled “Device and method for modifying the shape of a body organ, ” filed Jul. 24, 2007. |
Mathis et al., U.S. Appl. No. 11/782,527 entitled “Device and method for modifying the shape of a body organ, ” filed Jul. 24, 2007. |
Mathis et al; U.S. Appl. No. 11/963,417 entitled “Device and method for modifying the shape of a body organ,” filed Dec. 21, 2007. |
Gordon et al.; U.S. Appl. No. 11/971,174 entitled “Medical device delivery system,” filed Jan. 8, 2008. |
Gray, H. Anatomy of the Human Body. The Systemic Veins. Philadelphia: Lea & Febiger, 1918; Bartleby.com. 2000. Available at www.bartleby.com/107/. Accessed Jun. 7, 2006. |
Heartsite.com. Echocardiogram, 1999; p. 1-4. A.S.M. Systems Inc. Available at: http://www.heartsite.com/html/echocardiogram.html. Accessed Jul. 1, 2005. |
Papageorgiou, P., et al. Coronary Sinus Pacing Prevents Induction of Atrial Fibrillation. Circulation. 1997; 96(6): 1893-1898. |
Pai, Suresh; U.S. Appl. No. 60/329,694 entitled “Percutaneous cardiac support structures and deployment means,” filed Oct. 16, 2001. |
Mathis, Mark L.; U.S. Appl. No. 12/838,189 entitled “Mitral Valve Device Using Conditioned Shape Memory Alloy,” filed Jul. 16, 2010. |
Pelton et al. Medical uses of nitinol; Material Science Forum; vols. 327-328; pp. 63-70; 2000. |
Number | Date | Country | |
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20080140191 A1 | Jun 2008 | US |
Number | Date | Country | |
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Parent | 11132788 | May 2005 | US |
Child | 12016054 | US |
Number | Date | Country | |
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Parent | 10066426 | Jan 2002 | US |
Child | 11132788 | US |