Claims
- 1. A method for the preparation of 2-(2-fluoro-4-biphenylyl)propionic acid which comprises
- (a) reacting a mixture of 2-amino-4-methylbiphenyl, a fluoridizing agent and a diazotizing agent to form 2-fluoro-4-methylbiphenyl,
- (b) reacting said 2-fluoro-4-methylbiphenyl with N-bromosuccinimide or bromine under irradiation with light to form 2-fluoro-4-monobromomethylbiphenyl,
- (c) reacting said 2-fluoro-4-monobromomethylbiphenyl with an alkali metal cyanide to form 2-(2-fluoro-4-biphenylyl)acetonitrile,
- (d) reacting a mixture of said acetonitrile, a dialkyl carbonate and an alkali metal alkoxide, and then adding a methylating agent to form alkyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate,
- (e) reacting said cyanopropionate, an alkali metal alkoxide and an alcohol to form 2-(2-fluoro-4-biphenylyl)propionitrile, and then
- (f) reacting a mixture of said propionitrile and an alkali metal hydroxide in an aqueous-organic medium to form 2-(2-fluoro-4-biphenylyl)propionic acid.
- 2. A method for the preparation of 2-(2-fluoro-4-biphenylyl)propionitrile which comprises reacting ethyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate, an alkali metal alkoxide and an alcohol.
- 3. Ethyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate.
- 4. A method for the preparation of alkyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate which comprises reacting 2-(2-fluoro-4-biphenylyl)acetonitrile with a dialkyl carbonate and an alkali metal alkoxide, and then adding a methylating agent.
- 5. A method of claim 4 wherein said dialkyl carbonate is diethylcarbonate whereby said cyanopropionate is ethyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate.
REFERENCE TO RELATED APPLICATIONS
This is a division of application Ser. No. 189,779, filed Sept. 22, 1980, Pat. No. 4,371,473 which in turn is a division of application Ser. No. 53,060, filed June 28, 1979, now U.S. Pat. No. 4,278,516.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3755427 |
Adams et al. |
Aug 1973 |
|
3959364 |
Armitage et al. |
May 1976 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
53-116352 |
Oct 1978 |
JPX |
1445283 |
Aug 1976 |
GBX |
Divisions (2)
|
Number |
Date |
Country |
Parent |
189779 |
Sep 1980 |
|
Parent |
53060 |
Jun 1979 |
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