Formulations of a transdermal patch for pain management

Abstract

Various formulations (to be used in the form of a single-segment or multi-segment transdermal patch) of bioactive compounds for pain management are described/disclosed. The multi-segmented transdermal patch can include one or more compatible bioactive compounds in each segment. Furthermore, formulations may include silk fibroin and/or microemulsion/nanoemulsion of bioactive compounds and/or microencapsulation/nanoencapsulation of bioactive compounds.

Description

Chronic pain represents an emerging public health issue of massive proportions, particularly in view of aging populations in industrialized nations. About 19% of adults (about 38 million) in USA have chronic pain.

The present application discloses various compositions (as listed below) of bioactive compounds of a pressure sensitive transdermal patch (e.g., a pressure sensitive single-layer transdermal/multi-layer/reservoir transdermal patch) for pain management. Among the benefits of a pressure sensitive transdermal patch are reduced gastro-intestinal incompatibility, steady dosage rate/flux rate, self-administration and non-invasive procedure.

Pressure Sensitive Single-Layer Transdermal Patch: The adhesive layer of the pressure sensitive single-layer transdermal patch contains bioactive compounds. The adhesive layer not only adheres with the various layers together, along with the entire system to the skin, but also is responsible for the releasing of the bioactive compounds. The adhesive layer is surrounded by a temporary liner and a backing.

Pressure Sensitive Multi-Layer Transdermal Patch: One of the layers of the pressure sensitive multi-layer transdermal patch is for immediate release of bioactive compounds and other layer is for control release of the bioactive compounds from an embedded reservoir. It has both a temporary liner-layer and a permanent backing. The release of the bioactive compounds depends on membrane permeability and diffusion of drug molecules.

Pressure Sensitive Reservoir Transdermal Patch: Unlike the pressure sensitive single-layer transdermal patch and pressure sensitive multi-layer transdermal patch, the pressure sensitive reservoir transdermal patch has a separate layer of bioactive compounds in solution or suspension (separated by an adhesive layer). The reservoir of the bioactive compounds is encapsulated in a shallow compartment, which molded from a bioactives-impermeable metallic plastic laminate with rate-controlling polymer (e.g., vinyl acetate) membrane on one surface. This patch is also backed by the backing layer.

The adhesive (e.g., polyacrylates, polyisobutylene or silicon based adhesive) of the pressure sensitive single-layer transdermal/multi-layer plays a critical role for establishing (a) flux rate of the bioactive compounds to skin, (b) adhesion to skin, (c) stability/shelf life, (d) peel strength and (e) skin irritation.

Furthermore, a patch can utilize low-level electrical energy to transport bioactive compounds through the skin in a controlled manner.

Additionally, an array of micro-needles located on the surface of a pressure sensitive transdermal patch that comes in contact with the skin can be utilized to deliver bioactive compounds.

TABLE 1
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Astaxanthin                      2.5%
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      40%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 2
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      42.5%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 3
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      47.5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 4
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      52.5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 5
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract   20%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride     2.5%
Methylsufonlymethane (MSM)  5%
Menthol                     5%
S-Adenosyl Methionine (SAM) 5%
Total                       100%

TABLE 6
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract   20%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride     7.5%
Methylsufonlymethane (MSM)  5%
Menthol                     5%
Total                       100%

TABLE 7
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract   25%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride     7.5%
Menthol                     5%
Total                       100%

TABLE 8
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract   30%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride     7.5%
Total                       100%

TABLE 9
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract   30%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 65%
Total                       100%

TABLE 10
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract   30%
Chemicals
Pure* CBD (Or CBD Pro-Drug) 70%
Total                       100%

TABLE 11
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
Chemicals                   WT %
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 95%
Total                       100%

TABLE 12
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Astaxanthin                      2.5%
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      35%
Pure* CBC (Or CBC Pro-Drug)      5%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 13
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      37.5%
Pure* CBC (Or CBC Pro-Drug)      5%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 14
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      42.5%
Pure* CBC (Or CBC Pro-Drug)      5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 15
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Pure* CBD (Or CBD Pro-Drug)      47.5%
Pure* CBC (Or CBC Pro-Drug)      5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 16
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract   20%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 52.5%
Pure* CBC (Or CBC Pro-Drug) 5%
Lidocaine Hydrochloride     2.5%
Methylsufonlymethane (MSM)  5%
Menthol                     5%
S-Adenosyl Methionine (SAM) 5%
Total                       100%

TABLE 17
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract   20%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 57.5%
Pure* CBC (Or CBC Pro-Drug) 5%
Lidocaine Hydrochloride     2.5%
Methylsufonlymethane (MSM)  5%
Menthol                     5%
Total                       100%

TABLE 18
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract   25%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 57.5%
Pure* CBC (Or CBC Pro-Drug) 5%
Lidocaine Hydrochloride     2.5%
Menthol                     5%
Total                       100%

TABLE 19
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract   30%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 57.5%
Pure* CBC (Or CBC Pro-Drug) 5%
Lidocaine Hydrochloride     2.5%
Total                       100%

TABLE 20
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract   25%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 65%
Pure* CBC (Or CBC Pro-Drug) 5%
Total                       100%

TABLE 21
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
WT %
Botanical
Boswellia serrata Extract   25%
Chemicals
Pure* CBD (Or CBD Pro-Drug) 70%
Pure* CBC (Or CBC Pro-Drug) 5%
Total                       100%

TABLE 22
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
Chemicals                   WT %
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 90%
Pure* CBC (Or CBC Pro-Drug) 5%
Total                       100%

TABLE 23
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Astaxanthin                      2.5%
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 40%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 24
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 42.5%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 25
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 47.5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 26
Pharmaceutical Formulation [Active Composition Of Bioactive
Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 52.5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 27
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 28
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride          7.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
Total                            100%

TABLE 29
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        25%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride          7.5%
Menthol                          5%
Total                            100%

TABLE 30
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        30%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 57.5%
Lidocaine Hydrochloride          7.5%
Total                            100%

TABLE 31
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract   30%
Chemicals
Capsaicin                   5%
Pure* CBD (Or CBD Pro-Drug) 65%
Total                       100%

TABLE 32
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        30%
Chemicals
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 70%
Total                            100%

TABLE 33
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
Chemicals                        WT %
Capsaicin                        5%
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 95%
Total                            100%

TABLE 34
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
Chemicals                        WT %
Silk Fibroin Loaded With Pure* CBD (Or CBD Pro-Drug) 100%
Total                            100%

TABLE 35
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Astaxanthin                      2.5%
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD (Or CBD Pro-Drug) 35%
Silk Fibroin Loaded With Pure* Pure* CBC (Or CBC Pro-Drug) 5%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 36
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD 37.5%
(Or CBD Pro-Drug)
Silk Fibroin Loaded With Pure* Pure* CBC 5%
(Or CBC Pro-Drug)
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 37
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD 42.5%
(Or CBD Pro-Drug)
Silk Fibroin Loaded With Pure* Pure* CBC 5%
(Or CBC Pro-Drug)
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 38
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD 47.5%
(Or CBD Pro-Drug)
Silk Fibroin Loaded With Pure* Pure* CBC 5%
(Or CBC Pro-Drug)
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 39
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD 52.5%
(Or CBD Pro-Drug)
Silk Fibroin Loaded With Pure* Pure* CBC 5%
(Or CBC Pro-Drug)
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 40
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        20%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD 57.5%
(Or CBD Pro-Drug)
Silk Fibroin Loaded With Pure* Pure* CBC 5%
(Or CBC Pro-Drug)
Lidocaine Hydrochloride          2.5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
Total                            100%

TABLE 41
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        25%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD 57.5%
(Or CBD Pro-Drug)
Silk Fibroin Loaded With Pure* Pure* CBC 5%
(Or CBC Pro-Drug)
Lidocaine Hydrochloride          2.5%
Menthol                          5%
Total                            100%

TABLE 42
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        30%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD 57.5%
(Or CBD Pro-Drug)
Silk Fibroin Loaded With Pure* Pure* CBC 5%
(Or CBC Pro-Drug)
Lidocaine Hydrochloride          2.5%
Total                            100%

TABLE 43
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        25%
Chemicals
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD (Or CBD Pro-Drug) 65%
Silk Fibroin Loaded With Pure* Pure* CBC (Or CBC Pro-Drug) 5%
Total                            100%

TABLE 44
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
                                 WT %
Botanical
Boswellia serrata Extract        25%
Chemicals
Silk Fibroin Loaded With Pure* Pure* CBD (Or CBD Pro-Drug) 70%
Silk Fibroin Loaded With Pure* Pure* CBC (Or CBC Pro-Drug) 5%
Total                            100%

TABLE 45
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
Chemicals                        WT %
Capsaicin                        5%
Silk Fibroin Loaded With Pure* Pure* CBD (Or CBD Pro-Drug) 90%
Silk Fibroin Loaded With Pure* Pure* CBC (Or CBC Pro-Drug) 5%
Total                            100%

TABLE 46
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
Chemicals                        WT %
Silk Fibroin Loaded With Pure* Pure* CBD (Or CBD Pro-Drug) 90%
Silk Fibroin Loaded With Pure* Pure* CBC (Or CBC Pro-Drug) 10%
Total                            100%

TABLE 47
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        55%
Chemicals
Astaxanthin                      5%
Capsaicin                        5%
Chondroitin Sulfate              5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 48
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        55%
Chemicals
Capsaicin                        5%
Chondroitin Sulfate              7.5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 7.5%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 49
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        60%
Chemicals
Capsaicin                        5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 10%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          5%
Methylsufonlymethane (MSM)       5%
Menthol                          5%
S-Adenosyl Methionine (SAM)      5%
Total                            100%

TABLE 50
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        60%
Chemicals
Capsaicin                        5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 10%
Hyaluronic Acid                  5%
Lidocaine Hydrochloride          5%
Methylsufonlymethane (MSM)       10%
Menthol                          5%
Total                            100%

TABLE 51
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        60%
Chemicals
Capsaicin                        5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 10%
Hyaluronic Acid                  10%
Lidocaine Hydrochloride          5%
Methylsufonlymethane (MSM)       10%
Total                            100%

TABLE 52
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        65%
Chemicals
Capsaicin                        5%
Glucosamine Hydrochloride Or Glucosamine Sulfate 10%
Hyaluronic Acid                  10%
Methylsufonlymethane (MSM)       10%
Total                            100%

TABLE 53
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        70%
Chemicals
Glucosamine Hydrochloride Or Glucosamine Sulfate 10%
Hyaluronic Acid                  10%
Methylsufonlymethane (MSM)       10%
Total                            100%

TABLE 54
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        80%
Chemicals
Glucosamine Hydrochloride Or Glucosamine Sulfate 10%
Methylsufonlymethane (MSM)       10%
Total                            100%

TABLE 55
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        70%
Chemicals
Glucosamine Hydrochloride Or Glucosamine Sulfate 15%
Methylsufonlymethane (MSM)       15%
Total                            100%

TABLE 56
Pharmaceutical Formulation [Active
Composition Of Bioactive Compounds]
WT %
Botanical
Boswellia serrata Extract        70%
Chemicals
Glucosamine Hydrochloride Or Glucosamine Sulfate 30%
Total                            100%

Cannabidiol (CBD), a bioactive compound of marijuana plant (Cannabis sativa or Cannabis indica or its synthetic analogue) or its prodrug can blunt beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression.

Cannabichromene (CBC), a bioactive compound of marijuana plant (Cannabis sativa or Cannabis indica). Its molecular structure is described below.

• • THC content in CBD or CBC is below the federally approved legal limit.

Weight % of the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56 can vary +/−20%

To increase permeation the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56, wherein the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56 is embedded with an adhesive (of a pressure sensitive transdermal patch), a permeation enhancement compound (e.g., oleic acid/eucalyptol oil) can be utilized, a passive compound in the pharmaceutical formulations of Table-1 through Table-56

To reduce chemical reaction between bioactive compounds in the pharmaceutical formulations of Table-1 through Table-56, lecithin (e.g., soy-derived lecithin) a multi-segmented transdermal patch can be utilized instead of a single segmented patch, wherein each segment of the multi-segmented transdermal patch can include one or more compatible bioactive compounds.

To reduce chemical reaction between bioactive compounds in the pharmaceutical formulations of Table-1 through Table-56, lecithin (e.g., soy-derived lecithin) in Table-1 through Table-56 can be utilized.

To increase bioavailability the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56, a microemulsion/nanoemulsion of the bioactive compound(s) in Table-1 through Table-56 can be utilized.

To increase bioavailability the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56, a microencapsulation/nanoencapsulation of the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56 can be utilized.

For sustained delivery of the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56, a microencapsulation/nanoencapsulation of the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56 can be utilized.

For controlled delivery of the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56, a microencapsulation/nanoencapsulation of the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56 can be utilized.

By way of an example and not by way of any limitation, the nanoshell can be a boron nitride nanotube, carbon nanotube, Cornell-dot, cubisome, dendrimer (including plant based dendrimer), deoxyribonucleic acid (DNA) origami nanostructure, exosome, fullerene C₆₀ (e.g., malonic acid derivative of C₆₀), gold nanoparticles (suitably coated), grapefruit-derived nanovector (GNV), hollow magnetic cage molecule (e.g., Co₁₂C₆, Mn₁₂C₆ and Mn₂₄C₁₈), iron nanoparticle, lipidoid, liposome, mesoporous silica, micelle, nanocrystal, niosome, polysebacic acid (PSA), polysilsesquioxane (PSQ), porous silicon photonic crystal, quantum dot, quantum dot capped with glutathione, ribonucleic acid (RNA) origami nanostructure, self-assembling peptide (or self-assembling protein), solid-lipid nanoparticle, spherical nucleic acid (SNA), synthasome, tubular/tetrahedral structure fabricated/constructed, utilizing DNA/RNA origami process, virus (e.g., tobacco mosaic virus), zein-plant protein and zeolite-1-nanocrystal.

Silk fibroin is biodegradable and biocompatible. For sustained delivery of the bioactive compound(s) in the pharmaceutical formulations of Table-1 through Table-56, the bioactive compound(s) and/or the pharmaceutical formulations of Table-1 through Table-56 can be loaded with silk fibroin.

PREFERRED EMBODIMENTS OF SPECIFICATIONS

In the above disclosed specifications “/” has been used to indicate an “or”.

Any example in the above disclosed specifications is by way of an example only and not by way of any limitation. The best mode requirement “requires an inventor to disclose the best mode contemplated by him/her, as of the time he/she executes the application, of carrying out the invention.” “ . . . [T]he existence of a best mode is a purely subjective matter depending upon what the inventor actually believed at the time the application was filed.” See Bayer AG v. Schein Pharmaceuticals, Inc. The best mode requirement still exists under the America Invents Act (AIA). At the time of the invention, the inventor described preferred best mode embodiments of the present invention. The sole purpose of the best mode requirement is to restrain the inventor from applying for a patent, while at the same time concealing from the public preferred embodiments of their inventions, which they have in fact conceived. The best mode inquiry focuses on the inventor's state of mind at the time he/she filed the patent application, raising a subjective factual question. The specificity of disclosure required to comply with the best mode requirement must be determined by the knowledge of facts within the possession of the inventor at the time of filing the patent application. See Glaxo, Inc. v. Novopharm LTD., 52 F.3d 1043, 1050 (Fed. Cir. 1995).

The above disclosed specifications are the preferred best mode embodiments of the present invention. However, they are not intended to be limited only to the preferred best mode embodiments of the present invention. Numerous variations and/or modifications are possible within the scope of the present invention. Accordingly, the disclosed preferred best mode embodiments are to be construed as illustrative only. Those who are skilled in the art can make various variations and/or modifications without departing from the scope and spirit of this invention. The inventor of the present invention is not required to describe each and every conceivable and possible future embodiment in the preferred best mode embodiments of the present invention. See SRI Int'l v. Matsushita Elec. Corp. of America, 775F.2d 1107, 1121, 227 U.S.P.Q. (BNA) 577, 585 (Fed. Cir. 1985) (enbanc).

Claims

1. A transdermal patch for pain management, comprising:pharmaceutical formulation of

2. The transdermal patch according to claim 1, is a single segment transdermal patch.

3. The transdermal patch according to claim 1, comprises: cannabidiol (CBD) or cannabidiol (CBD) pro-drug in microemulsion.

4. The transdermal patch according to claim 1, further comprises: a permeation enhancement compound.

5. A transdermal patch for pain management, comprising:pharmaceutical formulation of

6. The transdermal patch according to claim 5, is a single segment transdermal patch.

7. The transdermal patch according to claim 5, comprises: cannabidiol (CBD) or cannabidiol (CBD) pro-drug in microemulsion.

8. The transdermal patch according to claim 5, further comprises: a permeation enhancement compound.

9. A transdermal patch for pain management, comprising:pharmaceutical formulation of

10. A transdermal patch for pain management, comprising:pharmaceutical formulation of(a) Boswellia serrata extract;(b) capsaicin;(c) silk fibroin, and(d) a bioactive compound astaxanthin.

11. The transdermal patch according to claim 10, is a single segment transdermal patch.

12. The transdermal patch according to claim 10, further comprises: a permeation enhancement compound.