Claims
- 1. An intranasal tramadol formulation comprising an active agent consisting essentially of tramadol in a form selected from the group consisting of tramadol free base, pharmaceutically acceptable salts thereof and any combinations thereof; said tramadol being dispersed within a pharmaceutically acceptable carrier for intranasal administration; said formulation being contained in a pharmaceutically acceptable dispenser for intranasal administration which dispenses an amount of said formulation to the mucousal surfaces in the nasal passages of a mammal to provide intranasal absorption of an analgesically effective amount of said tramadol.
- 2. The intranasal tramadol formulation according to claim 1, wherein said tramadol is in the form of the hydrochloride salt.
- 3. The intranasal tramadol formulation according to claim 1, wherein said pharmaceutically acceptable carrier is selected from the group consisting of a liquid solution, a suspension, an emulsion, a liposome, a paste, a cream and a gel.
- 4. The intranasal tramadol formulation according to claim 1, wherein said pharmaceutically acceptable carrier comprises isotonic saline solution or suspension.
- 5. The intranasal tramadol formulation according to claim 1, wherein said pharmaceutically acceptable carrier has a pH ranging from 4.0 to about pH 7.4.
- 6. The intranasal tramadol formulation according to claim 5, wherein said tramadol is present in an amount ranging from about 10 mg to about 300 mg per ml.
- 7. The intranasal tramadol formulation according to claim 1, wherein said dispenser administers drops.
- 8. The intranasal tramadol formulation according to claim 1, wherein said dispenser administers a spray.
- 9. The intranasal tramadol formulation according to claim 1, wherein said dispenser is a simple dropper.
- 10. The intranasal tramadol formulation according to claim 1, wherein said dispenser is a manually powered intranasal pump dispenser.
- 11. The intranasal tramadol formulation according to claim 1, wherein said dispenser is an electrically powered intranasal pump dispenser.
- 12. The intranasal tramadol formulation according to claim 1, wherein said dispenser is a squeeze bottle.
Parent Case Info
This application is a continuation of U.S. Ser. No. 09/435,009 filed on Nov. 5, 1999, now abandoned which is a continuation of U.S. Ser. No. 08/557,279 filed on Nov. 14, 1995, now U.S. Pat. No. 6,017,963.
US Referenced Citations (18)
Foreign Referenced Citations (9)
Number |
Date |
Country |
3602370 |
Aug 1987 |
DE |
4221256 |
Jan 1994 |
DE |
0189861 |
Aug 1986 |
EP |
6199701 |
Jul 1994 |
JP |
WO 9304675 |
Mar 1993 |
WO |
WO93157379 |
Aug 1993 |
WO |
WO94041339 |
Mar 1994 |
WO |
WO9410987 |
May 1994 |
WO |
WO94224459 |
Oct 1994 |
WO |
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts AN: 108:82103, Chrubasik et al., “Analgesic use by inhalation”, corresponds to DE 3602370 A1, Aug. 6, 1987. |
Remington's Pharmaceutical Sciences, p. 1451, 1986. |
Continuations (2)
|
Number |
Date |
Country |
Parent |
09/435009 |
Nov 1999 |
US |
Child |
09/930927 |
|
US |
Parent |
08/557279 |
Nov 1995 |
US |
Child |
09/435009 |
|
US |