Claims
- 1. The polymorph of the compound (E)-3-[6-[[(2,6-dichlorophenyl)-thio]methyl]-3-(2-phenylethoxy)-2-pyridinyl]-2-propenoic acid in the form having the following characteristics:
- (a) infra-red absorption bands at about 697, 743 and 884 cm.sup.-1,
- (b) a single melting endotherm which has a minimum onset at about 142.2.degree. C. as identified by differential scanning calorimetry, and
- (c) x-ray diffraction scattering Cu source, having peaks at 9.2, 16.4, 23.3, 26.8 and 27.3 degrees.
- 2. A pharmaceutical composition comprising the form of (E)-3-[6-[[(2,6-dichlorophenyl)-thio]methyl]-3-(2-phenylethoxy)-2-pyridinyl]-2-propenoic acid as described in claim 1 in association with a pharmaceutically acceptable carrier.
- 3. A pharmaceutical composition comprising a pharmaceutically acceptable excipient, the polymorph of claim 1, and the polymorph of (E)-3-[6-[[(2,6-dichloro-phenyl)-thio]methyl]-3-(2-phenylethoxy)-2-pyridinyl]-2-propenoic acid having the characteristics:
- (a) infra-red absorption bands at about 704, 758 and 896 cm.sup.-1,
- (b) a endotherm followed by a exotherm from 118.degree. C. to 138.degree. C. and a melting endotherm with onset at about 140.degree. C. as identified by differential scanning calorimetry, and
- (c) x-ray diffraction scattering, Cu source, having peaks at 10.1, 20.0, 23.0, 24.0 and 25.4 degrees.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9508137 |
Apr 1995 |
GBX |
|
Parent Case Info
This application is a 371 of PCT/EP96/01466 filed Apr. 2, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/EP96/01466 |
4/2/1996 |
|
|
12/16/1997 |
12/16/1997 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO96/33174 |
10/24/1996 |
|
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
WO9306085 |
Apr 1993 |
WOX |
WO9400437 |
Jan 1994 |
WOX |
WO9400433 |
Jan 1994 |
WOX |
WO9500487 |
Jan 1995 |
WOX |