Patent Application
20250050365
The present disclosure relates to the field of fluid dispensing devices and in particular to fluid dispensing devices configured as nasal inhalers. The disclosure further relates to spray devices configured to dispense a fluid or a liquid substance by way of spraying or atomizing. The disclosure also relates to a mechanical energy storage for use in a fluid dispensing device, e.g. for driving a discharge mechanism of the fluid dispensing device.
Fluid dispensing devices operable to atomize a liquid substance are as such known. Such devices typically comprise an outlet orifice, e.g. integrated in or provided by a nozzle. Upon application of a force by a user to an actuation lever or a button the fluid is dispensed via the outlet orifice. Such devices may be arranged to dispense a single or multiple doses and may be equipped with a container providing a reservoir for the fluid thus allowing and supporting the dispensing of several doses.
Such fluid dispensing devices may be provided with a mechanical energy storage operable to provide a force effect for discharging and/or atomizing of the fluid. Here, a user may induce a spray dispensing of the fluid by depressing a trigger by way of which mechanical energy provided by the mechanical energy storage is released for the fluid dispensing.
Charging or preloading of the mechanical energy storage may be induced by user interaction. With existing fluid dispensing devices a user has to recharge or preload the mechanical energy storage every time a fluid dispensing action has been triggered.
It is generally desirable to improve operability and user handling of such fluid dispensing devices. Moreover, user acceptance of such fluid dispensing device should be enhanced. Furthermore, it is intended to provide an improving mechanical energy storage that offers dispensing of several doses without an intermediate reloading or recharging.
In one example the present disclosure relates to a mechanical energy storage for driving a discharge mechanism of a fluid dispensing device. The mechanical energy storage comprises at least a first drive spring extending along a longitudinal direction (z). The drive spring comprises a first longitudinal end to engage with a housing of the fluid dispensing device. The drive spring further comprises a second longitudinal end opposite to the first longitudinal end. The second longitudinal end is configured to engage with a driver movable relative to the housing along the longitudinal direction (z).
The mechanical energy storage is reversibly transferable into a preloaded state by resiliently compressing the first drive spring in the longitudinal direction (z) thereby inducing a resilient deformation of the first drive spring in a first transverse direction (y), e.g. perpendicular to the longitudinal direction (z).
Furthermore, the mechanical energy storage is transferable from the preloaded state into an unloaded state by allowing the first drive spring to relax into or towards the undeformed configuration, e.g. in a laterally undeformed configuration, with regard to the first transverse direction (y). This relaxing motion or bending of the first drive spring is typically accompanied by a longitudinal extension or expansion of the drive spring. The longitudinal extension or expansion of the drive spring is accompanied by an increase of the longitudinal distance between the first longitudinal end and the second longitudinal end of the first drive spring.
In other words, and when the mechanical energy storage is transferred into the preloaded state the first drive spring is compressed along the longitudinal direction thereby reducing the longitudinal distance between the first longitudinal end and the second longitudinal end. Typically, the longitudinal compression leads to a deformation of the drive spring in the first direction (y) transverse to the longitudinal direction (z).
In an unbiased configuration of the drive spring, the drive spring comprises a rather straight and elongated shape. The material and/or the geometric shape of the drive spring is rather incompressible in longitudinal direction. Consequently and when the drive spring is subject to a longitudinal compression, the drive spring is subject to a lateral, hence transverse resilient deformation with regards to the first transverse direction (y). In the resiliently deformed state, the drive spring has a tendency to return into a rather straight and elongated shape, thereby increasing and hence maximizing the longitudinal distance between the first longitudinal end and the second longitudinal end.
Generally and as used herein, a preloaded state is a state, in which the mechanical engineering storage stores at least a non-zero portion of mechanical energy. Insofar the preloaded state is a loaded state. The term “preloaded” as used herein may further indicate and/or imply, that the fluid dispensing device can be stored in a loaded state, e.g. over a comparatively long-time interval. Then and while not in use the fluid dispensing device is and remains mechanically biased and is immediately ready to use for discharging a dose of the fluid. Typically, preloading of the mechanical energy storage may be provided at the end of a dose dispensing procedure.
According to a further example the material of the drive spring and/or portions of the drive spring adjacently located or adjacently adjoining as seen in longitudinal direction are substantially incompressible in longitudinal direction. When the first drive spring is subject to a longitudinal compression, e.g. when a longitudinal force effect is applied to a first longitudinal end relative to the second longitudinal end the first drive spring cannot compress as such but has to adapt a resilient deformation with regard to the first transverse direction (y).
At least a portion or numerous portions of the drive spring located between the first longitudinal end and the second longitudinal end are subject to an evasive movement along the first transverse direction (y) in response to a longitudinally directed force effect acting on one of the first and second longitudinal end of the drive spring.
With some examples, portions of the drive spring located between the first and the second longitudinal ends are configured to buckle or to bend with regards to the first transverse direction (y), e.g. perpendicular to the longitudinal direction (z).
This type of a drive spring is beneficial in many aspects. First of all, such a drive spring is rather compact and requires only a minimum of construction space. Second, the drive spring may be installed in the mechanical energy storage rather easily when in an elongated and hence unbiased configuration. Furthermore, the drive spring provides a rather constant spring force over a longitudinal displacement of the first longitudinal end relative to the second longitudinal end.
In this way, the first drive spring may provide a rather constant spring force almost irrespective of a degree of deformation or irrespective of a longitudinal displacement of one of the first and second longitudinal end relative to the other one of the first and second longitudinal end. Insofar the mechanical energy storage is particularly applicable for a discharge mechanism of a fluid dispensing device that provides a repeated partial release of the mechanical energy from the mechanical energy storage in order to trigger or to effectuate numerous dispensing procedures without an intermediate reloading or biasing of the mechanical energy storage.
According to a further example the first drive spring comprises an elongated rather and rather unwound spring rod. The spring rod may comprise a rather solid and hence monolithic material. Typically, the first drive spring is made of a metal. Insofar the metallic spring rod may be void of perforations or other empty spaces. The spring rod may comprise a homogeneous longitudinal profile extending from the first longitudinal end to the second longitudinal end. As seen in longitudinal direction the profile of the spring rod may be homogeneous and may be void of any alterations or modifications.
Such a spring rod is rather easy to manufacture at moderate or low costs. Moreover, such a spring rod provides a well-defined deformation capability and hence a rather well-defined spring constant or spring force.
According to a further example the first drive spring comprises an elongated straight shape when in the unloaded date. When in the unloaded state the first drive spring extends along the longitudinal direction (z). A rather elongated and straight shaped drive spring can be installed and arranged rather easily in the mechanical energy storage. With some examples the drive spring can be assembled in or with the mechanical energy storage in a completely unbiased configuration, which facilitates the assembly of the first drive spring in or with the mechanical energy storage.
According to another example the first drive spring comprises a planar-shaped longitudinal extending lateral profile. The drive spring may comprise a kind of a linear or straight shaped layer or slab profile. The slab profile may comprise an even and planar-shaped side surface on a first outside facing portion. The longitudinal extending slot may comprise a second planar-shaped surface on an opposite side. Such planar-shaped and longitudinal extending slab profiles enable a rather well-defined lateral or transverse deformation along the first direction.
Typically, the planar-shaped longitudinal extending slab profile comprises a first outside surface portion and a second outside facing surface portion. The first surface portion and the second surface portion comprise a surface normal extending substantially parallel to the first transverse direction (y) when the first drive spring is in the undeformed configuration.
Typically, the transverse extension of the longitudinally extending slab profile in a second transverse direction (x), i.e. perpendicular to the first transverse direction (y) and perpendicular to the longitudinal direction (y) is at least two times larger than the thickness of the longitudinal extending snap profile as seen in the first transverse direction (y). With some examples the extension of the planar-shaped longitudinal extending slab profile in the second transverse direction (x) is at least two times larger, three times larger or even four times larger than the thickness of the slab profile as seen in the first transverse direction (y).
This way, the drive spring may be made from a piece of a sheet metal. Accordingly, the slab profile of the first drive spring and hence the first drive spring as such may be manufactured by stamping or punching a piece of sheet metal.
According to a further example the first drive spring comprises at least a first spring element and a second spring element. The first spring element at least partially or completely overlaps with the second spring element. The first spring element and the second spring element are mutually connected or fixed. They may be mutually bonded, welded, fused, or laminated to form or to constitute the first drive spring. With some examples the first drive spring is produced by laminating at least a first, a second and optionally also a third and/or a fourth spring element together. Here, the first and the second spring elements may be arranged adjacently on top of each other, such that the outside profile of the first spring element overlaps with the outside profile of the second spring element.
Typically, and when the first drive spring comprises an elongated straight shape and/or size or when the first drive spring comprises a planar shaped longitudinal extending slab profile also the first spring element and the second spring element are of a respective geometric shape. Typically, the first spring element comprises a first planar shaped outside surface with a surface normal typically extending in the second transverse direction (x). The first spring element also comprises a second outside surface facing in the opposite direction. Likewise, the second spring element comprises a first planar shaped outside surface facing towards the second surface of the first spring element.
Insofar, the first spring element can be bonded, welded, fused, or laminated to the second spring element, wherein the second planar-shaped surface of the first spring element is in surface contact with the first planar-shaped surface of the second spring element. When there are provided further spring elements, such as a third and a fourth spring element for constituting the first drive spring, the respective planar shaped longitudinal extending slob profiles of the individual spring elements can be arranged flush on top of each other. In effect, the first drive spring comprises a multi-layer of numerous spring elements mutually bonded or connected in a force fitting manner.
According to a further example the first spring element comprises a first planar geometry. The second spring element comprises a second planar geometry. The first and the second planar geometries are substantially identical. In this way, the first spring element and the second spring element can be arranged in a completely overlapping manner so as to form the first drive spring having a planar geometry that is substantially identical to the planar geometry of the individual first and second spring elements.
According to a further example the first spring element and the second spring element each comprise the same or a different layer thickness. The layer thickness is the thickness of the spring element as seen along the first transverse direction (y). The planar geometry is typically defined by the longitudinal direction (z) and by the second transverse direction (x). With numerous spring elements having the same layer thickness manufacturing of the first drive spring can be simplified.
Here, individual first and second spring elements can be made of the same material or can be punched out of a common sheet metal. Manufacturing of the first drive spring may then only required to arrange the first and second spring elements flush on top of each other and to connect the respective spring elements to form the first drive spring.
Making use of at least a first and a second spring element to form the first drive spring a resulting spring constant of the respective drive spring can be individually modified and can be adapted to specific mechanical demands for the drive spring.
According to another example the first spring element is made of a first spring material. The second spring element is made of a second spring material. Hence, the first and the second spring materials are either equal or different. With equal spring elements, manufacturing of a drive spring can be provided in a rather simple and cost-efficient manner. Here, individual spring elements may be provided by punching a common sheet metal and by arranging numerous spring element on top of each other so as to form the first drive spring, e.g. by mutually bonding, welding, fusing, or laminating the individual spring elements.
With another example and wherein first and second spring materials are different, there may be provided a first spring element made from a first sheet-metal and there may be provided a second spring element made from a second sheet-metal. Here, by mutually bonding, welding, fusing, or laminating the individual spring elements arranged on top of each other a resulting spring constant of desired magnitude can be designed and provided.
According to another example the first drive spring comprises an undulated structure with at least one arc-shaped undulation extending in the first transverse direction (y) when the first drive spring is in the preloaded state. Such an arc-shaped undulation automatically evolves when the first and the second longitudinal ends of the drive spring are subject to a compression in the longitudinal direction (z).
Hence, by bringing one of the first and the second longitudinal ends closer to the other one of the first and the second longitudinal ends, there is induced a lateral deformation of the elongated drive spring towards an arc-shaped undulation. With only one arc-shaped undulation, typically a middle portion located midway between the first and the second longitudinal ends of the drive spring comprises a maximum deformation amplitude as seen in the first transverse direction (y).
Here, the constructional space of the discharge mechanism and/or of the mechanical energy storage provides sufficient room for such an arc-shaped undulated deformation of the first spring element as seen in the first transverse direction (y). Such a lateral deformation provides a rather constant spring force or force effect in the longitudinal direction, irrespective of the degree of lateral or transverse deformation.
According to a further example the first drive spring comprises an undulated structure with a sequence of at least two or three arc-shaped undulations when in the preloaded state. Here, undulations adjoining along the longitudinal direction are oriented oppositely with regards to the first transverse direction (y). Hence, as seen along the first transverse direction a first arc-shaped undulation may evolve in the positive first direction (+y) and a second undulation longitudinally adjoining the first undulation may evolve in a negative first direction (-y).
Typically, the undulations of the first drive spring evolve in a common two-dimensional plane, which is defined by the longitudinal direction and the first transverse direction
With numerous undulations evolving due to a longitudinal compression of the drive spring the spring requires less constructional space when transferring into the preloaded state. Insofar, increasing the number of undulations for a preloaded spring serves to reduce the required constructional space for spring deformation.
According to another example the mechanical energy storage further comprises a second drive spring comprising a first longitudinal end to engage with the housing of the fluid dispensing device and comprising a second longitudinal end opposite to the first longitudinal end. The second longitudinal end of the second drive spring is configured to engage with the driver which is movable relative to the housing along the longitudinal direction. The first drive spring and the second drive spring are typically arranged substantially parallel to each other.
The first drive spring may be in engagement with a first portion of the housing and also with a first portion of the driver. The second drive spring may be in engagement with a second portion of the housing and with a second portion of the driver. This way, there may be provided an at least twofold spring-supported sliding support for the driver for moving the driver relative to the housing. Typically, the first drive spring may be provided on a first side of the driver and the second drive spring may be provided on oppositely located second side of the driver.
This way, the driver may be supported in a twofold manner by first and second drive spring. Also, the driver may be sandwiched by the two-drive spring in one of the two transverse direction (x, y). The driver may be movable relative to the housing from an unbiased position into a biased position, wherein in the unbiased position the first and the second drive strings are in a substantially undeformed configuration and wherein the drive springs are in a deformed or preloaded configuration when the driver is in the biased position.
By supporting the driver in a twofold manner by a first drive spring and by a second drive spring, an uncontrolled tilt, cant, or misalignment of the driver relative to the housing can be effectively avoided. A return force for moving or biasing the driver towards the unbiased position can be provided by a pair of a first drive spring and a second drive spring. Hence, a respective return force as provided by the mechanical energy storage can be somehow symmetrically applied to the driver.
With some examples the first drive spring and the second drive spring are substantially identical with regard to their geometric shape and their geometric deformation capability as well as with regards to their resilient deformation capability or deformation characteristics. By way of numerous drive springs a force effect for moving the driver relative to the housing can be distributed among a number of spatially distributed drive springs, thereby preventing an uncontrolled lateral tilt or cant of the driver when been moved relative to the housing.
According to another example the first drive spring and the second drive spring are mutually connected and fixed to each other by a crossbar. This way, the first drive spring and the second drive spring may be integrally formed. They may be produced from a common piece of material, e.g. from a common sheet metal.
The first and the second drive spring may be provided as portions of one of several sheet metals. The first drive spring can be formed or provided by a first portion of the metal sheet and the second drive spring can be provided by a second portion of the metal sheet.
By way of the crossbar interconnecting the first and the second drive springs a kind of a drive spring assembly can be provided which is to be assembled inside the mechanical energy storage or inside the dispensing device as a single component. Accordingly, a mutual adjustment of the first and the second drive springs relative to each other becomes substantially superfluous. In addition, the total number of parts to be assembled can be effectively reduced. The process of device assembly can be thus facilitated and simplified.
The drive spring assembly comprising the first drive spring, the second drive spring and the crossbar may be produced by punching a sheet metal and by embossing or stamping the respective punched sheet metal. Manufacturing costs and manufacturing expenditure can be decreased accordingly while the drive spring assembly comprises a low degree of mechanical tolerances.
With another example the crossbar, the first drive spring and the second drive spring are made of the same material and are unitarily and/or integrally formed. Also here, the first drive spring and the second drive spring may comprise first, and second spring elements as described above in connection with the first drive spring.
According to another aspect the present disclosure also relates to a fluid dispensing device. The fluid dispensing device comprises a housing to accommodate a container with a fluid. The fluid dispensing device also comprises an outlet orifice and a discharge mechanism. The discharge mechanism is operable for spray discharging multiple doses of the fluid via the outlet orifice. The fluid dispensing device further comprises a mechanical energy storage as described above. The mechanical energy storage is coupled to the discharge mechanism and is reversibly transferable between a preloaded state and an unloaded state.
The discharge mechanism is further, configured to store mechanical energy in the preloaded state effective to produce a spray discharging of the fluid. The discharge mechanism comprises a driver operatively coupled to the mechanical energy storage and movable relative to at least one of the container and the outlet orifice to effectuate a spray discharging of the fluid. With some examples at least one of the container and the outlet orifice is connected to or fixed to the housing of the fluid dispensing device. Then, the driver is also movable relative to the housing to effectuate a spray discharging of the fluid.
The outlet orifice may be provided on or integrated into a nozzle. The outlet orifice may be provided at a free end or distal end of a tapered nozzle. Such a nozzle may be configured and shaped for insertion into a nostril of a user. The fluid dispensing device may be implemented as a nasal inhaler. The nozzle may be sized and configured for insertion into a nostril of a user.
Implementing of the mechanical energy storage in a fluid dispensing device is of particular benefit with regard to a reduced space required for the at least first drive spring. The mechanical energy storage enables and provides a rather compact design of the fluid dispensing device.
According to a further example the driver comprises a driver abutment to engage with the first longitudinal end of the first drive spring. The housing comprises a housing abutment to engage with the second longitudinal end of the first drive spring. This way, the driver is movable against the return action of the drive spring between a biased position and an unbiased position. When the driver is in the biased position the mechanical energy storage is in the preloaded state and the at least one drive spring is resiliently deformed and is hence in the resiliently deformed configuration.
When the driver is in the unbiased position the mechanical energy storage is typically in the unloaded state and the drive spring is typically in the initial or undeformed configuration.
Typically, the driver is longitudinally slidably guided in or on the housing between the biased position and the unbiased position. Moving of the driver from the unbiased position towards and into the biased position serves to transfer the mechanical energy storage into the preloaded state and leads to a resilient deformation of the at least first drive spring as described above. When in the biased position the driver and hence the mechanical energy storage may be retained in the preloaded state or biased position by a releasable interlock of the fluid dispensing device. The releasable interlock is operably engageable with a trigger mechanism. This way, the trigger mechanism is configured to release at least a first portion of the mechanical energy stored in the mechanical energy storage when actuated for a first time. The trigger mechanism may be also configured to release at least a second portion of the mechanical energy stored in the mechanical energy storage when actuated for a second or another time.
With some examples the releasable interlock is configured to retain the mechanical energy storage in at least a first partially loaded state after a first activation of the trigger mechanism. Hence, a first or single actuation of the trigger mechanism may be ineffective to transfer the mechanical energy storage from the preloaded state into the unloaded state. For transferring the mechanical energy storage into the unloaded state it is intended to actuate the trigger mechanism multiple times.
According to a further example the driver abutment is located at an inside of a longitudinal end of a V-shaped recess of the driver. The V-shaped recesses is typically provided in a plane provided or defined by the longitudinal direction and the first direction transverse to the longitudinal direction. This way, the first longitudinal end of the drive spring can be precisely aligned and fixed in the V-shaped recess of the driver.
According to a further example also the housing abutment is located at or on an inside of a longitudinal end of a V-shaped recess of the housing. The V-shaped recess of the housing is typically arranged and oriented opposite to the V-shaped recess of the driver.
While the V-shaped recess of the driver may face in a proximal longitudinal direction the V-shaped recess of the housing may face in the opposite, hence distal longitudinal direction. Also, the V-shaped recess of the housing is provided or formed in a plane as defined by the longitudinal direction and the first transverse direction. The longitudinal distance between the longitudinal end or crests of the V-shaped recess of the driver and the longitudinal end or crests of the V-shaped recess of the housing may coincide or may be substantially identical to the longitudinal extent of the first and/or second drive spring when in the undeformed configuration.
With some examples, a substantially undeformed longitudinally extending drive spring may be tightly squeezed between the longitudinal end of the oppositely oriented recesses of the driver and of the housing, respectively.
With some examples, the spring may have to be slightly deformed in order to fit into the free space provided between the V-shaped recesses of the housing abutment and the driver abutment. This way it may be guaranteed, that even in the substantiality unbiased position of the driver the respective first and/or second drive spring(s) is/are slightly pre-compressed or pre-biased.
According to a further example at least one of the driver and the housing comprises a spring fixing notch to confine the position of the first drive spring with regards to the first transverse direction (y). Here, the first drive spring extends in longitudinal direction through the spring fixing notch. The spring fixing notch may comprise a gap size as seen in the first direction that substantially matches or corresponds to the respective thickness of the drive spring. The size of the spring fixing notch may be slightly larger than the thickness of the drive spring in order to enable a smooth assembly of the drive spring and in order to enable a tilt of the drive spring with regard to the first transverse direction (y) relative to the spring fixing notch as the drive spring is subject to a respective deformation in the lateral or transverse direction.
By way of at least one spring fixing notch located between, e.g. located substantiality midway between, the housing abutment and the driver abutment, generation of at least three arc-shaped undulations can be enforced or supported when the first and second longitudinal ends of the drive spring are subject to a longitudinal compression relative to each other. In the region of the spring fixing notch the drive spring is effectively fixed with regards to the first transverse direction (y). In the deformed state or deformed configuration the drive spring comprises at least a first and a second undulation extending in the first transverse direction but in the opposite sense.
With one example, and with only one fixing notch e.g. located essentially midway between the housing abutment and the driver abutment there will be generated a first arc-shaped undulation between the driver abutment and the spring fixing notch. There will be generated a second undulation between the spring fixing notch and the housing abutment. Here, the first undulation extends in a positive first direction and the second undulation will be formed also in the first direction bus in an opposite sense. This way, there will be generated a kind of a S-shaped deformation of the drive spring.
With some examples there may be provided two spring fixing notches between the driver abutment and the housing abutment for the at least first drive spring. This way the drive spring will be deformed to generate three arc-shaped undulations, which in the region of the respective spring fixing notch merge into each other. Here and with two spring fixing notch separated in longitudinal direction there may be provided a kind of a M-shaped undulations or a M-shaped deformation of the first drive spring.
According to a further example at least one of the driver and the housing comprise a spring deformation guiding element adjacently arranged next to a first deformable or bendable portion of the first drive spring as seen on the first transverse direction (y). The spring deformation guiding element is particularly configured to induce a deformation of the first deformable or bendable portion of the first drive spring along or in the first transverse direction (y) away from the first spring deformation guiding element into the arc-shaped undulation.
Hence, the spring deformation guiding element serves to break an eventual symmetry of the first drive spring so that the first drive spring always assumes or adapts a well-defined transversely deformed structure when the first drive spring should be subject to a compression as seen in longitudinal direction.
Insofar, the first spring deformation guiding element may be located e.g. midway between a first spring fixing notch and a second spring fixing notch. The spring deformation guiding element or numerous spring deformation guiding elements may be also provided e.g. midway between a spring fixing notch and at least one of a housing abutment and a driver abutment of the fluid dispensing device.
Typically, the spring deformation guiding elements may be located slightly off-axis with regard to the longitudinal direction or longitudinal extent of the drive spring so as to induce the formation of at least one transverse or lateral undulation of the drive spring when subject to a compression in longitudinal direction.
According to a further example at least one of the driver and the housing comprises at least a second spring deformation guiding element adjacently arranged next to a second deformable or bendable portion of the first drive spring. The second spring deformation guiding element is configured to induce a deformation of the second deformable or bendable portion of the first drive spring along the first transverse direction away from the at least second spring deformation guiding element into an arc-shaped undulation.
According to a further example the first spring deformation guiding element and the at least second spring deformation guiding element are located adjacent to oppositely located side edges of the first drive spring as seen in the first transverse direction. The first spring deformation guiding element and the at least second spring deformation guiding element are separated from each other along the longitudinal direction. This way, there can be provided a formation of a first undulation by the first spring deformation guiding element in the first direction, i.e. in the positive first direction (+y) whereas the second spring deformation guiding element serves to generate an oppositely directed arc-shaped undulation of the drive spring, hence into the negative first transverse direction (−y).
According to a further example the spring fixing notch is provided or arranged longitudinally between the first spring deformation guiding element and the second spring deformation guiding element. This way, the spring fixing notch defines a kind of a lateral fixing for the drive spring and a portion of the drive spring fixed by the spring fixing notch is effectively prevented from deformation or deflection with regards to the first transverse direction (y).
According to a further example the fluid dispensing device is equipped with the container, which is filled with the fluid. The container is connected to the outlet orifice in a fluid transferring manner. Typically, the fluid dispensing device may comprise a pump or spray delivery mechanism by way of which the fluid located in the container can be withdrawn from the container and can be stored or accommodated in a dispensing chamber of a dispensing or discharge mechanism.
With some examples the container may be releasably attachable to the discharge mechanism. The container may be arranged in a removable manner inside the housing of the fluid dispensing device. Hence, the fluid dispensing device may be implemented as a reusable device offering to replace the container when empty. With other examples the fluid dispensing device is implemented as a disposable device. Here, the container filled with the fluid may be permanently located inside the housing of the fluid dispensing device. Then, the container may not be exchangeable arranged inside the housing. When the container is empty the entire fluid dispensing device may be intended to become discarded.
Generally, the scope of the present disclosure is defined by the content of the claims. The energy storage and/or the fluid dispensing device is not limited to specific embodiments or examples but comprises any combination of elements of different embodiments or examples. Insofar, the present disclosure covers any combination of claims and any technically feasible combination of the features disclosed in connection with different examples or embodiments.
In the present context the term ‘distal’ or ‘distal end’ relates to an end of the fluid dispensing device that faces towards an application site of a person or of an animal. The term ‘proximal’ or ‘proximal end’ relates to an opposite end of the injection device, which is furthest away from an application site of a person or of an animal.
The terms “fluid,” “drug” or “medicament” are used synonymously herein and may describe at least one of consumer health care product and a pharmaceutical formulation containing one or more active pharmaceutical ingredients or pharmaceutically acceptable salts or solvates thereof, and optionally a pharmaceutically acceptable carrier. An active pharmaceutical ingredient (“API”), in the broadest terms, is a chemical structure that has a biological effect on humans or animals. In pharmacology, a drug or medicament is used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well-being. A drug or medicament may be used for a limited duration, or on a regular basis for chronic disorders. A consumer health care product may be void of an active pharmaceutical ingredient. It may be commercially available free of prescription. As a nonlimiting examples consumer health care products may include products such as nasal sprays, cough syrups, eyedrops, creams, ointments, dietary and nutrition supplements and/or cosmetics.
As described below, a fluid, drug or medicament can include at least one API, or combinations thereof, in several types of formulations, for the treatment of one or more diseases. Examples of API may include small molecules having a molecular weight of 500 Da or less; polypeptides, peptides, and proteins (e.g., hormones, growth factors, antibodies, antibody fragments, and enzymes); carbohydrates and polysaccharides; and nucleic acids, double or single stranded DNA (including naked and cDNA), RNA, antisense nucleic acids such as antisense DNA and RNA, small interfering RNA (SIRNA), ribozymes, genes, and oligonucleotides. Nucleic acids may be incorporated into molecular delivery systems such as vectors, plasmids, or liposomes. Mixtures of one or more drugs are also contemplated.
The drug or medicament may be contained in a primary package or “drug container” adapted for use with a drug delivery device. The drug container may be, e.g., a cartridge, syringe, reservoir, or other solid or flexible vessel configured to provide a suitable chamber for storage (e.g., short-or long-term storage) of one or more drugs. For example, in some instances, the chamber may be designed to store a drug for at least one day (e.g., 1 to at least 30 days, alternatively 1 to at least 10, 15, 20, or 25 days). In some instances, the chamber may be designed to store a drug for about 1 month to about 2 years, alternatively from about 1 month to about 6 months, alternatively from about 1 month to about a year, alternatively from about 1 month to 1.5 years. Storage may occur at room temperature (e.g., about 20°° C.), or refrigerated temperatures (e.g., from about −4° C. to about 4° C.). In some instances, the drug container may be or may include a dual-chamber cartridge configured to store two or more components of the pharmaceutical formulation to-be-administered (e.g., an API and a diluent, or two different drugs) separately, one in each chamber. In such instances, the two chambers of the dual-chamber cartridge may be configured to allow mixing between the two or more components prior to and/or during dispensing into the human or animal body. For example, the two chambers may be configured such that they are in fluid communication with each other (e.g., by way of a conduit between the two chambers) and allow mixing of the two components when desired by a user prior to dispensing. Alternatively or in addition, the two chambers may be configured to allow mixing as the components are being dispensed into the human or animal body.
The drugs or medicaments contained in the drug delivery devices as described herein can be used for the treatment and/or prophylaxis of many diverse types of medical disorders. Examples of disorders include, e.g., diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy, thromboembolism disorders such as deep vein or pulmonary thromboembolism. Further examples of disorders are acute coronary syndrome (ACS), angina, myocardial infarction, cancer, macular degeneration, inflammation, hay fever, atherosclerosis and/or rheumatoid arthritis. Examples of APIs and drugs are those as described in handbooks such as Rote Liste 2014, for example, without limitation, main groups 12 (anti-diabetic drugs) or 86 (oncology drugs), and Merck Index, 15th edition.
Examples of APIs for the treatment and/or prophylaxis of type 1 or type 2 diabetes mellitus or complications associated with type 1 or type 2 diabetes mellitus include an insulin, e.g., human insulin, or a human insulin analogue or derivative, a glucagon-like peptide (GLP-1), GLP-1 analogues or GLP-1 receptor agonists, or an analogue or derivative thereof, a dipeptidyl peptidase-4 (DPP4) inhibitor, or a pharmaceutically acceptable salt or solvate thereof, or any mixture thereof. As used herein, the terms “analogue” and “derivative” refers to a polypeptide which has a molecular structure which formally can be derived from the structure of a naturally occurring peptide, for example that of human insulin, by deleting and/or exchanging at least one amino acid residue occurring in the naturally occurring peptide and/or by adding at least one amino acid residue. The added and/or exchanged amino acid residue can either be codable amino acid residues or other naturally occurring residues or purely synthetic amino acid residues. Insulin analogues are also referred to as “insulin receptor ligands”. In particular, the term “derivative” refers to a polypeptide which has a molecular structure which formally can be derived from the structure of a naturally occurring peptide, for example that of human insulin, in which one or more organic substituent (e.g. a fatty acid) is bound to one or more of the amino acids. Optionally, one or more amino acids occurring in the naturally occurring peptide may have been deleted and/or replaced by other amino acids, including non-codeable amino acids, or amino acids, including non-codeable, have been added to the naturally occurring peptide.
Examples of insulin analogues are Gly(A21), Arg(B31), Arg(B32) human insulin (insulin glargine); Lys(B3), Glu(B29) human insulin (insulin glulisine); Lys(B28), Pro(B29) human insulin (insulin lispro); Asp(B28) human insulin (insulin aspart); human insulin, wherein proline in position B28 is replaced by Asp, Lys, Leu, Val or Ala and wherein in position B29 Lys may be replaced by Pro; Ala(B26) human insulin; Des(B28-B30) human insulin; Des(B27) human insulin and Des(B30) human insulin.
Examples of insulin derivatives are, for example, B29-N-myristoyl-des(B30) human insulin, Lys(B29) (N-tetradecanoyl)-des(B30) human insulin (insulin detemir, Levemir®); B29-N-palmitoyl-des(B30) human insulin; B29-N-myristoyl human insulin; B29-N-palmitoyl human insulin; B28-N-myristoyl LysB28ProB29 human insulin; B28-N-palmitoyl-LysB28ProB29 human insulin; B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N-palmitoyl-ThrB29LysB30 human insulin; B29-N-(N-palmitoyl-gamma-glutamyl)-des(B30) human insulin, B29-N-omega-carboxypentadecanoyl-gamma-L-glutamyl-des(B30) human insulin (insulin degludec, Tresiba®); B29-N-(N-lithocholyl-gamma-glutamyl)-des(B30) human insulin; B29-N-(ω-carboxyheptadecanoyl)-des(B30) human insulin and B29-N-(ω-carboxyheptadecanoyl) human insulin.
Examples of GLP-1, GLP-1 analogues and GLP-1 receptor agonists are, for example, Lixisenatide (Lyxumia®), Exenatide (Exendin-4, Byetta®, Bydureon®, a 39 amino acid peptide which is produced by the salivary glands of the Gila monster), Liraglutide (Victoza®), Semaglutide, Taspoglutide, Albiglutide (Syncria®), Dulaglutide (Trulicity®), rExendin-4, CJC-1134-PC, PB-1023, TTP-054, Langlenatide/HM-11260C (Efpeglenatide), HM-15211, CM-3, GLP-1 Eligen, ORMD-0901, NN-9423, NN-9709, NN-9924, NN-9926, NN-9927, Nodexen, Viador-GLP-1, CVX-096, ZYOG-1, ZYD-1, GSK-2374697, DA-3091 March-701, MAR709, ZP-2929, ZP-3022, ZP-DI-70, TT-401 (Pegapamodtide), BHM-034. MOD-6030, CAM-2036, DA-15864, ARI-2651, ARI-2255, Tirzepatide (LY3298176), Bamadutide (SAR425899), Exenatide-XTEN and Glucagon-Xten.
An example of an oligonucleotide is mipomersen sodium (Kynamro®), a cholesterol-reducing antisense therapeutic for the treatment of familial hypercholesterolemia or RG012 for the treatment of Alport syndrome.
Examples of DPP4 inhibitors are Linagliptin, Vildagliptin, Sitagliptin, Denagliptin, Saxagliptin, Berberine.
Examples of hormones include hypophysis hormones or hypothalamus hormones or regulatory active peptides and their antagonists, such as Gonadotropine (Follitropin, Lutropin, Choriongonadotropin, Menotropin), Somatropine (Somatropin), Desmopressin, Terlipressin, Gonadorelin, Triptorelin, Leuprorelin, Buserelin, Nafarelin, and Goserelin.
Examples of polysaccharides include a glucosaminoglycane, a hyaluronic acid, a heparin, a low molecular weight heparin or an ultra-low molecular weight heparin or a derivative thereof, or a sulphated polysaccharide, e.g. a poly-sulphated form of the above-mentioned polysaccharides, and/or a pharmaceutically acceptable salt thereof. An example of a pharmaceutically acceptable salt of a poly-sulphated low molecular weight heparin is enoxaparin sodium. An example of a hyaluronic acid derivative is Hylan G-F 20 (Synvisc®), a sodium hyaluronate.
The term “antibody”, as used herein, refers to an immunoglobulin molecule or an antigen-binding portion thereof. Examples of antigen-binding portions of immunoglobulin molecules include F(ab) and F(ab′)2 fragments, which retain the ability to bind antigen. The antibody can be polyclonal, monoclonal, recombinant, chimeric, de-immunized or humanized, fully human, non-human, (e.g., murine), or single chain antibody. In some embodiments, the antibody has effector function and can fix complement. In some embodiments, the antibody has reduced or no ability to bind an Fc receptor. For example, the antibody can be an isotype or subtype, an antibody fragment or mutant, which does not support binding to an Fc receptor, e.g., it has a mutagenized or deleted Fc receptor binding region. The term antibody also includes an antigen-binding molecule based on tetravalent bispecific tandem immunoglobulins (TBTI) and/or a dual variable region antibody-like binding protein having cross-over binding region orientation (CODV).
The terms “fragment” or “antibody fragment” refer to a polypeptide derived from an antibody polypeptide molecule (e.g., an antibody heavy and/or light chain polypeptide) that does not comprise a full-length antibody polypeptide, but that still comprises at least a portion of a full-length antibody polypeptide that is capable of binding to an antigen. Antibody fragments can comprise a cleaved portion of a full-length antibody polypeptide, although the term is not limited to such cleaved fragments. Antibody fragments that are useful in the present invention include, for example, Fab fragments, F(ab′)2 fragments, scFv (single-chain Fv) fragments, linear antibodies, monospecific or multispecific antibody fragments such as bispecific, trispecific, tetraspecific and multispecific antibodies (e.g., diabodies, triabodies, tetrabodies), monovalent or multivalent antibody fragments such as bivalent, trivalent, tetravalent and multivalent antibodies, minibodies, chelating recombinant antibodies, tribodies or bibodies, intrabodies, nanobodies, small modular immunopharmaceuticals (SMIP), binding-domain immunoglobulin fusion proteins, camelized antibodies, and VHH containing antibodies. Additional examples of antigen-binding antibody fragments are known in the art.
The terms “Complementarity-determining region” or “CDR” refer to short polypeptide sequences within the variable region of both heavy and light chain polypeptides that are primarily responsible for mediating specific antigen recognition. The term “framework region” refers to amino acid sequences within the variable region of both heavy and light chain polypeptides that are not CDR sequences, and are primarily responsible for maintaining correct positioning of the CDR sequences to permit antigen binding. Although the framework regions themselves typically do not directly participate in antigen binding, as is known in the art, certain residues within the framework regions of certain antibodies can directly participate in antigen binding or can affect the ability of one or more amino acids in CDRs to interact with antigen.
Examples of antibodies are anti PCSK-9 mAb (e.g., Alirocumab), anti IL-6 mAb (e.g., Sarilumab), and anti IL-4 mAb (e.g., Dupilumab).
Pharmaceutically acceptable salts of any API described herein are also contemplated for use in a drug or medicament in a drug delivery device. Pharmaceutically acceptable salts are for example acid addition salts and basic salts.
Those of skill in the art will understand that modifications (additions and/or removals) of various components of the APIs, formulations, apparatuses, methods, systems, and embodiments described herein may be made without departing from the full scope and spirit of the present invention, which encompass such modifications and any and all equivalents thereof.
It will be further apparent to those skilled in the art that various modifications and variations can be made to the present disclosure without departing from the scope of the disclosure. Further, it is to be noted, that any reference numerals used in the appended claims are not to be construed as limiting the scope of the disclosure.
While the invention has been described and illustrated herein by references to various specific materials, it is understood that the invention is not restricted to the combinations of material and procedures selected for that purpose. Numerous variations of such details can be implied as will be appreciated by those skilled in the art. It is intended that the specification and examples be considered as exemplary, only, with the true scope and spirit of the invention being indicated by the following claims.
In the following, numerous examples of a fluid dispensing device will be described in greater detail by making reference to the drawings, in which:
In
The fluid container 110 may be entirely arranged inside the hollow and rather cup-shaped body 11 of the housing 10. The housing 10 further comprises a protective cap 12. The protective cap 12 is sized and shaped to enclose an outlet orifice 3, e.g. provided at or in a nozzle 14. The nozzle 14 may comprise a conically-shaped protrusion sized for insertion into a nostril of a user. A distal end of the nozzle 14 may be provided with the outlet orifice 3. The outlet orifice 3 may be part of an atomizer 2 configured and shaped to atomize or to nebulize the fluid when dispensed by or through the nozzle 14.
The nozzle 14 may be implemented as a part of a closure 13 configured for fastening to a distal end of the cup-shaped body 11. The closure 13 may be clip-fastened to the upper or distal end of the body 11. The closure 13 may be detachably or undetachably connected to the sidewall 18 of the body 11.
The protective cap 12 is pivotally supported or arranged on the housing 11. It may be hingedly attached to the housing 11 by way of a hinge 20. For this, the protective cap 12 comprises a hinge axis 21. The housing 11 comprises two oppositely located recesses 22 sized and shaped to receive an axial protrusion 152 of a pinion segment 151 integrally formed or attached to the protective cap 12 as illustrated in
The axial protrusions 152 may be snap fitted into the oppositely located recesses 22 and may be pivotally supported in the recesses 22 on the inside surface of the sidewall 18. This way, the protective cap 12 can be pivoted relative to the body 11 between a closed position as illustrated in
Inside the fluid dispensing device 1 there is provided a driver 30, which is longitudinally displaceable relative to the housing 10 along a longitudinal direction (z). The driver 30 is implemented as a part of a discharge mechanism 130. The discharge mechanism 130 comprises or forms a pump by way of which one or several doses of the fluid can be extracted or withdrawn from the fluid container 110 and by way of which one or multiple doses of the fluid can be expelled through the nozzle 14 by one or several spray delivery actions.
The driver 30 and hence the discharge mechanism 130 is biased by a mechanical energy storage 50. The mechanical energy storage 50 comprises at least one drive spring 51, 52 by way of which mechanical energy can be stored in the fluid dispensing device 1. The mechanical energy storage 50 is operatively coupled or engaged with the discharge mechanism 130 and is transferable between a preloaded state and an unloaded state. The mechanical energy storage 50 is configured to store mechanical energy in the preloaded state, which mechanical energy is effective and sufficient to produce the spray discharging of the fluid.
The fluid dispensing device 1 further comprises a releasable interlock 70, which is configured to retain the mechanical energy storage 50 in the preloaded state. The fluid dispensing device 1 further comprises a trigger mechanism 90 operably engageable or operably engaged with the interlock 70. When engaged with the trigger mechanism 90 the interlock is operable to release at least a first portion of the mechanical energy stored in the mechanical energy storage when actuated for a first time. The trigger mechanism 90 is further operable to release at least a second portion of the mechanical energy stored in the mechanical energy storage 50 when actuated for a second time.
In other words, the mechanical energy storage 50, the releasable interlock 70 and the trigger mechanism 90 are configured to provide numerous, i.e. at least a first and a second spray delivery or spray discharging of the fluid upon repeated actuation of the trigger mechanism without an intermediate preloading or re-charging of the mechanical energy storage 50.
As will be described below in greater detail the mechanical energy storage 50 can be preloaded or charged by transferring the protective cap 12 from the open position as illustrated in
With the presently illustrated example it is intended that the mechanical energy storage 50 is preloaded or charged with mechanical energy upon and by transferring the protective cap 12 from the open position into the closed position. This way it can be ensured, that the mechanical energy storage is sufficiently charged or preloaded since the closing action of the protective cap 12 is easily controllable by the end user and is inherently provided with a mechanical, haptic, and e.g. audible feedback, e.g. when a snap feature 5 as provided on one of the body 11 or a closure 13 engages with a complementary shaped counter snap feature 7 as provided on the protective cap 12.
Dispensing of a dose of the fluid contained inside the fluid container 110 is provided by moving the driver 30 relative to the nozzle 14. Since the nozzle 14 is rigidly connected or fixed to the body 11 delivery or dispensing of a dose of the fluid is also provided by moving the driver 30 relative to the housing 10 or relative to the body 11 along the longitudinal direction (z).
With the presently illustrated example a dose of the fluid is dispensed by moving the driver 30 relative to the housing 10 in longitudinal distal direction, hence towards the nozzle 14. The driver 30 is part of a discharge mechanism 130. The discharge mechanism 130 comprises a kind of a pump mechanism. The discharge mechanism 130 comprises an inlet valve 131 and an outlet valve 141 as illustrated in
The dispensing chamber 140 comprises a tubular sidewall 142 provided inside the nozzle 14 as illustrated in the sequence of
An outside surface of the inner tubular section 134 is sealed by a tubular sheath 138 of a flexible material. The tubular sheath 138 may comprise a polymeric or elastomeric material being elastically deformable. The inner tubular section 134 and hence its hollow interior is confined in distal direction by a closed end face 137. At a predefined distance from the distal end face 137 the sidewall 135 comprises at least one through opening 136. The through opening 136 or several through openings is/are a radially covered and sealed by the tubular sheath 138. A distal end face 139 of the tubular sheath 138 is flush with a respective outer end face of the inner tubular section 134.
Towards a proximal end, the dispensing chamber 140 is sealingly engaged with an outside surface of the tubular sheath 138. Here, an inside surface of the sidewall 142 is provided with a sealing lip 6. The sealing lip 6 may comprise an annular protrusion and may be in fluid-tight but longitudinally smoothly movable engagement with the outside surface of the tubular sheath 138. The tubular sheath 138 is tightly fitted to the outside surface of the inner tubular section 134. In situations, wherein a fluid pressure inside the dispensing chamber 140 is lower than a fluid pressure inside the inner tubular section 134 the fluid provided inside the hollow part of the inner tubular section 134 is sucked or drawn into the dispensing chamber 140.
Here, a pressure gradient between the dispensing chamber 140 and the hollow interior of the inner tubular section 134 serves to urge the fluid through the at least one through opening 136 into a slot or gap formed between the inside surface of the tubular sheath 138 and the outside surface of the inner tubular section 134. Due to the pressure gradient the distal end of the tubular sheath 138 may widen in radial direction so as to form a respective slot, gap, or slit and to enable a transfer of the fluid from the interior of the inner tubular section 134 into the dispensing chamber 140.
The distal end of the dispensing chamber 140 is sealed by the outlet valve 141. The outlet valve 141 and the inlet valve 131 are implemented in a technically similar or substantially identical manner. The outlet valve 141 comprises a tubular section 144 with a hollow interior in permanent fluid contact with the dispensing chamber 140. The tubular section 144 may extend distally from the dispensing chamber 140. The tubular section 144 may be stepped down in radial direction compared to the geometry or diameter of the dispensing chamber 140.
Towards the distal end the tubular section 144, hence the sidewall 145 of the outlet valve 141 is confined in distal direction by a closed end face 147. The sidewall 145 also comprises a through opening 146 or several through openings 146 near the distal end face 147. An outside surface of the sidewall 145 is also tightly engaged with another tubular sheath 148, which is elastically deformable at least in radial direction. As soon as a pressure inside the tubular section 144 is larger than a pressure outside the outlet the fluid provided in the dispensing chamber 140 will be urged through the through opening(s) 146 into a gap or a slit provided between the outside surface of the sidewall 146 and an inside surface of the radially widened tubular sheath 148 of elastic material.
This way, the fluid may flow into and through the atomizer 2 enclosing the distal end of the outlet valve 141. With the presently illustrated example the atomizer 2 is rigidly fastened, e.g. snap fitted on the distal end of the nozzle 14 and comprises the outlet orifice 3 located downstream and hence distally from the tubular section 144 of the outlet valve 141. Due to an increase of the fluid pressure inside the dispensing chamber 140 fluid is expelled through the hollow tubular section 144 of the outlet valve 141 through the at least one through opening 146, thereby radially widening the tubular sheath 148 so as to enter the orifice 3 by way of which the fluid expelled through the atomizer 2 is effectively atomized or nebulized.
With other examples (not illustrated) the outlet orifice 3 is in fluid connection with the dispensing chamber 140 and/or with the outlet valve 144 and is void of an atomizer 2. Here, the fluid dispensing device 1 may be configured to dispense other types of fluids, e.g. highly viscous fluids, such as syrups, that do not require to be atomized or nebulized. The outlet orifice 3 may be also configured to produce single or multiple drops or droplets of the fluid in a dispensing action. Generally, the outlet orifice 3 may be arranged the housing 10 or may be integrated into the housing 10 without a nozzle 14.
The dispensing chamber 140 can be filled with the fluid by moving the inlet valve 131 in proximal direction relative to the nozzle 14, which is downwardly in the illustration of
Accordingly, and due to the pressure gradient, the fluid will then start to flow through the at least one or several through openings 136, thereby slightly radially outwardly widening the tubular sheath 138. This way, the dispensing chamber 140 will the filled with the fluid.
For dispensing a dose of the fluid by the outlet valve 141 it is intended to longitudinally displace the inlet valve 131 in distal direction towards the outlet valve 141. This way, the volume of the dispensing chamber 140 is reduced and the fluid pressure inside the dispensing chamber 140 will raise. When the inside pressure of the dispensing chamber 140 is larger than an inherent resistance of the outlet valve 141 the rising fluid pressure will be effective to urge the fluid through the through opening(s) 146, thereby radially widening the tubular sheath 148 and expelling the fluid through the atomizer 2. In the sequence of
In
When the trigger mechanism 90 is actuated a second time, the driver 30 and the inlet valve 131 are subject to a further distally directed discrete movement, thus leading to a further reduction of the volume or size of the dispensing chamber 140″ as illustrated in
Moving of the inlet valve 131 and hence moving of the driver 30 towards a proximal direction is effective and configured to fill the dispensing chamber 140 with the fluid. Here, a respective amount of the fluid is withdrawn from the interior of the fluid container 110 by way of suction. For dispensing multiple doses or strokes the driver 30 and hence the inlet valve 131 is moved in numerous discrete steps in longitudinal distal direction relative to the outlet valve 141 as illustrated by the sequence of
The driver 30 is slidably displaced with regard to the longitudinal direction inside the body 11. The driver 30 is movable in longitudinal direction under the effect of the mechanical energy storage 50. The driver 30 is also operable to bias or to preload the mechanical energy storage 50. The driver 30 is longitudinally slidably guided in the housing 10 between a biased position as illustrated in
The driver 30 is displaceable towards the biased position, hence towards the proximal direction against the action of the mechanical energy storage 50. The driver 30 is movable in the opposite direction under the action of the mechanical energy storage. When the mechanical energy storage 50 releases mechanical energy this mechanical energy is operable to urge or to move the driver 30 in distal direction so as to effectuate a spray discharging by moving the inlet valve 131 relative to the outlet valve 141 as described above.
The driver as illustrated in
With the presently illustrated examples there are provided four outwardly extending guiding protrusions 49 on the outside surface of the sidewall 18 of the driver 30. This way, there can be provided a rather tilt-free and/or cant-free and hence rather smooth longitudinal guiding of the driver 30 inside the body 11 of the housing 10. The driver 30 is movably and slidably displaceable between the unbiased position as illustrated in
The mechanical energy storage 50 comprises a first drive spring 51 and a second drive spring 52. The first drive spring 51 and the second drive spring 52 are provided on opposite side edges of the driver 30. The driver 30 comprises a continues cross sectional profile extending in the longitudinal direction (z). The driver 30 and hence the carrier 31 comprises a sidewall 32 extending in longitudinal direction and comprises a somewhat rectangular shaped cross-section. A long side of the sidewall extends along a second transverse direction (x) and a short side of the sidewall extends along a first transverse direction (y).
The first and the second drive springs 51 are provided on the opposite side of the sidewall 32 of the driver 30 that are separated along the second direction (x). Towards or near the distal end 33 the driver 30 comprises an abutment 35 with a V-shaped recess 36. A distal end of the recess 36 forms a proximally facing abutment 35 for a respective distally located longitudinal end 53 of the drive spring 51, 52. In the opposite direction and hence towards the distal end the drive springs 51, 52 each comprise a proximal longitudinal end 54 that is in abutment with a distally facing abutment 15 provided at a respective V-shaped recess 16 on the inside surface of the body 11 as indicated in
Hence, the driver 30 comprises a driver abutment 35 to engage with the first longitudinal end 53 of the first drive spring 51 and/or of the second drive spring 52. The housing 10 comprises a housing abutment 15 to engage with the second longitudinal end 34 of the drive spring(s) 51, 52.
The mechanical energy storage 50 is reversibly transferable into a preloaded state by resiliently compressing the drive spring(s) 51, 52 in the longitudinal direction. As illustrated in
This way, the drive spring 51, 52 are compressible into a S-shaped, double S-shaped or M-shaped deformed configuration. In order to induce a well-defined transverse deformation of the drive springs 51, 52 at least one of the driver 30 and the housing 10 comprises a spring fixing notch 65, 66 through which the longitudinal extending slot profile of the drive spring 51, 52 is guided and/or fixed in longitudinal direction (z).
A free space of the spring fixing notch is 65, 66, through which the drive spring 51, 52 is longitudinally guided is only slightly larger than a thickness of the lateral profile of the drive spring 51, 56. Hence, in the region of the spring fixing notches 65, 66 the position of the drive spring 51, 52 is substantially fixed with regards to the first transverse direction (y).
The spring fixing notches 65, 66 are separated in longitudinal direction. This way, and when the oppositely located longitudinal ends 53, 54 of the drive spring(s) 51, 52 are subject to a compression in longitudinal direction (z) there will evolve oppositely directed arc-shaped undulations 57, 58, 59 extending in the first transverse direction (y). The undulations are provided by respective deformable portions 67, 68, 69 of the respective drive springs 51, 52.
As illustrated in
Between the second spring fixing notch 66 and the housing abutment 15 there is located a third bendable or deformable portion 69 of the drive spring 52. When subject to longitudinal compression the third bendable portion 69 also forms an arc-shaped undulation 59 extending in the same direction as the first undulation 57.
On the outside surface of the sidewall 32 of the driver 30 there are further provided spring deformation guiding elements 37, 38 and 39 that are located e.g. midway between adjacently arranged prefixing notches 65, 66 and between an upper or lower prefixing large and a respective abutment 15, 35 of the housing 10 and/or of the driver 30. A first spring deformation guiding element 37 is located longitudinally between the driver abutment 35 and the first prefixing notch 65. A second spring deformation guiding element 38 is located longitudinally between the first spring fixing notch 65 and the second spring fixing notch 66 and a third spring deformation guiding element 39 is located, e.g. longitudinally midway, between the second spring fixing notch 66 and the housing abutment 15.
Spring deformation guiding elements positioned adjacently in longitudinal direction (z) are located on opposite sides of the drive spring 51, 52 as seen with regards to the first transverse direction (y). The spring deformation guiding elements 37, 38, 39 are configured to induce a deformation of the first, second and third deformable or bendable portions 67, 68, 69 of the drive spring 51, 52 away from the respective spring deformation guiding element 37, 38, 39 into a respective arc-shaped undulation 57, 58, 59.
Insofar, the spring deformation guiding elements 37, 38, 39 are arranged and configured to break the longitudinal symmetry of the rather straight shaped elongated first and second drive springs 51, 52. A side edge of the spring deformation guiding elements, which protrude from the sidewall 32 of the driver 30 with regard to the second transverse direction (x) are arranged slightly offset from a virtual longitudinal center line of the first and second drive springs 51, 52 as seen in the first transverse direction (y).
This way, the drive springs 51, 52, which may be of substantially straight shape when in the completely unbiased position as illustrated in
By way of the V-shaped recesses 16, 36 as provided by the housing 10 and the driver 30, a rather precise abutment and alignment of the drive springs 51, 52 can be provided with regards to the first transverse direction (y). The V-shaped recesses 16, 36 provide a kind of a self-centered arrangement of the drive Springs 51, 52 with regard to the first transverse direction (y).
The drive springs 51, 52 as illustrated in
In effect, the longitudinally extending elongated and rather straight shaped drive springs 51, 52 are beneficial to provide a rather constant spring force in longitudinal direction (z) when subject to the deformation with regards to the first lateral direction (y). Rather independently of the degree of deformation in the first lateral direction (y) as illustrated in the various configurations of
The spring arrangement is further of particular benefit to provide a sequence of dispensing actions without an intermediate charging or reloading of the mechanical energy storage 50.
Hence, the mechanical energy stored by the drive springs 51, 52 and hence stored by the mechanical energy storage 50 can be released in a sequence of discrete steps, each of which releasing an amount of mechanical energy sufficient to effectuate a spray discharging of a dose of the fluid.
Apart from that, the longitudinal and rather elongated straight shape of the drive springs 51, 52 is beneficial with regards to a compact design of the mechanical energy storage 50. The drive springs 51, 52 only require a rather limited construction space.
In the example of
With the integrated drive spring assembly is also conceivable to implement a further spring element 73 into the drive spring assembly. The further spring 73 may belong to the releasable interlock 70 and may serve to keep a locking element 71, e.g. provided as a free end of the slab-like locking spring 73 in engagement with a complementary shaped counter locking structure 40 of the driver 30 as will be explained further below.
Here, all metal components of the fluid dispensing device 1 may be integrated in the drive spring assembly, thereby facilitating the mass manufacturing and assembly of individual parts of the fluid dispensing device 1. Also, the number of individual parts for assembly of the device 1 can be reduced.
As will be explained and described further below the locking element 71 of the interlock 70 is operable to retain the mechanical energy stored in the mechanical energy storage 50. The releasable interlock 70 is operably engaged with the trigger mechanism 90. Actuation of a trigger button 91 may at least temporally disengage the locking element 70 from the counter locking structure 40 and may thus allow to release at least a portion of the mechanical energy from the mechanical energy storage 50 in order to move the driver 30 towards the unbiased position, thereby dispensing a dose of the fluid.
In the illustration of
When the protective cap 12 is about to reach the closed position the abutment 8 gets in direct mechanical contact with the counter abutment 9. When reaching the closed position the abutment 8 is effective to press down onto the counter abutment 9 and to exert a respective proximally directed force effect onto the counter abutment 9, thereby inducing a further proximally directed movement of the driver 30 towards the proximal direction.
This leads to a kind of an over-pressing of the mechanical energy storage 50. As illustrated with this kind of a primed configuration as shown in
In
When the fastening structure 114 of the rigid fastening adapter 112 engages with the complementary or correspondingly shaped counter fastening structure 126 of the fluid dispensing device 1 there is provided a fluid-tight connection between the fluid discharge mechanism 130 of the dispensing device 1 and the outlet shaft 113 as provided by the rigid fastening adapter 112.
The flexible bag 120 provides a rather easy and smooth withdrawal of the fluid from the interior volume 123. When withdrawing a portion of the fluid from the interior volume 123, the flexible bag 120 may collapse due to the reduced interior volume 123. As indicated in
A collapsible sidewall 122 of the flexible bag 120 and hence a collapsible fluid-tight bag 120 allows and supports a suction-based withdrawal of the fluid from the interior volume 123.
The rigid fastening adapter 112 that is sealingly engaged with the bag outlet 124 provides a well-defined mechanical fastening of the fluid container 110 with the discharge mechanism 130.
As indicated in
With the example of
The fastening structure 114 and hence the beveled shaped snap element 116 may comprise an annular structure to engage with a complementary shaped annular structure of the counter snap element 128. In order to enable a rather smooth and easy mutual snap-fit engagement there may be provided at least one or several interruptions or recesses in the annular structure of at least one of the beveled shaped snap element 116 and the complementary shaped beveled counter snap element 128. As illustrated in the cross-section of
As particularly illustrated in
The outside surface of the tubular shaped valve inserts 132 and the inside surface of the receptacle 117 of the outlet shaft 113 are configured such that a fluid tight engagement is provided between the bag outlet 124 and the hollow portion of the valve insert 132 as the fastening structure 114 engages with the complementary-shaped counter fastening structure 126.
With another example occurs in not illustrated it is also conceivable, that the inlet valve 131 comprises a hollow shaft with a receptacle configured for receiving and insertion of the outlet shaft 113 of the fluid container 110.
As further illustrated in
With the example of
With some examples the outer rigid casing 111 is made of a material or a material composition comprising at least one of a high-density polyethylene and a polypropylene. With some examples the outer rigid casing comprises a multilayer structure with a first layer made of a high-density polyethylene and a second layer made of a polypropylene. The lexical bag 120 may be blow molded or injection molded into the outer rigid casing 111. With other examples the flexible bag 120 and the outer rigid casing 111 co-extruded. Any of these manufacturing methods may have certain advantages for a cost efficient and reliable mass manufacturing of such fluid containers.
With the example of
The rigid fastening adapter 112, comprises the hollow outlet shaft 113 protruding outwardly from the interior volume 123 of the flexible bag 120. An inside facing side of the shoulder portion 115 is in a sealing engagement with the flexible sidewall 122. Here, the shoulder portion 115 comprises numerous snap elements 116 protruding outwardly in distal direction from the shoulder portion 115. Alternatively or additionally, there may be provided respective snap elements 116 at a lateral side edge of the shoulder portion 115. Towards the inside the shoulder portion 150 may comprise a comparatively short sidewall portion 119 extending in longitudinal direction, e.g. forming a circumferentially closed rim.
The sidewall portion 119 may be in abutment with the longitudinal, hence with the distal end of the sidewall 122 of the flexible bag 120. Here, an inside surface of the sidewall 122 may be sealingly engaged with an outside surface of the sidewall portion 119. Alternatively, an outside surface of the sidewall is sealingly engaged with an inside surface of the sidewall portion 119.
Optionally, the fastening adapter 112 and hence the rather planar-shaped shoulder portion 115 may be connected with a cup-shaped rigid casing 111 as illustrated in the cross-section of
Even though not particularly shown, also here the sidewall 120 may comprise a bag outlet 124 comprising a diameter that is smaller than the diameter of the sidewall 122 near a proximal end or in a longitudinal middle portion of the sidewall 122. Also here, and as illustrated in the example of
Charging and/or preloading of the mechanical energy storage 50 is described below in further detail. For biasing or charging of the mechanical energy storage 50, there is provided a biasing mechanism 150 comprising a biasing member 160 as shown in
The biasing mechanism 150 with the biasing member 160 comprises a pinion segment 151 connection to or integrated into the protective cap 12. The biasing member 160 further comprises a rack segment 161 with numerous teeth engaged with the pinion segment 151, e.g. engaged with the teeth of the pinion segment. As illustrated in greater detail in
The rack segment 161 comprises numerous teeth that are arranged next to each other along the longitudinal direction (z). The rack segment 161 is of rather elongated shape and extends along the longitudinal direction. As the protective cap 12 is subject to a pivoting motion relative to the housing 10 the teeth of the pinion segment 151 successively engage with the teeth of the rack segment 161, thereby inducing a longitudinal sliding motion of the rack segment 161 and hence of the biasing member 160 relative to the housing 10 and relative to the body 11. The biasing member 160 comprises a somewhat U-shaped profile as seen in the transverse cross-section.
The biasing member 160 comprises a first sidewall section 162, a second side wall section 163 and a third sidewall section 164, wherein the first and the third sidewall sections 162, 164 extend substantially parallel to each other. They are separated with regards to the first transverse direction (y). The second sidewall section 163 extends between the first and the third side wall sections 162, 164. The numerous sidewall sections 162, 163, 164 are integrally formed. Hence, the biasing member 160 is implemented as a single piece.
On the outside surfaces of the first and the third sidewall sections 162, 164 there are provided longitudinal extending guiding ribs 165, 166 to engage with complementary shaped guiding ribs 24, 25 as provided on an inside surface of the sidewall 18 of the body 11. This way, the biasing member 160 is longitudinally guided in the body 11 of the housing 10. By way of a pair wise mutual engagement of guiding ribs 166, 25 and guiding ribs 165, 24 a rather smooth, tilt-free and/or cant-free longitudinal sliding displacement of the biasing member 160 relative to the body 11 can be provided.
The first sidewall section 162 further comprises a lateral protrusion 167 extending and protruding along the second lateral direction (x) from a lower portion of the second sidewall 162. The lateral protrusion 167 lies in the plane of the second sidewall section and forms an abutment face 169 facing in proximal direction. The abutment face 169 is formed by a lower edge of the lateral protrusion 167 and is complementary shaped to a counter stop face or counter abutment face 29 of the driver 30. Here, the driver 30 comprises a longitudinally recess 27 adjoining a distal end 33 of the side wall of the driver 30. The longitudinally extending recess 27 is provided in an outside section of the sidewall 32. It is complementary shaped to the lateral protrusion 167 and provides a supplemental guiding function for the longitudinal sliding motion of the biasing member 160.
As it is further apparent from
During a closing motion of the protective cap 12 and when the driver 30 is in the upper or distal end position, which coincides with the unbiased position of the driver 30, the pivoting motion of the protective cap 12 towards the closed position leads to a respective rotation of the pinion segment 151 which is directly transferred into a longitudinal sliding displacement of the biasing member 160 in longitudinal proximal direction relative to the body 11. In this configuration the proximally facing abutment or side edge 169 is in longitudinal abutment with a complementary shaped counter stop face 29 of the driver 30.
As the protective cap 12 is moved further towards the closed position the biasing member 160 applies a respective proximally directed force effect onto the driver 30, thereby moving the driver 30 against the action of the mechanical energy storage 50 into the proximal end position, hence into the biased position. When reaching the biased position the driver 30 engages with the interlock 70 by way of which the driver 30 is prevented from moving towards the distal direction, hence into the unbiased position. A re-opening of the protective cap 12 may then be accompanied by a respective distally directed motion of the biasing member 160 as illustrated in
From
In the following, interaction between the trigger mechanism 90 and the releasable interlock 70 for producing a sequence of dose dispensing procedures is described in greater detail. The driver 30 comprises a counter locking structure 40 on the sidewall 32. The counter locking structure 40 comprises numerous counter locking elements 41, 42, 43, 44 that are separated along the longitudinal direction (z). The interlock 70 comprises a locking element 71 sized and configured to engage with each one of the counter locking elements 41, 42, 43, 44. The mutual interaction between the locking element 71 with each one or with several of the counter locking elements 41, 42, 43, 44 is apparent by the sequence of
The locking element 71 of the releasable interlock 70 is provided on a longitudinal end of an elongated locking spring 73. The locking spring 73 serves to urge or to keep the locking element 71 in engagement with a counter locking structure 40. In the present case the locking spring 73 serves to displace the locking element 71 in the first transverse direction (y). The locking element comprises a pawl 72 configured to engage into recesses 45, 46 provided longitudinally between the row or sequence of the counter locking elements 41, 42, 43, 44. Towards the distal direction the free end of the locking element 71 comprises a beveled edge 74. This way and as the driver 30 provided with the counter locking structure 40 is subject to a longitudinal sliding displacement towards the proximal direction the beveled edge 74 slides along the sequence of counter locking elements 44, 43, 42, 41 and is thereby deflected against the action of the locking spring 73.
When the driver 30 has reached the biased position, and hence when the driver 30 is in a proximal end position the locking element 71 is in engagement with a first counter locking element 41. Here and as illustrated in
As indicated in
Depression of the trigger button 91 leads to an insertion of the trigger head 92 into the second side 48 of the through recess 45, thereby urging the retaining pawl 72 out of the respective recess 45 as illustrated in
Here, the retaining pawl 72, e.g. its free end 75, enters the through recess 46 and engages with its stop face 76 with the second counter locking element 42. Consequently, the dispensing motion of the driver 30 towards the unbiased position is stopped. During this distally directed longitudinal sliding movement of the driver 30 the trigger button 91 may still remain in the depressed configuration as illustrated in
The trigger button 91 is attached to the housing 10. It may be integrally formed with the closure 13. As illustrated in
The inwardly directed depression of the trigger button 91 urges the trigger head 92 into one of the through recesses 45, 46 as provided by the counter locking structure 40. When the driver 30 is subject to a distally directed dispensing motion while the trigger button 91 one is still depressed the trigger head 92 remains trapped in the respective through recess 45 as illustrated in
As shown in detail in
Now and when the trigger button 91 is released the resilient members 97, 98 serve to deflect the trigger button 91 into the initial configuration. As becomes apparent from the illustration of
This way, the trigger head 92 returns into an initial configuration or initial position relative to the trigger button 91. Since in effect, the relative position of the trigger head 91 to the trigger button 91 is the same in both configurations of
Accordingly, and when the trigger button 91 is released in
This way, the trigger mechanism 90 can be actuated at least two times or even several times thereby releasing only a portion of the mechanical energy stored in the mechanical energy storage 50. Between repeated actuations of the trigger mechanism 90 it is not necessary to reload or to recharge the mechanical energy storage 50. Once the user has opened the protective cap 12 the fluid dispensing device 1 can be readily used to dispense a first dose of the fluid e.g. in a first nostril and to subsequently dispense a second dose of the fluid into a second nostril.
While the invention has been described and illustrated herein by references to various specific materials, it is understood that the invention is not restricted to the combinations of material and procedures selected for that purpose. Numerous variations of such details can be implied as will be appreciated by those skilled in the art. It is intended that the specification and examples be considered as exemplary, only, with the true scope and spirit of the invention being indicated by the following claims.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/IB2021/061695 | 12/14/2021 | WO |
