Flavonoid Complexes

Abstract

The invention relates to complexes of specific flavonoid derivatives, to preparations containing derivatives of this type, to corresponding methods for producing said derivatives or preparations containing the latter and to the use of the latter, in particular for the care, preservation or improvement of the general condition of the skin or hair.

Description

The invention relates to complexes of certain flavonoid derivatives, to compositions which comprise such derivatives, to corresponding processes for the preparation of the flavonoid derivatives or the compositions comprising same, and to the use thereof, in particular for the care, preservation or improvement of the general condition of the skin or hair.

Luteolin and derivatives thereof have various advantageous properties. Luteolin is an excellent antioxidant and a very good free-radical scavenger. In addition, it inhibits both enzymatic and non-enzymatic lipid peroxidations. Luteolin has a favourable influence on the cardiovascular system and can prevent the occurrence of arteriosclerosis.

The anticarcinogenic action of luteolin is evident, inter alia, in the strong antiproliferative activity against various human tumour cell lines. Inflammation-inhibiting, antiviral, antibacterial and radioprotective properties of luteolin have likewise been reported. As an inhibitor of the enzyme aldose reductase, luteolin can also have a preventive action against the formation of diabetic cataracts. As an inhibitor of the enzyme hyaluronidase, it is furthermore a valuable active substance for the care of the skin and helps in the prevention of premature skin ageing, in particular by maintaining the skin moisture content.

On use of luteolin and derivatives thereof, there is a desire for administration forms which can be incorporated more easily into compositions whose compositions exhibit increased storage stability or in which the bioavailability of the compounds is increased.

Surprisingly, it has now been found that the complexing of these compounds with cyclodextrins results in products which meet the said requirements in an excellent manner.

The present invention therefore firstly relates to complex compounds of the formula I

• • in which
  • all R each, independently of one another, denote H, CH₃CO, alkyl or hydroxyalkyl radicals and where the alkyl and hydroxyalkyl groups may be branched or unbranched and can have 1 to 18 C atoms,
  • CD stands for a cyclodextrin molecule
  • o stands for the number 1 und
  • p stands for a number from the range 0.5 to 3, and where sulfate or phosphate may also each, independently of one another, be bonded to one or more hydroxyl groups of the radicals mentioned in the substituents R.

The present application secondly relates to compositions comprising a suitable excipient, characterised in that the compositions

• • comprises 0.005 to 99% by weight of a complex compound of the formula I according to claim 1 or the composition
  • comprises 0.002 to 70% by weight of cyclodextrin and
  • 0.001 to 60% by weight of at least one compound of the formula II or topically tolerated salts and/or derivatives thereof,
    • in which all R each, independently of one another, denote H, CH₃CO, alkyl or hydroxyalkyl radicals and where the alkyl and hydroxyalkyl groups may be branched or unbranched and may have 1 to 18 C atoms.

The compositions according to the invention here are usually either compositions which can be used topically, for example cosmetic or dermatological formulations, or medicaments or foods or food supplements or cosmetics to be used orally. The compositions comprise an excipient which is suitable cosmetically or dermatologically or pharmaceutically or for foods and optionally further suitable ingredients, depending on the desired property profile.

In a preferred embodiment of the present invention, the compositions are sprayable compositions. In particular, it may be advantageous here for these compositions to be built up on an aqueous or aqueous-alcoholic excipient basis.

Preference is given here to the use of aerosols. An aerosol is a disperse system in which a solid or liquid is extremely finely dispersed in a gas. The aerosol will itself generally only be formed on use with the aid of a suitable spray system by spraying solutions, emulsions or suspensions, to which end it is possible to use, for example, spray cans in which a liquefied compressed gas serves as propellant gas. On opening the pressure valve, the propellant/composition mixture escapes through a fine nozzle, the propellant evaporates and leaves the finely dispersed spray material behind as aerosol.

Active ingredients can be either dissolved in aerosol formulations or present in solid form; if they are in solid form, however, they must be correspondingly suspended in the propellant system.

Cosmetic and dermatological skin-care compositions based on emulsions which can be sprayed as aerosol are generally O/W systems in which hydrophilic active compounds are dissolved in the external water phase. The oil phase frequently comprises silicone-containing oils, which contribute to a pleasant skin feel after spraying.

Propellant gases which can be employed here are hydrophilic propellant gases—such as, for example, carbon dioxide—or lipophilic propellants, such as, for example, hydrocarbons. Other preferred compositions are pump sprays, in which the product is dispensed into an atomiser bottle and atomised by mechanical ejection.

Suitable sprayable W/O emulsions are, for example, those disclosed in the specifications DE-10162844-A1, DE-10162842-A1, DE-10162841-A1, DE-10162840-A1 or DE-10048683-A1.

Also suitable are W/O emulsions which can be sprayed as aerosols at room temperature, as described in WO2004030641, Emulsions of this type contain a fat phase which comprises at least 90% by weight of oil components which are liquid at room temperature and at most 4% by weight of substances selected from the group of the C3 to C4 esters of C12- to C18-alkanoic acids, C8- to C12-alkanols and silicone oils, and 20 to 85% by weight—based on the total weight of the composition—of water, and one or more W/O emulsifiers and one or more lipophilic propellant gases.

It is particularly preferred for the W/O emulsifier or the W/O emulsifiers to be selected from the group of PEG-30 dipolyhydroxystearate, decaglyceryl heptaoleate, polyglyceryl 3-diisostearate, PEG-8 distearate, diglycerin dipolyhydroxystearate, glycerin isostearate, sorbitan isostearate, polyglyceryl-3 methylglucose distearate, fatty alcohols having 8 to 30 carbon atoms, oligo- or polyglycerin ethers, cetyl dimethicone copolyols, alkyl methicone copolyols, alkyl dimethicone ethoxy glucoside, W/O emulsifiers which are additionally (poly 5)ethoxylated and/or (poly)propoxylated, for example polyethoxylated hydrogenated or unhydrogenated castor oil, ethoxylated cholesterol, ethoxylated fatty alcohols, such as steareth-2, ethoxylated fatty acids, such as PEG-2 stearate, PEG-40 sorbitan perisostearate. It is preferred for the W/O emulsifier(s) to be selected from the group PEG-30 dipolyhydroxystearate, polyglyceryl-3 diisostearate (=polyglycerin-3 diisostearate), diglycerin dipolyhydroxystearate, glycerin isostearate, cetyl PEG/PPG-10/1 dimethicone, sorbitan isostearate, polyglyceryl-3 methylglucose distearate, steareth-2, PEG-2 stearate, sorbitan stearate, cetyl alcohol, stearyl alcohol and/or cetearyl alcohol.

It is very particularly preferred for combinations of the above-mentioned W/O emulsifiers, in particular a combination of two emulsifiers, to be employed

The W/O emulsifier used or the W/O emulsifiers used in accordance with the invention is or are advantageously present in concentrations of 0.5 to 8% by weight (based on the total weight of the composition), although it is possible and advantageous to keep the content of emulsifiers low, for example up to 5% by weight, in each case based on the total weight of the composition. It may furthermore be advantageous to select the emulsifiers in such a way that combinations of W/O and O/W emulsifiers are used.

It may be advantageous for the compositions additionally to comprise stabilisers. The stabiliser used is preferably PEG-45/dodecyl glycol copolymer and/or PEG 22/dodecyl glycol copolymer and/or methoxy PEG-22/dodecyl glycol copolymer 10. Furthermore, poloxamers of the Pluronic type may also be preferred. The stabiliser(s) are advantageously present in concentrations of O to 8% by weight, although it is possible and advantageous to keep the content of stabilisers low, for example up to 5% by weight, in each case based on the total weight of the composition. It is very particularly advantageous to use stabilisers if the pH of the compositions is in the acidic range. It is very particularly preferred for combinations of the above-mentioned W/O emulsifiers and a stabiliser to be employed.

If the compositions according to the invention comprise UV filter substances, it is advantageous for the oil phase to comprise butylene glycol derivatives (such as, for example, butylene glycol dicaprylate), triglycerides (such as, for example, caprylic/capric 25 triglcyeride, C2-C5 alkyl benzoate and/or silicone oils or to consist entirely of such oils.

The amount of water can be up to about 85% by weight, based on the total weight of the compositions, where optimum water contents are usually selected in the range between 50 and 80% by weight.

The sprayable compositions according to the invention exhibit very good sensory properties, such as, for example, spreadability on the skin or ability to be absorbed into the skin, and are, in addition, distinguished by above-average skin care and a pleasant cooling effect.

Cyclodextrins are built up from 6, 7, 8 or even more α-1,4-linked glucose units, with cyclohexaamylose (alpha- or α-cyclodextrin) being distinguished by the structure

Cycloheptaamylose (beta- or β where bonded to this glycoside radical, in each case via an —O— group, is at least one radical selected from β-cyclodextrin) is distinguished by the structure

Cyclooctaamylose (gamma- or γ-cyclodextrin) is distinguished by the structure

Cycloenneaamylose (delta- or δ-cyclodextrin) is distinguished by the structure

Cyclodextrins may occur in underivatised form (R═H) or also in derivatised form, for example alkoxylated, hydroxyalkylated or alkylated, in particular propoxylated or methylated, in position R.

Bioflavonoid/cyclodextrin complexes here are known in principle:

• • K. Miyake, H. Arima et al. (Pharm. Dev. Techn. 5(3) 2000, 399-407 describe 1:1 complexes of rutin with beta-cyclodextrins and the solubility and liberation behaviour thereof. It was found here that the beta-cyclodextrin complex and the 2-hydroxypropyl-beta-cyclodextrin complex are particularly stable. Alpha- and gamma-cyclodextrin complexes are, according to this publication, generally less suitable for complexing rutin than are beta-cyclodextrin complexes.
  • T. K. Nguyen, H. Galons, C. Chemtob, Congr. Int. Technol. Pharm., 6th (1992), Vol 5, 408-16408-416 likewise describe various cyclodextrin complexes of rutin. The 2,6-di-O-methyl-beta-cyclodextrin complex proves to be particularly soluble here, with complexes having rutin:cyclodextrin molar ratios of 1:1 and 1:2 being described.
  • Complexes of isoflavones in soya beans or fermented soya beans with beta- and gamma-cyclodextrins are described in European Patent Application EP-A-796 624. The complexing increases the solubility of isoflavones and reduces their bitterness.
  • Rutin complexes with beta- and gamma-cyclodextrins and the use thereof as antioxidant are described in Japanese Patent Application JP 05/9137499.
  • Beverages comprising cyclodextrin complexes of quercetin glycosides are described in Japanese Patent Application JP 07/075536.
  • Japanese Patent Application JP 05/186344 describes compositions comprising vitamin C and cyclodextrin complexes of vitamin P which improve the bioabsorption of vitamin C. Complexes of rutin, hesperidin and eriocitrin, such as, for example, a rutin/beta-cyclodextrin complex having a molar ratio of 1.2, are described.
  • The action of a complex of 3-methoxyquercetin with hydroxypropyl-beta-cyclodextrin on nasal epithelial cells is investigated in S. Dimova, R. Mugabowindekwe et al. Int. J. Pharm. 26381-2) 2003, 95-103.
  • Beta-cyclodextrin complexes of various flavonoids (hesperetin, hesperidin, naringenin, naringin) are characterised in R. Ficarra, S. Tommasini et al.; J. Pharm. Biomed. Analysis 29(6) 2002, 1005-1014.
  • R.-L. Wang, Yu Yang et al.; Yingyong Huaxue 19(7) 2002 702-704 compare the stability and solubility of various beta-cyclodextrin complexes of various flavonoids (rutin, quercetin, morin). Methyl-beta-cyclodextrin complexes proved to have particularly high solubility here.
  • K. Hostettmann, M. Lederer and A. Marston; Phytochemical Analysis 1186) 2000, 380-382 investigate the eluting action of 2-hydroxypropyl-beta-cyclodextrin on flavonoids absorbed on cellulose.

It has been found, in an unforeseeable manner for the person skilled in the art, that compositions for topical use comprising the above-mentioned complex compounds of the formula I or compounds of the formula II and cyclodextrins remedy the disadvantages of the prior art.

It is particularly advantageous here if the cyclodextrins used are γ-cyclodextrins, preferably gamma-cyclodextrins which are substituted by C_1-24-alkyl or C_1-24-hydroxyalkyl on one or more hydroxyl groups, such as, in particular, hydroxypropyl-γ-cyclodextrin, or mixtures of cyclodextrins which comprise at least 30% by weight, based on the total weight of the cyclodextrin mixture, of the above-mentioned γ-cyclodextrins.

It is furthermore advantageous for the content of cyclodextrins to be 0.01-20.0% by weight, preferably 0.05-10.0% by weight, particularly preferably 0.1-5.0% by weight, in each case based on the total weight of the composition. The proportion of the compounds of the formula II in the composition here is preferably 0.01 to 20% by weight, particularly preferably 0.05 to 10% by weight and especially preferably 0.1 to 5% by weight, based on the composition as a whole. The proportion of the compounds of the formula II in the composition is very particularly preferably 0.1 to 2% by weight, based on the composition as a whole.

The active-ingredient combinations in accordance with the invention or cosmetic or dermatological compositions comprising such active-ingredient combinations are satisfactory preparations in every respect. It was not foreseeable for the person skilled in the art that the compositions in accordance with the invention

• • provide compounds of the formula II in increased bioavailability,
  • maintain or restore the barrier properties of the skin better,
  • counter drying-out of the skin better and
  • protect the skin against environmental influences better than the compositions of the prior art.

On use of the complex compounds used in accordance with the invention or cosmetic or topical dermatological compositions having an active content of active-ingredient combinations used in accordance with the invention, effective treatment, but also prophylaxis,

• • of deficient, sensitive or hypoactive skin states or deficient, sensitive or hypoactive states of skin appendages,
  • of adverse changes in the skin and skin appendages caused by the environment (smoke, smog, reactive oxygen species, free radicals) and in particular light,
  • of skin damage caused by light,
  • of pruritus,
  • of dry skin states and horny layer barrier defects,
  • of inflammatory skin states and atopic eczema, seborrhoeic eczema, polymorphic light dermatosis, psoriasis, vitiligo, is surprisingly possible. It is assumed that the complex compounds according to the invention or cosmetic or topical, dermatological compositions having an effective content of complex compounds according to the invention can also be employed
  • for soothing sensitive or irritated skin,
  • for pre- and after-treatment in the case of topical use of laser and abrasive treatments which serve, for example, to reduce wrinkles and scars, in order to counter the resultant skin irritation and to promote the regeneration processes in the injured skin.

It is therefore also in accordance with the invention to use the complex compounds of the formula I or the compositions comprising the compounds of the formula II and cyclodextrins

• • for the cosmetic or dermatological treatment or prophylaxis of undesired skin states,
  • for the prophylaxis and treatment of inflammatory skin states—also atopic eczema,
  • for skin protection in the case of dry skin determined to be sensitive,
  • for the protection of the skin against photoreactions,
  • for the treatment and prophylaxis of sensitive skin states,
  • for increasing the skin's own desoxidative protection,
  • and/or for improving the protection of the skin against environmental influences.

The complex compounds or compositions comprising the active-ingredient combination in accordance with the invention have a synergistic action in relation to the individual components in all these uses.

Advantageous in accordance with the invention is the use of cyclodextrins and/or cyclodextrin derivatives for increasing the solubility of compounds of the formula II. Furthermore advantageous is the use of cyclodextrins and/or cyclodextrin derivatives for improving the biological efficacy of compounds of the formula II.

In the flavonoid moieties of the compounds of the formula I or compounds of the formula II, the alkyl groups are preferably linear and have 1 to 12 and preferably 1 to 8 C atoms. In the flavonoid moieties of the compounds of the formula I or compounds of the formula II, the hydroxyalkoxy groups are preferably linear and have 2 to 12 and preferably 2 to 8 C atoms.

In a preferred embodiment of the invention, in particular if the water solubility of the flavonoid moieties of the compounds of the formula I or compounds of the formula II is to be increased, a polar group, for example, in each case independently of one another, a sulfate or phosphate group, is bonded to one or more hydroxyl groups of the radicals mentioned in the substituents R. Suitable counterions are, for example, the ions of the alkali or alkaline earth metals, these being selected, for example, from sodium or potassium.

In a further preferred embodiment, the flavonoid moiety of the compounds of the formula I or the compound of the formula II present in the compositions according to the invention is luteolin or trishydroxyethylluteolin.

Some flavonoid moieties of the compounds of the formula I or compounds of the formula II, such as, for example, luteolin, can be obtained from plants, for example from the plants Reseda luteola L., Achillea millefolium L., Chamomillae requtita, Cynara scolymus, Thymus vulgaris, Limonium sinuatum, Vitex rotundifolia, Erigeron canadensis L., Sophora angustifolia, Satureja obovate, and Lonicera japonica. These compounds can be processed further either in isolated form or also in unisolated form, i.e. incorporated into compositions, for example, in the form of an extract or in the form of a purified extract or also in the form of the pure substance prepared from the plant extract.

If the composition according to the invention comprises luteolin, this compound has, in a further preferred embodiment, been used for the preparation of the composition in the form of a plant extract, a purified plant extract or in the form of the pure substance prepared from the plant extract.

In compositions of this type, the plant extract comprises, for example, 1 to 100% by weight of luteolin. In one embodiment, the plant extract preferably comprises 5 to 90% by weight of luteolin. In a further embodiment, the plant extract preferably comprises 30 to 100% by weight, particularly preferably 60 to 100% by weight and especially preferably 90 to 100% by weight of luteolin.

In all uses according to the invention in which luteolin is used, luteolin can be used, for example, in the form of a synthetic substance, in the form of a plant extract, a purified plant extract or as individual substance or in the form of a pure substance obtained from the plant extract. In a preferred embodiment, luteolin is used here in the form of a plant extract, a purified plant extract or in the form of the pure substance prepared from the plant extract.

The flavonoid moieties of the compounds of the formula I or compounds of the formula II can be obtained or prepared by methods which are well known to the person skilled in the art and are described in the literature (for example in standard works, such as Houben-Weyl, Methoden der organischen Chemie [Methods of Organic Chemistry], Georg-Thieme-Verlag, Stuttgart).

For example, luteolin occurs in plants and can be obtained by extraction. The plant extracts are prepared by conventional methods of extraction of the plants or plant parts. Suitable extraction methods may be: maceration, remaceration, digestion, agitation maceration, fluidised-bed extraction, ultrasound extraction, countercurrent extraction, percolation, repercolation, evacolation, diacolation or solid-liquid extraction with continuous reflux, which is carried out in a Soxhlet extractor.

The solvents used for the extraction can be, for example, water or an alcohol. The way in which these extractions can be carried out in detail and the way in which the resultant crude extracts can be purified by generally familiar methods can be ascribed to the general knowledge of the person skilled in the art.

The synthesis of luteolin by means of a multistep synthesis from suitable chalcones and hesperidine is described in U. Achterrath-Tuckermann et al., Planta Med. 39 (1980) 38; D. Nagarathnam et al., J. Org. Chem. 56 (1991) 4884; Y.-H. Lu et al., Yao Hsueh Hsueh Pao 15 (1980) 477; G. Litkei et al., Liebigs Ann. 9 (1995) 1711; Y. Xing et al., Zhongguo Yiyao Gongye Zazhi 25 (1994) 484.

An advantageous synthetic route for luteolin or luteolin derivatives, such as trishydroxyethylluteolin, is described in WO 2000/26206. In this process, glycosylated precursors are reduced in aqueous alkaline medium using sodium dithionite Na₂S₂O₄. The corresponding disclosure content of WO 2000/26206 thus expressly also belongs to the disclosure content of the present application.

The complex compounds of the formula I can be prepared by reacting compounds of the formula II with cyclodextrins in solution, preferably at elevated temperature. The present invention furthermore relates to a corresponding process.

It has been found that complexes comprising about 2 mol of cyclodextrin per mole of flavonoid of the formula II meet the requirements according to the invention in a particular manner. It is therefore preferred in accordance with the invention for o in formula I to be equal to 1 and p to be in the range from 1.75 to 2.1, preferably for p to be equal to 2.

Corresponding compounds can be prepared if the cyclodextrin is employed in excess or precisely in the molar ratio 2:1, based on the flavonoid.

In a preferred embodiment of the present invention, the composition is a composition for the protection of body cells against oxidative stress, in particular for reducing skin ageing, characterised in that it comprises one or more further antioxidants besides the one or more compounds of the formula I or of the formula II.

There are many proven substances known from the specialist literature which can be used as antioxidants, for example amino acids (for example glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles, (for example urocanic acid) and derivatives thereof, peptides, such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (for example anserine), carotinoids, carotenes (for example α-carotene, β-carotene, ly-copene) and derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid and derivatives thereof (for example dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (for example thioredoxin, glutathione, cysteine, cystine, cystamine and the glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters thereof) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts), and sulfoximine compounds (for example buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta-, hexa- and hepta-thionine sulfoximine) in very low tolerated doses (for example pmol to μmol/kg), and also (metal) chelating agents, (for example α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (for example citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and derivatives thereof, unsaturated fatty acids and derivatives thereof, vitamin C and derivatives (for example ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (for example vitamin E acetate), vitamin A and derivatives (for example vitamin A palmitate), and coniferyl benzoate of benzoin resin, rutinic acid and derivatives thereof, α-glycosyl rutin, ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiaretic acid, trihydroxybutyrophenone, quercetin, uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (for example ZnO, ZnSO₄), selenium and derivatives thereof (for example selenomethionine), stilbenes and derivatives thereof (for example stilbene oxide, trans-stilbene oxide).

Mixtures of antioxidants are likewise suitable for use in the cosmetic compositions according to the invention. Known and commercial mixtures are, for example, mixtures comprising, as active ingredients, lecithin, L-(+)-ascorbyl palmitate and citric acid (for example (for example Oxynex® AP), natural tocopherols, L-(+)-ascorbyl palmitate, L-(+)-ascorbic acid and citric acid (for example Oxynex® K LIQUID), tocopherol extracts from natural sources, L-(+)-ascorbyl palmitate, L-(+)-ascorbic acid and citric acid (for example Oxynex® L LIQUID), DL-α-tocopherol, L-(+)-ascorbyl palmitate, citric acid and lecithin (for example Oxynex® LM) or butylhydroxytoluene (BHT), L-(+)-ascorbyl palmitate and citric acid (for example Oxynex® 2004). Antioxidants of this type are usually employed with compounds of the formula I or formula II in such compositions in ratios in the range from 1000:1 to 1:1000, preferably in amounts of 100:1 to 1:100.

The compositions according to the invention may comprise vitamins as further ingredients. The cosmetic compositions according to the invention preferably comprise vitamins and vitamin derivatives selected from vitamin A, vitamin A propionate, vitamin A palmitate, vitamin A acetate, retinol, vitamin B, thiamine chloride hydrochloride (vitamin B₁), riboflavin (vitamin B₂), nicotinamide, vitamin C (ascorbic acid), vitamin D, ergocalciferol (vitamin D₂), vitamin E, DL-α-tocopherol, tocopherol E acetate, tocopherol hydrogensuccinate, vitamin K₁, esculin (vitamin P active ingredient), thiamine (vitamin B₁), nicotinic acid (niacin), pyridoxine, pyridoxal, pyridoxamine, (vitamin B₆), pantothenic acid, biotin, folic acid and cobalamine (vitamin B₁₂), particularly preferably vitamin A palmitate, vitamin C and derivatives thereof, DL-α-tocopherol, tocopherol E acetate, nicotinic acid, pantothenic acid and biotin. Vitamins are usually employed here with compounds of the formula I or formula II in ratios in the range from 1000:1 to 1:1000, preferably in amounts of 100:1 to 1:100.

Of the phenols having an antioxidative action, the polyphenols, some of which are naturally occurring, are of particular interest for applications in the pharmaceutical, cosmetic or nutrition sector. For example, the flavonoids or bioflavonoids, which are principally known as plant dyes, frequently have an antioxidant potential. K. Lemanska, H. Szymusiak, B. Tyrakowska, R. Zielinski, I. M. C. M. Rietjens; Current Topics in Biophysics 2000, 24(2), 101-108, are concerned with effects of the substitution pattern of mono- and dihydroxyflavones. It is observed therein that dihydroxyflavones containing an OH group adjacent to the keto function or OH groups in the 3′,4′- or 6,7- or 7,8-position have antioxidative properties, while other mono- and dihydroxyflavones in some cases do not have antioxidative properties.

Quercetin (cyanidanol, cyanidenolon 1522, meletin, sophoretin, ericin, 3,3′,4′,5,7-pentahydroxyflavone) is frequently mentioned as a particularly effective antioxidant (for example C. A. Rice-Evans, N. J. Miller, G. Paganga, Trends in Plant Science 1997, 2(4), 152-159). K. Lemanska, H. Szymusiak, B. Tyrakowska, R. Zielinski, A. E. M. F. Soffers, I. M. C. M. Rietjens; Free Radical Biology & Medicine 2001, 31(7), 869-881, are investigating the pH dependence of the antioxidant action of hydroxyflavones. Quercetin exhibits the greatest activity amongst the structures investigated over the entire pH range.

Suitable antioxidants are furthermore compounds of the formula III

• • where R¹ to R¹⁰ may be identical or different and are selected from
    • H
    • OR¹¹
    • straight-chain or branched C₁- to C₂₀-alkyl groups,
    • straight-chain or branched C₃- to C₂₀-alkenyl groups,
    • straight-chain or branched C₁- to C₂₀-hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or
    • C₃- to C₁₀-cycloalkyl groups and/or C₃- to C₁₂-cycloalkenyl groups, where the rings may each also be bridged by —(CH₂)_n— groups, where n=1 to 3,
    • where all OR¹¹, independently of one another, stand for
      • OH
      • straight-chain or branched C₁- to C₂₀-alkoxy groups,
      • straight-chain or branched C₃- to C₂₀-alkenyloxy groups,
      • straight-chain or branched C₁- to C₂₀-hydroxyalkoxy groups, where the hydroxyl group(s) may be bonded to a primary or secondary carbon atom of the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or
      • C₃- to C₁₀-cycloalkoxy groups and/or C₃- to C₁₂-cycloalkenyloxy groups, where the rings may each also be bridged by —(CH₂)_n— groups, where n=1 to 3, and/or
      • mono- and/or oligoglycosyl radicals,
    • with the proviso that at least 4 radicals from R¹ to R⁷ stand for OH and that at least 2 pairs of adjacent —OH groups are present in the molecule,
    • or R², R⁵ and R⁶ stand for OH and the radicals R¹, R³, R⁴ and R^7-10 stand for H, as described in the earlier German patent application DE 10244282.7.

Compositions which are particularly preferred in accordance with the invention also comprise UV filters in addition to the compounds of the formula I or formula II.

On use of the dibenzoylmethane derivatives which are particularly preferred as UV-A filters in combination with the compounds of the formula I or formula II, an additional advantage arises: the UV-sensitive dibenzoylmethane derivatives are additionally stabilised by the presence of the compounds of the formula I or formula II. The present invention therefore furthermore relates to the use of the compounds of the formula I or formula II for the stabilisation of dibenzoylmethane derivatives in compositions.

In principle, all UV filters are suitable for combination with the compounds of the formula I or formula II according to the invention. Particular preference is given to UV filters whose physiological acceptability has already been demonstrated. Both for UVA and UVB filters, there are many proven substances known from the specialist literature, for example

benzylidenecamphor derivatives, such as 3-(4′-methylbenzylidene)-dl-camphor (for example Eusolex® 6300), 3-benzylidenecamphor (for example Mexoryl® SD), polymers of N-{(2 and 4)-[(2-oxoborn-3-ylidene)methyl]-benzyl}acrylamide (for example Mexoryl® SW), N,N,N-trimethyl-4-(2-oxoborn-3-ylidenemethyl)anilinium methylsulfate (for example Mexoryl® SK) or (2-oxoborn-3-ylidene)toluene-4-sulfonic acid (for example Mexoryl® SL),

benzoyl- or dibenzoylmethanes, such as 1-(4-tert-butylphenyl)-3-(4-meth-oxyphenyl)propane-1,3-dione (for example Eusolex® 9020) or 4-isopropyl-dibenzoylmethane (for example Eusolex® 8020),

benzophenones, such as 2-hydroxy-4-methoxybenzophenone (for example Eusolex® 4360) or 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its sodium salt (for example Uvinul® MS-40),

methoxycinnamic acid esters, such as octyl methoxycinnamate (for example Eusolex® 2292), isopentyl 4-methoxycinnamate, for example as a mixture of the isomers (for example Neo Heliopan® E 1000),

salicylate derivatives, such as 2-ethylhexyl salicylate (for example Eusolex® OS), 4-isopropylbenzyl salicylate (for example Megasol®) or 3,3,5-trimethylcyclohexyl salicylate (for example Eusolex® HMS),

4-aminobenzoic acid and derivatives, such as 4-aminobenzoic acid, 2-ethylhexyl 4-(dimethylamino)benzoate (for example Eusolex® 6007), ethoxylated ethyl 4-aminobenzoate (for example Uvinul® P25),

phenylbenzimidazolesulfonic acids, such as 2-phenylbenzimidazole-5-sulfonic acid and potassium, sodium and triethanolamine salts thereof (for example Eusolex® 232), 2,2-(1,4-phenylene)bisbenzimidazole-4,6-disulfonic acid and salts thereof (for example Neoheliopan® AP) or 2,2-(1,4-phenylene)bisbenzimidazole-6-sulfonic acid;

and further substances, such as

• • 2-ethylhexyl 2-cyano-3,3-diphenylacrylate (for example Eusolex® OCR),
  • 3,3′-(1,4-phenylenedimethylene)bis(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonic acid and salts thereof (for example Mexoryl® SX) and
  • 2,4,6-trianilino-(p-carbo-2′-ethylhexyl-1′-oxy)-1,3,5-triazine (for example Uvinul® T 150)
  • hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate (for example Uvinul®UVA Plus, BASF).

The compounds mentioned in the list should only be regarded as examples. It is of course also possible to use other UV filters.

These organic UV filters are generally incorporated into cosmetic formulations in an amount of 0.5 to 10 per cent by weight, preferably 1-8%.

Further suitable organic UV filters are, for example,

• • 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyloxy)disiloxanyl)propyl)phenol (for example Silatrizole®),
  • 2-ethylhexyl 4,4′-[(6-[4-((1,1-dimethylethyl)aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)diimino]bis(benzoate) (for example Uvasorb® HEB),
  • α-(trimethylsilyl)-ω-[trimethylsilyl)oxy]poly[oxy(dimethyl [and approximately 6% of methyl[2-[p-[2,2-bis(ethoxycarbonyl]vinyl]phenoxy]-1-methyleneethyl] and approximately 1.5% of methyl[3-[p-[2,2-bis(ethoxycarbonyl)vinyl])phenoxy)propenyl) and 0.1 to 0.4% of (methylhydrogen]silylene]] (n≈60) (CAS No. 207 574-74-1)
  • 2,2′-methylenebis(6-(2H-benzotriazol-2-yl )-4-(1,1,3,3-tetramethylbutyl)-phenol) (CAS No.103 597-45-1)
  • 2,2′-(1,4-phenylene)bis(1H-benzimidazole-4,6-disulfonic acid, mono-sodium salt) (CAS No.180 898-37-7) and
  • 2,4-bis{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (CAS No.103 597-45-, 187 393-00-6).
  • 2-ethylhexyl 4,4′-[(6-[4-((1,1-dimethylethyl)aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)diimino]bis(benzoate) (for example Uvasorb® HEB),

Further suitable UV filters are also methoxyflavones corresponding to the earlier German patent application DE 10232595.2.

Organic UV filters are generally incorporated into cosmetic formulations in an amount of 0.5 to 20 per cent by weight, preferably 1-15%.

Conceivable inorganic UV filters are those from the group of the titanium dioxides, such as, for example, coated titanium dioxide (for example Eusolex® T-2000, Eusolex® T-AQUA, Eusolex® T-AVO), zinc oxides (for example Sachtotec®), iron oxides or also cerium oxides. These inorganic UV filters are generally incorporated into cosmetic compositions in an amount of 0.5 to 20 per cent by weight, preferably 2-10%.

Preferred compounds having UV-filtering properties are 3-(4′-methylbenzylidene)-dl-camphor, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 4-isopropyldibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyl methoxycinnamate, 3,3,5-trimethylcyclohexyl salicylate, 2-ethylhexyl 4-(dimethylamino)benzoate, 2-ethylhexyl 2-cyano-3,3-diphenylacrylate, 2-phenylbenzimidazole-5-sulfonic acid and potassium, sodium and triethanolamine salts thereof.

The protective action against damaging effects of UV radiation can be optimised by combining one or more compounds of the formula I or formula II with further UV filters.

Optimised compositions may comprise, for example, the combination of the organic UV filters 4′-methoxy-6-hydroxyflavone with 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione and 3-(4′-methylbenzylidene)-dl-camphor. This combination gives rise to broad-band protection, which can be supplemented by the addition of inorganic UV filters, such as titanium dioxide microparticles.

All the said UV filters can also be employed in encapsulated form. In particular, it is advantageous to employ organic UV filters in encapsulated form. In detail, the following advantages arise:

• • The hydrophilicity of the capsule wall can be set independently of the solubility of the UV filter. Thus, for example, it is also possible to incorporate hydrophobic UV filters into purely aqueous compositions. In addition, the oily impression on application of the composition comprising hydrophobic UV filters, which is frequently regarded as unpleasant, is suppressed.
  • Certain UV filters, in particular dibenzoylmethane derivatives, exhibit only reduced photostability in cosmetic compositions. Encapsulation of these filters or compounds which impair the photostability of these filters, such as, for example, cinnamic acid derivatives, enables the photostability of the entire composition to be increased.
  • Skin penetration by organic UV filters and the associated potential for irritation on direct application to the human skin is repeatedly being discussed in the literature. The encapsulation of the corresponding substances which is proposed here suppresses this effect.
  • In general, encapsulation of individual UV filters or other ingredients enables composition problems caused by the interaction of individual composition constituents with one another, such as crystallisation processes, precipitation and agglomerate formation, to be avoided since the interaction is suppressed.

It is therefore preferred in accordance with the invention for one or more of the above-mentioned UV filters to be in encapsulated form. It is advantageous here for the capsules to be so small that they cannot be viewed with the naked eye. In order to achieve the above-mentioned effects, it is furthermore necessary for the capsules to be sufficiently stable and the encapsulated active ingredient (UV filter) only to be released to the environment to a small extent, or not at all.

Suitable capsules can have walls of inorganic or organic polymers. For example, U.S. Pat. No. 6,242,099 B1 describes the production of suitable capsules with walls of chitin, chitin derivatives or polyhydroxylated polyamines. Capsules which can particularly preferably be employed in accordance with the invention have walls which can be obtained by a sol-gel process, as described in the applications WO 00/09652, WO 00/72806 and WO 00/71084. Preference is again given here to capsules whose walls are built up from silica gel (silica; undefined silicon oxide hydroxide). The production of corresponding capsules is known to the person skilled in the art, for example from the cited patent applications, whose contents expressly also belong to the subject-matter of the present application.

The capsules in compositions according to the invention are preferably present in amounts which ensure that the encapsulated UV filters are present in the composition in the above-indicated amounts.

The compositions according to the invention may in addition comprise further conventional skin-protecting or skin-care active ingredients. These may in principle be any active ingredients known to the person skilled in the art.

These may be chromone derivatives. The term chromone derivatives here is preferably taken to mean certain chromen-2-one derivatives which are suitable as active ingredients for the preventive treatment of human skin and human hair against ageing processes and harmful environmental influences. At the same time, they exhibit a low irritation potential for the skin, have a positive effect on water binding in the skin, maintain or increase the elasticity of the skin and thus promote smoothing of the skin. These compounds preferably conform to the formula IV

where

R¹ and R² may be identical or different and are selected from

• • H, —C(═O)—R⁷, —C(═O)—OR⁷,
  • straight-chain or branched C₁- to C₂₀-alkyl groups,
  • straight-chain or branched C₃- to C₂₀-alkenyl groups, straight-chain or branched C₁- to C₂₀-hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or
  • C₃- to C₁₀-cycloalkyl groups and/or C₃- to C₁₂-cycloalkenyl groups, where the rings may each also be bridged by —(CH₂)_n— groups, where n=1 to 3,

R³ stands for H or straight-chain or branched C₁- to C₂₀-alkyl groups,

R⁴ stands for H or OR⁸,

R⁵ and R⁶ may be identical or different and are selected from

• • —H, —OH,
  • straight-chain or branched C₁- to C₂₀-alkyl groups,
  • straight-chain or branched C₃- to C₂₀-alkenyl groups,
  • straight-chain or branched C₁- to C₂₀-hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain and furthermore the alkyl chain may also be interrupted by oxygen, and

R⁷ stands for H, straight-chain or branched C₁- to C₂₀-alkyl groups, a polyhydroxyl compound, such as preferably an ascorbic acid radical or glycosidic radicals, and

R⁸ stands for H or straight-chain or branched C₁- to C₂₀-alkyl groups, where at least 2 of the substituents R¹, R² R⁴-R⁶ are not H or at least one substituent from R¹ and R² stands for —C(═O)—R⁷ or —C(═O)—OR⁷.

The proportion of one or more compounds selected chromone derivatives in the composition according to the invention is preferably from 0.001 to 5% by weight, particularly preferably from 0.01 to 2% by weight, based on the composition as a whole.

It may furthermore be preferred for the composition according to the invention to comprise at least one repellent, where the repellent is preferably selected from N,N-diethyl-3-methylbenzamide, ethyl 3-(acetylbutylamino)-propionate, dimethyl phthalate, butopyronoxyl, 2,3,4,5-bis(2-butylene)-tetrahydro-2-furaldehyde, N,N-diethylcaprylamide, N,N-diethylbenzamide, o-chloro-N,N-diethylbenzamide, dimethyl carbate, di-n-propyl isocinchomeronate, 2-ethylhexane-1,3-diol, N-octylbicycloheptenedicarboximide, piperonyl butoxide, 1-(2-methylpropoxycarbonyl)-2-(hydroxyethyl)piperidine, or mixtures thereof, where it is particularly preferably selected from N,N-diethyl-3-methylbenzamide, ethyl 3-(acetylbutylamino)propionate 1-(2-methylpropoxycarbonyl)-2-(hydroxyethyl)piperidine, or mixtures thereof.

The compositions according to the invention which comprise repellents are preferably insect repellents. Insect repellents are available in the form of solutions, gels, sticks, rollers, pump sprays and aerosol sprays, with solutions and sprays forming the majority of the commercially available products. The basis for these two product forms is usually formed by alcoholic or aqueous/alcoholic solutions with addition of fatting substances and slight perfuming.

Particularly preferred active ingredients are pyrimidinecarboxylic acids and/or aryl oximes.

Pyrimidinecarboxylic acids occur in halophilic microorganisms and play a role in osmoregulation of these organisms (E. A. Galinski et al., Eur. J. Biochem., 149 (1985) page 135-139). Of the pyrimidinecarboxylic acids, particular mention should be made here of ectoine ((S)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) and hydroxyectoine ((S,S)-1,4,5,6-tetrahydro-5-hydroxy-2-methyl-4-pyrimidinecarboxylic acid and derivatives thereof. These compounds stabilise enzymes and other biomolecules in aqueous solutions and organic solvents. Furthermore, they stabilise, in particular, enzymes against denaturing conditions, such as salts, extreme pH values, surfactants, urea, guanidinium chloride and other compounds.

Ectoine and ectoine derivatives, such as hydroxyectoine, can advantageously be used in medicaments. In particular, hydroxyectoine can be employed for the preparation of a medicament for the treatment of skin diseases. Other areas of application of hydroxyectoine and other ectoine derivatives are typically in areas in which, for example, trehalose is used as additive. Thus, ectoine derivatives, such as hydroxyectoine, can be used as protectant in dried yeast and bacterial cells. Pharmaceutical products, such as non-glycosylated, pharmaceutical active peptides and proteins, for example t-PA, can also be protected with ectoine or its derivatives.

Of the cosmetic applications, particular mention should be made of the use of ectoine and ectoine derivatives for the care of aged, dry or irritated skin. Thus, European Patent Application EP-A-0 671 161 describes, in particular, that ectoine and hydroxyectoine are employed in cosmetic compositions, such as powders, soaps, surfactant-containing cleansing products, lipsticks, rouge, make-ups, care creams and sunscreen preparations.

Preference is given here to the use of a pyrimidinecarboxylic acid of the following formula V in which R¹ is a radical H or C1-8-alkyl, R² is a radical H or C1-4-alkyl and R³, R⁴, R⁵ and R⁶ are each, independently of one another, a radical from the group H, OH, NH₂ and C1-4-alkyl. Preference is given to the use of pyrimidinecarboxylic acids in which R is a methyl or ethyl group, and R¹ or R⁵ and R⁶ are H. Particular preference is given to the use of the pyrimidinecarboxylic acids ectoine ((S)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) and hydroxyectoine ((S,S)-1,4,5,6-tetrahydro-5-hydroxy-2-methyl-4-pyrimidinecarboxylic acid). The compositions according to the invention preferably comprise pyrimidinecarboxylic acids of this type in amounts of up to 15% by weight. The pyrimidinecarboxylic acids are preferably employed here in ratios of 100:1 to 1:100 with respect to the compounds of the formula I, with ratios in the range 1:10 to 10:1 being particularly preferred.

Of the aryl oximes, preference is given to the use of 2-hydroxy-5-methyl-laurophenone oxime, which is also known as HMLO, LPO or F5. Its suitability for use in cosmetic compositions is disclosed, for example, in DE-A-41 16 123. Compositions which comprise 2-hydroxy-5-methyllaurophenone oxime are accordingly suitable for the treatment of skin diseases which are accompanied by inflammation. It is known that compositions of this type can be used, for example, for the therapy of psoriasis, various forms of eczema, irritative and toxic dermatitis, UV dermatitis and further allergic and/or inflammatory diseases of the skin and skin appendages. Compositions according to the invention which, in addition to the compound of the formula I, additionally comprise an aryl oxime, preferably 2-hydroxy-5-methyllaurophenone oxime, exhibit surprising antiinflammatory suitability. The compositions here preferably comprise 0.01 to 10% by weight of the aryl oxime, it being particularly preferred for the composition to comprise 0.05 to 5% by weight of aryl oxime.

In a further, likewise preferred embodiment of the present invention, the composition according to the invention comprises at least one self-tanning agent.

Advantageous self-tanning agents which can be employed are, inter alia:

Mention should also be made of 5-hydroxy-1,4-naphthoquinone (juglone), which is extracted from the shells of fresh walnuts

5-hydroxy-1,4-naphthoquinone (juglone)

and 2-hydroxy-1,4-naphthoquinone (lawsone), which occurs in henna leaves.

2-hydroxy-1,4-naphthoquinone (lawsone)

Very particular preference is given to 1,3-dihydroxyacetone (DHA), a trifunctional sugar which occurs in the human body, and derivatives thereof.

1,3-dihydroxyacetone (DHA)

Furthermore, the compositions according to the invention may also comprise dyes and coloured pigments. The dyes and coloured pigments can be selected from the corresponding positive list in the German Cosmetics Regulation or the EC list of cosmetic colorants. In most cases, they are identical with the dyes approved for foods. Advantageous coloured pigments are, for example, titanium dioxide, mica, iron oxides (for example Fe₂O₃, Fe₃O₄, FeO(OH)) and/or tin oxide. Advantageous dyes are, for example, carmine, Berlin Blue, Chromium Oxide Green, Ultramarine Blue and/or Manganese Violet. It is particularly advantageous to select the dyes and/or coloured pigments from the following list. The Colour Index numbers (CINs) are taken from the Rowe Colour Index, 3rd Edition, Society of Dyers and Colourists, Bradford, England, 1971.

Chemical or other name	CIN	Colour
Pigment Green	10006	green
Acid Green 1	10020	Green
2,4-Dinitrohydroxynaphthalene-7-sulfonic acid	10316	Yellow
Pigment Yellow 1	11680	Yellow
Pigment Yellow 3	11710	Yellow
Pigment Orange 1	11725	Orange
2,4-Dihydroxyazobenzene	11920	Orange
Solvent Red 3	12010	Red
1-(2′-Chloro-4′-nitro-1′-phenylazo)-2-hydroxynaphthalene	12085	Red
Pigment Red 3	12120	Red
Ceres Red; Sudan Red; Fat Red G	12150	Red
Pigment Red 112	12370	Red
Pigment Red 7	12420	Red
Pigment Brown 1	12480	Brown
4-(2′-Methoxy-5′sulfonyldiethylamide-1′-phenylazo)-3-	12490	Red
hydroxy-5″-chloro-2″,4″-dimethoxy2-naphthanilide
Disperse Yellow 16	12700	Yellow
1-(4-Sulfo-1-phenylazo)-4-aminobenzene-5-sulfonic acid	13015	Yellow
2,4-Dihydroxyazobenzene-4′-sulfonic acid	14270	Orange
2-(2,4-Dimethylphenylazo-5-sulfonyl)-1-hydroxynaphthalene-	14700	Red
4-sulfonic acid
2-(4-Sulfo-1-naphthylazo)-1-naphthol-4-sulfonic acid	14720	Red
2-(6-Sulfo-2,4-xylylazo)-1-naphthol-5-sulfonic acid	14815	Red
1-(4′-Sulfophenylazo)-2-hydroxynaphthalene	15510	Orange
1-(2-Sulfonyl-4-chloro-5-carboxy-1-phenylazo)-2-	15525	Red
hydroxynaphthalene
1-(3-Methylphenylazo-4-sulfonyl)-2-hydroxynaphthalene	15580	Red
1-(4′,(8′)-Sulfonylnaphthylazo)-2-hydroxynaphthalene	15620	Red
2-Hydroxy-1,2′-azonaphthalene-1′-sulfonic acid	15630	Red
3-Hydroxy-4-phenylazo-2-naphthylcarboxylic acid	15800	Red
1-(2-Sulfo-4-methyl-1-phenylazo)-2-naphthylcarboxylic	15850	Red
acid
1-(2-Sulfo-4-methyl-5-chloro-1-phenylazo)-2-hydroxynaphthalene-	15865	Red
3-carboxylic acid
1-(2-Sulfo-1-naphthylazo)-2-hydroxynaphthalene-3-carboxylic	15880	red
acid
1-(3-Sulfo-1-phenylazo)-2-naphthol-6-sulfonic acid	15980	Orange
1-(4-Sulfo-1-phenylazo)-2-naphthol-6-sulfonic acid	15985	Yellow
Allura Red	16035	Red
1-(4-Sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid	16185	Red
Acid Orange 10	16230	Orange
1-(4-Sulfo-1-naphthylazo)-2-naphthol-6,8-disulfonic acid	16255	Red
1-(4-Sulfo-1-naphthylazo)-2-naphthol-3,6,8-trisulfonic	16290	Red
acid
8-Amino-2-phenylazo-1-naphthol-3,6-disulfonic acid	17200	Red
Acid Red 1	18050	Red
Acid Red 155	18130	Red
Acid Yellow 121	18690	Yellow
Acid Red 180	18736	Red
Acid Yellow 11	18820	Yellow
Acid Yellow 17	18965	Yellow
4-(4-Sulfo-1-phenylazo)-1-(4-sulfophenyl)-5-hydroxy-	19140	Yellow
pyrazolone-3-carboxylic acid
Pigment Yellow 16	20040	Yellow
2,6-(4′-Sulfo-2″,4″-dimethyl)bisphenylazo)1,3-dihydroxy-	20170	Orange
benzene
Acid Black 1	20470	Black
Pigment Yellow 13	21100	Yellow
Pigment Yellow 83	21108	Yellow
Solvent Yellow	21230	Yellow
Acid Red 163	24790	Red
Acid Red 73	27290	Red
2-[4′-(4″-Sulfo-1″-phenylazo)-7′-sulfo-1′-naphthylazo]-1-	27755	black
hydroxy-7-aminonaphthalene-3,6-disulfonic acid
4-[4″-Sulfo-1″-phenylazo)-7′-sulfo-1′-naphthylazo]-1-	28440	Black
hydroxy-8-acetylaminonaphthalene-3,5-disulfonic acid
Direct Orange 34, 39, 44, 46, 60	40215	Orange
Food Yellow	40800	Orange
trans-β-Apo-8′-carotene aldehyde (C30)	40820	Orange
trans-Apo-8′-carotinic acid (C30) ethyl ester	40850	Orange
Canthaxanthine	40850	Orange
Acid Blue 1	42045	Blue
2,4-Disulfo-5-hydroxy-4′-4″-	42051	Blue
bis(diethylamino)triphenylcarbinol
4-[(-4-N-Ethyl-p-sulfobenzylamino)phenyl-(4-hydroxy-2-	42053	Green
sulfophenyl)(methylene)-1-(N-ethylN-p-sulfobenzyl)-2,5-
cyclohexadienimine]
Acid Blue 7	42080	Blue
(N-Ethyl-p-sulfobenzylamino)phenyl-(2-sulfophenyl)-	42090	Blue
methylene-(N-ethyl-N-p-sulfobenzyl)Δ2,5-cyclohexadienimine
Acid Green 9	42100	Green
Diethyldisulfobenzyldi-4-amino-2-chlorodi-2-methylfuchsonimmonium	42170	Green
Basic Violet 14	42510	Violet
Basic Violet 2	42520	Violet
2′-Methyl-4′-(N-ethyl-N-m-sulfobenzy)amino-4″-(N-	42735	Blue
diethyl)-amino-2-methyl-N-ethylN-m-sulfobenzylfuchsonimmonium
4′-(N-Dimethyl)amino-4″-(N-phenyl)aminonaphtho-N-di-	44045	Blue
methylfuchsonimmonium
2-Hydroxy-3,6-disulfo-4,4′-bisdimethylaminonaphthofuchsonimmonium	44090	Green
Acid Red 52	45100	Red
3-(2′-Methylphenylamino)-6-(2′-methyl-4′-sulfophenylamino)-	45190	Violet
9-(2″-carboxyphenyl)xanthenium salt
Acid Red 50	45220	Red
Phenyl-2-oxyfluorone-2-carboxylic acid	45350	yellow
4,5-Dibromofluorescein	45370	Orange
2,4,5,7-Tetrabromofluorescein	45380	Red
Solvent Dye	45396	Orange
Acid Red 98	45405	Red
3′,4′,5′,6′-Tetrachloro-2,4,5,7-tetrabromofluorescein	45410	Red
4,5-Diiodofluorescein	45425	Red
2,4,5,7-Tetraiodofluorescein	45430	Red
Quinophthalone	47000	Yellow
Quinophthalonedisulfonic acid	47005	Yellow
Acid Violet 50	50325	Violet
Acid Black 2	50420	Black
Pigment Violet 23	51319	Violet
1,2-Dioxyanthraquinone, calcium/aluminium complex	58000	Red
3-Oxypyrene-5,8,10-sulfonic acid	59040	Green
1-Hydroxy-4-N-phenylaminoanthraquinone	60724	Violet
1-Hydroxy-4-(4′-methylphenylamino)anthraquinone	60725	Violet
Acid Violet 23	60730	Violet
1,4-Di(4′-methylphenylamino)anthraquinone	61565	Green
1,4-Bis(o-sulfo-p-toluidino)anthraquinone	61570	Green
Acid Blue 80	61585	Blue
Acid Blue 62	62045	Blue
N,N′-Dihydro-1,2,1′,2′-anthraquinonazine	69800	Blue
Vat Blue 6; Pigment Blue 64	69825	Blue
Vat Orange 7	71105	orange
Indigo	73000	Blue
Indigodisulfonic acid	73015	Blue
4,4′-Dimethyl-6,6′-dichlorothioindigo	73360	Red
5,5′Dichloro-7,7′-dimethylthioindigo	73385	violet
Quinacridone Violet 19	73900	violet
Pigment Red 122	73915	Red
Pigment Blue 16	74100	blue
Phthalocyanines	74160	blue
Direct Blue 86	74180	blue
Chlorinated phthalocyanines	74260	green
Natural Yellow 6, 19; Natural Red 1	75100	yellow
Bixin, Nor-Bixin	75120	orange
Lycopene	75125	yellow
trans-alpha-, -beta-or-gamma-Carotene	75130	orange
Keto and/or hydroxyl derivatives of carotene	75135	yellow
Guanine or pearlescent agent	75170	white
1,7-Bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-	75300	yellow
dione
Complex salt (Na, Al, Ca) of carminic acid	75470	Red
Chlorophyll a and b; copper compounds of chlorophylls	75810	green
and chlorophyllines
Aluminium	77000	white
Aluminium hydroxide	77002	white
Water-containing aluminium silicates	77004	white
Ultramarine	77007	blue
Pigment Red 101 and 102	77015	Red
Barium sulfate	77120	white
Bismuth oxychloride and mixtures thereof with mica	77163	white
Calcium carbonate	77220	white
Calcium sulfate	77231	white
Carbon	77266	black
Pigment Black 9	77267	black
Carbo medicinalis vegetabilis	77268:1	black
Chromium oxide	77288	green
Chromium oxide, water-containing	77278	green
Pigment Blue 28, Pigment Green 14	77346	green
Pigment Metal 2	77400	brown
Gold	77480	brown
Iron oxides and hydroxides	77489	orange
Iron oxide	77491	red
Iron oxide hydrate	77492	yellow
Iron oxide	77499	black
Mixtures of iron(II) and iron(III) hexacyanoferrate	77510	blue
Pigment White 18	77713	white
Manganese ammonium diphosphate	77742	violet
Manganese phosphate; Mn3(PO4)2•7H2O	77745	red
Silver	77820	white
Titanium dioxide and mixtures thereof with mica	77891	white
Zinc oxide	77947	white
6,7-Dimethyl-9-(1′-D-ribityl)isoalloxazine, lactoflavin		yellow
Sugar dye		brown
Capsanthin, capsorubin		orange
Betanin		red
Benzopyrylium salts, anthocyans		red
Aluminium, zinc, magnesium and calcium stearate		white
Bromothymol Blue		blue

It may furthermore be favourable to select, as dye, one or more substances from the following group:

2,4-dihydroxyazobenzene, 1-(2′-chloro-4′-nitro-1′phenylazo)-2-hydroxynaphthalene, Ceres Red, 2-(4-sulfo-1-naphthylazo)-1-naphthol-4-sulfonic acid, the calcium salt of 2-hydroxy-1,2′-azonaphthalene-1′-sulfonic acid, the calcium and barium salts of 1-(2-sulfo-4-methyl-1-phenylazo)-2-naphthylcarboxylic acid, the calcium salt of 1-(2-sulfo-1-naphthylazo)-2-hydroxynaphthalene-3-carboxylic acid, the aluminium salt of 1-(4-sulfo-1-phenylazo)-2-naphthol-6-sulfonic acid, the aluminium salt of 1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid, 1-(4-sulfo-1-naphthylazo)-2-naphthol-6,8-disulfonic acid, the aluminium salt of 4-(4-sulfo-1-phenylazo)-2-(4-sulfophenyl)-5-hydroxypyrazolone-3-carboxylic acid, the aluminium and zirconium salts of 4,5-dibromofluorescein, the aluminium and zirconium salts of 2,4,5,7-tetrabromofluorescein, 3′,4′,5′,6′-tetrachloro-2,4,5,7-tetrabromofluorescein and its aluminium salt, the aluminium salt of 2,4,5,7-tetraiodofluorescein, the aluminium salt of quinophthalonedisulfonic acid, the aluminium salt of indigodisulfonic acid, red and black iron oxide (CIN: 77 491 (red) and 77 499 (black)), iron oxide hydrate (CIN: 77492), manganese ammonium diphosphate and titanium dioxide.

Also advantageous are oil-soluble natural dyes, such as, for example, paprika extract, β-carotene or cochineal.

Also advantageous for the purposes of the present invention are gel creams comprising pearlescent pigments. Particular preference is given to the types of pearlescent pigment listed below:

• • 1. Natural pearlescent pigments, such as, for example,
    • 1. “pearl essence” (guanine/hypoxanthine mixed crystals from fish scales) and
    • 2. “mother-of-pearl” (ground mussel shells)
  • 2. Monocrystalline pearlescent pigments, such as, for example, bismuth oxychloride (BiOCl)
  • 3. Layered substrate pigments: for example mica/metal oxide

The basis for pearlescent pigments is formed by, for example, pulverulent pigments or castor oil dispersions of bismuth oxychloride and/or titanium dioxide as well as bismuth oxychloride and/or titanium dioxide on mica. The lustre pigment listed under CIN 77163, for example, is particularly advantageous.

Also advantageous are, for example, the following pearlescent pigment types based on mica/metal oxide:

		Coating/
	Group	layer thickness	Colour
	Silver-white pearlescent	TiO2: 40-60 nm	silver
	pigments
	Interference pigments	TiO2: 60-80 nm	yellow
		TiO2: 80-100 nm	red
		TiO2: 100-140 nm	blue
		TiO2: 120-160 nm	green
	Coloured lustre pigments	Fe2O3	bronze
		Fe2O3	copper
		Fe2O3	red
		Fe2O3	red-violet
		Fe2O3	red-green
		Fe2O3	black
	Combination pigments	TiO2/Fe2O3	gold shades
		TiO2/Cr2O3	green
		TiO2/Berlin Blue	dark blue

Particular preference is given to, for example, the pearlescent pigments available from Merck under the trade names Timiron, Colorona or Dichrona.

The list of the said pearlescent pigments is of course not intended to be limiting. Pearlescent pigments which are advantageous for the purposes of the present invention can be obtained by numerous routes known per se. For example, other substrates apart from mica can also be coated with further metal oxides, such as, for example, silica and the like. For example, TiO₂- and Fe₂O₃-coated SiO₂ particles (“Ronasphere” grades), which are marketed by Merck and are particularly suitable for the optical reduction of fine wrinkles, are advantageous.

It may additionally be advantageous to completely omit a substrate such as mica. Particular preference is given to pearlescent pigments prepared using SiO₂. Such pigments, which may additionally also have goniochromatic effects, are available, for example, from BASF under the trade name Sicopearl Fantastico.

It may also be advantageous to employ Engelhard/Mearl pigments based on calcium sodium borosilicate coated with titanium dioxide. These are available under the name Reflecks. Due to their particle size of 40-80 μm, they have a glitter effect in addition to the colour.

Also particularly advantageous are effect pigments available from Flora Tech under the trade name Metasomes Standard/Glitter in various colours (yellow, red, green, blue). The glitter particles here are in the form of mixtures with various assistants and dyes (such as, for example, the dyes with the Colour Index (CI) numbers 19140, 77007, 77289, 77491).

The dyes and pigments can be in individual form or in the form of a mixture and mutually coated with one another, with different colour effects generally being caused by different coating thicknesses. The total amount of dyes and colouring pigments is advantageously selected from the range from, for example, 0.1% by weight to 30% by weight, preferably 0.5 to 15% by weight, in particular 1.0 to 10% by weight, in each case based on the total weight of the compositions.

All compounds or components which can be used in the compositions are either known and commercially available or can be synthesised by known processes.

The one or more compounds of the formula I can be incorporated into cosmetic or dermatological compositions in the customary manner. Suitable compositions are those for external use, for example in the form of a cream, lotion, gel or as a solution which can be sprayed onto the skin. Suitable for internal use are administration forms such as capsules, coated tablets, powders, tablet solutions or solutions.

Examples which may be mentioned of application forms of the compositions according to the invention are: solutions, suspensions, emulsions, PIT emulsions, pastes, ointments, gels, creams, lotions, powders, soaps, surfactant-containing cleansing preparations, oils, aerosols and sprays. Examples of other application forms are sticks, shampoos and shower compositions. Any desired customary excipients, auxiliaries and, if desired, further active ingredients may be added to the composition.

Preferred auxiliaries originate from the group of the preservatives, antioxidants, stabilisers, solubilisers, vitamins, colorants, odour improvers.

Ointments, pastes, creams and gels may comprise the customary excipients, for example animal and vegetable fats, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silica, talc and zinc oxide, or mixtures of these substances.

Powders and sprays may comprise the customary excipients, for example lactose, talc, silica, aluminium hydroxide, calcium silicate and polyamide powder, or mixtures of these substances. Sprays may additionally comprise the customary propellants, for example chlorofluorocarbons, propane/butane or dimethyl ether.

Solutions and emulsions may comprise the customary excipients, such as solvents, solubilisers and emulsifiers, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol, oils, in particular cottonseed oil, peanut oil, wheatgerm oil, olive oil, castor oil and sesame oil, glycerol fatty acid esters, polyethylene glycols and fatty acid esters of sorbitan, or mixtures of these substances.

Suspensions may comprise the customary excipients, such as liquid diluents, for example water, ethanol or propylene glycol, suspending agents, for example ethoxylated isostearyl alcohols, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminium metahydroxide, bentonite, agar-agar and tragacanth, or mixtures of these substances.

Soaps may comprise the customary excipients, such as alkali metal salts of fatty acids, salts of fatty acid monoesters, fatty acid protein hydrolysates, isothionates, lanolin, fatty alcohol, vegetable oils, plant extracts, glycerol, sugars, or mixtures of these substances.

Surfactant-containing cleansing products may comprise the customary excipients, such as salts of fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, fatty acid protein hydrolysates, isothionates, imidazolinium derivatives, methyl taurates, sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable and synthetic oils, lanolin derivatives, ethoxylated glycerol fatty acid esters, or mixtures of these substances.

Face and body oils may comprise the customary excipients, such as synthetic oils, such as fatty acid esters, fatty alcohols, silicone oils, natural oils, such as vegetable oils and oily plant extracts, paraffin oils, lanolin oils, or mixtures of these substances.

Further typical cosmetic application forms are also lipsticks, lip-care sticks, mascara, eyeliner, eye-shadow, rouge, powder make-up, emulsion make-up and wax make-up, and sunscreen, pre-sun and after-sun preparations.

The preferred composition forms according to the invention include, in particular, emulsions.

Emulsions according to the invention are advantageous and comprise, for example, the said fats, oils, waxes and other fatty substances, as well as water and an emulsifier, as usually used for a composition of this type.

The lipid phase may advantageously be selected from the following group of substances:

• • mineral oils, mineral waxes;
  • oils, such as triglycerides of capric or caprylic acid, furthermore natural oils, such as, for example, castor oil;
  • fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with alcohols having a low carbon number, for example with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids having a low carbon number or with fatty acids;
  • silicone oils, such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

For the purposes of the present invention, the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions is advantageously selected from the group of the esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 3 to 30 C atoms and saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 3 to 30 C atoms, or from the group of the esters of aromatic carboxylic acids and saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 3 to 30 C atoms. Ester oils of this type can then advantageously be selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of esters of this type, for example jojoba oil.

The oil phase may furthermore advantageously be selected from the group of the branched and unbranched hydrocarbons and wax, silicone oils, dialkyl ethers, the group of the saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides, specifically the triglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18, C atoms. The fatty acid triglycerides may advantageously be selected, for example, from the group of the synthetic, semi-synthetic and natural oils, for example olive oil, sunflower oil, soya oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.

Any desired mixtures of oil and wax components of this type may also advantageously be employed for the purposes of the present invention. It may also be advantageous to employ waxes, for example cetyl palmitate, as the only lipid component of the oil phase.

The oil phase is advantageously selected from the group 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C₁₂-₁₅-alkyl benzoate, caprylic/capric acid triglyceride and dicapryl ether.

Particularly advantageous are mixtures of C₁₂-₁₅-alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C₁₂-₁₅-alkyl benzoate and isotridecyl isononanoate, as well as mixtures of C₁₂-₁₅-alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.

Of the hydrocarbons, paraffin oil, squalane and squalene may advantageously be used for the purposes of the present invention.

Furthermore, the oil phase may also advantageously have a content of cyclic or linear silicone oils or consist entirely of oils of this type, although it is preferred to use an additional content of other oil-phase components in addition to the silicone oil or the silicone oils.

The silicone oil to be used in accordance with the invention is advantageously cyclomethicone(octamethylcyclotetrasiloxane). However, it is also advantageous for the purposes of the present invention to use other silicone oils, for example hexamethylcyclotrisiloxane, polydimethylsiloxane or poly(methylphenylsiloxane).

Also particularly advantageous are mixtures of cyclomethicone and isotridecyl isononanoate, of cyclomethicone and 2-ethylhexyl isostearate.

The aqueous phase of the compositions according to the invention optionally advantageously comprises alcohols, diols or polyols having a low carbon number, and ethers thereof, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore alcohols having a low carbon number, for example ethanol, isopropanol, 1,2-propanediol, glycerol, and, in particular, one or more thickeners, which may advantageously be selected from the group silicon dioxide, aluminium silicates, polysaccharides and derivatives thereof, for example hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageously from the group of the polyacrylates, preferably a polyacrylate from the group of the so-called Carbopols, for example Carbopol grades 980, 981, 1382, 2984 or 5984, in each case individually or in combination.

In particular, mixture of the above-mentioned solvents are used. In the case of alcoholic solvents, water may be a further constituent.

Emulsions according to the invention are advantageous and comprise, for example, the said fats, oils, waxes and other fatty substances, as well as water and an emulsifier, as usually used for a formulation of this type.

In a preferred embodiment, the compositions according to the invention comprise hydrophilic surfactants.

The hydrophilic surfactants are preferably selected from the group of the alkylglucosides, acyl lactylates, betaines and coconut amphoacetates.

The alkylglucosides are themselves advantageously selected from the group of the alkylglucosides which are distinguished by the structural formula where R represents a branched or unbranched alkyl radical having 4 to 24 carbon atoms, and where DP denotes a mean degree of glucosylation of up to 2.

The value DP represents the degree of glucosidation of the alkylglucosides used in accordance with the invention and is defined as $\stackrel{\_}{\mathrm{DP}}=\frac{p_1}{100}·1+\frac{p_2}{100}·2+\frac{p_3}{100}·3+\dots =\sum \frac{p_i}{100}·i$ in which p₁, p₂, p₃ . . . p_i represent the proportion of mono-, di-, tri- . . . i-fold glucosylated products in per cent by weight. Advantageous in accordance with the invention is the selection of products having degrees of glucosylation of 1-2, particularly advantageously of 1.1 to 1.5, very particularly advantageously of 1.2-1.4, in particular of 1.3.

The value DP takes into account the fact that alkylglucosides are generally, as a consequence of their preparation, in the form of mixtures of mono- and oligoglucosides. A relatively high content of monoglucosides, typically in the order of 40-70% by weight, is advantageous in accordance with the invention.

Alkylglycosides which are particularly advantageously used in accordance with the invention are selected from the group octyl glucopyranoside, nonyl glucopyranoside, decyl glucopyranoside, undecyl glucopyranoside, dodecyl glucopyranoside, tetradecyl glucopyranoside and hexadecyl glucopyranoside.

It is likewise advantageous to employ natural or synthetic raw materials and auxiliaries or mixtures which are distinguished by an effective content of the active ingredients used in accordance with the invention, for example Plantaren® 1200 (Henkel KGaA), Oramix® NS 10 (Seppic).

The acyllactylates are themselves advantageously selected from the group of the substances which are distinguished by the structural formula where R¹ denotes a branched or unbranched alkyl radical having 1 to 30 carbon atoms, and M⁺ is selected from the group of the alkali metal ions and the group of ammonium ions which are substituted by one or more alkyl and/or one or more hydroxyalkyl radicals, or corresponds to half an equivalent of an alkaline earth metal ion.

For example, sodium isostearyl lactylate, for example the product Pathionic® ISL from the American Ingredients Company, is advantageous.

The betaines are advantageously selected from the group of the substances which are distinguished by the structural formula where R² denotes a branched or unbranched alkyl radical having 1 to 30 carbon atoms.

R² particularly advantageously denotes a branched or unbranched alkyl radical having 6 to 12 carbon atoms.

For example, capramidopropylbetaine, for example the product Tego® Betain 810 from Th. Goldschmidt AG, is advantageous.

A coconut amphoacetate which is advantageous in accordance with the invention is, for example, sodium coconut amphoacetate, as available under the name Miranol® Ultra C32 from Miranol Chemical Corp.

The compositions according to the invention are advantageously characterised in that the hydrophilic surfactant(s) is (are) present in concentrations of 0.01-20% by weight preferably 0.05-10% by weight, particularly preferably 0.1-5% by weight, in each case based on the total weight of the composition.

For use, the cosmetic and dermatological compositions according to the invention are applied to the skin and/or the hair in an adequate amount in the usual manner for cosmetics.

Cosmetic and dermatological compositions according to the invention may exist in various forms. Thus, they may be, for example, a solution, a water-free composition, an emulsion or microemulsion of the water-in-oil (W/O) type or of the oil-in-water (O/W) type, a multiple emulsion, for example of the water-in-oil-in-water (W/O/W) type, a gel, a solid stick, an ointment or an aerosol. It is also advantageous to administer ectoines in encapsulated form, for example in collagen matrices and other conventional encapsulation materials, for example as cellulose encapsulations, in gelatine, wax matrices or liposomally encapsulated. In particular, wax matrices, as described in DE-A 43 08 282, have proven favourable. Preference is given to emulsions. O/W emulsions are particularly preferred. Emulsions, W/O emulsions and O/W emulsions are obtainable in a conventional manner.

Emulsifiers that can be used are, for example, the known W/O and O/W emulsifiers. It is advantageous to use further conventional co-emulsifiers in the preferred O/W emulsions according to the invention.

Co-emulsifiers which are advantageous in accordance with the invention are, for example, O/W emulsifiers, principally from the group of the substances having HLB values of 11-16, very particularly advantageously having HLB values of 14.5-15.5, so long as the O/W emulsifiers have saturated radicals R and R′. If the O/W emulsifiers have unsaturated radicals R and/or R′ or in the case of isoalkyl derivatives, the preferred HLB value of such emulsifiers may also be lower or higher.

It is advantageous to select the fatty alcohol ethoxylates from the group of ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols). Particular preference is given to the following: polyethylene glycol (13) stearyl ether (steareth-13), polyethylene glycol (14) stearyl ether (steareth-14), polyethylene glycol (15) stearyl ether (steareth-15), polyethylene glycol (16) stearyl ether (steareth-16), polyethylene glycol (17) stearyl ether (steareth-17), polyethylene glycol (18) stearyl ether (steareth-18), polyethylene glycol (19) stearyl ether (steareth-19), polyethylene glycol (20) stearyl ether (steareth-20), polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether (isosteareth-13), polyethylene glycol (14) isostearyl ether (isosteareth-14), polyethylene glycol (15) isostearyl ether (isosteareth-15), polyethylene glycol (16) isostearyl ether (isosteareth-16), polyethylene glycol (17) isostearyl ether (isosteareth-17), polyethylene glycol (18) isostearyl ether (isosteareth-18), polyethylene glycol (19) isostearyl ether (isosteareth-19), polyethylene glycol (20) isostearyl ether (isosteareth-20), polyethylene glycol (13) cetyl ether (ceteth-13), polyethylene glycol (14) cetyl ether (ceteth-14), polyethylene glycol (15) cetyl ether (ceteth-15), polyethylene glycol (16) cetyl ether (ceteth-16), polyethylene glycol (17) cetyl ether (ceteth-17), polyethylene glycol (18) cetyl ether (ceteth-18), polyethylene glycol (19) cetyl ether (ceteth-19), polyethylene glycol (20) cetyl ether (ceteth-20), polyethylene glycol (13) isocetyl ether (isoceteth-13), polyethylene glycol (14) isocetyl ether (isoceteth-14), polyethylene glycol (15) isocetyl ether (isoceteth-15), polyethylene glycol (16) isocetyl ether (isoceteth-16), polyethylene glycol (17) isocetyl ether (isoceteth-17), polyethylene glycol (18) isocetyl ether (isoceteth-18), polyethylene glycol (19) isocetyl ether (isoceteth-19), polyethylene glycol (20) isocetyl ether (isoceteth-20), polyethylene glycol (12) oleyl ether (oleth-12), polyethylene glycol (13) oleyl ether (oleth-13), polyethylene glycol (14) oleyl ether (oleth-14), polyethylene glycol (15) oleyl ether (oleth-15), polyethylene glycol (12) lauryl ether (laureth-12), polyethylene glycol (12) isolauryl ether (isolaureth-12), polyethylene glycol (13) cetylstearyl ether (ceteareth-13), polyethylene glycol (14) cetylstearyl ether (ceteareth-14), polyethylene glycol (15) cetylstearyl ether (ceteareth-15), polyethylene glycol (16) cetylstearyl ether (ceteareth-16), polyethylene glycol (17) cetylstearyl ether (ceteareth-17), polyethylene glycol (18) cetylstearyl ether (ceteareth-18), polyethylene glycol (19) cetylstearyl ether (ceteareth-19), polyethylene glycol (20) cetylstearyl ether (ceteareth-20).

It is furthermore advantageous to select the fatty acid ethoxylates from the following group:

polyethylene glycol (20) stearate, polyethylene glycol (21) stearate,

polyethylene glycol (22) stearate, polyethylene glycol (23) stearate,

polyethylene glycol (24) stearate, polyethylene glycol (25) stearate,

polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate,

polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate,

polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate,

polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate,

polyethylene glycol (20) isostearate, polyethylene glycol (21) isostearate,

polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate,

polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate,

polyethylene glycol (12) oleate, polyethylene glycol (13) oleate,

polyethylene glycol (14) oleate, polyethylene glycol (15) oleate,

polyethylene glycol (16) oleate, polyethylene glycol (17) oleate,

polyethylene glycol (18) oleate, polyethylene glycol (19) oleate,

polyethylene glycol (20) oleate,

An ethoxylated alkyl ether carboxylic acid or salt thereof which can be used is advantageously sodium laureth-11 carboxylate. An alkyl ether sulfate which can advantageously be used is sodium laureth-14 sulfate. An ethoxylated cholesterol derivative which can advantageously be used is polyethylene glycol (30) cholesteryl ether. Polyethylene glycol (25) soyasterol has also proven successful. Ethoxylated triglycerides which can advantageously be used are the polyethylene glycol (60) evening primrose glycerides.

It is furthermore advantageous to select the polyethylene glycol glycerol fatty acid esters from the group polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, polyethylene glycol (6) glyceryl caprate/caprinate, polyethylene glycol (20) glyceryl oleate, polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate(cocoate.

It is likewise favourable to select the sorbitan esters from the group polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, polyethylene glycol (20) sorbitan monooleate.

Optional W/O emulsifiers, but ones which may nevertheless be advantageously employed in accordance with the invention are the following:

fatty alcohols having 8 to 30 C atoms, monoglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C atoms, monoglycerol ethers of saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol ethers of saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 8 to 24, in particular 12-18 C atoms, propylene glycol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C atoms, and sorbitan esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C atoms.

Particularly advantageous W/O emulsifiers are glyceryl monostearate, glyceryl monoisostearate, glyceryl monomyristate, glyceryl monooleate, diglyceryl monostearate, diglyceryl monoisostearate, propylene glycol monostearate, propylene glycol monoisostearate, propylene glycol monocaprylate, propylene glycol monolaurate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monocaprylate, sorbitan monoisooleate, sucrose distearate, cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, isobehenyl alcohol, selachyl alcohol, chimyl alcohol, polyethylene glycol (2) stearyl ether (steareth-2), glyceryl monolaurate, glyceryl monocaprinate, glyceryl monocaprylate.

The preferred compositions in accordance with the invention are particularly suitable for protecting human skin against ageing processes and against oxidative stress, i.e. against damage caused by free radicals, as are produced, for example, by solar irradiation, heat or other influences. In this connection, it is in the various administration forms usually used for this application. For example, it may, in particular, be in the form of a lotion or emulsion, such as in the form of a cream or milk (O/W, W/O, O/W/O, W/O/W), in the form of oily-alcoholic, oily-aqueous or aqueous-alcoholic gels or solutions, in the form of solid sticks or may be formulated as an aerosol.

The composition may comprise cosmetic adjuvants which are usually used in this type of composition, such as, for example, thickeners, softeners, moisturisers, surface-active agents, emulsifiers, preservatives, antifoams, perfumes, waxes, lanolin, propellants, dyes and/or pigments which colour the composition itself or the skin, and other ingredients usually used in cosmetics.

The dispersant or solubiliser used can be an oil, wax or other fatty substance, a lower monoalcohol or lower polyol or mixtures thereof. Particularly preferred monoalcohols or polyols include ethanol, isopropanol, propylene glycol, glycerol and sorbitol.

A preferred embodiment of the invention is an emulsion in the form of a protective cream or milk which, apart from the compound(s) of the formula I or formula II, comprises, for example, fatty alcohols, fatty acids, fatty acid esters, in particular triglycerides of fatty acids, lanolin, natural and synthetic oils or waxes and emulsifiers in the presence of water.

Further preferred embodiments are oily lotions based on natural or synthetic oils and waxes, lanolin, fatty acid esters, in particular triglycerides of fatty acids, or oily-alcoholic lotions based on a lower alcohol, such as ethanol, or a glycerol, such as propylene glycol, and/or a polyol, such as glycerol, and oils, waxes and fatty acid esters, such as triglycerides of fatty acids.

The composition according to the invention may also be in the form of an alcoholic gel which comprises one or more lower alcohols or polyols, such as ethanol, propylene glycol or glycerol, and a thickener, such as siliceous earth. The oily-alcoholic gels also comprise natural or synthetic oil or wax.

The solid sticks consist of natural or synthetic waxes and oils, fatty alcohols, fatty acids, fatty acid esters, lanolin and other fatty substances.

If a composition is formulated as an aerosol, the customary propellants, such as alkanes, fluoroalkanes and chlorofluoroalkanes, are generally used.

The cosmetic composition may also be used to protect the hair against photochemical damage in order to prevent colour changes, bleaching or damage of a mechanical nature. In this case, a suitable formulation is in the form of a rinse-out shampoo, lotion, gel or emulsion, the composition in question being applied before or after shampooing, before or after colouring or bleaching or before or after permanent waving. It is also possible to select a composition in the form of a lotion or gel for styling and treating the hair, in the form of a lotion or gel for brushing or blow-waving, in the form of a hair lacquer, permanent waving composition, colorant or bleach for the hair. Besides the compound(s) of the formula I or formula II, the composition having light-protection properties may comprise various adjuvants used in this type of composition, such as surface-active agents, thickeners, polymers, softeners, preservatives, foam stabilisers, electrolytes, organic solvents, silicone derivatives, oils, waxes, antigrease agents, dyes and/or pigments which colour the composition itself or the hair, or other ingredients usually used for hair care.

The present invention furthermore relates to a process for the preparation of a composition which is characterised in that at least one compound of the formula I or formula II having radicals as described above is mixed with an excipient which is suitable cosmetically or dermatologically or for food, and to the use of a compound of the formula I or formula II for the preparation of a composition.

The compositions according to the invention can be prepared using techniques which are well known to the person skilled in the art.

The mixing can result in dissolution, emulsification or dispersion of the compound of the formula I or formula II in the excipient.

It has also been noted that compounds of the formula I or formula II can have a stabilising effect on the composition. When used in corresponding products, the latter thus also remain stable for longer and do not change their appearance. In particular, the effectiveness of the ingredients, for example vitamins, is retained even in the case of application over extended periods or extended storage. This is, inter alia, particularly advantageous in the case of compositions for protecting the skin against the effect of UV rays since these cosmetics are exposed to particularly high stresses by UV radiation.

The positive effects of compounds of the formula I or formula II give rise to their particular suitability for use in cosmetic or pharmaceutical compositions.

The properties of compounds of the formula I or formula II should likewise be regarded as positive for use in foods or as food supplements or as functional food or in cosmetics to be administered orally (oral cosmetics). The further explanations given for foods also apply correspondingly to food supplements and functional food or oral cosmetics.

The foods which can be enriched with one or more compounds of the formula I or formula II in accordance with the present invention include all materials which are suitable for consumption by animals or consumption by humans, for example vitamins and provitamins thereof, fats, minerals or amino acids.

The compositions of the foods food supplements, functional food or oral cosmetic may be solid, but also liquid, i.e. in the form of a beverage

The present invention accordingly furthermore relates to the use of a compound of the formula I or formula II as additive for human or animal nutrition, and to compositions which are foods or food supplements or oral cosmetics and comprise a compound of the formula I or formula II and corresponding excipients.

Foods which can be enriched with one or more compounds of the formula I or formula II in accordance with the present invention are, for example, also foods which originate from a single natural source, such as, for example, sugar, unsweetened juice, squash or puree of a single plant species, such as, for example, unsweetened apple juice (for example also a mixture of different types of apple juice), grapefruit juice, orange juice, apple compote, apricot squash, tomato juice, tomato sauce, tomato puree, etc. Further examples of foods which can be enriched with one or more compounds of the formula I or formula II in accordance with the present invention are corn or cereals from a single plant species and materials produced from plant species of this type, such as, for example, cereal syrup, rye flour, wheat flour or oat bran. Mixtures of foods of this type are also suitable for being enriched with one or more compounds of the formula I or formula II in accordance with the present invention, for example multivitamin preparations, mineral mixtures or sweetened juice. As further examples of foods which can be enriched with one or more compounds of the formula I or formula II in accordance with the present invention, mention may be made of food compositions, for example prepared cereals, biscuits, mixed drinks, foods prepared especially for children, such as yoghurt, diet foods, low-calorie foods or animal feeds.

The foods which can be enriched with one or more compounds of the formula I or formula II in accordance with the present invention thus include all edible combinations of carbohydrates, lipids, proteins, inorganic elements, trace elements, vitamins, water or active metabolites of plants and animals.

The food supplements or oral cosmetics which can be enriched with one or more compounds of the formula I or formula II in accordance with the present invention are preferably administered orally, for example in the form of meals, pills, tablets, capsules, powders, syrup, solutions or suspensions.

The foods according to the invention enriched with one or more compounds of the formula I or formula II can be prepared using techniques which are well known to the person skilled in the art.

Due to their action, compounds of the formula I or formula II are also suitable as medicament ingredient Compounds of the formula I or formula II can be used, for example, for the preventative treatment of inflammation and allergies of the skin and in certain cases for preventing certain types of cancer. Compounds of the formula I or formula II are particularly suitable for the preparation of a medicament for the treatment of inflammation, allergies and irritation, in particular of the skin. It is furthermore possible to prepare medicaments which act as vein tonic, as chemical, physical or actinic erythema inhibitor, as agent for the treatment of sensitive skin, as decongestant, as slimming agent, as anti-wrinkle agent, as stimulators for the synthesis of components of the extracellular matrix, as strengthening agent for improving skin elasticity, and as anti-ageing agent. Furthermore, compounds of the formula I or formula II which are preferred in this connection exhibit antiallergic and antiinflammatory and antiirritative actions. They are therefore suitable for the preparation of medicaments for the treatment of inflammation or allergic reactions.

In particular, it has been found that the complex compounds of the formula I and the compositions according to the invention can be employed particularly advantageously in the treatment of atopic eczema, such as, in particular, milk crust, neurormatitis, prurigo and dermatitis sicca.

It has been found here that they

• • are able greatly to reduce the acute symptoms,
  • are able to reduce the frequency of occurrence of acute symptoms,
  • in general contribute to an improvement in the skin picture.

The compositions comprising one or more compounds of the formula I are also suitable for the protection of human skin or for the protection of body cells against oxidative stress, i.e., for example, against damage by free radicals, as generated, for example, by sunlight, heat or other influences. The compositions comprising one or more compounds of the formula I are particularly suitable for reducing skin ageing.

The present invention thus also relates to the use of one or more compounds of the formula I as active ingredient for protection against oxidative stress. The present invention furthermore relates to the use of one or more compounds of the formula I for preventing skin ageing.

The compounds of the formula I have antiallergic, antiinflammatory, inflammation-inhibiting and antiirritative properties and can thus be used for the treatment or preventative treatment of allergies, inflammation and irritation, in particular of the skin. The present invention therefore furthermore relates to the use of one or more compounds of the formula I as active ingredient having an antiallergic, antiinflammatory, inflammation-inhibiting and antiirritative action.

Uses preferred in accordance with the invention of the compounds of the formula I or of compositions comprising at least one compound of the formula I here are, in particular, the use for prophylaxis against time- and/or light-induced ageing processes of the human skin or human hair, in particular for prophylaxis against dry skin, wrinkling and/or pigment defects, and/or for reducing or preventing damaging effects of UV rays on the skin, and for prophylaxis against or reduction of skin unevenness, such as wrinkles, fine lines, rough skin or large-pored skin.

If the compounds to be employed in accordance with the invention have free hydroxyl groups, they additionally exhibit, in addition to the properties described, an action as antioxidant and/or free-radical scavenger. Preference is therefore also given to compositions having light-protection properties comprising at least one compound of the formula I which is characterised in that at least one of the radicals R¹ to R³ stands for OH, where preferably at least one of the radicals R¹ and R² stands for OH.

In order that the compounds of the formula I are able to develop their positive action as free-radical scavengers on the skin particularly well, it may be preferred to allow the compounds of the formula I to penetrate into deeper skin layers. Several possibilities are available for this purpose. Firstly, the compounds of the formula I can have an adequate lipophilicity in order to be able to penetrate through the outer skin layer into epidermal layers. As a further possibility, corresponding transport agents, for example liposomes, which enable transport of the compounds of the formula I through the outer skin layers may also be provided in the composition. Finally, systemic transport of the compounds of the formula I is also conceivable. The composition is then designed, for example, in such a way that it is suitable for oral administration.

In general, the substances of the formula I act as free-radical scavengers. Free radicals of this type are not generated only by sunlight, but instead are formed under various conditions. Examples are anoxia, which blocks the flow of electrons upstream of the cytochrome oxidases and causes the formation of superoxide free-radical anions; inflammation associated, inter alia, with the formation of superoxide anions by the membrane NADPH oxidase of the leucocytes, but also associated with the formation (through disproportionation in the presence of iron(II) ions) of the hydroxyl free radicals and other reactive species which are normally involved in the phenomenon of phagocytosis; and lipid autoxidation, which is generally initiated by a hydroxyl free radical and produces lipidic alkoxy free radicals and hydroperoxides.

It is assumed that the preferred compounds of the formula I also act as enzyme inhibitors. They presumably inhibit histidine decarboxylase, protein kinases, elastase, aldose reductase and hyaluronidase, and therefore enable the intactness of the basic substance of vascular sheaths to be maintained. Furthermore, they presumably inhibit non-specifically catechol O-methyl transferase, causing the amount of available catecholamines and thus the vascular strength to be increased. Furthermore, they are thought to inhibit AMP phosphodiesterase, giving the substances potential for inhibiting thrombocyte aggregation.

Owing to these properties, the compositions according to the invention are, in general, suitable for immune protection and for the protection of DNA and RNA. In particular, the compositions are suitable for the protection of DNA and RNA against oxidative attack, against free radicals and against damage due to radiation, in particular UV radiation. A further advantage of the compositions according to the invention is cell protection, in particular protection of Langerhans cells against damage due to the above-mentioned influences. All these uses and the use of the compounds of the formula I for the preparation of compositions which can be employed correspondingly are expressly also a subject-matter of the present invention.

In particular, preferred compositions according to the invention are also suitable for the treatment of skin diseases associated with a defect in keratinisation which affects differentiation and cell proliferation, in particular for the treatment of acne vulgaris, acne comedonica, polymorphic acne, acne rosaceae, nodular acne, acne conglobata, age-induced acne, acne which arises as a side effect, such as acne solaris, medicament-induced acne or acne professionalis, for the treatment of other defects in keratinisation, in particular ichthyosis, ichthyosiform states, Darier's disease, keratosis palmoplantaris, leukoplakia, leukoplakiform states, herpes of the skin and mucous membrane (buccal) (lichen), for the treatment of other skin diseases associated with a defect in keratinisation and which have an inflammatory and/or immunoallergic component and in particular all forms of psoriasis which affect the skin, mucous membranes and fingers and toenails, and psoriatic rheumatism and skin atopy, such as eczema or respiratory atopy, or hypertrophy of the gums, it furthermore being possible for the compounds to be used for some inflammation which is not associated with a defect in keratinisation, for the treatment of all benign or malignant excrescence of the dermis or epidermis, which may be of viral origin, such as verruca vulgaris. verruca plana, epidermodysplasia verruciformis, oral papillomatosis, papillomatosis florida, and excrescence which may be caused by UV radiation, in particular epithelioma baso-cellulare and epithelioma spinocellulare, for the treatment of other skin diseases, such as dermatitis bullosa and diseases affecting the collagen, for the treatment of certain eye diseases, in particular corneal diseases, for overcoming or combating light-induced skin ageing associated with ageing, for reducing pigmentation and keratosis actinica and for the treatment of all diseases associated with normal ageing or light-induced ageing, for the prevention or healing of wounds/scars of atrophy of the epidermis and/or dermis caused by locally or systemically applied corticosteroids and all other types of skin atrophy, for the prevention or treatment of defects in wound healing, for the prevention or elimination of stretch marks caused by pregnancy or for the promotion of wound healing, for combating defects in sebum production, such as hyperseborrhoea in acne or simple seborrhoea, for combating or preventing cancer-like states or pre-carcinogenic states, in particular promyelocytic leukaemia, for the treatment of inflammatory diseases, such as arthritis, for the treatment of all virus-induced diseases of the skin or other areas of the body, for the prevention or treatment of alopecia, for the treatment of skin diseases or diseases of other areas of the body with an immunological component, for the treatment of cardiovascular diseases, such as arteriosclerosis or hypertension, and of non-insulin-dependent diabetes, for the treatment of skin problems caused by UV radiation.

Furthermore, compounds of the formula I have only a weak inherent colour. The weak inherent colour is, for example, a major advantage if an inherent colour of the ingredients is undesired in the products for aesthetic reasons.

The proportion of the compounds of the formula I in the composition is preferably 0.01 to 20% by weight, particularly preferably 0.05 to 10% by weight and especially preferably 0.1 to 5% by weight, based on the composition as a whole. The proportion of the compounds of the formula I in the composition is very particularly preferably 0.1 to 2% by weight, based on the composition as a whole.

Even without further comments, it is assumed that a person skilled in the art will be able to utilise the above description in the broadest scope. The preferred embodiments should therefore merely be regarded as descriptive disclosure which is absolutely not limiting in any way. The complete disclosure content of all applications and publications mentioned above and below is incorporated into this application by way of reference. The following examples are intended to illustrate the present invention. However, they should in no way be regarded as limiting. All compounds or components which can be used in the compositions are either known and commercially available or can be synthesised by known methods. The INCI names of the raw materials used are as follows:

EXAMPLES

List of Raw Materials Employed

Raw material               INCI name
Abil WE 09                 Polyglyceryl 4-Isostearate, Cetyl
                           Dimethicone Copolyol, Hexyl Laurate
Antaron V-220              PVP/Eicosene Copolymer
Arlacel 80                 Sorbitan Oleate
Arlacel 165 V              Glyceryl Stearate, PEG-100 Stearate
Avocado oil                Persea Gratissima
Beeswax                    Beeswax
Biobase ™ EP               Glyceryl Stearate, Cetearyl Alcohol,
                           Sodium Stearoyl Lactylate, Lecithin
Carbopol ETD 2050          Carbomer
Cetiol V                   Decyl Oleate
Cetyl alcohol              Cetyl Alcohol
Cetyl isononanoate         Cetyl Isononanoate
Cutina HR                  Hydrogenated Castor Oil
Dimeticon                  Dimethicone
Eusolex ® 232              Phenylbenzimidazole Sulfonic Acid
Eusolex ® 2292             Octyl Methoxycinnamate, BHT
Eusolex ® 6300             4-Methylbenzylidene Camphor
Eusolex 8300               4-Methylbenzylidene
Eusolex ® 9020             Butyl Methoxydibenzoylmethane
Eusolex ® HMS              Homosalate
Eusolex T-Aqua             Aqua (Water), Titanium Dioxide,
                           Alumina, Sodium Metaphosphate,
                           Phenoxyethanol, Sodium Methyl-
                           paraben
Eutanol G                  Octyldodecanol
Germaben II                Propylene Glycol, Diazolidinyl Urea,
                           Methylparaben, Propylparaben
Germaben II-E              Propylene Glycol, Diazolidinyl Urea,
                           Methylparaben, Propylparaben
Glycerin                   Glycerin
Glycerin (87%)             Glycerin
Glycerin (87% extra pure)  Glycerin
Glycerin, anhydrous        Glycerin
Hetester PHA               Propylene Glycol Isoceteth-3 Acetate
Hexyl laurate              Hexyl Laurate
Imwitor 960 K flakes       Glyceryl Stearate SE
Isolan PDI                 Diisostearoyl Polyglyceryl
                           3-Diisostearate
Isopropyl myristate        Isopropyl Myristate
Isopropyl palmitate        Isopropyl Palmitate
Jojoba oil                 Buxus Quinensis (Jojoba Oil)
Karion F liquid            Sorbitol
Keltrol RD                 Xanthan Gum
Magnesium sulfate          Magnesium Sulfate
Magnesium sulfate          Magnesium Sulfate
heptahydrate
Methyl 4-hydroxybenzoate   Methylparaben
Miglyol 812                Caprylic/Capric Triglyceride
Miglyol 812 N              Caprylic/Capric Triglyceride
Miglyol 812, neutral oil   Caprylic/Capric Triglyceride
Mirasil CM5                Cyclomethicone
Mirasil DM 350             Dimethicone
Montanov 68                Cetearyl Alcohol, Cetearyl Glucoside
Sodium chloride            Sodium Chloride
Sodium hydroxide           Sodium Hydroxide
solution, 10%
Oxynex ® K                 PEG-8, Tocopherol, Ascorbyl Palmitate,
                           Ascorbic Acid, Citric Acid
Panthenol-D                Panthenol
Paracera M                 Microwax
Paraffin oil, liquid       Mineral Oil
Perfume oil TND-2417       Perfume
Pemulen TR-1               Acrylates/C10-30 Alkyl Acrylate
                           Crosspolymer
Pemulen ® TR-2             Acrylates/C10-30 Alkyl Acrylate
                           Crosspolymer
Performa ® V 825           Synthetic Wax
Polyglyceryl 2-            Polyglyceryl-2 Dipolyhydroxystearate
dipolyhydroxy-
stearate
Prisorine 2021             Isopropyl Isostearate
1,2-Propanediol            Propylene Glycol
Propyl 4-hyd roxybenzoate  Propylparaben
Rhodicare S                Xanthan Gum
RonaCare ™ ASC III         Aqua, Lecithin, Dipalmitoyl
                           Hydroxyproline, Phenoxyethanol, Tall
                           Oil Sterol, Linoleic Acid, Tocopherol,
                           Sodium Ascorbate, Mannitol,
                           Methylparaben, Ethylparaben,
                           Propylparaben, Butylparaben
RonaCare ™ Bisabolol       Bisabolol
RonaCare ™ Ectoine         Ectoine
RonaCare ™ LPO             Lauryl p-Cresol Ketoxime
RonaCare ™ Tocopherol      Tocopheryl Acetate
acetate
Sepigel 305                Polyacrylamide, C13-14 Isoparaffin,
                           Laureth-7
SFE 839                    Cyclopentasiloxane, Dimethicone/
                           Vinyldimethicone Crosspolymer
Shea butter                Shea Butter
Steareth-2                 Steareth-2
Steareth-10                Steareth-10
Stearic acid               Stearic Acid
DL-α-tocopherol acetate    Tocopherol Acetate
Triethanolamine            Triethanolamine
Triethanolamine extra pure Triethanolamine
Water, demineralised       Aqua (Water)
Zinc stearate              Zinc Stearate

Example A

Preparation of a Luteolin/Cyclodextrin Complex

3.1 g of hydroxypropyl-gamma-cyclodextrin (Aldrich; 2′-hydroxypropylcyclooctaamylose; Cas.-No. 128446-34-4) are initially introduced in 25 ml of water and warmed to 50° C. 0.25 g of luteolin are dissolved in 25 ml of ethanol and added dropwise to the initially introduced solution. The solution is stirred at 50° C. for three days. The ethanol is distilled off from the solution. The residue is evaporated to dryness in vacuo, and the solid which remains is subsequently dried overnight at 40° C. and 200 mbar.

Yield: 1.71 g of pale-yellow solid

Characterisation:

Luteolin Content in the Solid (HPLC Determination)

6.3 mg of luteolin are dissolved in 3 ml of methanol and 1 ml of THF and made up to 10.0 ml with eluent (acetonitrile/H₂O 2/8) in a volumetric flask. (Peak area of 33097443).

22.2 mg of complex are dissolved in 3 ml of methanol and 1 ml of tetrahydrofuran and made up to 10.0 ml with eluent (acetonitrile/H₂O 2/8) in a volumetric flask. (Peak area 8201418).

It follows that the complex consists of 7.0% by weight of luteolin. This corresponds to a molar ratio of 1:2. The complex compound is a [luteolin][hydroxypropyl-gamma-cyclodextrin]₂ complex.

Solubility of the Luteolin/Cyclodextrin Complex:

0.5 g of complex is dissolved in 1 ml of water without reaching saturation. This corresponds to a solubility, based on pure luteolin, of at least 34.6 g/l.

In the following example recipes 1 to 6, luteolin is in each case employed as luteolin/hydroxypropyl-gamma-cyclodextrin complex in accordance with Example A.

Example 1

Lotion (W/O) for Application to the Skin

	% by wt.
	A	Polyglyceryl 2-dipolyhydroxystearate	5.0
		Beeswax	0.5
		Zinc stearate	0.5
		Hexyl laurate	9.0
		Cetyl isononanoate	6.0
		Shea butter	0.5
		DL-α-tocopherol acetate	1.0
		Luteolin	0.5
	B	Glycerol	5.0
		Magnesium sulfate heptahydrate	1.0
		Preservatives	q.s.
		Water, demineralised	to 100

Preparation

Phase A is warmed to 75° C. and phase B to 80° C. Phase B is slowly added to phase A with stirring. After homogenisation, the mixture is cooled with stirring. Perfumes are added at a temperature of 40° C.

The following are used as preservatives:

0.05% of propyl 4-hydroxybenzoate

0.15% of methyl 4-hydroxybenzoate

Example 2

Lotion (W/O) for Application to the Skin

	% by wt.
	A	Polyglyceryl 2-dipolyhydroxystearate	5.0
		Beeswax	0.5
		Zinc stearate	0.5
		Hexyl laurate	9.0
		Cetyl isononanoate	6.0
		Shea butter	0.5
		DL-α-tocopherol acetate	1.0
	B	Luteolin	1.0
		Glycerol	5.0
		Magnesium sulfate heptahydrate	1.0
		Preservatives	q.s.
		Water, demineralised	to 100

Preparation

Phase A is warmed to 75° C. and phase B to 80° C. Phase B is slowly added to phase A with stirring. After homogenisation, the mixture is cooled with stirring. Perfumes are added at a temperature of 40° C.

The following are used as preservatives:

0.05% of propyl 4-hydroxybenzoate

0.15% of methyl 4-hydroxybenzoate

Example 3

Lotion (W/O) for Application to the Skin

	% by wt.
	A	4,6,3′,4′-Tetrahydroxybenzylcoumaranone-3	1.0
		Polyglyceryl 2-dipolyhydroxystearate	5.0
		Beeswax	0.5
		Zinc stearate	0.5
		Hexyl laurate	9.0
		Cetyl isononanoate	6.0
		Shea butter	0.5
		DL-α-tocopherol acetate	1.0
		Luteolin	1.0
	B	Glycerol	5.0
		Magnesium sulfate heptahydrate	1.0
		Preservatives	q.s.
		Water, demineralised	to 100

Preparation

Phase A is warmed to 75° C. and phase B to 80° C. Phase B is slowly added to phase A with stirring. After homogenisation, the mixture is cooled with stirring. Perfumes are added at a temperature of 40° C.

The following are used as preservatives:

0.05% of propyl 4-hydroxybenzoate

0.15% of methyl 4-hydroxybenzoate

Example 4

A cream (O/W) comprising ectoine is prepared from the following components:

	% by wt.
	A	Paraffin, liquid	(1)	8.0
		Isopropyl myristate	(1)	4.0
		Mirasil CM5	(2)	3.0
		Stearic acid	(1)	3.0
		Arlacel 165 V	(3)	5.0
		Luteolin		1.0
	B	Glycerol (87%)	(1)	3.0
		Germaben II	(4)	0.5
		Water, demineralised		to 100
	C	RonaCare ™ ectoine	(1)	1.0

Preparation

Firstly, phases A and B are warmed separately to 75° C. Phase A is then slowly added to phase B with stirring and stirred until a homogeneous mixture has formed. After homogenisation of the emulsion, the mixture is cooled to 30° C. with stirring. The mixture is subsequently warmed to 35° C., phase C is added, and the mixture is stirred until homogeneous.

Sources of Supply

(1) Merck KGaA
(2) Rhodia
(3) Uniqema
(4) ISP

Example 5

Topical Composition as W/O Emulsion

	% by wt.
	A	Isolan PDI	(2)	3.0
		Paraffin oil, liquid	(1)	17.0
		Isopropyl myristate		5.0
		Beeswax		0.2
		Cutina HR	(2)	0.3
		Luteolin		1.0
	B	Water, demineralised		to 100
		Glycerol (87%)		4.0
		Magnesium sulfate		1.0
		Germaben II-E	(3)	1.0
	C	RonaCare ™ LPO	(1)	2.0

Preparation

Phases A and B are warmed to 75° C. Phase B is added to phase A with stirring. The mixture is subsequently homogenised at 9000 rpm for 2 min. using the Turrax. The resultant mixture is cooled to 30 to 35° C., and C is stirred in.

Sources of Supply

(1) Merck KGaA
(2) Goldschmidt AG
(3) ISP

Example 6

Pump Spray

                        % by wt.
Luteolin                1.0
Ethanol 96%             40.0
PEG-20 Glyceryl Laurate 7.0
1,2-Propanediol         5.0
Water, demineralised    to 100

Preparation

Luteolin/CD is dissolved in water, and the remaining constituents are added with stirring.

Example 7

Compositions

Formulations of cosmetic compositions which comprise the luteolin/2-hydroxypropyl-gamma-cyclodextrin complex (=luteolin/CD) in accordance with Examples A are indicated by way of example below. In addition, the INCI names of the commercially available compounds are indicated.

UV-Pearl, OMC stands for the composition having the INCI name: Water (for EU: Aqua), Ethylhexyl Methoxycinnamate, Silica, PVP, Chlorphenesin, BHT; this composition is commercially available from Merck KGaA, Darmstadt, under the name Eusolex®UV Pearl™OMC.

The other UV-Pearls indicated in the tables each have an analogous composition, with OMC being replaced by the UV filters indicated.

TABLE 1
W/O emulsions (numbers in % by weight)
	1-1	1-2	1-3	1-4	1-5	1-6	1-7	1-8	1-9	1-10
Titanium dioxide		2	5							3
Luteolin/CD	5	3	2	1	2	1	2	1	1	1
Zinc oxide								5	2
UV-Pearl, OMC	30	15	15	15	15	15	15	15	15	15
Polyglyceryl-3 Dimerate	3	3	3	3	3	3	3	3	3	3
Cera Alba	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3
Hydrogenated Castor Oil	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2
Paraffinium Liquidum	7	7	7	7	7	7	7	7	7	7
Caprylic/Capric Triglyceride	7	7	7	7	7	7	7	7	7	7
Hexyl Laurate	4	4	4	4	4	4	4	4	4	4
PVP/Eicosene Copolymer	2	2	2	2	2	2	2	2	2	2
Propylene Glycol	4	4	4	4	4	4	4	4	4	4
Magnesium Sulfate	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6
Tocopherol	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Tocopheryl Acetate	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Cyclomethicone	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Propylparabene	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Methylparabene	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15
Water	to	to	to	to	to	to	to	to	to	to
	100	100	100	100	100	100	100	100	100	100
	1-11	1-12	1-13	1-14	1-15	1-16	1-17	1-18
Titanium dioxide	3		2		3		2	5
Benzylidene malonate polysiloxane		1	0.5
Methylene Bis-Benztriazolyl	1	1	0.5
Tetramethylbutylphenol
Luteolin/CD	1	3	2	5	1	3	7	2
Polyglyceryl-3-Dimerate	3	3	3	3
Cera Alba	0.3	0.3	0.3	0.3	2	2	2	2
Hydrogenated Castor Oil	0.2	0.2	0.2	0.2
Paraffinium Liquidum	7	7	7	7
Caprylic/Capric Triglyceride	7	7	7	7
Hexyl Laurate	4	4	4	4
PVP/Eicosene Copolymer	2	2	2	2
Propylene Glycol	4	4	4	4
Magnesium Sulfate	0.6	0.6	0.6	0.6
Tocopherol	0.5	0.5	0.5	0.5
Tocopheryl Acetate	0.5	0.5	0.5	0.5	1	1	1	1
Cyclomethicone	0.5	0.5	0.5	0.5
Propylparabene	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Methylparabene	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15
Dicocoyl Pentyerythrityl Citrate (and)					6	6	6	6
Sorbitan Sesquioleate (and) Cera
Alba (and) Aluminium Stearate
PEG-7 Hydrogenated Castor Oil					1	1	1	1
Zinc Stearate					2	2	2	2
Oleyl Erucate					6	6	6	6
Decyl Oleate					6	6	6	6
Dimethicone					5	5	5	5
Tromethamine					1	1	1	1
Glycerol					5	5	5	5
Allantoin					0.2	0.2	0.2	0.2
Water	to	to	to	to	to	to	to	to
	100	100	100	100	100	100	100	100
	1-19	1-20	1-21	1-22	1-23	1-24	1-25	1-26	1-27	1-28	1-29
Titanium dioxide		2	5							3	3
Benzylidene malonate polysiloxane				1					1	1
Zinc oxide								5	2
Luteolin/CD	5	5	5	5	7	5	5	5	5	5	8
UV-Pearl, OCR		10									5
UV-Pearl, EthylhexylDimethylPABA			10
UV-Pearl, Homosalate				10
UV-Pearl, Ethylhexyl salicylate					10
UV-Pearl, OMC, BP-3						10
UV-Pearl, OCR, BP-3							10
UV-Pearl, Ethylhexyl Dimethyl								10
PABA, BP-3
UV-Pearl, Homosalate, BP-3									10
UV-Pearl, Ethylhexyl salicylate, BP-3										10
BMDBM											2
UV-Pearl OMC,	25
4-Methylbenzylidene Camphor
Polyglyceryl-3-Dimerate	3	3	3	3	3	3	3	3	3	3	3
Cera Alba	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3
Hydrogenated Castor Oil	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2
Paraffinium Liquidum	7	7	7	7	7	7	7	7	7	7	7
Caprylic/Capric Triglyceride	7	7	7	7	7	7	7	7	7	7	7
Hexyl Laurate	4	4	4	4	4	4	4	4	4	4	4
PVP/Eicosene Copolymer	2	2	2	2	2	2	2	2	2	2	2
Propylene Glycol	4	4	4	4	4	4	4	4	4	4	4
Magnesium Sulfate	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6
Tocopherol	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Tocopheryl Acetate	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Cyclomethicone	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Propylparabene	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Methylparabene	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15
Water	to 100

TABLE 2
O/W emulsions, numbers in % by weight
	2-1	2-2	2-3	2-4	2-5	2-6	2-7	2-8	2-9	2-10
Titanium dioxide		2	5							3
Methylene Bis-Benztriazolyl						1	2	1
Tetramethylbutylphenol
2-(1-Ethylhexyl)-5,7-dihydroxy-				1	2				1	1
chromen-4-one
4′-Methoxy-6-hydroxyflavone	1	3		2		5		5	2
Luteolin/CD	5	5	5	5	5	5	5	5	5	5
2-Carboxyl-5,7-dihydroxy-	1	5	4		6		7		2	1
chromen-4-one
4-Methylbenzylidene Camphor	2		3		4		3		2
BMDBM	1	3		3	3		3	3	3
Stearyl Alcohol (and) Steareth-7	3	3	3	3	3	3	3	3	3	3
(and) Steareth-10
Glyceryl Stearate (and) Ceteth-	3	3	3	3	3	3	3	3	3	3
20
Glyceryl Stearate	3	3	3	3	3	3	3	3	3	3
Microwax	1	1	1	1	1	1	1	1	1	1
Cetearyl Octanoate	11.5	11.5	11.5	11.5	11.5	11.5	11.5	11.5	11.5	11.5
Caprylic/Capric Triglyceride	6	6	6	6	6	6	6	6	6	6
Oleyl Oleate	6	6	6	6	6	6	6	6	6	6
Propylene Glycol	4	4	4	4	4	4	4	4	4	4
Glyceryl Stearate SE
Stearic Acid
Persea Gratissima
Propylparabene	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Methylparabene	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15
Tromethamine			1.8
Glycerol
Water	to	to	to	to	to	to	to	to	to	to
	100	100	100	100	100	100	100	100	100	100
	2-11	2-12	2-13	2-14	2-15	2-16	2-17	2-18
Titanium dioxide	3		2				2	5
Benzylidene malonate polysiloxane		1	0.5
Methylene Bis-Benztriazolyl	1	1	0.5
Tetramethylbutylphenol
4′-Methoxy-7-β-glucosidylflavone				1	2
Luteolin/CD	1	3	0.1	2	0.5	5	0.2	5
2-Carboxyl-7-hydroxy-chromen-4-	5	5	5	5	5	5	5	5
one
Ectoin	1	5	4		6		7
Zinc oxide			2
UV-Pearl, OMC	15	15	15	30	30	30	15	15
4-Methylbenzylidene Camphor				3
BMDBM				1
Phenylbenzimidazole Sulfonic Acid					4
Stearyl Alcohol (and) Steareth-7	3	3	3	3
(and) Steareth-10
Glyceryl Stearate (and) Ceteth-20	3	3	3	3
Glyceryl Stearate	3	3	3	3
Microwax	1	1	1	1
Cetearyl Octanoate	11.5	11.5	11.5	11.5
Caprylic/Capric Triglyceride	6	6	6	6	14	14	14	14
Oleyl Oleate	6	6	6	6
Propylene Glycol	4	4	4	4
Glyceryl Stearate SE					6	6	6	6
Stearic Acid					2	2	2	2
Persea Gratissima					8	8	8	8
Propylparabene	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Methylparabene	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15
Tromethamine					1.8
Glycerol					3	3	3	3
Water	to	to	to	to	to	to	to	to
	100	100	100	100	100	100	100	100
	2-19	2-20	2-21	2-22	2-23	2-24	2-25	2-26	2-27	2-28
Titanium dioxide							3	3		2
Benzylidene malonate polysiloxane	1	2				1	1		1	0.5
7,8,3,4′-Tetrahydroxyflavone				1	2				1	1
Luteolin/CD	1	3	0.2	2	0.3	5	0.5	5	2	0.8
2-Methyl-5,7-dihydroxy-	5	5	5	5	5	5	5	5	5	5
chromen-4-one
Methylene Bis-Benztriazolyl			1	2	1			1	1	0.5
Tetramethylbutylphenol
Zinc oxide					5	2				2
UV-Pearl, OMC	15	15	15	15	15	15	15	15	15	15
Caprylic/Capric Triglyceride	14	14	14	14	14	14	14	14	14	14
Glyceryl Stearate SE	6	6	6	6	6	6	6	6	6	6
Stearic Acid	2	2	2	2	2	2	2	2	2	2
Persea Gratissima	8	8	8	8	8	8	8	8	8	8
Propylparabene	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Methylparabene	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15
Glycerol	3	3	3	3	3	3	3	3	3	3
Water	to	to	to	to	to	to	to	to	to	to
	100	100	100	100	100	100	100	100	100	100

	TABLE 3
	Gels, numbers in % by weight
	3-1	3-2	3-3	3-4	3-5	3-6	3-7	3-8	3-9	3-10
a = aqueous gel
Titanium dioxide		2	5							3
Luteolin/CD	1	3	0.2	2	0.5	5	1	5	2	1.5
Benzylidene malonate polysiloxane			1	1	2				1	1
Methylene Bis-Benztriazolyl		1				1	2	1
Tetramethylbutylphenol
Zinc oxide				2				5	2
UV-Pearl, Ethylhexyl Methoxy-	30	15	15	15	15	15	15	15	15	15
cinnamate
4-Methylbenzylidene Camphor					2
Butylmethoxydibenzoylmethane		1
Phenylbenzimidazole Sulfonic Acid			4
Prunus Dulcis	5	5	5	5	5	5	5	5	5	5
Tocopheryl Acetate	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Caprylic/Capric Triglyceride	3	3	3	3	3	3	3	3	3	3
Octyldodecanol	2	2	2	2	2	2	2	2	2	2
Decyl Oleate	2	2	2	2	2	2	2	2	2	2
PEG-8 (and) Tocopherol (and)	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Ascorbyl Palmitate (and) Ascorbic
Acid (and) Citric Acid
Sorbitol	4	4	4	4	4	4	4	4	4	4
Polyacrylamide (and) C13-14	3	3	3	3	3	3	3	3	3	3
Isoparaffin (and) Laureth-7
Propylparabene	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Methylparabene	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15	0.15
Tromethamine			1.8
Water	to	to	to	to	to	to	to	to	to	to
	100	100	100	100	100	100	100	100	100	100

Claims

1. Complex compound of the formula I

2. Complex compound according to claim 1, characterised in that the cyclodextrin CD is an alpha-, beta-, or gamma-cyclodextrin, preferably a gamma-cyclodextrin which is optionally substituted by C1-24-alkyl or C1-24-hydroxyalkyl on one or more hydroxyl groups, particularly preferably hydroxypropyl-gamma-cyclodextrin.

3. Complex compound according to claim 1, characterised in that the flavonoid moiety is luteolin or trishydroxyethylluteolin.

4. Complex compound according to claim 1, characterised in that the flavonoid moiety is employed in the form of a plant extract or a purified plant extract or in the form of the pure substance prepared from the plant extract, where the plant extract comprises 5 to 90% by weight of the flavonoid of the formula I.

5. Complex compound according to at least one of the claim 1, characterised in that o in formula I is equal to 1 and p is in the range 1.75 to 2.1, where p is preferably equal to 2.

6. Process for the preparation of complex compounds according to claim 1, characterised in that compounds of the formula II

7. Process according to claim 6, characterised in that the cyclodextrin is employed in excess or precisely in the molar ratio 2:1, based on the flavonoid of the formula II.

8. Composition comprising a suitable excipient, characterised in that the composition comprises 0.005 to 99% by weight of a complex compound of the formula I according to claim 1 or the composition comprises 0.002 to 70% by weight of cyclodextrin and 0.001 to 60% by weight of at least one compound of the formula II in which all R each, independently of one another, denote H, CH3E alkyl or hydroxyalkyl radicals and where the alkyl and hydroxyalkyl groups may be branched or unbranched and can have 1 to 18 C atoms, where sulfate or phosphate may also each, independently of one another, be bonded to one or more hydroxyl groups of the radicals mentioned in the substituents —OR, are reacted with cyclodextrins CD in solution, preferably at elevated temperature or topically tolerated salts and/or derivatives thereof.

9. Composition according to claim 8, characterised in that the one or more compounds of the formula I are present in the composition in amounts of 0.01 to 20% by weight, preferably 0.05 to 10% by weight and particularly preferably 0.1 to 5% by weight.

10. Composition according to claim 9, characterised in that the content of cyclodextrins in the composition is 0.01-20.0% by weight, preferably 0.05-10.0% by weight, particularly preferably 0.1-5.0% by weight, in each case based on the total weight of the composition, and the content of compounds of the formula II in the composition is 0.01 to 20% by weight, preferably 0.05 to 10% by weight and particularly preferably 0.1 to 5% by weight, based on the composition as a whole, where the the proportion of the compounds of the formula II in the composition is very particularly preferably in the range from 0.1 to 2% by weight, based on the composition as a whole.

11. Composition according to claim 1, characterised in that the composition comprises one or more antioxidants and/or one or more UV filters.

12. Composition according to claim 1, characterised in that the composition is a food or food supplement or oral cosmetic.

13. Composition according to claim 1, characterised in that the composition is a sprayable composition, it being particularly preferred for this composition to comprise an aqueous or aqueous-alcoholic excipient.

14. Use of a complex compound of the formula I or a composition according to claim 8 for the care, preservation or improvement of the general condition of the skin or hair.

15. Use of a complex compound of the formula I or a composition according to claim 8 for prophylaxis against time- and/or light-induced ageing processes of the human skin or human hair, in particular for prophylaxis against dry skin, wrinkling and/or pigment defects, and/or for reducing or preventing damaging effects of UV rays on the skin.

16. Use of a complex compound of the formula I or a composition according to claim 8 for prophylaxis against or reduction of skin unevenness, such as wrinkles, fine lines, rough skin or large-pored skin.

17. Use of a complex compound of the formula I or a composition according to claim 8 for the prophylaxis and/or therapy of inflammation or allergic reactions.

18. Process for the preparation of a composition according to claim 8, characterised in that at least one compound of the formula II and a cyclodextrin or at least one compound of the formula I having radicals as described above is mixed with an excipient which is suitable cosmetically or dermatologically or for foods or food supplements or oral cosmetics.

19. Use of a compound of the formula I for the preparation of a composition according to claim 8.