The present disclosure relates to fluid manifolds.
Fluid manifolds are often used where fluid flow paths are joined together. For instance, fluid manifolds can permit passage of fluid from a first conduit to one or more secondary conduits. Traditionally, fluid manifolds for distributing fluid flow to multiple output conduits utilize a main passageway with a number of fluid output openings commensurate with a number of output conduits to be attached to the fluid manifold.
In certain fields of use, such as in pharmaceuticals and the development of certain biological fluids, fluid manifolds distribute expensive, high cost materials. Retention of such materials within the fluid manifold can be costly to the manufacturer. Thus, industries using fluid manifolds continue to demand improvements in fluid manifolds to increase operational output while minimizing waste.
Embodiments are illustrated by way of example and are not intended to be limited in the accompanying figures.
The following description in combination with the figures is provided to assist in understanding the teachings disclosed herein. The following discussion will focus on specific implementations and embodiments of the teachings. This focus is provided to assist in describing the teachings and should not be interpreted as a limitation on the scope or applicability of the teachings. However, other embodiments can be used based on the teachings as disclosed in this application.
The terms “comprises,” “comprising,” “includes,” “including,” “has,” “having” or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a method, article, or apparatus that comprises a list of features is not necessarily limited only to those features but may include other features not expressly listed or inherent to such method, article, or apparatus. Further, unless expressly stated to the contrary, “or” refers to an inclusive-or and not to an exclusive-or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).
The terms “generally,” “substantially,” “approximately,” and the like are intended to cover a range of deviations from the given value. In a particular embodiment, the terms “generally,” “substantially,” “approximately,” and the like refer to deviations in either direction of the value within 10% of the value, within 9% of the value, within 8% of the value, within 7% of the value, within 6% of the value, within 5% of the value, within 4% of the value, within 3% of the value, within 2% of the value, or within 1% of the value.
Also, the use of “a” or “an” is employed to describe elements and components described herein. This is done merely for convenience and to give a general sense of the scope of the invention. This description should be read to include one, at least one, or the singular as also including the plural, or vice versa, unless it is clear that it is meant otherwise. For example, when a single item is described herein, more than one item may be used in place of a single item. Similarly, where more than one item is described herein, a single item may be substituted for that more than one item.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The materials, methods, and examples are illustrative only and not intended to be limiting. To the extent not described herein, many details regarding specific materials and processing acts are conventional and may be found in textbooks and other sources within the fluid transport arts.
In accordance with an aspect described herein, a fluid manifold can include a body defining a fluid inlet, a plurality of fluid outlets, and a volume disposed between and in fluid communication with the fluid inlet and the plurality of fluid outlets. The volume can define a first width, WI, as measured at a first location near the fluid inlet, a second width, WO, as measured at a second location near the plurality of fluid outlets, a first thickness, TI, as measured at the first location perpendicular to WI, and a second thickness, TO, as measured at the second location perpendicular to WO. In an embodiment, WO>WI>TI>TO. In a more particular embodiment, WO>WI>TI>TO.
In another aspect, a fluid manifold can include a body defining a fluid inlet, a plurality of fluid outlets, and a volume disposed between and in fluid communication with the fluid inlet and the plurality of fluid outlets. The volume can have a tapered width and a tapered thickness. The tapered width can taper in a direction opposite of the tapered thickness.
In an embodiment, at least some of the plurality of fluid outlets can be disposed along a same plane. In a more particular embodiment, all of the plurality of fluid outlets can be disposed along a same plane. In another particular embodiment, the plurality of fluid outlets is disposed along at least two planes. The two planes can be parallel with respect to one another. In an embodiment, the internal ends of the plurality of fluid outlets can be disposed along a line extending perpendicular to a central axis of the fluid inlet. In another embodiment, least one of the plurality of fluid outlets has a central axis parallel with a central axis of the fluid inlet. In a more particular embodiment, all of the plurality of fluid outlets can have a central axis parallel with a central axis of the fluid inlet.
In an embodiment, the volume can define a triangular cross section, as viewed from a top view. In another embodiment, the volume can define a quadrilateral cross section, as viewed from a side view. In another embodiment, the inlet can have a diameter greater than a diameter of any of the plurality of outlets. In yet another embodiment, all of the plurality of outlets can have the same diameters as one another.
In an embodiment, the body of the fluid manifold can be monolithic. In an embodiment, each of the plurality of fluid outlets can define an opening adapted to receive an end of a hose. The opening can have a diameter greater than a diameter of the fluid outlet. In an embodiment, the opening can define a diameter approximately equal to an outer diameter of the hose. The fluid outlet can define a diameter approximately equal to an inner diameter of the hose.
In an embodiment, the body can define an inlet sidewall thickness, as measured along a fluid inlet coupling portion, and a volume sidewall thickness as measured along the volume. The volume sidewall thickness can be greater than the inlet sidewall thickness. In an embodiment, the volume sidewall thickness can taper, as measured between the fluid inlet and the plurality of fluid outlets.
In an embodiment, adjacent fluid outlets can be spaced apart from one another by a wall of the body. In a particular embodiment, the upstream side of the wall can define a curved profile. The upstream side of the wall can be closest to the volume defined by the volume of the body. In an embodiment, the volume can define a storage area for fluid not yet passed out of the plurality of fluid outlets. The storage area can be less than 250 cc, less than 100 cc, less than 50 cc, less than 25 cc, less than 10 cc, or less than 5 cc. In an embodiment, the fluid manifold is adapted to prevent fluid retention within the volume after use.
In a particular aspect, a fluid system can include a fluid inlet hose, a plurality of fluid outlet hoses, and a fluid manifold coupled between the fluid inlet hose and the plurality of fluid outlet hoses, wherein the fluid manifold comprises a volume disposed between fluid inlets and fluid outlets, and wherein the volume has a tapered width and a tapered thickness, and wherein the tapered width tapers in a direction opposite of the tapered thickness.
Referring to
In an embodiment, all of the plurality of fluid outlets 106 can have central axis 114 oriented parallel, or generally parallel, with respect to one another. In another embodiment, the central axis 114 of at least one of the fluid outlets 106 can be angularly offset from the central axis 114 of another one of the fluid outlets 106.
In an embodiment, the central axis 114 of the fluid outlets 106, or at least one of the fluid outlets 106, can be parallel with a central axis of the fluid inlet 104. In certain instances, parallel flow paths can reduce fluid turbulence within the fluid manifold 100. Reduced turbulence can mitigate fluid shear during fluid transfer operations.
In an embodiment, the fluid outlets 106 can define diameters, DO, less than the diameter, DI, of the fluid inlet 104. In an embodiment, DO can be less than 1 DI, less than 0.99 DI, less than 0.98 DI, less than 0.97 DI, less than 0.96 DI, less than 0.95 DI, less than 0.94 DI, less than 0.93 DI, less than 0.92 DI, less than 0.91 DI, less than 0.9 DI, less than 0.8 DI, less than 0.7 DI, less than 0.6 DI, less than 0.5 DI, or less than 0.4 DI. In another embodiment, DO is no less than 0.01 DI, no less than 0.1 DI, or no less than 0.25 DI.
In certain embodiments, the cumulative opening size of the fluid outlets 106 can be no less than the opening size of the fluid inlet 104. That is, fluid introduced into the fluid manifold 100 can exit the fluid outlets 106 without generating internal pressure within the fluid manifold 100. This can reduce shear and culture damage to cells contained within the fluid. In another embodiment, the cumulative opening size of the fluid outlets 106 can be at least the size of the opening size of the fluid inlet 104. In a more particular embodiment, the cumulative opening size of the fluid outlets 106 can be greater than the size of the opening size of the fluid inlet 104.
In an embodiment, the fluid outlets 106 can lie along a straight line. For instance, as illustrated in the embodiment of
The fluid manifold 100 can further include a volume 118 disposed between the fluid inlet 104 and the plurality of fluid outlets 106. In an embodiment, the volume 118 can define a central aperture adapted to permit fluid communication between the fluid inlet 104 and the fluid outlets 106.
In an embodiment, the volume 118 can define a quadrilateral, or generally quadrilateral, cross section, as viewed from a side view. For instance, the volume 118 can define an upper major surface (not illustrated) and a lower major surface 120 spaced apart by the volume 118. In an embodiment, the upper and lower major surfaces can be parallel with one another. In the illustrated embodiment, the upper and lower major surfaces of the volume 118 are angularly offset from one another by at least 1°, at least 2°, at least 3°, at least 4°, at least 5°, at least 10°, or at least 20°. In another embodiment, the upper and lower major surfaces of the volume 118 can be angularly offset from one another by no greater than 85°, no greater than 70°, no greater than 55°, no greater than 40°, or no greater than 25°. Moreover, the upper and lower major surfaces of the volume 118 can be angularly offset from one another by an angle in a range between any of the values provided above, such as between 1° and 85°, between 5° and 70°, or between 10° and 20°.
In the illustrated embodiment, the volume 118 can define a tapered profile, as created by straight walls angled at a constant rate. In another embodiment, the volume 118 can taper through the use of one or more steps, or varying angled wall portions connected together.
In an embodiment, a tallest portion of the volume 118, i.e., a portion of the volume 118 with a largest thickness as measured between the major surfaces, can be near the fluid inlet 104. In another embodiment, a shortest portion of the volume 118 can be near the fluid outlets 106. In certain instances, the rate of taper can be uniform, or generally uniform, as measured laterally across the volume 118. That is, for instance, the thickness of the volume 118 can be constant as measured along a line oriented perpendicular to the central axis of the fluid inlet 104.
In an embodiment, the volume 118 can define a tapered width and a tapered thickness oriented opposite of one another. That is, as the width of the volume 118 increases, the thickness can decrease. In a particular embodiment, the thickness of the volume 118 can be constant, or generally constant, as measured along the width of the volume 118. That is, a line oriented parallel with the line 116 illustrated in
In an embodiment, the body 102 can define an inlet sidewall thickness, as measured along a fluid inlet coupling portion 122, and a volume sidewall thickness, as measured along the volume 118, different from the inlet sidewall thickness. In a particular embodiment, the volume sidewall thickness can be greater than the inlet sidewall thickness. In another embodiment, the volume sidewall thickness can vary, as measured along the volume 118. For instance, the volume sidewall thickness can taper, as measured between the fluid inlet 104 and the fluid outlets 106. In a more particular embodiment, the volume sidewall thickness can taper from thickest near the fluid inlet 104 to thinner near the fluid outlets 106. In another embodiment, the taper of the volume sidewall thickness can be thickest near the fluid outlets 106.
In an embodiment, the area of the volume 118, as viewed parallel with the plane 112 (
In an embodiment, adjacent fluid outlets, e.g., fluid outlets 108 and 110, can be spaced apart from one another by a wall 124. In a particular embodiment, the wall 124 can be part of the body 102 of the fluid manifold 100. For example, the wall 124 can be integral with the body 102. In an embodiment, all of the fluid outlets 106 can be separated by a wall 124. In a more particular embodiment, the walls 124 between adjacent fluid outlets 106 can have the same shape or size. In another embodiment, the walls 124 can be different from one another in shape, size, or another attribute.
In an embodiment, the fluid inlet 104 can define a diameter greater than the diameters of at least one of the plurality of fluid outlets 106. In a more particular embodiment, the fluid inlet 104 can define a diameter greater than the diameter of all of the plurality of fluid outlets 106. In certain instances, the plurality of fluid outlets 106 can share a same diameter as compared to one another.
In use, the fluid outlets 106 can selectively receive hoses for transport of fluid from the fluid manifold 100 to one or more areas, such as one or more pharmaceutical containers or processing areas. In a particular embodiment, the fluid outlets 106 can define openings 126 adapted to receive ends of hoses (not illustrated). The openings 126 can define diameters greater than the diameter of the corresponding fluid outlet 106. The opening 126 can define a diameter approximately equal to an outer diameter of the hose. The fluid outlet 106 can define a diameter approximately equal to an inner diameter of the hose. Thus, the difference between the opening 126 and fluid outlet 106 can define a sidewall thickness of the hose to be received in the fluid outlet 106.
In certain instances, the volume 118 can define a storage area for fluid not yet passed from the plurality of fluid outlets 106. That is, after fluid transport through the fluid manifold 100 is completed, a certain volume of fluid can be retained within the volume 118. Such fluid retention can be undesirable as the fluids being retained within the volume 118 can be expensive, and the loss thereof can be financially costly. In accordance with embodiments described herein, the fluid manifold 100 can be adapted to prevent fluid retention within the volume 118 after use. In a particular embodiment, the storage area, i.e., the volume 118, can be less than 250 cc, less than 100 cc, less than 50 cc, less than 25 cc, less than 10 cc, or less than 5 cc. In a more particular embodiment, the storage area can be less than 4 cc, less than 3 cc, or less than 2 cc.
In an embodiment, the body 102 of the fluid manifold 100 can be monolithic. For instance, the body 102 can be formed from a single piece by molding, such as injection molding, pressing, stamping, or another similar forming operation. In other embodiments, the body 102 can include a multi-piece construction. For example, the body 102 can include two halves joined together at a seam. Alternatively, the body 102 can include multiple portions coupled together, such as an inlet portion, an outlet portion, and a volume portion disposed between the inlet and outlet portions.
Exemplary materials for the body 102 can include polymers, metals, alloys, organic compounds, and combinations thereof. By way of non-limiting example, the body 102 can include, for instance, nylon, polyether ether ketone (PEEK), polyether sulfone (PES), polytetrafluoroethylene (PTFE), polyimide, or an organic or inorganic composite. Further exemplary polymers include fluorinated ethylene-propylene (FEP), polyvinylidenfluoride (PVDF), polychlorotrifluoroethylene (PCTFE), ethylene chlorotrifluoroethylene (ECTFE), perfluoroalkoxy alkane (PFA), polyacetal, polybutylene terephthalate (PBT), polyethylene terephthalate (PET), polyimide (PI), polyetherimide, polyethylene (PE), polysulfone, polyamide (PA), polyphenylene oxide, polyphenylene sulfide (PPS), polyurethane, polyester, liquid crystal polymers (LCP), or any combination thereof. In particular embodiments, the body 102 can further include a filler. Exemplary fillers include glass fibers, carbon fibers, silicon, PEEK, aromatic polyester, carbon particles, bronze, fluoropolymers, thermoplastic fillers, aluminum oxide, polyamidimide (PAI), PPS, polyphenylene sulfone (PPSO2), LCP, aromatic polyesters, molybdenum disulfide, tungsten disulfide, graphite, grapheme, expanded graphite, boron nitrade, talc, calcium fluoride, or any combination thereof. Additionally, the filler can include alumina, silica, titanium dioxide, calcium fluoride, boron nitride, mica, Wollastonite, silicon carbide, silicon nitride, zirconia, carbon black, pigments, or any combination thereof.
In certain instances, the fluid manifold 100 can include integral hoses coupled with the fluid manifold 100. In a particular embodiment, the integral hoses, or portions thereof, can be monolithic with the body 102.
A fluid manifold comprising: a body defining: a fluid inlet; a plurality of fluid outlets; and a volume disposed between and in fluid communication with the fluid inlet and the plurality of fluid outlets, wherein the volume defines: a first width, WI, as measured at a first location near the fluid inlet, a second width, WO, as measured at a second location near the plurality of fluid outlets, a first thickness, TI, as measured at the first location perpendicular to WI, and a second thickness, TO, as measured at the second location perpendicular to WO, and wherein WO>WI>TI>TO.
A fluid manifold comprising: a body defining: a fluid inlet; a plurality of fluid outlets; and a volume disposed between and in fluid communication with the fluid inlet and the plurality of fluid outlets, wherein the volume has a tapered width and a tapered thickness, and wherein the tapered width tapers in a direction opposite of the tapered thickness.
The fluid manifold of any one of the preceding embodiments, wherein the plurality of fluid outlets are disposed along a same plane.
The fluid manifold of any one of embodiments 1 and 2, wherein the plurality of fluid outlets are disposed along at least two planes, and wherein the at least two planes are parallel with respect to one another.
The fluid manifold of any one of the preceding embodiments, wherein internal ends of the plurality of fluid outlets are disposed along a line extending perpendicular to a central axis of the fluid inlet.
The fluid manifold of any one of the preceding embodiments, wherein at least one of the plurality of fluid outlets has a central axis parallel with a central axis of the fluid inlet.
The fluid manifold of any one of the preceding embodiments, wherein all of the plurality of fluid outlets have central axis parallel with a central axis of the fluid inlet.
The fluid manifold of any one of the preceding embodiments, wherein the volume defines a triangular cross section, as viewed from a top view.
The fluid manifold of any one of the preceding embodiments, wherein the volume defines a quadrilateral cross section, as viewed from a side view.
The fluid manifold of any one of the preceding embodiments, wherein the inlet has a diameter greater than any of the plurality of outlets.
The fluid manifold of any one of the preceding embodiments, wherein all of the plurality of outlets have the same diameter as one another.
The fluid manifold of any one of the preceding embodiments, wherein the body is monolithic.
The fluid manifold of any one of the preceding embodiments, wherein each of the plurality of fluid outlets defines an opening adapted to receive an end of a hose.
The fluid manifold of embodiment 13, wherein the opening has a diameter greater than a diameter of the fluid outlet.
The fluid manifold of any one of embodiments 13 and 14, wherein the opening defines a diameter approximately equal to an outer diameter of the hose, and wherein the fluid outlet defines a diameter approximately equal to an inner diameter of the hose.
The fluid manifold of any one of the preceding embodiments, wherein the body defines an inlet sidewall thickness as measured along a fluid inlet coupling portion, and a volume sidewall thickness as measured along the volume, and wherein the volume sidewall thickness is greater than the inlet sidewall thickness.
The fluid manifold of embodiment 16, wherein the volume sidewall thickness tapers, as measured between the fluid inlet and the plurality of fluid outlets.
The fluid manifold of any one of the preceding embodiments, wherein adjacent fluid outlets are spaced apart from one another by a wall of the body, and wherein an upstream side of the wall defines a curved profile.
The fluid manifold of any one of the preceding embodiments, wherein the volume defines a storage area for fluid not yet passed out of the plurality of fluid outlets, and wherein the storage area is less than 250 cc, less than 100 cc, less than 50 cc, less than 25 cc, less than 10 cc, or less than 5 cc.
The fluid manifold of any one of the preceding embodiments, wherein the fluid manifold is adapted to prevent fluid retention within the volume after use.
A fluid system comprising: a fluid inlet hose; a plurality of fluid outlet hoses; and a fluid manifold coupled between the fluid inlet hose and the plurality of fluid outlet hoses, wherein the fluid manifold comprises a volume disposed between fluid inlets and fluid outlets, and wherein the volume has a tapered width and a tapered thickness, and wherein the tapered width tapers in a direction opposite of the tapered thickness.
The fluid system of embodiment 21, wherein the fluid inlet hose and the plurality of fluid outlet hoses are spaced apart from the volume.
The fluid system of any one of embodiments 21 and 22, wherein the fluid inlet hose and the plurality of fluid outlet hoses are oriented along generally parallel central axis.
The fluid system of any one of embodiments 21-23, wherein ends of the plurality of fluid outlet hoses are disposed along a line extending perpendicular to a central axis of at least one of the plurality of fluid outlet hoses.
The fluid system of any one of embodiments 21-24, wherein the volume defines a first width, WI, as measured at a first location near the fluid inlet hose, a second width, WO, as measured at a second location near the plurality of fluid outlet hoses, a first thickness, TI, as measured at the first location perpendicular to WI, and a second thickness, TO, as measured at the second location perpendicular to WO, and wherein WO>WI>TI>TO.
The fluid system of any one of embodiments 21-25, wherein WO>WI>TI>TO.
The fluid system of any one of embodiments 21-26, wherein the plurality of fluid outlet hoses comprises at least 4 fluid outlet hoses, at least 5 fluid outlet hoses, at least 6 fluid outlet hoses, at least 8 fluid outlet hoses, or at least 10 fluid outlet hoses.
Note that not all of the activities described above in the general description or the examples are required, that a portion of a specific activity may not be required, and that one or more further activities may be performed in addition to those described. Still further, the order in which activities are listed is not necessarily the order in which they are performed.
Benefits, other advantages, and solutions to problems have been described above with regard to specific embodiments. However, the benefits, advantages, solutions to problems, and any feature(s) that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as a critical, required, or essential feature of any or all the claims.
The specification and illustrations of the embodiments described herein are intended to provide a general understanding of the structure of the various embodiments. The specification and illustrations are not intended to serve as an exhaustive and comprehensive description of all of the elements and features of apparatus and systems that use the structures or methods described herein. Separate embodiments may also be provided in combination in a single embodiment, and conversely, various features that are, for brevity, described in the context of a single embodiment, may also be provided separately or in any subcombination. Further, reference to values stated in ranges includes each and every value within that range. Many other embodiments may be apparent to skilled artisans only after reading this specification. Other embodiments may be used and derived from the disclosure, such that a structural substitution, logical substitution, or another change may be made without departing from the scope of the disclosure. Accordingly, the disclosure is to be regarded as illustrative rather than restrictive.
This application claims priority under 35 U.S.C. § 119(e) to U.S. Patent Application No. 62/771,959 entitled “FLUID MANIFOLD,” by Michael R. HUSCHKE, filed Nov. 27, 2018, which is assigned to the current assignee hereof and incorporated herein by reference in its entirety.
Number | Date | Country | |
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62771959 | Nov 2018 | US |