FORMULATION FOR IMPROVING SKIN ADHESIVE EFFECTIVENESS

Abstract

A cyanoacrylate monomer is used as an adhesion-enhancement material for enhancing at least an initial bond between a person's skin and a hydrocolloid adhesive of e.g., an ostomy or wound care appliance, for attachment to the skin. The monomer is applied to the skin in a non-activated state. Polymerization of the momoner is initiated by a material in the hydrocolloid adhesive when the adhesive appliance is pressed on the skin thereafter. The adhesion-enhancement material may further comprise a plasticizer having a low Tg (e.g., <10° C.).

Description

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a flow-diagram of the steps of a first example for attaching an adhesive appliance to skin.

FIG. 2 is a schematic cross-section of an adhesion-enhancement material applied to a person's peristomal skin as a skin preparation material in accordance with the first example.

FIG. 3 is a schematic cross-section of an adhesive portion of an adhesive appliance applied to the skin in accordance with the first example.

FIG. 4 is a flow-diagram of the steps of a second example for attaching an adhesive appliance to skin.

Claims

1. An adhesion-enhancement material for enhancing the adhesion between a person's skin and a skin-friendly adhesive of an adhesive appliance, wherein the adhesion-enhancement material comprises a monomer for application without a polymerization activator, to serve as an interface material between the adhesive appliance and the person's skin, and wherein the monomer is configured to be initiated by a material contained in the adhesive appliance.

2. The adhesion-enhancement material of claim 1, wherein the adhesion-enhancement material is configured to be applied without a polymerization activator directly to the person's skin.

3. The adhesion-enhancement material of claim 1, wherein the adhesion-enhancement material is configured to be applied without a polymerization activator directly to an adhesive surface of the adhesive appliance.

4. The adhesion-enhancement material of claim 1, wherein the adhesion-enhancement material is configured to be initiated by a weak nucleophile and/or by a weak basic compound.

5. The adhesion-enhancement material of claim 1, wherein the monomer is a 1,1-disustituted ethylene monomer.

6. The adhesion-enhancement material of claim 5, wherein the 1,1-disubstituted ethylene monomer is a cyanoacrylate monomer.

7. The adhesion-enhancement material of claim 6, wherein the cyanoacrylate monomer has the formula:

8. The adhesion-enhancement material of claim 1, wherein the adhesion-enhancement material further comprises a plasticizer.

9. The adhesion-enhancement material of claim 8, wherein the plasticizer has a low Tg.

10. The adhesion-enhancement material of claim 8, wherein the plasticizer has a Tg less than about 10° C.

11. The adhesion-enhancement material of claim 8, wherein the plasticizer comprises at least one material selected from siloxane, citrate, and end-capped polyethylene glycol.

12. The adhesion-enhancement material of claim 1, wherein the adhesion-enhancement material is configured for use with a hydrocolloid adhesive.

13. The adhesion-enhancement material of claim 1, wherein the adhesion-enhancement material is configured such that an initial bond strength between the skin and the adhesion-enhancement material and between the adhesion-enhancement material and the adhesive, is greater than an initial bond strength between the adhesive and the skin.

14. The adhesion-enhancement material of claim 1, wherein the adhesion-enhancement material is configured such that a bond strength between the adhesion-enhancement material and the skin declines over a shorter period of time than does a bond strength between the adhesion-enhancement material and the adhesive.

15. An adhesion-enhancement material for enhancing a bond between skin and an adhesive appliance for attachment to the skin, the adhesion-enhancement material comprising: a monomer; anda plasticizer having a low Tg.

16. The adhesion-enhancement material of claim 15, wherein the monomer is initiated by a weak nucleophile

17. The adhesion-enhancement material of claim 15, wherein the monomer is initiated by a weak basic compound.

18. The adhesion-enhancement material of claim 15, wherein the monomer is a 1,1-disubstituted ethylene monomer.

19. The adhesion-enhancement material of claim 18, wherein the 1,1-disubstituted ethylene monomer is a cyanoacrylate monomer.

20. The adhesion-enhancement material of claim 19, wherein the cyanoacrylate monomer has the formula:

21. The adhesion-enhancement material of claim 15, wherein the plasticizer has a Tg less than about 10C.

22. The adhesion-enhancement material of claim 15, wherein the plasticizer comprises at least one material selected from siloxane, citrate, and end-capped polyethylene glycol.

23. A material comprising a skin-friendly adhesive material and an adhesion-enhancement material for contacting the adhesive material to enhance adhesion, wherein: the adhesive material comprises a pressure sensitive adhesive and one item selected from: a monomer and an activator for the monomer;the adhesion-enhancement material comprises the other item selected from said monomer and said activator for the monomer;

24. The material of claim 23, wherein the adhesive material comprises the activator, and the adhesion-enhancement material comprises the monomer.

25. The material of claim 23, wherein the activator comprises a weak nucleophile and/or a weak basic compound.

26. The material of claim 25, wherein the activator comprises a carboxymethylcellulose.

27. The material of claim 23, wherein the adhesive material comprises a hydrocolloid adhesive.

28. The material of claim 23, wherein the monomer is a 1,1-disubstituted ethylene monomer.

29. The material of claim 28, wherein the 1,1-disubstituted ethylene monomer is a cyanoacrylate monomer.

30. The material of claim 29, wherein the cyanoacrylate monomer has the formula:

31. The material of claim 23, further comprising a plasticizer.

32. The material of claim 31, wherein the plasticizer is comprised in the same material as the monomer.

33. The material of claim 31, wherein the plasticizer is comprised in the adhesion-enhancement material.

34. The material of claim 31, wherein the plasticizer has a low Tg.

35. The material of claim 31, wherein the plasticizer has a Tg in a range of from 0° C. to not significantly more than 10° C.

36. The material of claim 31, wherein the plasticizer comprises at least one material selected from: siloxane, citrate, and end-capped polyethylene glycol.

37. The material of claim 23, wherein an initial bond strength between the skin and the polymerized monomer and between the polymerized monomer and the adhesive material, is greater than an initial bond strength between the adhesive material and the skin.

38. The material of claim 23, wherein a bond strength between the polymerized monomer and the skin declines over a shorter period of time than does a bond strength between the polymerized monomer and the adhesive material.

39. The method of interfacing an adhesion-enhancement material between skin and an adhesive appliance to enhance at least an initial bond strength between the skin and the adhesive appliance, wherein the adhesion-enhancement material comprises a monomer polymerizable by a material contained in the adhesive appliance.

40. The method of claim 39, wherein the monomer is applied directly to the skin in a non-activated state.

41. The method of claim 40, wherein the adhesive appliance is applied over the monomer after the monomer is applied to the skin.

42. The method of claim 39, wherein the adhesive appliance comprises a hydrocolloid adhesive.

43. A method of enhancing at least an initial bond strength between skin and adhesive appliance for attachment to the skin, the method comprising: applying in a non-activated state a monomer polymerizable by a material contained in the adhesive appliance, the monomer being applied to serve as an interface between the skin and the adhesive appliance.

44. The method of claim 43, wherein the step of applying the monomer comprises applying the monomer directly to the skin.

45. The method of claim 44, further comprising the step of applying the adhesive appliance to the skin after the monomer has been applied to the skin.

46. A method of providing an attachment for attaching an adhesive appliance to a person's skin, the method comprising: providing a monomer polymerizable to form a bond with the skin; andproviding said adhesive appliance comprising (i) a activator for polymerizing the monomer, and (ii) a pressure sensitive adhesive for bonding to the skin independently of the monomer;

47. A method for attaching an adhesive appliance to a person's skin, comprising: providing a monomer polymerizable to form a bond with the skin;providing said adhesive appliance comprising (i) an activator for polymerizing the monomer, and (ii) a pressure sensitive adhesive for bonding to the skin independently of the monomer; andusing the monomer with the adhesive appliance to attach the adhesive appliance to the skin.