FLUORESCENT INDICATORS FOR CYTOSOLIC LITHIUM ION

Information

• Research Project
• 3503467

• ApplicationId

  3503467

• Core Project Number

  R43MH051492

• Full Project Number

  1R43MH051492-01

• Serial Number

  51492

• FOA Number

• Sub Project Id

• Project Start Date

  8/1/1993 - 31 years ago

• Project End Date

  1/31/1994 - 30 years ago

• Program Officer Name

• Budget Start Date

  8/1/1993 - 31 years ago

• Budget End Date

  1/31/1994 - 30 years ago

• Fiscal Year

  1993

• Support Year

  1

• Suffix

• Award Notice Date

  7/15/1993 - 31 years ago

Organizations

• COVALENT ASSOCIATES, INC.

We propose to synthesize and test new fluorescent indicators for the lithium ion in aqueous solution. The indicators are designed to be water soluble and to respond selectively to Li+ by undergoing a shift in absorption and emission wavelengths. The proposed compounds will be of primary interest for determining the concentration of cytosolic Li+ and for monitoring the flux of Li+ in single cells acted on by neurotransmitters. The indicators will be of use to cell physiologists and neuroscientists studying the influence of Li+ on the phosphatidylinositol cycle implicated in the mechanism by which Li+ functions in the treatment of manic-depressive psychosis. The indicator may also be of use for measuring the concentration of Li+ in the serum of patients undergoing therapy.

IC Name

• Activity

  R43

• Administering IC

  MH

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  126

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  MHSB

• Study Section Name

  Mental Health Small Business Research Review Committee

• Organization Name

  COVALENT ASSOCIATES, INC.

• Organization Department

• Organization DUNS

• Organization City

  WOBURN

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  01801

• Organization District

  UNITED STATES