Patent Grant
8795243
The present invention generally relates to treatment of wounds, and more specifically to an improved apparatus and method for treating all or a portion of a wound on a body by applying reduced pressure to the portion of the wound for which treatment is desired. In this context, the terms “wound” and “body” are to be interpreted broadly, to include any body part of a patient that may be treated using reduced pressure.
The treatment of open or chronic wounds that are too large to spontaneously close or otherwise fail to heal by means of applying reduced pressure to the site of the wound is well known in the art. One such system is disclosed in U.S. patent application Ser. No. 10/652,100, which was filed by the present inventor with the U.S. Patent and Trademark Office on Aug. 28, 2003. The disclosure of this U.S. patent application is incorporated herein by reference. Another system is disclosed in a U.S. patent application entitled “Improved Reduced Pressure Wound Treatment Appliance,” which was filed by the present inventor with the U.S. Patent and Trademark Office on or about Dec. 30, 2004. The disclosure of this U.S. patent application is also incorporated herein by reference.
Reduced pressure wound treatment systems currently known in the art commonly involve placing a cover that is impermeable to liquids over the wound, using various means to seal the cover to the tissue of the patient surrounding the wound, and connecting a source of reduced pressure (such as a vacuum pump) to the cover in a manner so that an area of reduced pressure is created under the cover in the area of the wound. However, the covers currently known and used in the art have a number of disadvantages. For example, in one version they tend to be in the form of a flexible sheet of material that is placed over the wound and sealed to the surrounding tissue using an adhesive, adhesive tape, or other similar means. As tissue swelling in the area of the wound decreases during the healing process, the adhesive may begin to stretch the surrounding tissue, as well as tissue within the wound, resulting in discomfort and pain to the patient. This may necessitate more frequent cover changes, increasing the time medical staff must expend in treating the wound. This additional time, of course, also tends to increase the expense involved in treating the wound. In addition, these types of covers can typically only be used where there is normal tissue adjacent to the wound to which the adhesive seal can be attached. Otherwise, the seal must be made in a portion of the area of the wound, and exudate from the wound tends to break the seal so that reduced pressure cannot be maintained beneath the wound cover. Thus, such covers (and many other covers requiring adhesive seals) may typically only be used to treat an entire wound, as opposed to only a portion of a wound. Further, the adhesive seal creates discomfort for the patient when the sheet cover is removed. In other versions, the covers tend to be rigid or semi-rigid in nature so that they are held away from the surface of the wound. In these versions, the covers are sometimes difficult to use because the shape and contour of the patient's body in the area of the wound do not readily adapt to the shape of the cover. In such cases, additional time is required for the medical staff to adapt the cover for its intended use. This also increases the expense of wound treatment. In addition, it is also often necessary to use an adhesive, adhesive tape, or other similar means to seal the rigid or semi-rigid cover to the tissue surrounding the wound. In these instances, the same disadvantages discussed above with respect to the first version also apply to this version as well. In still other cases, the rigid and semi-rigid covers must be used with padding in the area where the cover is adjacent to the patient to prevent the edges of the cover from exerting undue pressure on the tissue surrounding the wound. Without the padding, the patient may experience pain and discomfort. The additional padding, which may make the cover itself more expensive, may also take a greater amount of time to place on the patient for treatment purposes. These covers may also have the problem of placing tension on the surrounding tissue as the swelling in the area of the wound decreases during the healing process. In yet another version, covers are constructed of combinations of flexible materials and rigid materials. In these versions, a flexible member, such as a flexible sheet, is typically supported by a rigid or semi-rigid structure that is either placed between the flexible member and the wound or in the area above and outside the flexible member. In either case, the flexible member must usually be sealed to the tissue surrounding the wound using an adhesive, adhesive tape, or other similar means. This seal creates the same problems described above. In addition, the same problems described above with respect to rigid and semi-rigid structures are also often present. In all of the versions described above, it may be difficult to tell if reduced pressure in the area of the wound under the cover has been lost because the cover itself does not generally provide a visual clue of such loss.
Therefore, there is a need for a reduced pressure wound treatment system that has a means to enclose all or a portion of a wound without the need for an adhesive seal. There is also a need for such enclosing means to be flexible, so that it adapts to changing shapes and contours of the patient's body as wound healing progresses. Further, there is a need for an enclosing means that is adaptable to a wide variety of patient body shapes and contours. There is also a need for an enclosing means that is simple to apply to the patient's body, and simple to remove from the patient's body. Such enclosing means would also take less time to apply and remove, reducing the expense involved in wound treatment. There is also a need for an enclosing means that is relatively inexpensive, while meeting the needs described above. In addition, there is a need for an enclosing means that may be used within the wound (or a portion thereof), without the need to seal the enclosing means to normal tissue surrounding the wound. Further, there is a need for an enclosing means that flexes with movement of the portion of the body surrounding the wound, without the need for an adhesive seal or rigid or semi-rigid structure. Finally, there is a need for an enclosing means that provides a visual clue of loss of reduced pressure in the area of the wound under the enclosing means.
The present invention is directed to a reduced pressure wound treatment appliance and methods that satisfy the needs described above. As described in greater detail below, they have many advantages over existing reduced pressure wound treatment apparatus and methods when used for their intended purpose, as well as novel features that result in a new reduced pressure wound treatment appliance and methods that are not anticipated, rendered obvious, suggested, or even implied by any of the prior art apparatus or methods, either alone or in any combination thereof.
In accordance with the present invention, a wound treatment appliance is provided for treating all or a portion of a wound by applying reduced pressure (i.e., pressure that is below ambient atmospheric pressure) to the portion of the wound to be treated in a controlled manner for a selected time period in a manner that overcomes the disadvantages of currently existing apparatus. The application of reduced pressure to a wound provides such benefits as faster healing, increased formation of granulation tissue, closure of chronic open wounds, reduction of bacterial density within wounds, inhibition of burn penetration, and enhancement of flap and graft attachment. Wounds that have exhibited positive response to treatment by the application of negative pressure include infected open wounds, decubitus ulcers, dehisced incisions, partial thickness burns, and various lesions to which flaps or grafts have been attached.
In a first aspect of a first version of the present invention, the wound treatment appliance is comprised of an impermeable flexible overlay and reduced pressure supply means, which are described in more detail below and are used to connect the flexible overlay to a reduced pressure supply source that provides a supply of reduced pressure to the flexible overlay. In this first aspect of the first version of the invention, the flexible overlay is adapted to be placed over and enclose all or a portion of a wound on the surface of the body of a patient. The flexible overlay is also adapted to maintain reduced pressure under the flexible overlay in the area of the wound. The flexible overlay collapses in the approximate direction of the area of the wound to be treated when reduced pressure is supplied to the volume under the flexible overlay in the area of the wound. This collapse causes the formation of an approximately hermetic seal (described in more detail below) between the flexible overlay and the body in the area of the wound. In some embodiments of this first aspect of the first version of the invention, the flexible overlay is further comprised of an interior surface facing the area of the wound to be treated, wherein the surface area of the interior surface is greater than the surface area of the portion of the body to be enclosed by the flexible overlay. In other embodiments of this first aspect of the first version of the invention, the flexible overlay is further comprised of a bottom portion having an approximately elongated conical shape with an approximately elliptically-shaped open end at the base of the elongated conical bottom portion. In these embodiments, the approximately elliptically-shaped open end at the base is sized to be placed over and enclose the area of the wound to be treated. In yet other embodiments of this first aspect of the first version of the invention, the flexible overlay (as opposed to only the bottom portion thereof) has an approximately elongated conical shape having an approximately elliptically-shaped open end at its base. In these embodiments, the approximately elliptically-shaped perimeter of the open end at the base of the flexible overlay is positioned over all or a portion of the wound on the surface of the body. In some of these embodiments, the flexible overlay further comprises a port located approximately at the apex of the elongated conically-shaped flexible overlay. In these embodiments, the reduced pressure supply means is operably connected to the port. In yet other embodiments of this first aspect of the first version of the invention, the flexible overlay is comprised of at least three cover portions, each of such cover portions being approximately triangular in shape. One point of each of the at least three triangular-shaped cover portions are joined to form an apex of the flexible overlay and one side of each at least three triangular-shaped cover portions adjacent to the apex is joined to an adjacent side of another of such at least three triangular-shaped cover portions so that the bases of the at least three triangular-shaped cover portions form an opening sized to be placed over and enclose the area of the wound to be treated. In some of these embodiments, the flexible overlay is further comprised of a port located approximately at the apex of the flexible overlay and the reduced pressure supply means is operably connected to the port. In still other embodiments of this first aspect of the first version of the invention, at least one fold forms in the surface of the flexible overlay when it collapses, so that fluids aspirated by the wound flow along the at least one fold to the reduced pressure supply means, where they are removed from the flexible overlay by means of the reduced pressure supply means cooperating with the reduced pressure supply source. In other embodiments, the appliance further comprises supplemental sealing means, which are described in more detail below, to form a seal between the flexible overlay and the body in the area of the wound. In yet other embodiments, the appliance further comprises a suction drain and suction drain connecting means, which are described in more detail below, to operably connect the reduced pressure supply means to the suction drain so that the suction drain is in fluid communication with the reduced pressure supply means and reduced pressure is supplied to the volume under the flexible overlay in the area of the wound by means of the suction drain. The suction drain extends from the reduced pressure supply means into the volume under the flexible overlay in the area of the wound.
In a second aspect of the first version of the present invention, the wound treatment appliance is comprised of a wound treatment device and a vacuum system. In this second aspect of the first version of the invention, the vacuum system is further comprised of a reduced pressure supply source that provides a supply of reduced pressure and reduced pressure supply means to operably connect the wound treatment device to the reduced pressure supply source, so that the volume under the wound treatment device in the area of the wound is supplied with reduced pressure by the reduced pressure supply source. In various embodiments of this second aspect of the first version of the invention, the wound treatment device and the reduced pressure supply means may generally have substantially the same structure, features, characteristics and operation as the appliance described above in connection with the first aspect of the first version of the invention.
In some embodiments of this second aspect of the first version of the invention, the reduced pressure supply source is comprised of a vacuum pump. In some of these embodiments, the reduced pressure supply source further comprises a control system for the vacuum pump, wherein the control system may control at least the level of suction produced by the vacuum pump or the rate of fluid flow produced by the vacuum pump, or any combination of rate of suction and rate of fluid flow of the vacuum pump. In other embodiments, the reduced pressure supply source further comprises a filter operably positioned between the vacuum pump and the reduced pressure supply means. In these embodiments, the filter prevents the venting of and contamination of the vacuum pump by micro-organisms aspirated from the wound or fluids aspirated from the wound or both. In yet other embodiments, the vacuum pump is comprised of a portable vacuum pump. In still other embodiments of this second aspect of the first version of the invention, the reduced pressure supply means is comprised of flexible tubing. In other embodiments, the reduced pressure supply means is further comprised of a collection system that is operably positioned between the wound treatment device and the reduced pressure supply source. In some of these embodiments, the collection system comprises a container to receive and hold fluid aspirated from the wound and pressure halting means to halt the application of reduced pressure to the wound when the fluid in the container exceeds a predetermined amount. In other embodiments of this second aspect of the first version of the invention, the reduced pressure under the flexible overlay in the area of the wound is in the range from approximately 20 mm of Hg below atmospheric pressure to approximately 125 mm of Hg below atmospheric pressure. In yet other embodiments, the reduced pressure is applied in a cyclic nature, the cyclic nature providing alternating time periods of application of reduced pressure and without application of reduced pressure. In some embodiments of this second aspect of the first version of the invention, the wound treatment appliance further comprises tissue protection means, which are described in more detail below, to protect and strengthen the body tissue that is adjacent to the flexible overlay at the wound site. In some of these embodiments, the tissue protection means is a hydrocolloid material.
In a third aspect of the first version of the invention, the wound treatment appliance is comprised of a wound treatment device, a vacuum system, and wound packing means, which are described in more detail below, that are positioned between the wound treatment device and the portion of the wound to be treated. In various embodiments of this third aspect of the first version of the invention, the wound treatment device and the vacuum system may generally have substantially the same structure, features, characteristics and operations as the wound treatment device and the vacuum system, respectively, described above in connection with the second aspect of the first version of the invention. In this third aspect of the first version of the invention, the flexible overlay of the wound treatment device is placed over all or a portion of the wound and the wound packing means when the flexible overlay is positioned on the surface of the body at the wound site. In some embodiments of this third aspect of the first version of the invention, the wound packing means is comprised of absorbent dressings, antiseptic dressings, nonadherent dressings, water dressings, or combinations of such dressings. In some of these embodiments, the wound packing means is preferably comprised of gauze or cotton or any combination of gauze and cotton. In still other embodiments, the wound packing means is comprised of an absorbable matrix adapted to encourage growth of the tissue in the area of the wound under the flexible overlay into the matrix. The absorbable matrix is constructed of an absorbable material that is absorbed into the epithelial and subcutaneous tissue in the wound as the wound heals. Because of the absorbable nature of the absorbable matrix, the matrix should require less frequent changing than other dressing types during the treatment process. In other circumstances, the matrix may not need to be changed at all during the treatment process. In some of these embodiments, the absorbable matrix is comprised of collagen or other absorbable material. In some embodiments of this third aspect of the first version of the invention, the appliance further comprises a suction drain and suction drain connecting means, which are described in more detail below, to operably connect the reduced pressure supply means to the suction drain so that the suction drain is in fluid communication with the reduced pressure supply means and reduced pressure is supplied to the volume under the impermeable flexible overlay in the area of the wound by means of the suction drain. In these embodiments, the suction drain extends from the reduced pressure supply means into the volume under the impermeable flexible overlay in the area of the wound. In some of these embodiments, the suction drain is further comprised of a distal end portion and the distal end portion has at least one perforation in the surface thereof. In some of these embodiments, the distal end portion of the suction drain is positioned within the interior volume of the wound packing means.
In a fourth aspect of the first version of the invention, the wound treatment appliance is comprised of a wound treatment device and a vacuum system. In various embodiments of this fourth aspect of the first version of the invention, the wound treatment device is comprised of an impermeable overlay and a seal. The impermeable overlay is sized to be placed over and enclose the area of the wound to be treated and is adapted to maintain reduced pressure in the area of the wound to be treated. The seal seals the impermeable flexible overlay to the body in the area of the wound in a manner so that reduced pressure is maintained under the impermeable overlay in the area of the wound to be treated. In addition, in the various embodiments of this fourth aspect of the first version of the invention, the vacuum system is comprised of a suction bulb, which may (but not necessarily) provide a source of reduced pressure, and reduced pressure supply means, which are described in more detail below, to operably connect the impermeable overlay to the suction bulb, so that the area of the wound under the impermeable overlay may be supplied with reduced pressure by the suction bulb. In some embodiments of this fourth aspect of the first version of the invention, the impermeable overlay is comprised of a rigid or semi-rigid wound cover. In other embodiments, the impermeable overlay is comprised of a flexible wound cover. In some of these embodiments, the flexible wound cover may be comprised of a flexible overlay that has substantially the same structure, features, characteristics and operation as the flexible overlay described above in connection with the first aspect of this first version of the invention. In some embodiments of this fourth aspect of the first version of the invention, the suction bulb is further comprised of an inlet port and an outlet port, wherein the inlet port is operably connected to the reduced pressure supply means, and the vacuum system further comprises an exhaust tubing member operably connected to the outlet port. In some of these embodiments, the vacuum system further comprises an exhaust control valve operably connected to the exhaust tubing member. In other embodiments, the vacuum system is further comprised of a filter operably connected to the exhaust tubing member, which prevents the venting of micro-organisms aspirated from the wound or fluids aspirated from the wound or both. In yet other embodiments, the vacuum system is further comprised of a supplemental vacuum system that is operably connected to the exhaust tubing member. In these embodiments, the supplemental vacuum system may generally have substantially the same structure, features, characteristics and operation as the vacuum system described above in connection with the second and third aspects of the first version of the invention.
A fifth aspect of the first version of the present invention discloses a method of treating a wound on a body. In one embodiment of this fifth aspect of the first version of the invention, the method comprises the following steps. First, positioning an flexible overlay on the body over the area of the wound to be treated, wherein the flexible overlay is sized to be placed over and enclose the area of the wound to be treated and adapted to maintain reduced pressure in the area of the wound to be treated. Second, operably connecting the flexible overlay with a vacuum system for producing reduced pressure in the volume under the flexible overlay in the area of the wound to be treated. Third, collapsing the flexible overlay in the approximate direction of the wound when reduced pressure is supplied to the volume under the flexible overlay in the area of the wound so that an approximately hermetic seal (described in more detail below) is formed between the impermeable flexible overlay and the body in the area of the wound. Fourth, maintaining the reduced pressure until the area of the wound being treated has progressed toward a selected stage of healing. In other embodiments of this fifth aspect of the first version of the invention, the method further comprises the step of placing tissue protection means on the tissue of the body that is to be approximately adjacent to the flexible overlay, such step being performed prior to positioning the flexible overlay over the area of the wound to be treated. The tissue protection means, which is described in more detail below, protects and strengthens the tissue of the body adjacent to the flexible overlay at the wound site. In yet other embodiments of this fifth aspect of the first version of the invention, the method further comprises the step of placing wound packing means (described in more detail above) between the wound and the flexible overlay in the area of the wound to be treated, such step being performed prior to positioning the flexible overlay over the area of the wound to be treated. In still other embodiments of this fifth aspect of the first version of the invention, the vacuum system is comprised of a suction bulb and the method further comprises the step of squeezing the suction bulb to reduce its volume and then releasing the suction bulb, so that reduced pressure is produced in the volume under the flexible overlay in the area of the wound. In other embodiments of this fifth aspect of the first version of the invention, the reduced pressure under the impermeable overlay in the area of the wound is in the range from approximately 20 mm of Hg below atmospheric pressure to approximately 125 mm of Hg below atmospheric pressure. In still other embodiments of this fifth aspect of the first version of the invention, the reduced pressure is applied in a cyclic nature, the cyclic nature providing alternating time periods of application of reduced pressure and without application of reduced pressure.
As is illustrated in the detailed descriptions herein, the wound treatment appliance of the present invention meets the needs discussed above in the Background section. For example, in the preferred embodiment of a flexible overlay having a bottom portion with an approximately elongated conical shape, the flexible overlay is placed over and encloses all or a portion of the wound. When the flexible overlay is enclosing all or a portion of the wound, the portions of the flexible overlay positioned adjacent to the surface of the body at the wound site are at (or can be deformed to be at) a relatively acute angle relative to such surface of the body. When reduced pressure is applied to the area under the flexible overlay, the flexible overlay is drawn downward, collapsing the flexible overlay in the approximate direction of the wound. As the flexible overlay collapses, the portions of the flexible overlay adjacent to the perimeter of the opening of the flexible overlay are drawn tightly against the surface of the body at the wound site, thus forming an approximately hermetic seal. References to an “approximately hermetic seal” herein refer generally to a seal that is gas-tight and liquid-tight for purposes of the reduced pressure treatment of the wound. It is to be noted that this seal need not be entirely gas-tight and liquid-tight. For example, the approximately hermetic seal may allow for a relatively small degree of leakage, so that outside air may enter the volume under the flexible overlay in the area of the wound, as long as the degree of leakage is small enough so that the vacuum system can maintain the desired degree of reduced pressure in the volume under the flexible overlay in the area of the wound. In some uses where the collapsing flexible overlay may not produce an approximately hermetic seal that is solely capable of maintaining the reduced pressure in the volume under the impermeable overlay in the area of the wound, it may be necessary to provide supplemental sealing means, which are described in more detail below, and which are used to provide a seal between the portions of the flexible overlay and the body where the approximately hermetic seal is not adequate. As a result, the flexible overlay is simple to apply to the patient. There is also often no need for any other sealing means in most cases, which means that there is usually no need for medical staff to take the time to make a separate seal. Even where the geometry of the surface of the body surrounding the wound may require that supplemental sealing means be used to provide some limited assistance to ensure a seal, the amount of such assistance (such as by applying an adhesive) is limited, especially when compared to current covers in the art. In addition, as swelling of tissue at the wound site decreases, the flexible nature of the flexible overlay allows it to further deform to conform to the changing shape and contours at the wound site. This prevents the patient from being discomforted as the swelling decreases. It also reduces the need to change the covering over the wound as healing progresses. This is generally not true in cases involving flexible, semi-rigid and rigid covers that exist in the art. For example, even where semi-rigid and rigid covers do not utilize an adhesive seal and rely solely upon the reduced pressure to hold them in place, they do not generally change shape enough to flex with substantial changes in the shape and contour of the surrounding body surface. Thus, they may not be appropriate for use with body portions that are subject to such changes, while the flexible nature of the flexible overlay, along with its increased surface area that can bend and flex, allow it to be used in such circumstances without the need for an adhesive seal. In the same way, the flexible overlay may generally be used for unusual geometries of the body at or surrounding the wound because of the overlay's flexible nature and relatively large surface area. In contrast, flexible sheets and semi-rigid and rigid covers may require substantial modification and means to provide an adequate seal. In addition, such covers may require that the patient be partially or wholly immobilized during the treatment process to avoid movement in the area of the body surrounding the wound to avoid breaking the seal. And such covers must usually be sealed to normal tissue surrounding the wound. The flexible overlay, however, may be used within the perimeter of a wound in many cases because there is not typically a need to seal the flexible overlay to normal tissue surrounding the wound. Further, because there is typically no need for an adhesive seal, removal of the flexible overlay merely requires removal of the reduced pressure from the area under the flexible overlay. It is thus simple to remove from the patient. For this reason, it will tend to reduce the time required of medical staff for wound treatment, which will also tend to reduce the cost of wound treatment. In addition, there is no pain and discomfort for the patient when the flexible overlay is removed. Even if a limited amount of supplemental sealing means (such as an adhesive) are required to provide a seal at a portion of the flexible overlay that is adjacent to the surface surrounding the wound, the reduced amount of supplemental sealing means will cause a corresponding reduction in the amount of such pain and discomfort. Further, the preferred embodiments of the collapsed flexible overlay will have folds in its surface while in the collapsed state, so that fluid aspirated by the wound may flow along the folds to be removed from under the flexible overlay. In addition, if reduced pressure is lost under the flexible overlay, the flexible overlay will expand outward from the wound, providing a visual indication that reduced pressure has been lost. Finally, in its preferred embodiments, the flexible overlay is relatively inexpensive to manufacture, even though it meets the described needs.
In a first aspect of a second version of the present invention, the wound treatment appliance is comprised of a fluid impermeable flexible overlay, a collection chamber to receive and hold fluid aspirated from the wound, collection chamber attachment means to operably attach the collection chamber to the flexible overlay, as described in more detail below, and reduced pressure supply means, which are described in more detail below. In this first aspect of the second version of the invention, the flexible overlay is adapted to be placed over and enclose all or a portion of the wound. In the various embodiments of this first aspect of the second version of the invention, except as described in more detail below, the flexible overlay has substantially the same structure, features characteristics and operation as the flexible overlay described above in connection with the first aspect of the first version of the invention. In addition, in this first aspect of the second version of the invention, the reduced pressure supply means is used to operably connect the collection chamber to a reduced pressure supply source that provides a supply of reduced pressure to the collection chamber, so that the volume within the collection chamber and under the impermeable overlay in the area of the wound to be treated are supplied with reduced pressure by the reduced pressure supply source. In the various embodiments of this second version of the invention, except as described in more detail below, the reduced pressure supply means to connect the reduced pressure supply source to the collection chamber in the embodiments of this second version of the invention may have substantially the same structure, features, characteristics and operation as the reduced pressure supply means described above in connection with the first version of the invention.
In this first aspect of the second version of the invention, the flexible overlay is attached by collection chamber attachment means to a collection chamber that receives and holds fluid aspirated from the wound. In some embodiments, the collection chamber may be approximately cylindrical in shape. In the various embodiments of this first aspect of the second version of the invention, the collection chamber attachment means operably attaches the collection chamber to the flexible overlay in a manner so that the fluid and reduced pressure are permitted to flow between the collection chamber and the volume under the flexible overlay in the area of the wound. In some embodiments of this first aspect of the second version of the invention, the collection chamber is positioned approximately adjacent to the impermeable flexible overlay on the side of the impermeable flexible overlay opposite the wound and the collection chamber attachment means is a rigid or semi-rigid connecting member positioned between the collection chamber and the impermeable flexible overlay. In these embodiments, the connecting member has a port therein that extends between the collection chamber and the flexible overlay. In embodiments where the flexible overlay is approximately elongated-conically shaped, the collection chamber and the collection chamber attachment means may be positioned approximately at the apex of the flexible overlay on the side of the impermeable flexible overlay opposite the wound. In some embodiments, the collection chamber may be approximately cylindrical in shape. In other embodiments, the collection chamber attachment means may be further comprised of a flow control means, which is described in more detail below, operably positioned between the collection chamber and the flexible overlay. In these embodiments, the flow control means permit the fluid to flow from the volume under the flexible overlay in the area of the wound into the collection chamber, but not in the opposite direction. In some of these embodiments, the flow control means may be comprised of a valve. In some of these embodiments, the valve may be comprised of a flapper-type valve. In yet other embodiments, the collection chamber is positioned approximately adjacent to the impermeable flexible overlay on the side of the impermeable flexible overlay opposite the wound and the collection chamber attachment means is comprised of a membrane. In these embodiments, the membrane acts as a barrier separating the collection chamber and the impermeable flexible overlay, so that the membrane acts as a portion of the surface of the collection chamber and a portion of the surface of the impermeable flexible overlay. In addition, the membrane has at least one port therein so that the volume within the collection chamber is in fluid communication with the volume under the impermeable flexible overlay in the area of the wound. In embodiments where the impermeable flexible overlay has an approximately conical shape or approximately elongated conical shape, the impermeable flexible overlay may have a base end opening and a top end opening opposite the base end opening. In these embodiments, the base end opening may have an either approximately circular shape or approximately elliptical shape sized to be placed over and enclose the area of the wound to be treated. The top end opening may have either an approximately circular shape or approximately elliptical shape. In these embodiments, the membrane is sized to be of the same shape and size as the top end opening and the membrane is positioned so that it is attached to the entire perimeter of the top end opening and covers the entire top end opening. In some embodiments, the collection chamber may have an approximately conical shape or approximately elongated conical shape with a chamber bottom end opening and a reduced pressure supply port positioned at the apex of the collection chamber opposite the chamber bottom end opening. In various embodiments, the chamber bottom end opening may have an either approximately circular shape or approximately elliptical shape adapted to be of approximately the same size and shape as the top end opening of the impermeable flexible overlay. In some of these embodiments, the perimeter of the chamber bottom end opening is attached to the membrane in a manner so that the collection chamber is airtight, except for the port in the membrane and the reduced pressure supply port. The reduced pressure supply port operably connects the reduced pressure supply means to the collection chamber. In some embodiments, the collection chamber attachment means is further comprised of flow control means operably connected with the at least one port, wherein the flow control means permits fluid aspirated from the wound to flow from the volume under the impermeable flexible overlay in the area of the wound through the at least one port to the collection chamber, but not in the opposite direction. In some of these embodiments, the flow control means is comprised of a valve. Preferably, this valve is comprised of a flapper-type valve.
In a second aspect of the second version of the present invention, the wound treatment appliance is comprised of a wound treatment device and a vacuum system, which is further comprised of a reduced pressure supply source that provides a supply of reduced pressure and reduced pressure supply means to operably connect the wound treatment device to the reduced pressure supply source. In various embodiments of this second aspect of the second version of the invention, except as described below, the wound treatment device and the reduced pressure supply means may generally have substantially the same structure, features, characteristics and operations as the appliance described above in connection with the first aspect of the second version of the invention. In these embodiments, the reduced pressure supply means operably connect the wound treatment device to the reduced pressure supply source so that the volume within the collection chamber and under the wound treatment device in the area of the wound is supplied with reduced pressure by the reduced pressure supply source.
In some embodiments of this second aspect of the second version of the invention, the reduced pressure supply source is comprised of a vacuum pump. In some of these embodiments, the reduced pressure supply source further comprises a control system for the vacuum pump, wherein the control system controls the operation of the vacuum pump. In other embodiments, the reduced pressure supply source further comprises a filter operably positioned between the vacuum pump and the reduced pressure supply means. In these embodiments, the filter prevents the venting of and contamination of the vacuum pump by micro-organisms aspirated from the wound or fluids aspirated from the wound or both. In yet other embodiments, the vacuum pump is comprised of a portable vacuum pump. In still other embodiments, the reduced pressure supply means is comprised of flexible tubing. In other embodiments of this second aspect of the second version of the invention, the reduced pressure under the flexible overlay in the area of the wound is in the range from approximately 20 mm of Hg below atmospheric pressure to approximately 125 mm of Hg below atmospheric pressure. In yet other embodiments, the reduced pressure is applied in a cyclic nature, the cyclic nature providing alternating time periods of application of reduced pressure and without application of reduced pressure. In some embodiments of this second aspect of the second version of the invention, the wound treatment appliance further comprises tissue protection means, which are described in more detail below, to protect and strengthen the body tissue that is adjacent to the flexible overlay at the wound site. In some of these embodiments, the tissue protection means is a hydrocolloid material. In still other embodiments, wound packing means, which are described in more detail herein, are positioned between the wound treatment device and the portion of the wound to be treated.
A third aspect of the second version of the present invention discloses a method of treating a wound on a body. In one embodiment of this third aspect of the second version of the invention, the method comprises the following steps. First, a wound treatment device is positioned on the body over the area of the wound to be treated, wherein the wound treatment device is comprised of an impermeable flexible overlay, a collection chamber, and collection chamber attachment means, which are described in more detail below. In this embodiment, the flexible overlay is sized to be placed over and enclose the area of the wound to be treated and adapted to maintain reduced pressure in the area of the wound to be treated. In addition, in this embodiment, the collection chamber receives and holds fluid aspirated from the wound and the collection chamber attachment means, which is described in more detail below, operably attaches the collection chamber to the impermeable flexible overlay in a manner so that reduced pressure and the fluid are permitted to flow between the collection chamber and the impermeable flexible overlay. Second, the collection chamber is operably connected with a vacuum system for producing reduced pressure in the volume within the collection chamber and in the volume under the flexible overlay in the area of the wound to be treated. Third, the flexible overlay is collapsed in the approximate direction of the wound when reduced pressure is supplied to the volume under the flexible overlay in the area of the wound so that an approximately hermetic seal (described in more detail herein) is formed between the impermeable flexible overlay and the body in the area of the wound. Fourth, reduced pressure is maintained until the area of the wound being treated has progressed toward a selected stage of healing. In other embodiments of this third aspect of the first version of the invention, the method further comprises the step of placing tissue protection means on the tissue of the body that is to be approximately adjacent to the impermeable flexible overlay, such step being performed prior to positioning the impermeable flexible overlay over the area of the wound to be treated. The tissue protection means, which is described in more detail below, protects and strengthens the tissue of the body adjacent to the flexible overlay at the wound site. In yet other embodiments of this third aspect of the first version of the invention, the method further comprises the step of placing wound packing means (described in more detail herein) between the wound and the impermeable flexible overlay in the area of the wound to be treated, such step being performed prior to positioning the impermeable flexible overlay over the area of the wound to be treated. In still other embodiments of this third aspect of the first version of the invention, the reduced pressure under the impermeable overlay in the area of the wound is in the range from approximately 20 mm of Hg below atmospheric pressure to approximately 125 mm of Hg below atmospheric pressure. In still other embodiments of this third aspect of the first version of the invention, the reduced pressure is applied in a cyclic nature, the cyclic nature providing alternating time periods of application of reduced pressure and without application of reduced pressure.
There has thus been outlined, rather broadly, the more primary features of the present invention. There are additional features that are also included in the various embodiments of the invention that are described hereinafter and that form the subject matter of the claims appended hereto. In this respect, it is to be understood that the invention is not limited in its application to the details of construction and to the arrangements of the components set forth in the following description or illustrated in the following drawings. This invention may be embodied in the form illustrated in the accompanying drawings, but the drawings are illustrative only and changes may be made in the specific construction illustrated and described within the scope of the appended claims. The invention is capable of other embodiments and of being practiced and carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein are for the purpose of the description and should not be regarded as limiting.
The foregoing summary, as well as the following detailed description of the preferred embodiments of the present invention, will be better understood when read in conjunction with the appended drawings, in which:
In accordance with the present invention, a wound treatment appliance is provided for treating all or a portion of a wound by applying reduced pressure (i.e., pressure that is below ambient atmospheric pressure) to the portion of the wound to be treated in a controlled manner for a selected time period in a manner that overcomes the disadvantages of currently existing apparatus. One embodiment of a first aspect of a first version of the invention is a wound treatment appliance 10 that is comprised of the fluid impermeable flexible overlay 20 illustrated in
The preferred shape and size of the flexible overlay 20, 20a, 20b is dependent upon the size of the portion of the wound to be treated, the shape and contour of the portion of the body that is to be covered by the flexible overlay 20, 20a, 20b at the site of the wound, the magnitude of the reduced pressure to be maintained under the flexible overlay 20, 20a, 20b. More preferred, as illustrated in
In the embodiment of the flexible overlay 20 illustrated in
In the various embodiments of this first aspect of the first version of the invention, the flexible overlay 20, 20a, 20b may be comprised of almost any medical grade flexible material that is currently known in the art or that may be developed in the art in the future, as long as such material is fluid-impermeable, suitable for purposes of wound treatment (e.g., can be sterilized and does not absorb significant amounts of wound exudate), and is capable of forming an approximately hermetic seal with the surface of the body at the site of the wound, as described in more detail below. For example, the flexible overlay 20, 20a, 20b may be comprised of rubber (including neoprene), and flexible polymer materials, such as silicone, silicone blends, silicone substitutes, polyester, vinyl, polyimide, polyethylene napthalate, polycarbonates, polyester-polycarbonate blends, or a similar polymer, or combinations of all such materials. Preferably, the flexible overlay 20, 20a, 20b is comprised of silicone. Although the raised beads 26, 26a, 26b may be constructed of a material different from the material comprising the remainder of the flexible overlay 20, 20a, 20b in various embodiments of the invention, the raised beads 26, 26a, 26b are preferably constructed from the same material comprising the remainder of the flexible overlay 20, 20a, 20b. In other embodiments, the raised beads 26, 26a, 26b may be placed on the flexible overlay 20, 20a, 20b by means of a mark, such as indelible ink, on the surface of the flexible overlay 20, 20a, 20b. It is to be noted that in various embodiments of this first aspect of the first version of the invention, the flexible overlay 20, 20a, 20b may be constructed in whole or in part of gas-permeable materials, allowing limited amounts of oxygen to penetrate the flexible overlay 20, 20a, 20b so that the area of the wound under the flexible overlay 20, 20a can “breathe.” It is also to be noted that all portions of the flexible overlay 20, 20a, 20b are preferably constructed of one type of polymer material, such as silicone. The flexible overlay 20, 20a, 20b may be constructed using any suitable means currently known in the art or that may be developed in the art in the future. For example, a flexible overlay 20, 20a, 20b constructed of silicone may be manufactured by means of injection molding.
In the embodiments of the flexible overlay 20, 20a, 20b illustrated in
An embodiment of a second aspect of the first version of the present invention is the wound treatment appliance 110 illustrated in
In the embodiment illustrated in
In the embodiment of the second aspect of the first version of the invention illustrated in
In the embodiment illustrated in
The embodiment of the collection system 142 illustrated in
In some embodiments of this second version of the invention, the wound treatment appliance 110 further comprises tissue protection means 175 to protect and strengthen the body tissue 171 that is adjacent to the flexible overlay 120 at the wound site 161. The tissue protection means 175 protects the tissue 171 by preventing abrasion and maceration of the tissue. Preferably, the tissue protection means 175 is a hydrocolloid material, such as COLOPAST Hydrocolloid 2655, anhydrous lanoline, or any combination of such hydrocolloid materials. More preferably, the tissue protection means 175 is COLOPAST Hydrocolloid 2655. The tissue protection means 175 may be applied to the body tissue 171 to be protected, or it may be applied to the surface of the flexible overlay 120 that is to be in contact with the body tissue 171, or both, prior to placing the flexible overlay 120 on the surface of the body 170 at the wound site 161. It is to be noted that application of the tissue protection means 175 to the body tissue 171 that is adjacent to the flexible overlay 120 at the wound site 161 may only entail application of the tissue protection means 175 to the portion of the body tissue 171 adjacent to the flexible overlay 120 that requires such protection.
An embodiment of a third aspect of the first version of the invention is the wound treatment appliance 210 illustrated in
In the embodiment of the third aspect of the first version of the invention illustrated in
In the embodiment of the third aspect of the first version of the invention illustrated in
In some embodiments of this first version of the invention, as illustrated in
In the embodiment of this third aspect of the first version of the invention illustrated in
In the embodiment of the first version of the invention illustrated in
In some embodiments of these third and forth aspects of the first version of the invention illustrated in
The suction bulb 281 may be constructed of almost any fluid impermeable flexible or semi-rigid material that is suitable for medical use and that can be readily deformed by application of pressure to the outside surface of the suction bulb 281 by users of the appliance 210 and still return to its original shape upon release of the pressure. For example, the suction bulb 281 may be constructed of rubber, neoprene, silicone, or other flexible or semi-rigid polymers, or any combination of all such materials. In addition, the suction bulb 281 may be of almost any shape, such as cubical, ellipsoidal, or polygonal. The suction bulb 281 may also be of varying size depending upon the anticipated use of the suction bulb 281, the size of the wound treatment device 215, use of a supplemental vacuum system 250a, the level of reduced pressure desired, and the preference of the user of the appliance 210. In the embodiment of the invention illustrated in
Except as described below, the wound treatment appliance 210 described above and illustrated in connection with
Another embodiment of the first version of the invention is the wound treatment appliance 310 illustrated in
In the embodiment of the first version of the invention illustrated in
In the embodiment of the first version of the invention illustrated in
An embodiment of a second version of the invention is the wound treatment appliance 410 illustrated in
In the embodiment of the appliance 410 illustrated in
In the various embodiments of this second version of the invention, the collection chamber attachment means operably attaches the collection chamber 490 to the impermeable overlay 420 in a manner so that exudate and reduced pressure are permitted to flow between the collection chamber 490 and the volume under the impermeable overlay 420 in the area of the wound 460. Also, in the various embodiments of the second version of the invention, as illustrated by the appliance 410 in
In some embodiments of this second version of the invention, as illustrated in
The embodiment of the appliance 410 illustrated in
Another embodiment of the second version of the invention is the wound treatment appliance 510 illustrated in
In the embodiment illustrated in
In the embodiment of the appliance 510 illustrated in
In the embodiment of the second version of the invention illustrated in
This application is a divisional of U.S. patent application Ser. No. 11/064,813, filed on Feb. 24, 2005, which claims the benefit of U.S. provisional application No. 60/573,655, filed on May 21, 2004. The full disclosure of these two patent applications is hereby incorporated by reference as if fully set forth herein.
| Number | Name | Date | Kind |
|---|---|---|---|
| 1480562 | Mock | Jan 1924 | A |
| 2280915 | Johnson | Apr 1941 | A |
| 2568933 | Robbins | Sep 1951 | A |
| 2632443 | Lesher | Mar 1953 | A |
| 2682873 | Evans et al. | Jul 1954 | A |
| 3367332 | Groves | Feb 1968 | A |
| 3486504 | Austin et al. | Dec 1969 | A |
| 3572340 | Lloyd et al. | Mar 1971 | A |
| 3610238 | Rich et al. | Oct 1971 | A |
| 3874387 | Barbieri | Apr 1975 | A |
| 3993080 | Loseff | Nov 1976 | A |
| RE29319 | Nordby et al. | Jul 1977 | E |
| 4112947 | Nehring | Sep 1978 | A |
| 4136696 | Nehring | Jan 1979 | A |
| 4184510 | Murry et al. | Jan 1980 | A |
| 4217894 | Franetzki | Aug 1980 | A |
| 4219019 | Coates | Aug 1980 | A |
| 4224945 | Cohen | Sep 1980 | A |
| 4250882 | Adair | Feb 1981 | A |
| 4316466 | Babb | Feb 1982 | A |
| 4382441 | Svedman | May 1983 | A |
| 4465485 | Kashmer et al. | Aug 1984 | A |
| 4468227 | Jensen | Aug 1984 | A |
| 4525166 | Leclerc | Jun 1985 | A |
| 4534356 | Papadakis | Aug 1985 | A |
| 4551141 | McNeil | Nov 1985 | A |
| 4573965 | Russo | Mar 1986 | A |
| 4655766 | Theeuwes et al. | Apr 1987 | A |
| 4710165 | McNeil et al. | Dec 1987 | A |
| 4778446 | Jensen | Oct 1988 | A |
| 4778456 | Lokken | Oct 1988 | A |
| 4792328 | Beck et al. | Dec 1988 | A |
| 4795435 | Steer | Jan 1989 | A |
| 4820284 | Hauri | Apr 1989 | A |
| 4921488 | Maitz et al. | May 1990 | A |
| 4936834 | Beck et al. | Jun 1990 | A |
| 4950483 | Ksander et al. | Aug 1990 | A |
| 4969880 | Zamierowski | Nov 1990 | A |
| 4972829 | Knerr | Nov 1990 | A |
| 4979944 | Luzsicza | Dec 1990 | A |
| 5055198 | Shettigar | Oct 1991 | A |
| 5056510 | Gilman | Oct 1991 | A |
| 5073172 | Fell | Dec 1991 | A |
| 5100396 | Zamierowski | Mar 1992 | A |
| 5149331 | Ferdman et al. | Sep 1992 | A |
| 5152757 | Eriksson | Oct 1992 | A |
| 5167613 | Karami et al. | Dec 1992 | A |
| 5176663 | Svedman et al. | Jan 1993 | A |
| 5261893 | Zamierowski | Nov 1993 | A |
| 5266928 | Johnson | Nov 1993 | A |
| 5279608 | Cherif Cheikh | Jan 1994 | A |
| 5328614 | Matsumura | Jul 1994 | A |
| 5358494 | Svedman | Oct 1994 | A |
| 5380280 | Peterson | Jan 1995 | A |
| 5437651 | Todd et al. | Aug 1995 | A |
| 5445604 | Lang | Aug 1995 | A |
| 5489280 | Russell | Feb 1996 | A |
| 5498338 | Kruger et al. | Mar 1996 | A |
| 5527293 | Zamierowski | Jun 1996 | A |
| 5549584 | Gross | Aug 1996 | A |
| 5636643 | Argenta et al. | Jun 1997 | A |
| 5643189 | Masini | Jul 1997 | A |
| 5645081 | Argenta et al. | Jul 1997 | A |
| 5759570 | Arnold | Jun 1998 | A |
| 5785688 | Joshi et al. | Jul 1998 | A |
| 5830496 | Freeman | Nov 1998 | A |
| 5833646 | Masini | Nov 1998 | A |
| 5857502 | Buchalter | Jan 1999 | A |
| 5868933 | Patrick et al. | Feb 1999 | A |
| 5964723 | Augustine | Oct 1999 | A |
| 6071267 | Zamierowski | Jun 2000 | A |
| 6110197 | Augustine et al. | Aug 2000 | A |
| 6135116 | Vogel et al. | Oct 2000 | A |
| D434150 | Tumey et al. | Nov 2000 | S |
| 6142982 | Hunt et al. | Nov 2000 | A |
| 6168800 | Dobos et al. | Jan 2001 | B1 |
| 6176307 | Danos et al. | Jan 2001 | B1 |
| 6225523 | Masini | May 2001 | B1 |
| 6254567 | Treu et al. | Jul 2001 | B1 |
| 6255552 | Cummings et al. | Jul 2001 | B1 |
| 6287521 | Quay et al. | Sep 2001 | B1 |
| 6345623 | Heaton et al. | Feb 2002 | B1 |
| 6398767 | Fleischmann | Jun 2002 | B1 |
| 6402724 | Smith et al. | Jun 2002 | B1 |
| 6450773 | Upton | Sep 2002 | B1 |
| 6458109 | Henley et al. | Oct 2002 | B1 |
| 6465708 | Augustine | Oct 2002 | B1 |
| 6471685 | Johnson | Oct 2002 | B1 |
| 6471982 | Lydon et al. | Oct 2002 | B1 |
| 6482491 | Samuelsen et al. | Nov 2002 | B1 |
| 6491684 | Joshi et al. | Dec 2002 | B1 |
| 6553998 | Heaton et al. | Apr 2003 | B2 |
| 6599262 | Masini | Jul 2003 | B1 |
| 6648862 | Watson | Nov 2003 | B2 |
| 6673028 | Argenta et al. | Jan 2004 | B1 |
| 6676610 | Morton et al. | Jan 2004 | B2 |
| 6685681 | Lockwood et al. | Feb 2004 | B2 |
| 6695823 | Lina et al. | Feb 2004 | B1 |
| 6695824 | Howard et al. | Feb 2004 | B2 |
| 6752794 | Lockwood et al. | Jun 2004 | B2 |
| 6755807 | Risk, Jr. et al. | Jun 2004 | B2 |
| 6764462 | Risk, Jr. et al. | Jul 2004 | B2 |
| 6767334 | Randolph | Jul 2004 | B1 |
| 6814079 | Heaton et al. | Nov 2004 | B2 |
| 6824533 | Risk, Jr. et al. | Nov 2004 | B2 |
| 6855135 | Lockwood et al. | Feb 2005 | B2 |
| 6856821 | Johnson | Feb 2005 | B2 |
| 6936037 | Bubb et al. | Aug 2005 | B2 |
| 6951553 | Bubb et al. | Oct 2005 | B2 |
| 6977323 | Swenson | Dec 2005 | B1 |
| 6979324 | Bybordi et al. | Dec 2005 | B2 |
| 6994702 | Johnson | Feb 2006 | B1 |
| 7004915 | Boynton et al. | Feb 2006 | B2 |
| 7022113 | Lockwood et al. | Apr 2006 | B2 |
| 7070584 | Johnson et al. | Jul 2006 | B2 |
| 7077832 | Fleischmann | Jul 2006 | B2 |
| 7108683 | Zamierowski | Sep 2006 | B2 |
| 7118545 | Boyde | Oct 2006 | B2 |
| 7128735 | Weston | Oct 2006 | B2 |
| 7195624 | Lockwood | Mar 2007 | B2 |
| 7216651 | Argenta et al. | May 2007 | B2 |
| 7361184 | Joshi | Apr 2008 | B2 |
| 7381859 | Hunt et al. | Jun 2008 | B2 |
| 7438705 | Karpowicz et al. | Oct 2008 | B2 |
| 7494482 | Orgill et al. | Feb 2009 | B2 |
| 7524315 | Blott et al. | Apr 2009 | B2 |
| 7534240 | Johnson | May 2009 | B1 |
| 7534927 | Lockwood | May 2009 | B2 |
| 7569742 | Haggstrom et al. | Aug 2009 | B2 |
| 7611500 | Lina et al. | Nov 2009 | B1 |
| 7615036 | Joshi et al. | Nov 2009 | B2 |
| 7645269 | Zamierowski | Jan 2010 | B2 |
| 7699830 | Martin | Apr 2010 | B2 |
| 7708724 | Weston | May 2010 | B2 |
| 7723560 | Lockwood et al. | May 2010 | B2 |
| 7753894 | Blott et al. | Jul 2010 | B2 |
| 7759537 | Bishop et al. | Jul 2010 | B2 |
| 7759538 | Fleischmann | Jul 2010 | B2 |
| 7759539 | Shaw et al. | Jul 2010 | B2 |
| 7775998 | Riesinger | Aug 2010 | B2 |
| 7776028 | Miller et al. | Aug 2010 | B2 |
| 7779625 | Joshi et al. | Aug 2010 | B2 |
| 7790945 | Watson, Jr. | Sep 2010 | B1 |
| 7794438 | Henley et al. | Sep 2010 | B2 |
| 7815616 | Boehringer et al. | Oct 2010 | B2 |
| 7828782 | Suzuki | Nov 2010 | B2 |
| 7846141 | Weston | Dec 2010 | B2 |
| 7883494 | Martin | Feb 2011 | B2 |
| 7909805 | Weston | Mar 2011 | B2 |
| 7959624 | Riesinger | Jun 2011 | B2 |
| 7964766 | Blott et al. | Jun 2011 | B2 |
| 7976519 | Bubb et al. | Jul 2011 | B2 |
| 7998125 | Weston | Aug 2011 | B2 |
| 8062272 | Weston | Nov 2011 | B2 |
| 8062273 | Weston | Nov 2011 | B2 |
| 8080702 | Blott et al. | Dec 2011 | B2 |
| 8100887 | Weston | Jan 2012 | B2 |
| 8118794 | Weston | Feb 2012 | B2 |
| 8128615 | Blott | Mar 2012 | B2 |
| 8152785 | Vitaris | Apr 2012 | B2 |
| 20010029956 | Argenta et al. | Oct 2001 | A1 |
| 20010034499 | Sessions et al. | Oct 2001 | A1 |
| 20020065494 | Lockwood et al. | May 2002 | A1 |
| 20020068913 | Fleischmann | Jun 2002 | A1 |
| 20020115952 | Johnson et al. | Aug 2002 | A1 |
| 20020120185 | Johnson | Aug 2002 | A1 |
| 20020143286 | Turney | Oct 2002 | A1 |
| 20020150720 | Howard et al. | Oct 2002 | A1 |
| 20020161346 | Lockwood et al. | Oct 2002 | A1 |
| 20020183702 | Henley et al. | Dec 2002 | A1 |
| 20020198503 | Risk et al. | Dec 2002 | A1 |
| 20020198504 | Risk et al. | Dec 2002 | A1 |
| 20030014022 | Lockwood et al. | Jan 2003 | A1 |
| 20030014025 | Allen et al. | Jan 2003 | A1 |
| 20030021775 | Freeman | Jan 2003 | A1 |
| 20030040687 | Boynton et al. | Feb 2003 | A1 |
| 20030050594 | Zamierowski | Mar 2003 | A1 |
| 20030088202 | Gilman | May 2003 | A1 |
| 20030108587 | Orgill et al. | Jun 2003 | A1 |
| 20030144619 | Augustine | Jul 2003 | A1 |
| 20030171675 | Rosenberg | Sep 2003 | A1 |
| 20030175798 | Raees et al. | Sep 2003 | A1 |
| 20030212357 | Pace | Nov 2003 | A1 |
| 20030212431 | Brady et al. | Nov 2003 | A1 |
| 20030225347 | Argenta et al. | Dec 2003 | A1 |
| 20040019342 | Nagasuna et al. | Jan 2004 | A1 |
| 20040030304 | Hunt et al. | Feb 2004 | A1 |
| 20040039391 | Argenta et al. | Feb 2004 | A1 |
| 20040054338 | Bybordi et al. | Mar 2004 | A1 |
| 20040064132 | Boehringer et al. | Apr 2004 | A1 |
| 20040073151 | Weston | Apr 2004 | A1 |
| 20040122434 | Argenta et al. | Jun 2004 | A1 |
| 20040127834 | Sigurjonsson et al. | Jul 2004 | A1 |
| 20040127863 | Bubb et al. | Jul 2004 | A1 |
| 20040225208 | Johnson | Nov 2004 | A1 |
| 20040241214 | Kirkwood et al. | Dec 2004 | A1 |
| 20050004534 | Lockwood et al. | Jan 2005 | A1 |
| 20050010153 | Lockwood et al. | Jan 2005 | A1 |
| 20050028828 | Heaton et al. | Feb 2005 | A1 |
| 20050070835 | Joshi | Mar 2005 | A1 |
| 20050080372 | Nielsen et al. | Apr 2005 | A1 |
| 20050148913 | Weston | Jul 2005 | A1 |
| 20050203452 | Weston et al. | Sep 2005 | A1 |
| 20050222527 | Miller et al. | Oct 2005 | A1 |
| 20050222528 | Weston | Oct 2005 | A1 |
| 20050261615 | Weston | Nov 2005 | A1 |
| 20050261642 | Weston | Nov 2005 | A1 |
| 20050261643 | Bybordi et al. | Nov 2005 | A1 |
| 20060015087 | Risk, Jr. et al. | Jan 2006 | A1 |
| 20060025727 | Boehringer et al. | Feb 2006 | A1 |
| 20060029650 | Coffey | Feb 2006 | A1 |
| 20060041247 | Petrosenko et al. | Feb 2006 | A1 |
| 20060100594 | Adams et al. | May 2006 | A1 |
| 20060116620 | Oyaski | Jun 2006 | A1 |
| 20060155260 | Blott et al. | Jul 2006 | A1 |
| 20070038172 | Zamierowski | Feb 2007 | A1 |
| 20070066945 | Martin | Mar 2007 | A1 |
| 20070129707 | Blott et al. | Jun 2007 | A1 |
| 20070141128 | Blott et al. | Jun 2007 | A1 |
| 20070265585 | Joshi et al. | Nov 2007 | A1 |
| 20070265586 | Joshi et al. | Nov 2007 | A1 |
| 20070293830 | Martin | Dec 2007 | A1 |
| 20080082059 | Fink et al. | Apr 2008 | A1 |
| 20080167593 | Fleischmann | Jul 2008 | A1 |
| 20080183119 | Joshi | Jul 2008 | A1 |
| 20080188820 | Joshi | Aug 2008 | A1 |
| 20080223378 | Henderson et al. | Sep 2008 | A1 |
| 20090012483 | Blott et al. | Jan 2009 | A1 |
| 20090054855 | Blott et al. | Feb 2009 | A1 |
| 20090069759 | Blott et al. | Mar 2009 | A1 |
| 20090131888 | Joshi | May 2009 | A1 |
| 20090192499 | Weston et al. | Jul 2009 | A1 |
| 20090204084 | Blott et al. | Aug 2009 | A1 |
| 20090216170 | Robinson et al. | Aug 2009 | A1 |
| 20090221977 | Blott et al. | Sep 2009 | A1 |
| 20090227969 | Jaeb et al. | Sep 2009 | A1 |
| 20090234309 | Vitaris et al. | Sep 2009 | A1 |
| 20090240185 | Jaeb et al. | Sep 2009 | A1 |
| 20090254054 | Blott et al. | Oct 2009 | A1 |
| 20090299251 | Buan | Dec 2009 | A1 |
| 20090299255 | Kazala, Jr. et al. | Dec 2009 | A1 |
| 20090299256 | Barta et al. | Dec 2009 | A1 |
| 20090299257 | Long et al. | Dec 2009 | A1 |
| 20090299306 | Buan | Dec 2009 | A1 |
| 20090299307 | Barta et al. | Dec 2009 | A1 |
| 20090299341 | Kazala, Jr. et al. | Dec 2009 | A1 |
| 20090299342 | Cavanaugh, II et al. | Dec 2009 | A1 |
| 20090306580 | Blott et al. | Dec 2009 | A1 |
| 20090306609 | Blott et al. | Dec 2009 | A1 |
| 20090312723 | Blott et al. | Dec 2009 | A1 |
| 20090312728 | Randolph et al. | Dec 2009 | A1 |
| 20100036367 | Krohn | Feb 2010 | A1 |
| 20100069858 | Olson | Mar 2010 | A1 |
| 20100069863 | Olson | Mar 2010 | A1 |
| 20100100063 | Joshi et al. | Apr 2010 | A1 |
| 20100106114 | Weston et al. | Apr 2010 | A1 |
| 20100121286 | Locke et al. | May 2010 | A1 |
| 20100122417 | Vrzalik et al. | May 2010 | A1 |
| 20100125258 | Coulthard et al. | May 2010 | A1 |
| 20100160879 | Weston | Jun 2010 | A1 |
| 20100174251 | Weston | Jul 2010 | A1 |
| 20100249733 | Blott et al. | Sep 2010 | A9 |
| 20100268198 | Buan et al. | Oct 2010 | A1 |
| 20100286635 | Watson, Jr. | Nov 2010 | A1 |
| 20100298793 | Blott et al. | Nov 2010 | A1 |
| 20100305490 | Coulthard et al. | Dec 2010 | A1 |
| 20100324510 | Andresen et al. | Dec 2010 | A1 |
| 20100331797 | Patel et al. | Dec 2010 | A1 |
| 20110004172 | Eckstein et al. | Jan 2011 | A1 |
| 20110009835 | Blott | Jan 2011 | A1 |
| 20110009838 | Greener | Jan 2011 | A1 |
| 20110028918 | Hartwell | Feb 2011 | A1 |
| 20110034892 | Buan | Feb 2011 | A1 |
| 20110046584 | Haggstrom et al. | Feb 2011 | A1 |
| 20110046585 | Weston | Feb 2011 | A1 |
| 20110054421 | Hartwell | Mar 2011 | A1 |
| 20110054422 | Locke et al. | Mar 2011 | A1 |
| 20110054423 | Blott et al. | Mar 2011 | A1 |
| 20110087176 | Blott | Apr 2011 | A2 |
| 20110092927 | Wilkes et al. | Apr 2011 | A1 |
| 20110105963 | Hu et al. | May 2011 | A1 |
| 20110106030 | Scholz | May 2011 | A1 |
| 20110112492 | Bharti et al. | May 2011 | A1 |
| 20110172615 | Greener | Jul 2011 | A2 |
| 20110230849 | Coulthard et al. | Sep 2011 | A1 |
| 20110251567 | Blott et al. | Oct 2011 | A1 |
| 20110282309 | Adie et al. | Nov 2011 | A1 |
| 20120041399 | Blott et al. | Feb 2012 | A1 |
| Number | Date | Country |
|---|---|---|
| 2198243 | Feb 1996 | CA |
| 2367460 | Oct 2000 | CA |
| 2390513 | May 2001 | CA |
| 2121688 | Jul 2001 | CA |
| 2408305 | Nov 2001 | CA |
| 2458285 | Mar 2003 | CA |
| 2157772 | Sep 2003 | CA |
| 3935818 | May 1991 | DE |
| 40 12 232 | Oct 1991 | DE |
| 198 44 355 | Apr 2000 | DE |
| 20 2005 019 670 | Jun 2006 | DE |
| 0020662 | Jul 1984 | EP |
| 0355186 | Feb 1990 | EP |
| 0777504 | Oct 1998 | EP |
| 0782421 | Jul 1999 | EP |
| 0708620 | May 2003 | EP |
| 1088569 | Aug 2003 | EP |
| 1440667 | Mar 2006 | EP |
| 1284777 | Apr 2006 | EP |
| 1171065 | Mar 2007 | EP |
| 1476217 | Mar 2008 | EP |
| 1121163 | Nov 2008 | EP |
| 2 098 257 | Sep 2009 | EP |
| 1 163 907 | Oct 1958 | FR |
| 114754 | Apr 1918 | GB |
| 641061 | Aug 1950 | GB |
| 1 224 009 | Mar 1971 | GB |
| 1549756 | Aug 1979 | GB |
| 2195255 | Apr 1988 | GB |
| 2378392 | Feb 2003 | GB |
| 2003-165843 | Jun 2003 | JP |
| 1251912 | Aug 1986 | SU |
| WO 8401904 | May 1984 | WO |
| WO 9011795 | Oct 1990 | WO |
| WO 9100718 | Jan 1991 | WO |
| WO 9220299 | Nov 1992 | WO |
| WO 9605873 | Feb 1996 | WO |
| WO 9901173 | Jan 1999 | WO |
| WO 0007653 | Feb 2000 | WO |
| WO 0050143 | Aug 2000 | WO |
| WO 0059424 | Oct 2000 | WO |
| WO 0119430 | Mar 2001 | WO |
| WO 0134223 | May 2001 | WO |
| WO 0185248 | Nov 2001 | WO |
| WO 0193793 | Dec 2001 | WO |
| WO 02083046 | Oct 2002 | WO |
| WO 02092783 | Nov 2002 | WO |
| WO 03092620 | Nov 2003 | WO |
| WO 2004024300 | Mar 2004 | WO |
| WO 2004037334 | May 2004 | WO |
| WO 2005025666 | Mar 2005 | WO |
| WO 2005051461 | Jun 2005 | WO |
| WO 2005070480 | Aug 2005 | WO |
| WO 2005082435 | Sep 2005 | WO |
| Entry |
|---|
| Webster's Revised Unabridged Dictionary, published 1913 by C. & G. Merriam Co. |
| U.S. Appl. No. 11/064,813, filed Feb. 24, 2005, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. No. 12/719,715, filed Mar. 9, 2010 including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. No. 12/726,161, filed Mar. 17, 2010 including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. No. 12/848,817, filed Aug. 2, 2010 and its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. No. 12/744,055, filed May 20, 2010, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. No. 12/744,277, filed Sep. 20, 2010, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. 12/938,291, filed Nov. 2, 2010, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents). |
| U.S. Appl. No. 12/940,788, filed Nov. 5, 2010 and its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. No. 12/744,218, filed Sep. 20, 2010, including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially relevant documents. |
| U.S. Appl. No. 60/559,727, filed Apr. 5, 2004, Weston. |
| U.S. Appl. No. 60/573,655, filed May 21, 2004, Weston. |
| U.S. Appl. No. 12/941,390, filed Nov. 8, 2010, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents), Weston. |
| Achterberg et al., “Hydroactive dressings and serum proteins: an in vitro study,” Journal of Wound Care, vol. 5, No. 2, Feb. 1996. |
| Argenta, Louis C., et al., “Vacuum-Assisted Closure: A New Method for Wound Control and Treatment; Clinical Experience”, Ann Plas Surg 1997;38:563-577 (Dec. 10, 1996). |
| Aubrey, D.A., et al., Treatment of the Perineal Wound after Proctectomy by Intermittent Irrigation, Arch. Surg., Oct. 1984, 119, pp. 1141-1144. |
| Bagautdinov, N.A. “Variant of External Vacuum Aspiration in the Treatment of Purulent Diseases of Soft Tissues,” in Current Problems in Modern Clinical Surgery: Interdepartmental Collection, edited by V.Ye. Volkov et al. (Chuvashia State University, Cheboksary, USSR 1986) pp. 94-96. |
| Biblehimer, Helen L., “Dealing With a Wound that Drains 1.5 Liters a Day,” RN, Aug. 1986, pp. 21-23, USA. |
| Bier, A., Hyperemia as a Therapeutic Agent, Ed. Dr. Gustavus M. Blech, A. Robertson & Co., Chicago 1905, pp. 74-85. |
| Brubacher, “To Heal a Draining Wound”, RN Mar. 1982, 7 pages. |
| Bucalo et al. “Inhibition of Cell Proliferation by Chronic Wound Fluid.” Wound Repair and Regeneration, Miami, 1993, pp. 181-186. |
| Chariker, M.E., et al, Effective Management of Incisional and Cutaneous Fistulae with Closed Suction Wound Drainage, Contemporary Surgery. Jun. 1989, vol. 34 USA, pp. 59-63. |
| Chintamani, et al., “Half versus full vacuum suction drainage after modified radical mastectomy for breast cancer—a prospective randomized clinical trial”, Research Article (Jan. 27, 2005), 1-5. |
| Costunchenok, BM, Effect of Vacuum on Surgical Purulent Wounds, Vestnik Chirurgia, 1986, 6 pages. |
| Davydov et al. “Pathogenic Mechanism of the Effect of Vacuum Therapy on the Course of the Wound Process” pp. 43-46 (Dec. 1990). |
| Davydov, Yu A., et al., “Concepts for Clinical Biological Management of the Wound Process in the Treatment of Purulent Wounds Using Vacuum Therapy”, The Kremlin Papers: Perspectives in Wound Care, Russian Journal: Vestnik Khirurgii, BlueSky Publishing, La Costa, California (2004), 15-17. |
| Davydov, Yu A., et al., “The Bacteriological and Cytological Assessment of Vacuum Therapy of Purulent Wounds”, The Kremlin Papers: Perspectives in Wound Care, Russian Journal: Vestnik Khirurgii, BlueSky Publishing, La Costa, California (2004), 11-14. |
| Davydov, Yu A., et al., “Vacuum Therapy in the Treatment of Purulent Lactation Mastitis”, The Kremlin Papers: Perspectives in Wound Care, Russian Journal: Vestnik Khirurgii, BlueSky Publishing, La Costa, California (2004), 5-7. |
| De Lange, M.Y. , et al., “Vacuum-Assisted Closure: Indications and Clinical Experience”, Eur J Plast Surg (2000) 2;178-182 (Feb. 9, 2000). |
| Dilmaghani et al., A Method for Closed Irrigation and Suction Therapy in Deep Wound Infections, Journal of Bone and Joint Surgery, 1969, vol. 51-A, No. 2, pp. 323-342. |
| Fleischmann, Vacuum sealing: indication, technique, and results, European Journal of Orthopaedic Surgery & Traumatology (1995), pp. 37-40. |
| Fleischmann, W. Wund Forum Spezial. IHW '94. “Vakuumversiegelung zur Behandlung von Problemwuden” (with English translation: Vacuum Sealing for Treatment of Problematical Wounds). |
| Garcia-Rinaldi, R., et al., Improving the Efficiency of Wound Drainage Catheters, Amer. Journ. of Surg., Sep. 1975, pp. 130, 372-373. |
| Hartz, R.S., et al., Healing of the Perineal Wound, Arch. Surg., Apr. 1980, 115, pp. 471-474. |
| Health Technology, Literature R., “Vacuum Assisted Closure Therapy for Wound Care”, Health Technology Literature Review (Dec. 2004), 3-59. |
| International Preliminary Report on Patentability of International Application No. PCT/US05/17225 consisting of 6 pages, Jul. 31, 2006. |
| International Search Report of International Application No. PCT/NL2004/000565 consisting of 5 pages, Jul. 29, 2005. |
| International Search Report of International Application No. PCT/GB2000/01566 consisting of 2 pages, Sep. 25, 2000. |
| International Search Report of International Application No. PCT/GB2000/04278 consisting of 2 pages, Feb. 22, 2001. |
| International Search Report of International Application No. PCT/US05/17225 consisting of 1 page, Oct. 4, 2005. |
| International Search Report of International Application No. PCT/US2007/011278 consisting of 6 pages, May 11, 2006. |
| Jeter, K.F., et al, “Managing Draining Wounds and Fistulae: New and Established Methods”, Chronic Wound Care, pp. 240-246. |
| Johnson, F.E., An Improved Technique for Skin Graft Placement using a Suction Drain, Surgery, Gynecology and Obstetrics, Dec. 1984, 3 pages. |
| KCI Inc., If It's Not VAC Therapy, It's Not Negative Pressure Wound Therapy, Jan. 2005. |
| Khirugii, Vestnik, “A Collection of Published Studies Complementing the Research and Innovation of Wound Care”,The Kremlin Papers, Perspectives in Wound Care, Russian Medical Journal, Vestnik Khirugii, Blue Sky Publishing (2004), 2-17. |
| Kostiuchenok, B. M., et al., “The Vacuum Effect in the Surgical Treatment of Purulent Wounds”, The Kremlin Papers: Perspectives in Wound Care, Russian Journal: Vestnik Khirurgii, BlueSky Publishing, La Costa, California (2004), 3-4. |
| Kremlin Papers, A Collection of Published Studies Complementing the Research and Innovation of Wound Care, from Vestnik Khirurgii, BlueSky Publishing, A Div. of BlueSky Medical Group Inc., 2004. |
| Landes, R.R. and I. Melnick, An Improved Suction Device for Draining Wounds, Arch. Surg., May 1972, 104, p. 707. |
| Linden, Willem van der, et al, “Randomized Trial of Drainage After Cholecystectomy: Suction Versus Static Drainage Through a Main Wound Versus a Stab Incision”, American Journal of Surgery, Feb. 1981, vol. 141, pp. 289-294. |
| Mcfarlane, R.M., The Use of Continuous Suction under Skin Flaps, Br. Journ. Plast. Surg., pp. 77-86. |
| Mclaughlan, J, et al, “Sterile Microenvironment for Postoperative Wound Care”, The Lancet, Sep. 2, 1978, pp. 503-504. |
| Meyer, W. and V. Schmeiden, Bier's Hyperemic Treatment, Published 1908 W. B. Saunders Company, pp. 44-65. |
| Morykwas, Michael J., et al., “Vacuum-Assisted Closure: A New Method for Wound Control and Treatment: Animal Studies and Basic Foundation”, Ann Plast Surg 1997;38:553-562 (Dec. 10, 1996). |
| Nakayama, Y, et al, “A New Method for the Dressing of Free Skin Grafts”, Plastic and Reconstructive Surgery, Dec. 1990 pp. 1216-1219, UK. |
| PCT International Search Report of PCT/US2007/011321, International Filing Date May 10, 2007. |
| Ramirez, O.M., et al., Optimal Wound Healing under Op-Site Dressing, Ideas and Innovations, 73(3), pp. 474-475. |
| Ranson, J. H. C., et al, “Safer Intraperitoneal Sump Drainage”, Surgery, Gynecology & Obstetrics, Nov. 1973, vol. 137, pp. 841-842. |
| Sames, C.P., Sealing of Wounds with Vacuum Drainage, Br. Med. Journ., Nov. 5, 1977, p. 1223, Correspondence. |
| Solovev et al., “The Method of Treatment of Immature External Fistulas in the Upper Gastrointestinal Tract,” USSR Ministry of Health, S.M. Kirov Gorky State Medical Institute, 1987. |
| Stewart, Joanne, “Next generation products for wound management,” http://www.worldwidewounds.com/2003/april/Stewart/Next-Generation-Products.html, Nov. 2002. |
| Svedman, P., A Dressing Allowing Continuous Treatment of a Biosurface, IRCS Med. Science: Biomed. Tech.; Clinic. Med.; Surg. and Transplantation, 1979, 7, p. 221. |
| Svedman, P., et al., A Dressing System Providing Fluid Supply and Suction Drainage Used for Continuous or Intermittent irrigation, Annals of Plastic Surgery, vol. 17, No. 2, Aug. 1986, pp. 125-133. |
| Svedman, P., Irrigation Treatment in Split-Thickness Skin Grafting of Intractable Leg Ulcers, Scand J. Plast. Reconst. Surg., 1985, 19, pp. 211-213. |
| Svedman, P., Irrigation Treatment of Leg Ulcers, The Lancet, Sep. 1983, pp. 532-534. |
| Swift, et al, Quorum Sensing in Aeromonas hydrophila and Aeromonas salmoncida: Identification of LuxRI Homologs AhyRI and AsaRI and Their Cognate N-Acylhomoserine Lactone Signal Molecules, J. Bacteriol., 1997, 179(17):5271-5281. |
| Teder and Svedman et al., Continuous Wound Irrigation in the Pig, Journal of Investigative Surgery, 1990, vol. 3, pp. 399-407. |
| Tribble, David E. M.D., An Improved Sump Drain-Irrigation Device of Simple Construction, Archives of Surgery New York, 1972, vol. 105, pp. 511-513. |
| Usypov, Y. N., et al., “Active Wound Drainage”, The Kremlin Papers: Perspectives in Wound Care, Russian Journal: Vestnik Khirurgii, BlueSky Publishing, La Costa, California (2004), 8-10. |
| Venturi, Mark L., “Mechanisms and Clinical Applications of the Vacuum-Assisted Closure (VAC) Device”, Am J Clin Dermatol (2005) 693, 185-194; Review Article (2005),185-194. |
| Vijanto, J. and J. Raekallio, Local Hyperalimentation of Open Wounds, Br. J. surg., 1976, 63, pp. 427-430. |
| Westaby, S., et al., A Wound Irrigation Device, The Lancet, Sep. 2, 1978, pp. 503-504. |
| Wooding-Scott, Margaret, et al., No Wound is Too Big for Resourceful Nurses, RN, USA, Dec. 1988, pp. 22-25. |
| Written Opinion of the International Search Report of PCT/US2007/011278 consisting of 7 pages, Dec. 11, 2007. |
| Written Opinion of the International Searching Authority of PCT International Search Report of PCT/US2007/011321, International Filing Date May 10, 2007. |
| Wu, W.S., et al. Vacuum therapy as an intermediate phase in would closure: a clinical experience, Eur J Plast Surg (2000) 23: pp. 174-177. |
| U.S. Appl. No. 10/599,720, filed Oct. 6, 2006, Blott et al. |
| U.S. Appl. No. 12/192,000, filed Aug. 14, 2008, Hartwell et al. |
| U.S. Appl. No. 12/719,715, filed Mar. 8, 2010, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents, Weston. |
| U.S. Appl. No. 12/832,031, filed Jul. 7, 2010, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents, Weston. |
| U.S. Appl. No. 13/217,074, filed Aug. 24, 2011, including its ongoing prosecution history, including without limitation Office Actions, Amendments, Remarks, and any other potentially relevant documents, Blott et al. |
| U.S. Appl. No. 13/287,897, filed Nov. 2, 2011, Adie et al. |
| U.S. Appl. No. 13/287,959, filed Nov. 2, 2011, Allen et al. |
| U.S. Appl. No. 13/302,175, filed Nov. 22, 2011, including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents, Weston. |
| U.S. Appl. No. 13/302,980, filed Nov. 22, 2011, including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents, Blott et al. |
| U.S. Appl. No. 12/419,542, filed Apr. 7, 2009, including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents. |
| U.S. Appl. No. 12/832,032, filed Jul. 7, 2010, and its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents. |
| U.S. Appl. No. 12/416,829, filed Apr. 1, 2009, including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents. |
| U.S. Appl. No. 12/744,055, filed May 20, 2010, and its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents. |
| U.S. Appl. No. 12/981,337, filed Dec. 29, 2010, including its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents. |
| U.S. Appl. No. 13/092,042, filed Apr. 21, 2011, including its ongoing prosecution history, including without limitation Office Actions, Amendments (including Preliminary Communication filed Nov. 8, 2010), Remarks, and any other potentially, relevant documents. |
| U.S. Appl. No. 13/212,039, filed Aug. 17, 2011, and its ongoing prosecution history, including without limitation, Office Actions, Amendments, Remarks, and any other potentially, relevant documents. |
| Solovev, V.A. “Treatment and Prevention of Suture Failures after Gastric Resection” (Dissertation Abstract) (S.M. Kirov Gorky State Medical Institute, Gorky USSR 1988). |
| Webb, New Techniques in Wound Management: Vacuum-Assisted Wound Closure, Journal of the American Academy of Orthopaedic Surgeons, v. 10, No. 5, pp. 303-311, Sep. 2002. |
| U.S. Appl. No. 13/302,175, filed Nov. 22, 2011, Reduced Pressure Treatment System. |
| U.S. Appl. No. 12/419,542, filed Apr. 7, 2009, Enclosure-Based Reduced Pressure Treatment System. |
| U.S. Appl. No. 12/719,715, filed Mar. 8, 2010, Reduced Pressure Wound Treatment System. |
| U.S. Appl. No. 12/832,031, filed Jul. 7, 2010, Flexible Reduced Pressure Treatment Appliance. |
| U.S. Appl. No. 12/416,829, filed Apr. 1, 2009, Apparatus for Aspirating, Irrigating and Cleansing Wounds. |
| U.S. Appl. No. 12/981,337, filed Dec. 29, 2010, Apparatus for Aspirating, Irrigating and Cleansing Wounds. |
| U.S. Appl. No. 12/832,032, filed Jul. 7, 2010, Wound Cleansing Apparatus With Heat. |
| U.S. Appl. No. 13/212,039, filed Aug. 17, 2011, Wound Cleansing Apparatus In-Situ. |
| U.S. Appl. No. 13/217,074, filed Aug. 24, 2011, Wound Cleansing Apparatus In-Situ. |
| U.S. Appl. No. 13/302,980, filed Nov. 22, 2011, Wound Cleansing Apparatus In-Situ. |
| U.S. Appl. No. 12/744,055, filed May 20, 2010, Vacuum Assisted Wound Dressing. |
| U.S. Appl. No. 13/092,042, filed Nov. 17, 2011, Wound Dressing and Method of Use. |
| Number | Date | Country | |
|---|---|---|---|
| 20100160880 A1 | Jun 2010 | US | |
| 20110087178 A2 | Apr 2011 | US |
| Number | Date | Country | |
|---|---|---|---|
| 60573655 | May 2004 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 11064813 | Feb 2005 | US |
| Child | 12719767 | US |
