Other objects and many of the attendant advantages of embodiments of the present invention will be readily appreciated and become better understood by reference to the following more detailed description of embodiments in connection with the accompanied drawing(s). Features that are substantially or functionally equal or similar will be referred to by the same reference sign(s).
The controlled condition 13 is influenced or rather dependent on a flow rate 15 of a fluidic system 17. The fluidic system 17 is also coupled to the controlled system 9 or rather to the sensor 11 of the controlled system 9. The flow rate 15 of the fluidic system 17 is a disturbance variable 19 of the controlled system 9.
The controlled condition 13 of the controlled system 9 can be, for example, the system pressure at an outlet of the fluidic system 17. The controlled condition 13 can be any other characteristic value of the flow rate 15 of the fluidic system 17, for example, the level within a container coupled to the outlet of the fluidic system 17.
The control element 7 can comprise a volumetric displacement flow meter or rather negative-displacement flow meter, for example, a piston type flow meter, wherein the control unit 5 actively controls a sucking rate 21 of the displacement flow meter. Advantageously, under the premise of a constant controlled condition 13, the amount of the actively controlled sucking rate 21 of the control element 7 of the flow meter 1 is substantially equal to the amount of the disturbance value 19 representing the flow rate 15 of the fluidic system 17.
The control unit 5 calculates a control value 23 that controls the control element 7, wherein the sucking rate 21 depends on the control value 23 according to the transfer characteristic of the control element 7. Thus, the controlled condition 13 as measured by the sensor 11 and/or a calculated control value 23 for controlling the control element 7 of the control unit 5 can be used for determining the sucking rate 21 and consequently the flow rate 15 of the fluidic system 17.
For receiving the flow rate 15, the flow meter 1 can comprise a data interface 25 as symbolized with two arrows 27. The data interface 25 can be coupled to a storage device 28, for example, adapted for storing a series of measurements, for example, for a certain period of time.
The level of the controlled condition can be selected by changing a set point 29 of the control unit 5 of the closed-loop control system 3.
The Y-junction valve 35 can be adapted for branching off, for example by multiplexing and/or branching off a continuous flow, a variable percentage of a flow of the flow source 45. Thus, not the complete flow delivered by the flow source has to be sucked into the metering device for determining the flow rate of the flow source 45. Due to the known percentage branched off, the flow rate of the flow source can be calculated. Such known percentage can achieved by time slices (pulse width modulation). Advantageously, the metering device can be designed for a lower sucking rate. In other embodiments, the multiplexer can comprise a plurality of inlets and/or a plurality of outlets, for example for coupling a plurality of flow sources 45 to a plurality of flow meters 1. For example, one flow source can be measured and/or checked after the other. Furthermore, the multiplexer can be used for coupling the flow source 45 to any other downstream device, for example, to a mass spectrograph. Advantageously, a quick performance check can be executed at a point of time when the mass spectrograph has not to be fed by the flow source. Thereafter, the mass spectrograph can be coupled to the flow source again.
The fluidic system 17 can be adapted for analyzing a fluid containing a fluidic sample, for example, with a high performance liquid chromatography process. For this purpose, the fluidic system 17 can comprise a chromatographic column 40 and a detection area 41. The chromatographic column 40 can be coupled to and arranged downstream of a flow source 45, for example to a high-pressure pump, via a third conduit 43. The flow source 45 can comprise a high-pressure meter pump system, for example, comprising one or more pistons, and/or comprising a combination of a master and a slave pump. Due to the high pressure needed for the chromatographic column 40, undesired side effects can occur in the flow source 45. This can lead to an undesired inaccurate flow rate 15 of the flow source 45. An inaccurate flow rate 15 can reduce the quality of the analysis executed with the fluidic system 17. Advantageously, such side effects can be minimized by calibrating the flow source 45, for example, over a gradient of two fluids delivered by the flow source 45. For this purpose, the flow accuracy of the flow rate 15 of the flow source 45 can be measured by the flow meter 1.
For measuring the flow rate 15 of the flow source 45, the flow meter 1 comprises a two-piston metering device 47 coupled to and arranged downstream of the pressure sensor 31 via a fourth conduit 49, a rotary valve 51 and a fifth and sixth conduit 53 and 55.
The rotary valve 51 comprises four ports 57, wherein two of each are coupled by two channels 59. The rotary valve 51 couples the fourth conduit 49 alternatively to a first pumping chamber 61 via the fifth conduit 53 and to a second pumping chamber 63 via the sixth conduit 55. Besides this, each of the pumping chambers 61 and 63 are coupled alternatively to a waste 65 via a seventh conduit 67.
Consequently, one of the pumping chambers 61 and 63 is coupled to the fluidic system 17 and the other one of the pumping chambers 61 and 63 is coupled to the waste 65. In
The rotary valve 51 is set by an actuator 71 controlled by a control unit 5 of the closed-loop control system 3 of the flow meter 1.
The pumping chambers 61 and 63 are component parts of the metering device 47 of the flow meter 1. The metering device 47 is realized as a two-piston metering device. The metering device 47 comprises a first piston 75 and a second piston 77 each actuated by a screw link actuator 79. The screw link actuators 79 of the metering device 73 are each coupled to one gear 81. The gears 81 mesh with each other, thus the screw link actuators 79 of the pistons 75 and 77 can be rotated oppositely. Consequently, the pistons 75 and 77 can be actuated opposite in direction as indicated with two double arrows 83, for example, in a blockwise, rectangular motion sequence.
One of the gears 81 of the screw link actuators 79 meshes with a drive gear 85 coupled to a servo drive 87 of the metering device 73. The servo drive 87 of the metering device can comprise, for example, an electro motor controlled by the control unit 5. In other words, the control unit 5 can control the motion sequence of the pistons 75 and 77 of the metering device 73. For this purpose, the control unit 5 can calculate the motion sequence of the pistons 75 and 77 as a control value 23 of the control unit 5 of the closed-loop control system 3 of the flow meter 1.
Besides this, the control value 3 can comprise the position of the servo drive 87, the velocity of the servo drive 87, the positions of the pistons 75 and 77, and/or the velocity of the piston 75 and 77. Besides this, the flow meter 1 or rather the piston 75 and 77 of the flow meter 1 can comprise a negative force feedback with a force sensor, wherein any force exerted to the pistons exceeding a limit value effects a movement of the pistons reducing said force. For example, the force exerted to the pistons 75 and 77 can be a control value of the control unit 5. The force exerted on the pistons 75 and/or 77 is a characteristic value of the pressure within the fifth and sixth conduit 53 and 55 coupled to the pumping chambers 61 and 63. Advantageously, thus the pressure sensor can be integrated in the metering device 47 and/or in the servo drive 87 of the metering device 47. For example, the current flow rate can be determined by interpreting the actual position of the servo drive 87, for example, by the control unit 5.
The pistons 75 and 77 protrude into the pumping chambers 61 and 63 and displace the volume of the pumping chambers 61 and 63.
The pressure sensor 31 is coupled to the control unit 5 and measures a controlled condition 13, the system pressure of the fluidic system 17 between the chromatographic column 9 and the metering device 47.
Thus, the second and the third conduits 37 and 49, and the pressure sensor 31 realize a—pressure—controlled system 9. For adjusting the controlled condition 13—the pressure—the control unit 5 controls the servo drive 87, the rotary valve 51 via the actuator 71, and the Y-junction valve 35. For receiving the flow rate 15 of the flow source 45, the flow meter 1 or rather the control unit 5 of the flow meter 1 comprises a data interface 25 as indicated in
Advantageously, the graph 101 of
The actuator 71 of the rotary valve 51 can comprise an incremental encoder. The pressure sensor 31 can be realized as a high-pressure sensor. The pressure control routines of the control unit 5 tune the flow value (as a negative flow) or rather the sucking rate 21 of the metering device 47 of the flow meter 1. The flow value can be recorded, for example, by the mass storage device 28, wherein a data trace, for example the graph 101 of
Advantageously, the flow meter 1 can be used as a diagnostic feature to catch any undesired leakage flow of the fluidic system 17. The calibration routines, for example, based on the graph 101 as show in
Advantageously, a pressure control valve is not necessary because the control unit 5 can adjust any desired set point 29 as the measuring pressure. For example, the system can be operated at higher pressure. By this, any undesired gassing of the fluid delivered by the flow source 45 can be avoided. The flow rate can be measured at the same pressure as at the end of the chromatographic column 39 or at any desired higher pressure adjustable by the closed-loop control system 3 of the metering device 1. For example, at zero pressure differential to reference value, for example ambient pressure, to prevent any undesired leakages of the control element (7).
Advantageously, the metering device of the flow meter can be used as described above or as a reference flow source. For this purpose, the flow meter can be coupled with a fluid delivery system, for example, a fluid container.
The fluidic system 17 can be adapted for analyzing liquid. More specifically, the fluidic system 17 can be adapted for executing at least one microfluidic process, for example an electrophoresis and/or a liquid chromatographic process, for example a high performance liquid chromatographic process (HPLC). Therefore, the fluidic system 17 can be coupled to a liquid delivery system 45, in particular to a pump, and/or to a power source. For analyzing liquid or rather one or more components within the liquid, the fluidic system 17 can comprise a detection area 41, such as an optical detection area and/or an electrical detection area being arranged close to a flow path within the fluidic system 17. The fluidic system 17 can be coupled to the flow meter 1 for determining or measuring the flow rate of the liquid delivery system 45. Otherwise, the fluidic system 17 can be coupled to a laboratory apparatus, for example to a mass spectrometer, for analyzing the liquid. For executing an electrophoresis, the flow path can comprise a gel. Besides this, the fluidic system 17 can be a component part of a laboratory arrangement.
The control unit 740 receives an input pressure value Pi (from a pressure sensor 750) indicative of an input pressure at the input 720 of the volume displacement device 700. The control unit 740 in the example of
The control unit 740 might further comprise an amplifier 770 adapted for converting the output signal of the comparator 760 into corresponding energy required for driving the drive 730.
In the example of
In the example of
In both
Other types of gear pumps 900 might be used accordingly, e.g. as the gear pumps disclosed in U.S. Pat. No. 5,184,519 A, U.S. Pat. No. 4,409,829, U.S. Pat. No. 4,815,318, WO 2005/119185 A1, or U.S. Pat. No. 6,658,747 B2.
Readout of the actual displacement rate can be done by monitoring the driving speed of the volume displacement device 700 or a sensing device may be employed, which records the actual speed or volumetric displacement.
It is to be understood, that embodiments described are not limited to the particular component parts of the devices described or to process features of the methods described as such devices and methods may vary. It is also to be understood, that different features as described in different embodiments, for example illustrated with different Fig., may be combined to new embodiments. It is finally to be understood, that the terminology used herein is for the purposes of describing particular embodiments only and it is not intended to be limiting. It must be noted, that as used in the specification and the appended claims, the singular forms of “a”, “an”, and “the” include plural referents until the context clearly dictates otherwise.
Number | Date | Country | Kind |
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06117671.5 | Jul 2006 | EP | regional |