Fragrance compositions and uses thereof

Information

  • Patent Grant
  • 10138441
  • Patent Number
    10,138,441
  • Date Filed
    Tuesday, June 7, 2016
    8 years ago
  • Date Issued
    Tuesday, November 27, 2018
    5 years ago
Abstract
The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.
Description
FIELD OF THE INVENTION

The present invention relates to the field of perfumery. In particular, it provides compositions comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator for improving or enhancing the fidelity and/or longevity of the fragrance profile. The invention also relates to methods of making and using said compositions.


BACKGROUND OF THE INVENTION

Conventional perfuming compositions have a fragrance profile characterized by the classical fragrance pyramid three-tiered structure, which contains a higher amount of the base notes, a medium amount of the heart notes, and a lower amount of the top notes (see FIG. 1a). The conventional pyramid structure is used because higher levels of the base notes are relied upon to provide the intensity of the overall fragrance profile over time and replace the heart notes when those are declining. Simply increasing the levels of heart and top notes does not provide the required longevity because of their fast evaporation.


Perfumers typically classify fragrance materials as a base, heart or top note according to their specific characters. For instance, the fragrance material “Hedione®” (or also known as “methyl dihydrojasmonate”) is commonly classified as a heart note based on its perceived floral character. However, due to the somewhat subjective nature of characters, there has been no universal convention for objectively classifying fragrance materials. As a result of the subjective classification approach, fragrance formulation has been inconsistent. For example, two compositions having the exact same classification of fragrance materials constructed according to the classical fragrance pyramid structure could have two different, possibly very different, fragrance profiles.


With the classical fragrance pyramid structure, “base notes” make up from greater than 30 wt %, typically greater than 40 wt % or typically greater than 50 wt %, relative to the total weight of the perfume formulation. Base notes are characterized by providing animalic, woody, sweet, amber or musky characters, and not being very volatile. The “heart or middle notes”, make up from about 0.1 wt % to about 60 wt % relative to the total weight of the perfume formulation and have an intermediate volatility. Heart notes are associated with desirable characters such as floral characters (e.g., jasmin, rose), fruity, marine, aromatic or spicy characters. The “top or head notes” provide citrusy, green, light, or fresh characters, and make up from about 0.1 wt % to about 40 wt % relative to the total weight of the perfume formulation. Top notes tend to evaporate quickly due to their high volatility.


There are at least one of several drawbacks to the above described classical formulation approach. Firstly, classification of fragrance materials by their characters is subjective and therefore results in inconsistency in the fragrance profile under classical fragrance pyramid construction rules. Secondly, the perceived intensity of the fragrance profile of the conventional perfume compositions, particularly those characters attributable to the more volatile fragrance materials, decreases rapidly over time due to their quick evaporation. Accordingly, conventional perfume compositions will typically change their overall fragrance profile over time. This is a problem because it is desirable to maintain “fragrance profile fidelity” over time. In other words, it is desirable to maintain the same or substantively similar fragrance profile for a commercial fragrance over time, particularly over long periods of time (at least 4 hrs, 6 hrs, or even 8 hours after application). Thirdly, with the classical fragrance pyramid construction, the possible types of fragrance profiles have been somewhat limited. The consequence of using base notes at high levels is that many fragrance dry-downs appear repetitive, boring, non-memorable and un-interesting to consumers. However, if base notes are reduced or excluded then the fragrance intensity weakens over time and does not last for a sufficient duration. Lastly, it is generally accepted that some consumers desire prolonged intensity of select characters, particularly the floral, spicy or aromatic characters derived from the heart notes. Unfortunately, the consequence of using high levels of base notes is that they may impart particularly undesirable characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the more desirable fragrance characters over time, particular over long periods of time. Thus, the unique challenge remains of selectively extending the more desirable characters attributable from the heart and/or top notes, particularly the heart notes, and even more particularly extending these desirable characters over long periods of time.


Previous attempts to overcome these problems have been through the use of various “fixatives” or “modulators” to retard the evaporation of the more volatile fragrance ingredients present in fragrance compositions. For instance, U.S. Pat. No. 6,737,396B2 (Firmenich) describes a perfume composition formed by mixing 2-30%, relative to the weight of the composition, of a fixative, (1-ethoxyethoxy)cyclododecane, to fix or exalt the musky or aromatic-type notes. U.S. Pat. No. 6,440,400B1 (Takasago Perfumery) describes a composition using trimethylcyclohexane derivatives as perfuming-holding agents and melanin-formation inhibitors. U.S. Pat. No. 4,313,855 (Dragoco) describes the use in cosmetic compositions of 1-(2,6,6-trimethylcyclohexyl)-hexane-3-ol as an odourless fixative for increasing the perfume's intensity. U.S. Pat. No. 6,147,049 (Givaudan) discloses a perfume fixative derived from tera-hydronaphthalenese for use in a wide range of fragrance compositions. WO85/04803 (Diagnostica) describes the use of hyaluronic acid/hyaluronate as fixatives (via molecular encapsulation) in fragrance products to improve persistent of the fragrance. JP Patent No. 61-083114 (Kanebo) describes ether derivatives as aroma-preserving agent for fine perfume composition. JP Patent No. 61-063612 (Kanebo) discloses diethylene glycol ether derivatives as fragrance adjusting agent showing effects as a fixative and a solubilizer. JP Patent No. 62-084010 (Shiseido) describes hydroquinone glycoside as perfume fixatives applicable for all kinds of perfume and blended perfume. U.S. Pat. No. 7,196,052 (Takasago Int. Corp.) describes fragrance compositions containing glycerol ether derivatives as fixatives or fragrance note-improving agent. EP Patent Publication No. 616800A2 (Givaudan) discloses odourant compositions containing panethenol ethyl ether having improved prolonged diffusion of the perfume materials from the skin, without notably modifying the olfactive note of the product. U.S. Pat. No. 4,110,626 (Shiseido) describes the use of aliphatic dibasic acid diester as “perfume controlling agent” for improved fixing effect on fragrance component. PCT Publication No. WO2014/155019 (LVMH) describes aliphatic ether derivatives to increase the stability of alcoholic fragrance composition and more particularly to preserve the original olfactive notes.


These attempts have advocated the use of such fixatives or modulators indiscriminately without regard to the fragrance profile. Further, these attempts do not teach how to objectively classify the fragrance materials as low, moderate or high volatile fragrance materials. Further, the use of fixatives or modulators in these attempts often shows effects on single fragrance material, which are often not observed in a fragrance composition of a mixture of fragrance materials where a number of such fragrance materials are competing with each other to interact with said fixatives or modulators. They do not teach how to formulate with fixatives or modulators in fragrance mixtures, which is not trivial. As a result, these attempts, while disclosing compositions that retain the perfume by way of fixatives or modulators, neither teach the fragrance diamond construction in compositions nor the particular type or levels of fragrance materials to include for delivering the benefits of improved fidelity to the perceived fragrance profile over time, or improved longevity of the fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance materials.


On the other hand, other attempts propose a selective approach aimed at the selection of specific fixatives or modulators and defined amounts of fragrance materials. For instance, U.S. Pat. No. 7,538,081 (Takasago Perfumery) approaches the problem of fixing a perfume and/or extending the perfume release from a fragrance composition. More particularly, said document describes the use of L-menthoxy ether derivatives as fixatives in fragrance compositions comprising at least one note selected from: floral, citrus, fruity, green, mint, herb and marine. U.S. Patent Publication No. 2011/0104089A1 (Symrise) describes certain compositions containing neopentyl glycol diisononanoate as a fixative for top note perfume oils by increasing their adhereance to skin and hair. U.S. Patent Publication No. 2011/0091404 (Symrise) discloses the use of N-hexadecyl n-nonanoate and N-octadecyl n-nonanoate as fixatives of fragrance substances, particularly the readily volatile top notes, by lowering their vapor pressure to allow for a time-delayed release of the perfume oil components from a composition.


However, these attempts tend not to describe how to formulate with fixatives or modulators in complex mixtures of fragrance materials. For those references that do describe mixtures of fragrance materials, they have different fragrance design criteria and are directed to specific preferred fixatives or modulators.


SUMMARY OF THE INVENTION

The inventors have discovered new rules for objectively classifying fragrance materials according to their vapor pressures into low, moderate and high volatile fragrance materials for formulating into fragrance mixtures, preferably complex mixtures having a diamond construction.


In a first aspect, the present invention is directed to a composition comprising a diamond construction fragrance formulation (see FIG. 1b) and at least one substantially non-odorous fragrance modulator for delivering enhanced intensity of the perceived fragrance profile over time, preferably the components attributable from the moderate and high volatile fragrance materials. In particular, the present invention is directed to a composition comprising: (i) a fragrance component present in an amount of from about 0.04 wt % to about 30 wt %, relative to the total weight of the composition; (ii) at least one substantially non-odorous fragrance modulator present in the amount of from about 0.1 wt % to about 20 wt %, relative to the total weight of the composition; (iii) a volatile solvent present in an amount of from about 50 wt % to about 80 wt %, relative to the total weight of the composition; and (iv) optionally water. The fragrance component comprises: (a) at least one low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C. present in an amount of from about 10 wt % to about 30 wt %, relative to the total weight of the fragrance component; (b) at least one moderate volatile fragrance material having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C. present in an amount of from about 40 wt % to about 80 wt %, relative to the total weight of the fragrance component; and (c) at least one high volatile fragrance material having a vapor pressure greater than 0.1 Torr (0.0133 kPa) at 25° C. present in an amount of from about 1 wt % to about 30 wt %, relative to the total weight of the fragrance component.


In another aspect, the present invention is directed to a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair with the composition of the present invention.


Thus, it is an advantage of the present invention to provide new rules for objectively classifying fragrance materials according to their volatility using their their vapor pressures defined at suitable temperature, instead of their characters. The new rules operate irrespective of perfumers performing the classification. In particular, the new rules classify the fragrance materials into low, moderate or high volatile fragrance materials for formulating into fragrance mixtures, particularly ones having a diamond construction. It is a further advantage of the present invention to provide compositions having improved fidelity to the perceived fragrance profile over time. It is yet a further advantage to provide a composition, wherein the character attributable to moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, remains significantly consistent from its initial impression to the end. It is yet a further advantage to provide compositions having improved longevity of the perceived fragrance profile, preferably the characters attributable from the moderate or high volatile fragrance materials, particularly the moderate volatile fragrance material. It is yet a further advantage to provide compositions having stable quality of end product (e.g., fragrance profile, visual appearance) substantially comparable to the classical fragrance pyramid three-tiered structure, preferably even after three months storage at 40° C. It is yet a further advantage to be able to create new to the world fragrance profiles wherein one, or several, well-recognized moderate volatile fragrance material characters, are maintained over time, preferably for long periods of time (e.g., greater than 4, 6, or even 8 hours).


These and other features of the present invention will become apparent to one skilled in the art upon review of the following detailed description when taken in conjunction with the appended claims.





BRIEF DESCRIPTION OF THE DRAWINGS

While the specification concludes with claims particularly pointing out and distinctly claiming the invention, it is believed that the invention will be better understood from the following description of the accompanying figures wherein:



FIG. 1a is a diagram of the classical fragrance pyramid structure of the prior art.



FIG. 1b is a diagram of a fragrance diamond construction according to an embodiment of the present invention.



FIG. 2 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition A9 comprising Indocolore fragrance material and Expert Gel® 56 substantially non-odorous fragrance modulator as compared to Composition B9, a control absent of a substantially non-odorous fragrance modulator (Expert Gel® 56), and as a function of time elapsed since application of the composition.



FIG. 3 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition C9 comprising Dimethyl Benzyl Carbinol fragrance material and Kolliphor® EL substantially non-odorous fragrance modulator as compared to Composition D9, a control absent of a substantially non-odorous fragrance modulator (Kolliphor® EL), and as a function of time elapsed since application of the composition.



FIG. 4 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition E9 comprising Eugenol fragrance material and Kolliphor® EL substantially non-odorous fragrance modulator as compared to Composition F9, a control absent of a substantially non-odorous fragrance modulator (Kolliphor® EL), and as a function of time elapsed since application of the composition.



FIG. 5 provides the panel test results of perceived fragrance profile, particularly improved fragrance profile longevity of Composition G9 comprising Phenethyl alcohol (PEA) fragrance material and Kolliphor® EL substantially non-odorous fragrance modulator as compared to Composition H9, a control absent of a substantially non-odorous fragrance modulator (Kolliphor® EL), and as a function of time elapsed since application of the composition.



FIG. 6 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Floral Magnifica Fragrance Example 4b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 7 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 8 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Floral Magnifica Fragrance Example 4b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 9 provides the panel test results of the fragrance profile longevity, particularly intensity of the character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 10 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Floral Magnifica Fragrance Example 4b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 11 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) substantially non-odorous fragrance modulator as compared to Composition C4, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 12 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition D4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Caprylyl/Capryl Glucoside (i.e., Plantacare® 810 UP) substantially non-odorous fragrance modulator as compared to Composition F4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 13 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition G4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Undecyl Glucoside (i.e., Simulsol® SL 11W) substantially non-odorous fragrance modulator as compared to Composition I4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 14 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition J4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Isocetyl Alcohol (i.e., Ceraphyl® ICA) substantially non-odorous fragrance modulator as compared to Composition L4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 15 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Floral Magnifica Fragrance Example 4b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 16 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition A2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and Diisobutyl Adipate substantially non-odorous fragrance modulator as compared to Composition C2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 17 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition J2 comprising Diamond Floral Magnifica Fragrance Example 4b, and PPG-11 Stearyl Ether substantially non-odorous fragrance modulator as compared to Composition L2, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 18 provides the panel test results of fragrance profile fidelity, particularly the dominance of the floral character attributable to the volatile fragrance materials, of Composition J2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-11 Stearyl Ether substantially non-odorous fragrance modulator as compared to Composition L2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator, and as a function of time elapsed since application of the composition.



FIG. 19 provides the evaporation profile results for a representative component (i.e., indole) of test composition (MOD1) comprising a volatile fragrance mixture and PPG-3 Myristyl Ether (i.e., Tegosoft® APM) substantially non-odorous fragrance modulator as compared to a control composition (REF), and as a function of time elapsed since application of the composition.



FIG. 20 provides the evaporation profile results for a representative component (i.e., indole) of test composition (MOD2) comprising a volatile fragrance mixture and Neopentyl Glycol Diethylhexanoate (i.e., Scherecemol™ NGDO) substantially non-odorous fragrance modulator as compared to a control composition (REF), and as a function of time elapsed since application of the composition.



FIG. 21 provides the evaporation profile results for a representative component (i.e., indole) of test composition (MOD3) comprising a volatile fragrance material mixture and Kolliphor® EL substantially non-odorous fragrance modulator as compared to a control composition (REF), and as a function of time elapsed since application of the composition.



FIGS. 22(a)(i) and 22(a)(ii) provide the headspace chromatography of the fragrance profile of Composition L2, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



FIGS. 22(b)(i) and 22(b)(ii) provide the headspace chromatography of the fragrance profile of Composition J2 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-11 Stearyl Ether substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



FIGS. 23(a)(i) and 23(a)(ii) provide the headspace chromatography of the fragrance profile of Composition C4, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



FIGS. 23(b)(i) and 23(b)(ii) provide the headspace chromatography of the fragrance profile of Composition A4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and PPG-20 Methyl Glucose Ether (i.e., GLUCAM™ P-20) substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



FIGS. 24(a)(i) and 24(a)(ii) provide the headspace chromatography of the fragrance profile of Composition L4, comprising Traditional Floral Magnifica Fragrance Example 4a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



FIGS. 24(b)(i) and 24(b)(ii) provide the headspace chromatography of the fragrance profile of Composition J4 comprising Diamond Floral Magnifica Fragrance Example 4b, and Isocetyl Alcohol (i.e., Ceraphyl® ICA) substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



FIGS. 25(a)(i) and 25(a)(ii) provides the headspace chromatography of the fragrance profile of Composition I4, comprising Traditional Muguesia Magnifica Fragrance Example 5a, and absent of a substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.



FIGS. 25(b)(i) and 25(b)(ii) provide the headspace chromatography of the fragrance profile of Composition G4 comprising Diamond Muguesia Magnifica Fragrance Example 5b, and Undecyl Glucoside (i.e., Simulsol® SL 11W) substantially non-odorous fragrance modulator as a function of time elapsed, after 10 mins and 60 mins evaporation, respectively.





DETAILED DESCRIPTION OF THE INVENTION
Definitions

As used herein, articles such as “a” and “an” when used in a claim, are understood to mean one or more of what is claimed or described.


As used herein, the terms “include”, “includes” and “including” are meant to be non-limiting.


As used herein, the term “body splash” means a body care formulation that is applied to the body. Typically, the body splash is applied to the body after bathing and provides a subtle hint of scent to the body. Body splashes are commonly used by consumers who prefer less strong fragrance compositions. A body splash may comprise an ethanol-free composition according to the present invention which comprises from 0.2-8 wt %, relative to the total weight of the composition, of a fragrance component. The body splash may further comprise alkyl polyglucosides as non-ionic surfactants.


As used herein, the term “body spray” means a formulation comprising fragrance materials intended to be applied to the body to prevent or mask body odor caused by the bacterial breakdown of perspiration on the body (e.g., armpits, feet, and other areas of the body). The body spray may also provide a fragrance expression to the consumers. Typically, body spray compositions are applied as an aerosol spray in an effective amount on the skin of a consumer.


As used herein, the term “composition” includes a fine fragrance composition intended for application to a body surface, such as for example, skin or hair, i.e., to impart a pleasant odor thereto, or cover a malodour thereof. They are generally in the form of perfume concentrates, perfumes, eau de parfums, eau de toilettes, aftershaves, or colognes. The fine fragrance compositions may be an ethanol-based composition. The term “composition” may also include a cosmetic composition, which comprises a fragrance material for the purposes of delivering a pleasant smell to drive consumer acceptance of the cosmetic composition. The term “composition” may also include body splashes or body sprays. The term “composition” may also include cleaning compositions, such as fabric care composition or home care compositions, including air care compositions (e.g., air fresheners), for use on clothing or other substrates such as hard surfaces (e.g., dishes, floors, countertops). Additional non-limiting examples of “composition” may also include facial or body powder, deodorant, foundation, body/facial oil, mousse, creams (e.g., cold creams), waxes, sunscreens and blocks, bath and shower gels, lip balms, self-tanning compositions, masks and patches.


As used herein, the term “consumer” means both the user of the composition and the observer nearby or around the user.


As used herein, the term “diamond construction” means a fragrance formulation as shown in FIG. 1b. In particular, the diamond construction relates to the relative weight % of the fragrance materials classified according to their vapor pressure category (i.e., low, moderate or high). A diamond constructed fragrance has a substantially greater amount of the perfume raw materials of a moderate volatility as compared to the low and high volatile fragrance materials.


As used herein, the term “fragrance material” and “fragrance materials” relates to a perfume raw material (“PRM”), or a mixture of perfume raw materials (“PRMs”), that are used to impart an overall pleasant odour or fragrance profile to a composition. “Fragrance materials” can encompass any suitable perfume raw materials for fragrance uses, including materials such as, for example, alcohols, aldehydes, ketones, esters, ethers, acetates, nitriles, terpene hydrocarbons, nitrogenous or sulfurous heterocyclic compounds and essential oils. However, naturally occurring plant and animal oils and exudates comprising complex mixtures of various chemical components are also know for use as “fragrance materials”. The individual perfume raw materials which comprise a known natural oil can be found by reference to Journals commonly used by those skilled in the art such as “Perfume and Flavourist” or “Journal of Essential Oil Research”, or listed in reference texts such as the book by S. Arctander, Perfume and Flavor Chemicals, 1969, Montclair, N.J., USA and more recently re-published by Allured Publishing Corporation Illinois (1994). Additionally, some perfume raw materials are supplied by the fragrance houses (Firmenich, International Flavors & Fragrances, Givaudan, Symrise) as mixtures in the form of proprietary speciality accords. Non-limiting examples of the fragrance materials useful herein include pro-fragrances such as acetal pro-fragrances, ketal pro-fragrances, ester pro-fragrances, hydrolyzable inorganic-organic pro-fragrances, and mixtures thereof. The fragrance materials may be released from the pro-fragrances in a number of ways. For example, the fragrance may be released as a result of simple hydrolysis, or by a shift in an equilibrium reaction, or by a pH-change, or by enzymatic release.


As used herein, the term “fragrance profile” means the description of how the fragrance is perceived by the human nose at any moment in time. The fragrance profile may change over time. It is a result of the combination of the low, moderate and high volatile fragrance materials, if present, of a fragrance. A fragrance profile is composed of 2 characteristics: ‘intensity’ and ‘character’. The ‘intensity’ relates to the perceived strength whilst ‘character’ refers to the odour impression or quality of the perfume, i.e., fruity, floral, woody, etc.


As used herein, the terms “modulator”, and “fragrance modulator” are used interchangeably to designate an agent having the capacity to affect the fragrance profile, such as for example, by impacting the fragrance materials' evaporation rate. The modulator may mediate its effect by lowering the vapor pressure of the fragrance materials and increasing their adherence to the substrate (skin and/or hair) thus ensuring a longer-lasting impression of the fragrance. By incorporating the modulator, it is desired that the fragrance profile, preferably the fragrance components of the diamond construction attributable to the moderate and high volatile fragrance materials of the composition can be perceived by a consumer, over a longer period of time, as compared to the same perception in the absence of the fragrance diamond construction and the modulator. Suitable examples of the modulator are provided herein below. However, as discovered by the inventors, simply adding modulators to a traditionally constructed fragrance composition (i.e., classical fragrance pyramid construction) will not ensure an improved or enhanced fidelity and/or longevity of the fragrance profile over time. Instead, it is only when the modulators are added in the presence of the fragrance diamond construction can the improved or enhanced fidelity and/or longevity of the fragrance profile, preferably attributable to the moderate and high volatile fragrance materials, be perceived as compared to control composition absent the fragrance diamond construction and modulators.


As used herein, the term “substantially non-odorous” means an agent that does not impart an odour of its own when added into a composition of the present invention. For example, a “substantially non-odorous fragrance modulator” does not impart a new odour that alters the character of the fragrance profile of the composition to which it is added. The term “substantially non-odorous” also encompasses an agent that may impart a minimal or slight odour of its own when added into a composition of the present invention. However, the odour imparted by the “substantially non-odorous fragrance modulator” is generally undetectable or tends to not substantively alter the character of the fragrance profile of the composition to which it is added initially or preferably over time. Furthermore, the term “substantially non-odorous” also includes materials that are perceivable only by a minority of people or those materials deemed “anosmic” to the majority of people. Furthermore, the term “substantially non-odorous” also includes materials that may, from particular suppliers, contain an odour due to impurities, such as when the materials contain the impurities at not more than about 5 wt %, preferably not more than 1 wt %, often even not more than 1 part per million (ppm). These impurities maybe removed by purification techniques known in the art as required to make them suitable for use in fragrance compositions of the present invention.


As used herein, the term “vapor pressure” means the partial pressure in air at a defined temperature (e.g., 25° C.) and standard atmospheric pressure (760 mmHg) for a given chemical species. It defines a chemical species' desire to be in the gas phase rather than the liquid or solid state. The higher the vapor pressure the greater the proportion of the material that will, at equilibrium, be found in a closed headspace. It is also related to the rate of evaporation of a fragrance material which is defined in an open environment where material is leaving the system. The vapor pressure is determined according to the reference program Advanced Chemistry Development (ACD/Labs) Software Version 14.02, or preferably the latest version update).


It is understood that the test methods that are disclosed in the Test Methods Section of the present application must be used to determine the respective values of the parameters of Applicants' inventions as described and claimed herein.


In all embodiments of the present invention, all percentages are by weight of the total composition, as evident by the context, unless specifically stated otherwise. All ratios are weight ratios, unless specifically stated otherwise, and all measurements are made at 25° C., unless otherwise designated.


Compositions


The inventors have surprisingly discovered a revolutionary new way of objectively classifying fragrance materials and then formulating those fragrance materials into complex fragrance mixtures having improved fragrance profile fidelity and longevity. Essentially, the solution is to formulate the fragrance materials into a diamond construction in the presence of a substantially non-odorous fragrance modulator to provide for improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters derived from the more volatile fragrance materials (i.e., moderate and high vapor pressure range of the perfumer's palette). In fact, the inventors have discovered that in the complete absence of the low volatile fragrance materials or at very low levels of the low volatilie fragrance materials (less than 10 wt % relative to the total weight of the fragrance component) there is insufficient character complexity and roundness of the fragrance profile for consumer acceptance of the composition. Therefore the level of low volatile fragrance materials needs to be carefully chosen between 10 wt % and 30 wt %, relative to the total weight of the fragrance component, to balance consumer acceptance and the desired improved or enhanced longevity and/or fidelity of the fragrance profile, particularly amongst characters attributable to the moderate and/or high volatile fragrance materials.


Unlike previous proposed classification of fragrance materials according to their characteristic characters, which tends to be subjective, the inventors have established new rules to objectively classifying fragrance materials into low, moderate or high volatile fragrance materials according to their volatility using their vapor pressures defined at a suitable temperature. For example, methyl dihydrojasmonate which has been typically classified as a heart note under the traditional approach is now classified as a low volatile fragrance material because it has a vapor pressure of 0.00071000 Torr (0.000095 kPa) at 25° C. This new classification better reflects methyl dihydrojasmonate's technical properties of slow evaporation and long lasting.


Also unlike previous proposed uses of modulators to enhance fragrance profile, the inventors have established that the improved aforementioned advantages are not tied to a particular modulator of specific nature/structure but can be reapplied broadly. In fact, what the inventors have established is a systematic approach for providing longer lasting fragrance profiles that is totally unexpected and advantageous contribution to the perfumery technology.


Specifically, in one aspect, the present invention provides for a composition comprising a fragrance component present in an amount of from about 0.04 wt % to 30 wt %, preferably 1 wt % to about 30 wt %, more preferably less than about 25 wt %, yet more preferably less than about 20 wt %, yet even more preferably less than about 15 wt %, yet even more preferably less than about 10 wt % or most preferably less than about 8 wt %, relative to the total weight of the composition. Alternatively, the fragrance component is present in an amount of from about 0.04 wt %, 0.3 wt %, 1 wt %, 8 wt % or 10 wt %, to about 15 wt %, 20 wt %, 25 wt % or 30 wt %, relative to the total weight of the composition.


(i) Low Volatile Fragrance Materials


The fragrance component comprises at least one low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C. Preferably the composition according to the present invention comprises at least 3 low volatile fragrance materials, or at least 5 low volatile fragrance materials, or at least 7 low volatile fragrance materials. It is preferred that the composition of the present invention comprises low, preferably very low levels of the low volatile fragrance materials, lower than would traditionally be present in a fragrance pyramid three-tiered structure. As such, compositions of the present invention can comprise low levels of the low volatile fragrance material present in an amount of from about 10 wt % to about 30 wt %, preferably less than about 30 wt %, or preferably less than about 29 wt %, or preferably less than about 28 wt %, or preferably less than about 27 wt %, or preferably less than about 26 wt %, or preferably less than about 25 wt %, relative to the total weight of the fragrance component. Alternatively, the low volatile fragrance material is present in an amount of from about 10 wt %, 12 wt %, 15 wt %, 20 wt %, 25 wt % or 30 wt %, relative to the total weight of the fragrance component. If there is more than one low volatile fragrance materials, then the ranges provided hereinabove cover the total of all of the low volatile fragrance materials. Preferable examples of low volatile fragrances materials are provided in Table 1 below.


(ii) Moderate Volatile Fragrance Materials


The fragrance component comprises at least one moderate volatile fragrance material having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C. Preferably the composition according to the present invention comprises at least 3 moderate volatile fragrance materials, or at least 5 moderate volatile fragrance materials, or at least 7 moderate volatile fragrance materials. It is preferred that the composition of the present invention comprises high, preferably higher levels of the moderate volatile fragrance materials than would traditionally be present in a fragrance pyramid three-tiered structure. As such, compositions of the present invention can comprise high levels of the moderate volatile fragrance materials present in an amount of from about 40 wt % to about 80 wt %, preferably at least about 45 wt %, or preferably at least about 50 wt %, or preferably at least about 55 wt %, or preferably at least about 60 wt %, or preferably at least about 65 wt %, relative to the total weight of the fragrance component. Alternatively, the moderate volatile fragrance material is present in an amount less than about 75 wt %, or preferably less than 72 wt %, or preferably less than 70 wt %, relative to the total weight of the fragrance component. If there is more than one moderate volatile fragrance materials, then the ranges provided hereinabove cover the total of all of the moderate volatile fragrance materials. Preferable examples of moderate volatile fragrances materials are provided in Table 2 below.


(iii) High Volatile Fragrance Materials


The fragrance component comprises at least one high volatile fragrance material having a vapor pressure greater than 0.1 Torr (0.0133 kPa) at 25° C. Preferably the composition according to the present invention comprises at least 3 high volatile fragrance materials, or at least 5 high volatile fragrance materials, or at least 7 high volatile fragrance materials. It is preferred that the composition of the present invention comprises high volatile fragrance materials present in an amount of from about 1 wt % to about 30 wt %, preferably less than about 25 wt %, or preferably less than about 22 wt %, or preferably less than about 20 wt %, relative to the total weight of the fragrance component. Alternatively, the low volatile fragrance material is present in an amount of from about 6 wt %, 8 wt %, 10 wt %, 12 wt %, 14 wt % or 16 wt % relative to the total weight of the fragrance component. If there is more than one high volatile fragrance materials, then the ranges provided hereinabove cover the total of all of the high volatile fragrance materials. Preferable examples of high volatile fragrances materials are provided in Table 3 below.


(iv) Fragrance Modulators


The composition further comprises at least one substantially non-odorous fragrance modulator as described herein below. Preferable examples of the substantially non-odorous fragrance modulators are provided in Table 4 below.


Preferably, the substantially non-odorous fragrance modulator is present in an amount of from about 0.1 wt % to about 20 wt %, preferably from about 0.5 wt % to about 18 wt % or more preferably from about 2.5 wt % to about 15 wt % or combinations thereof, relative to the total weight of the composition. Alternatively, the substantially non-odorous fragrance modulator is present in an amount of from about 0.1 wt %, 0.5 wt % or 2.5 wt % to about 15 wt %, 18 wt % or 20 wt %, relative to the total weight of the composition. If there is more than one substantially non-odorous fragrance modulators, then the ranges provided hereinabove cover the total of all of the substantially non-odorous fragrance modulators.


The substantially non-odorous fragrance modulator of the present invention may be a liquid at temperatures lower than 100° C., preferably at ambient temperature. The substantially non-odorous fragrance modulators may be fully miscible with the fragrance materials to form a single phase liquid. However, if the fragrance materials are not entirely miscible, or are immiscible, then co-solvents (e.g., dipropylene glycol (DPG), triethyl citrate, or others as well known to those skilled in the art) can be added to aid in the solubility of the fragrance materials.


Preferably, the composition according to the present invention, wherein the substantially non-odorous fragrance modulator does not comprise: (i) isocetyl alcohol, PPG-3 myristyl ether, neopentyl glycol diethylhexanoate or their mixtures; and (ii) n-hexadecyl n-nonanoate, n-octadecyl n-nonanoate or their mixtures.


Preferably, the composition according to the present invention, wherein the substantially non-odorous fragrance modulator and fragrance component are present in a weight ratio from about 3:1 to about 1:3.


The inventors have surprisingly discovered that by formulating the fragrance component into a diamond construction in a composition, the effect of the substantially non-odorous fragrance modulator on the fragrance profile, particularly the characters of the fragrance profile which is attributable to the moderate and high volatile fragrance materials, preferably the moderate volatile fragrance materials, can be improved. By “improved” it is meant that the fragrance profile of the composition, particular the components contributed by the moderate and high volatile fragrance materials, can be perceived by the consumer at later time points such as, for example, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 10 hours, and possibly all the way up to 24 hrs after application as compared to controls, i.e., compositions containing the classical fragrance pyramid three-tiered structure and the substantially non-odorous fragrance modulator or compositions containing the classical fragrance pyramid three-tiered structure and no substantially non-odorous fragrance modulator.


Alternatively, by “improved” it can mean that the perception, by the consumer, of the fidelity of the fragrance profile contributed by the moderate and high volatile fragrance materials is markedly increased or enhanced as compared to the controls. “Increased” or “enhanced” means that the consumer perceives the fragrance profile, preferably the characters attributable to the moderate and/or high volatile fragrance materials, of a composition as not changing from its initial impression or the changes are minimal from when the composition was first applied to when it dissipates. In other words, the fidelity of the perceived fragrance profile of the composition is maintained over time.


Typically, it has been very difficult to formulate fragrance profile, particularly a floral or spicy character of the moderate volatile fragrance materials, which can last for very long periods, especially throughout the life of the composition after its application, without giving way to the stronger characters of the low volatile fragrance materials. The present invention of the diamond construction of fragrance materials with the substantially non-odorous fragrance modulators allows perfumers to increase the olfactive perception of the moderate and high volatile fragrance materials, particularly the moderate volatile fragrance materials, to create new characters and address a re-occurring consumer issue that particular fragrance profiles, particularly those having floral or aromatic and spicy characters, do not last long enough.


Such a solution as presented herein provides enhanced or improved fidelity and/or longevity of the fragrance profile, particularly amongst those composition formulated from volatile fragrance materials having moderate to high vapor pressure ranges (greater than or equal to 0.001 Torr (0.000133 kPa) at 25° C.), without having to rely on the presence or significant amounts of the low volatile fragrance materials, which has a tendency to overpower and alter the overall fragrance profile, particularly over time. As a result, the present invention provides the perfumer options to formulate compositions having new fragrance profiles not possible before.


Volatile Solvents


The present invention provides the solution to the problem of extending the longevity of the fragrance profile of compositions, particularly fine fragrance and cosmetic compositions, preferably fine fragrance compositions, which commonly contain high levels of a volatile solvent. Preferably, the composition according to the present invention, further comprising a volatile solvent present in the amount of from about 50 wt % to about 80 wt %, or preferably from about 55 wt % to about 75 wt %, relative to the total weight of the composition, and wherein the solvent is a branch or unbranched C1 to C10 alkyl, alkenyl or alkynyl group having at least one alcohol moiety, preferably ethanol, or isopropanol, or other alcohols (e.g., methanol, propanol, isopropanol, butanol, and mixtures thereof) commonly found in commercial fine fragrance products.


Accordingly, ethanol may be present in any of the compositions of the present invention, and more specifically, it will form from about 10 wt % to about 80 wt %, or even from about 25 wt % to about 75 wt % of the composition, or combinations thereof, relative to the total weight of the composition. Alternatively, ethanol may be present in an amount of from about 10 wt % or 25 wt % to about 75 wt % or 80 wt %, relative to the total weight of the composition. The ethanol useful in the present invention may be any acceptable quality of ethanol, compatible and safe for the specific intended use of the composition such as, for example, topical applications of fine fragrance or cosmetic compositions.


Water


In yet another aspect, water may be present in any of the compositions of the present invention, and more specifically, it shall not exceed about 40 wt %, preferably about 20 wt % or less, or more preferably about 10 wt % or less, relative to the total weight of the composition. Alternatively, water may be present in an amount of from about 10 wt % or about 20 wt % to about 40 wt %, relative to the total weight of the composition. When the composition is a cosmetic composition the level of water should not be so high that the product becomes cloudy thus negatively impacting the product aesthetics. It is understood that the amount of water present in the composition may be from the water present in the volatile solvent (e.g., ethanol) used in the composition, as the case may be.


Non-Volatile Solvents


The composition may comprise a non-volatile solvent or a mixture of non-volatile solvents. Non-limiting examples of non-volatile solvents include benzyl benzoate, diethyl phthalate, isopropyl myristate, propylene glycol, dipropylene glycol, triethyl citrate, and mixtures thereof. These solvents often are introduced to the product via the perfume oil as many perfume raw materials may be purchased as a dilution in one of these solvents. Where non-volatile solvents are present, introduced either with the perfume materials or separately, then for the purposes of calculating the proportion of fragrance component having a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25° C. the total fragrance components does not include non-volatile solvents. Where non-volatile solvents are present, introduced either with the perfume materials or separately, then for the purposes of calculating the total level of fragrance component this does not include non-volatile solvents. In addition if present with cyclic oligosaccharides, the non-volatile solvent may be included at a weight ratio of the non-volatile solvent to the cyclic oligosaccharide of less than 1:1, less than 1:2, less than 1:10, or less than 1:100.


Entrapment Materials


In yet another aspect, compositions of the present invention may comprise an entrapment material at a level such that the weight ratio of the entrapment material to the fragrance materials is in the range of from about 1:20 to about 20:1. Preferably, the composition may comprise an entrapment material present in the amount of from about 0.001 wt % to about 40 wt %, from about 0.1 wt % to about 25 wt %, from about 0.3 wt % to about 20 wt %, from about 0.5 wt % to about 10 wt %, or from about 0.75 wt % to about 5 wt %, relative to the total weight of the composition. The compositions disclosed herein may comprise from 0.001 wt % to 40%, from 0.1 wt % to 25 wt %, from 0.3 wt % to 20 wt %, from 0.5 wt % to 10 wt % or from 0.75 wt % to 5 wt %, relative to the total weight of the composition, of a cyclic oligosaccharide.


Suitable entrapment materials for use herein are selected from polymers; capsules, microcapsules and nanocapsules; liposomes, absorbents; cyclic oligosaccharides and mixtures thereof. Preferred are absorbents and cyclic oligosaccharides and mixtures thereof. Highly preferred are cyclic oligosaccharides (see PCT Publication Nos. WO2000/67721 (Procter & Gamble); and WO2000/67720 (Procter & Gamble); and U.S. Pat. No. 6,893,647 (Procter & Gamble)).


As used herein, the term “cyclic oligosaccharide” means a cyclic structure comprising six or more saccharide units. Preferred for use herein are cyclic oligosaccharides having six, seven or eight saccharide units and mixtures thereof, more preferably six or seven saccharide units and even more preferably seven saccharide units. It is common in the art to abbreviate six, seven and eight membered cyclic oligosaccharides to α, β and γ respectively.


The cyclic oligosaccharide of the compositions used for the present invention may comprise any suitable saccharide or mixtures of saccharides. Examples of suitable saccharides include, but are not limited to, glucose, fructose, mannose, galactose, maltose and mixtures thereof. However, preferred for use herein are cyclic oligosaccharides of glucose. The preferred cyclic oligosaccharides for use herein are α-cyclodextrins or β-cyclodextrins, or mixtures thereof, and the most preferred cyclic oligosaccharides for use herein are β-cyclodextrins.


The cyclic oligosaccharide, or mixture of cyclic oligosaccharides, for use herein may be substituted by any suitable substituent or mixture of substituents. Herein the use of the term “mixture of substituents” means that two or more different suitable substituents can be substituted onto one cyclic oligosaccharide. The derivatives of cyclodextrins consist mainly of molecules wherein some of the OH groups have been substituted. Suitable substituents include, but are not limited to, alkyl groups; hydroxyalkyl groups; dihydroxyalkyl groups; (hydroxyalkyl)alkylenyl bridging groups such as cyclodextrin glycerol ethers; aryl groups; maltosyl groups; allyl groups; benzyl groups; alkanoyl groups; cationic cyclodextrins such as those containing 2-hydroxy-3-(dimethylamino) propyl ether; quaternary ammonium groups; anionic cyclodextrins such as carboxyalkyl groups, sulphobutylether groups, sulphate groups, and succinylates; amphoteric cyclodextrins; and mixtures thereof.


The substituents may be saturated or unsaturated, straight or branched chain. Preferred substituents include saturated and straight chain alkyl groups, hydroxyalkyl groups and mixtures thereof. Preferred alkyl and hydroxyalkyl substituents are selected from C1-C8 alkyl or hydroxyalkyl groups or mixtures thereof, more preferred alkyl and hydroxyalkyl substituents are selected from C1-C6 alkyl or hydroxyalkyl groups or mixtures thereof, even more preferred alkyl and hydroxyalkyl substituents are selected from C1-C4 alkyl or hydroxyalkyl groups and mixtures thereof. Especially preferred alkyl and hydroxyalkyl substituents are propyl, ethyl and methyl, more especially hydroxypropyl and methyl and even more preferably methyl.


Preferred cyclic oligosaccharides for use in the present invention are unsubstituted, or are substituted by only saturated straight chain alkyl, or hydroxyalkyl substituents. Therefore, preferred examples of cyclic oligosaccharides for use herein are α-cyclodextrin, β-cyclodextrin, methyl-α-cyclodextrin, methyl-β-cyclodextrin, hydroxypropyl-α-cyclodextrin and hydroxypropyl-β-cyclodextrin. Most preferred examples of cyclic oligosaccharides for use herein are methyl-α-cyclodextrin and methyl-β-cyclodextrin. These are available from Wacker-Chemie GmbH Hanns-Seidel-Platz 4, Munchen, Del. under the tradename Alpha W6 M and Beta W7 M respectively. Especially preferred is methyl-β-cyclodextrin.


The cyclic oligosaccharides of the compositions used for the present invention are preferably soluble in water, ethanol, or both water and ethanol. As used herein “soluble” means at least about 0.1 g of solute dissolves in 100 mL of solvent, at 25° C. and 1 standard atmospheric pressure (760 mmHg). Preferably the cyclic oligosaccharides for use herein have a solubility of at least about 1 g/100 mL, at 25° C. and 1 atm of pressure. Preferred is that cyclic oligosaccharides are only present at levels up to their solubility limits in a given composition at room temperature. A person skilled in the art will recognise that the levels of cyclic oligosaccharides used in the present invention will also be dependent on the components of the composition and their levels, for example the solvents used or the exact fragrance oils, or combination of fragrance oils, present in the composition. Therefore, although the limits stated for the entrapment material are preferred, they are not exhaustive.


Propellants


The compositions described herein may include a propellant. Some examples of propellants include compressed air, nitrogen, inert gases, carbon dioxide, and mixtures thereof. Propellants may also include gaseous hydrocarbons like propane, n-butane, isobutene, cyclopropane, and mixtures thereof. Halogenated hydrocarbons like 1,1-difluoroethane may also be used as propellants. Some non-limiting examples of propellants include 1,1,1,2,2-pentafluoroethane, 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, trans-1,3,3,3-tetrafluoroprop-1-ene, dimethyl ether, dichlorodifluoromethane (propellant 12), 1,1-dichloro-1,1,2,2-tetrafluoroethane (propellant 114), 1-chloro-1,1-difluoro-2,2-trifluoroethane (propellant 115), 1-chloro-1,1-difluoroethylene (propellant 142B), 1,1-difluoroethane (propellant 152A), monochlorodifluoromethane, and mixtures thereof. Some other propellants suitable for use include, but are not limited to, A-46 (a mixture of isobutane, butane and propane), A-31 (isobutane), A-17 (n-butane), A-108 (propane), AP70 (a mixture of propane, isobutane and n-butane), AP40 (a mixture of propane, isobutene and n-butane), AP30 (a mixture of propane, isobutane and n-butane), and 152A (1,1 diflouroethane). The propellant may have a concentration from about 15%, 25%, 30%, 32%, 34%, 35%, 36%, 38%, 40%, or 42% to about 70%, 65%, 60%, 54%, 52%, 50%, 48%, 46%, 44%, or 42% by weight of the total fill of materials stored within the container.


Antiperspirant Active


The compositions described herein may be free of, substantially free of, or may include an antiperspirant active (i.e., any substance, mixture, or other material having antiperspirant activity). Examples of antiperspirant actives include astringent metallic salts, like the inorganic and organic salts of aluminum, zirconium and zinc, as well as mixtures thereof. Such antiperspirant actives include, for example, the aluminum and zirconium salts, such as aluminum halides, aluminum hydroxyhalides, zirconyl oxyhalides, zirconyl hydroxyhalides, and mixtures thereof.


Other Ingredients


In yet another aspect, the composition consists essentially of the recited ingredients but may contain small amounts (not more than about 10 wt %, preferably no more than 5 wt %, or preferably no more than 2 wt % thereof, relative to the total weight of the composition) of other ingredients that do not impact on the fragrance profile, particularly the evaporation rate and release of the fragrance materials. For example, a fine fragrance composition may comprise stabilizing or anti-oxidant agents, UV filters or quenchers, or colouring agents, commonly used in perfumery. There are a number of other examples of additional ingredients that are suitable for inclusion in the present compositions, particularly in compositions for cosmetic use. These include, but are not limited to, alcohol denaturants such as denatonium benzoate; UV stabilisers such as benzophenone-2; antioxidants such as tocopheryl acetate; preservatives such as phenoxyethanol, benzyl alcohol, methyl paraben, and propyl paraben; dyes; pH adjusting agents such as lactic acid, citric acid, sodium citrate, succinic acid, phosphoric acid, sodium hydroxide, and sodium carbonate; deodorants and anti-microbials such as farnesol and zinc phenolsulphonate; humectants such as glycerine; oils; skin conditioning agents such as allantoin; cooling agents such as trimethyl isopropyl butanamide and menthol; silicones; solvents such as hexylene glycol; hair-hold polymers such as those described in PCT Publication No. WO94/08557 (Procter & Gamble); salts in general, such as potassium acetate and sodium chloride and mixtures thereof.


In yet another aspect, the composition of the present invention, depending on its intended use, is a mixture of fragrance materials possibly together with other ingredients such as, for example, perfume carriers. By the term “perfume carrier”, it is meant to include materials which are practically neutral from a perfumery point of view, i.e., which does not significantly alter the organoleptic properties of perfuming components. The perfume carrier may be a compatible liquid or solid fillers, diluents, and the like. The term “compatible”, as used herein, means that the components of the compositions of this invention are capable of being combined with the primary actives of the present invention, and with each other, in a manner such that there is no interaction which would substantially reduce the efficacy of the composition under ordinary use situations. The type of carrier utilized in the present invention depends on the type of product desired and may comprise, but are not limited to, solutions, aerosols, emulsions (including oil-in-water or water-in-oil), gels, and liposomes. Preferably, the carrier is a liquid and will be a solvent such as, for example, dipropyleneglycol, diethyl phthalate, isopropyl myristate, benzyl benzoate, 2-(2-ethoxyethoxy)-1-ethanol, or ethyl citrate (triethyl citrate).


In yet another aspect, the compositions for use in the present invention may take any form suitable for use, more preferably for perfumery or cosmetic use. These include, but are not limited to, vapor sprays, aerosols, emulsions, lotions, liquids, creams, gels, sticks, ointments, pastes, mousses, powders, granular products, substrates, cosmetics (e.g., semi-solid or liquid makeup, including foundations) and the like. Preferably the compositions for use in the present invention take the form of a vapor spray. Compositions of the present invention can be further added as an ingredient to other compositions, preferably fine fragrance or cosmetic compositions, in which they are compatible. As such they can be used within solid composition or applied substrates etc.


Preferably, the compositions of the present invention comprise:

    • (i) a fragrance component present in an amount of from about 0.04 wt % to about 30 wt %, relative to the total weight of the composition, and wherein the fragrance component comprises:
      • (a) at least one low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C.;
      • (b) at least one moderate volatile fragrance material having a vapor pressure from greater than or equal to 0.001 Torr to 0.1 Torr (0.000133 kPa to 0.0133 kPa) at 25° C.; and
      • (c) at least one high volatile fragrance material having a vapor pressure greater than 0.1 Torr (0.0133 kPa) at 25° C.;
        • wherein the weight ratio of (a) versus the combination of (b) and (c) are present in the range of from about 1:2.33 to about 1:9;
    • (ii) at least one substantially non-odorous fragrance modulator present in the amount of from about 0.1 wt % to about 20 wt %, relative to the total weight of the composition;
    • (iii) a volatile solvent present in an amount of from about 50 wt % to about 80 wt %, relative to the total weight of the composition; and
    • (iv) optionally water.


Preferably, the present invention relates to a fine fragrance composition, preferably in the form of a perfume concentrate, a perfume, a parfum, an eau de toilette, an eau de parfum, or a cologne.


Preferably, the present invention relates to a composition, wherein the composition is in the form of a body splash or a body spray.


Therefore, it goes without saying that the compositions of the present invention encompasses any composition comprising any of the ingredients cited herein, in any embodiment wherein each such ingredient is independently present in any appropriate amount as defined herein. Many such compositions, than what is specifically set out herein, can be encompassed.


Article of Manufacture


The composition may be included in an article of manufacture comprising a spray dispenser. The spray dispenser may comprise a vessel for containing the composition to be dispensed. The spray dispenser may comprise an aerosolized composition (i.e., a composition comprising a propellant) within the vessel as well. Other non-limiting examples of spray dispensers include non-aerosol dispensers (e.g., vapor sprays), manually activated dispensers, pump-spray dispensers, or any other suitable spray dispenser available in the art.


Methods of Using the Compositions


The composition of the present invention according to any embodiments described herein is a useful perfuming composition, which can be advantageously used as consumer products intended to perfume any suitable substrate. As used herein, the term “substrate” means any surface to which the composition of the present invention may be applied to without causing any undue adverse effect. For example, this can include a wide range of surfaces including human or animal skin or hair, paper (fragranced paper), air in a room (air freshener or aromatherapy composition), fabric, furnishings, dishes, hard surfaces and related materials. Preferred substrates include body surfaces such as, for example, hair and skin, most preferably skin.


The composition of the present invention may be used in a conventional manner for fragrancing a substrate. An effective amount of the composition, typically from about 1 μL to about 10,000 μL, preferably from about 10 μL to about 1,000 μL, more preferably from about 25 μL to about 500 μL, or most preferably from about 50 μL to about 100 μL, or combinations thereof, is applied to the suitable substrate. Alternatively, an effective amount of the composition of the present invention is from about 1 μL, 10 μL, 25 μL or 50 μL to about 100 μL, 500 μL, 1,000 μL or 10,000 μL. The composition may be applied by hand or applied utilizing a delivery apparatus such as, for example, vaporizer or atomizer. Preferably, the composition is allowed to dry after its application to the substrate. The scope of the present invention should be considered to cover one or more distinct applications of the composition or the continuous release of a composition via a vaporizer or other type of atomizer.


The present invention provides a method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition of the present invention. It is preferred that the method is for imparting, intensifying or modifying the longevity of a floral character or aromatic/spicy character on human skin or human hair, wherein the perceived intensity of the floral character or aromatic/spicy character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein.


Non-limiting examples of floral character is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, a patchouli-type note and the like.


Non-limiting examples of aromatic (or haerbaceous) and spicy character include: cinnamon, cloves, coriander, ginger, saffron, peppers of various kinds (e.g.: black pepper, pink pepper), caraway, cardamom, anise, tea, coffee, cumin, nutmeg, coumarin, basil, rosemary, thyme, mint, tarragon, marjoram, fennel, sage, juniper and the like.


Preferably, the fragrance profile or character of the composition of the present invention is detectable by a consumer at later time points such as, for example, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 10 hours, and possibly all the way up to 24 hours after application of the composition to a substrate as compared to controls (i.e., classical fragrance pyramid three-tiered structure).


The present invention also relates to compositions of the present invention that may be used as consumer products or articles selected from the group consisting of a fabric care product, an air care product, or a home care product. Therefore, according to this embodiment, the present invention provides a method of modifying or enhancing the odour properties of a substrate, preferably fabric, furnishings, dishes, hard surfaces and related materials, comprising contacting or treating the substrate with a composition of the present invention.


In another aspect, the present invention is also directed to a method of producing a consumer product comprising bringing into contact or mixing into the product an organoleptically active quantity of a composition of the present invention.


Fragrance Materials


In order that the compositions can be developed with the appropriate fragrance profile for the present invention, the “fragrance materials” have been classified as low, moderate or high volatile fragrance materials according to their volatility by their vapor pressure. This method of classifying fragrance materials by their vapor pressure avoids the problem of different classifications for the same fragrance material according to the traditional approach that relies on their subjective characteristic character. For the purpose of clarity, when the fragrance materials refer to a single individual compound, its vapor pressure should be determined according to the reference program cited above. In the case that the fragrance materials are a natural oil, extract or absolute, which comprises a mixture of several compounds, the vapor pressure of the complete oil should be treated a mixture of the individual perfume raw material components using the reference program cited above. The individual components and their level, in any given natural oil or extract, can be determined by direct injection of the oil into a GC-MS column for analysis as known by one skilled in the art. In the scenario that the fragrance materials are a proprietary specialty accord, so called ‘bases’, the vapor pressure, using the reference program cited above, should preferably be obtained from the supplier. However, it is understood by one skilled in the art that they can physically analyze the composition of a full fragrance oil available commercially to identity the fragrance raw materials and their levels using standard GC-MS techniques. This would be irrespective of whether they had been added to the fragrance oil as individual chemicals, as components of naturals or from proprietary bases. Although proprietary bases and naturals are included in our examples, when analyzing a commercially available fragrance via GC-MS one could simply identify the components of the base or natural oil as part of the overall fragrance mixture and their levels, without being able to identify which proprietary base or natural oil the fragrance had come from.


The nature and type of fragrance materials in the compositions according to the present invention can be selected by the skilled person, on the basis of its general knowledge together with the teachings contained herein, with reference to the intended use or application of the composition and the desired fragrance profile effect. Examples of suitable fragrance materials are disclosed in U.S. Pat. No. 4,145,184, U.S. Pat. No. 4,209,417, U.S. Pat. No. 4,515,705, and U.S. Pat. No. 4,152,272.


(i) Low Volatile Fragrance Materials


Preferable examples of fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C. are provided in Table 1 Low Volatile Fragrance Materials. Preferably, the low volatile fragrance material is selected from at least 1 material, or at least 2 materials, or at least 3 materials, or at least 5 materials, or at least 7 low volatile fragrance materials as disclosed in Table 1.









TABLE 1







Low Volatile Fragrance Materials












CAS


Vapor Pressure


No.
Number
IUPAC Name
Common Name**
(Torr at 25° C.)*














1.
1211-29-6
Cyclopentaneacetic acid, 3-oxo-2-
Methyl jasmonate
0.00096500




(2Z)-2-penten-1-yl-, methyl ester,




(1R,2R)-


2.
28219-
2-Buten-1-ol, 2-methyl-4-(2,2,3-
Hindinol
0.00096100



60-5
trimethyl-3-cyclopenten-1-yl)-


3.
93-08-3
Ethanone, 1-(2-naphthalenyl)-
Methyl beta-naphthyl
0.00095700





ketone


4.
67633-
3-Decanone, 1-hydroxy-
Methyl Lavender
0.00095100



95-8

Ketone


5.
198404-
Cyclopropanemethanol, 1-methyl-
Javanol ®
0.00090200



98-7
2-[(1,2,2-trimethylbicyclo[3.1.0]




hex-3-yl)methyl]-


6.
121-32-4
Benzaldehyde, 3-ethoxy-4-
Ethyl vanillin
0.00088400




hydroxy-


7.
72403-
3-Cyclohexene-1-methanol, 4-(4-
Myraldylacetate
0.00087900



67-9
methyl-3-penten-1-yl)-, 1-acetate


8.
28940-
2H-1,5-Benzodioxepin-3(4H)-one,
Oxalone ®
0.00083100



11-6
7-methyl-


9.
139504-
2-Butanol, 1-[[2-(1,1-
Amber core
0.00080300



68-0
dimethylethyl)cyclohexyl]oxy]-


10.
502847-
Spiro[5.5]undec-8-en-1-one, 2,2,7,
Spiro[5.5]undec-8-en-
0.00073100



01-0
9-tetramethyl-
1-one, 2,2,7,9-





tetramethyl-


11.
2570-03-8
Cyclopentaneacetic acid, 3-oxo-2-
trans-Hedione
0.00071000




pentyl-, methyl ester, (1R,2R)-rel-


12.
24851-
Cyclopentaneacetic acid, 3-oxo-2-
Methyl
0.00071000



98-7
pentyl-, methyl ester
dihydrojasmonate or





alternatives1


13.
101-86-0
Octanal, 2-(phenylmethylene)-
Hexyl cinnamic
0.00069700





aldehyde


14.
365411-
Indeno[4,5-d]-1,3-dioxin, 4,4a,5,6,
Nebulone
0.00069200



50-3
7,8,9,9b-octahydro-7,7,8,9,9-




pentamethyl-


15.
37172-
Cyclopentanecarboxylic acid, 2-
Dihydro Iso Jasmonate
0.00067500



53-5
hexyl-3-oxo-, methyl ester


16.
65113-
3-Cyclopentene-1-butanol, α,β,2,2,
Sandalore ®
0.00062500



99-7
3-pentamethyl-


17.
68133-
Cyclopentanone, 2-(3,7-dimethyl-
Apritone
0.00062000



79-9
2,6-octadien-1-yl)-


18.
7212-44-4
1,6,10-Dodecatrien-3-ol, 3,7,11-
Nerolidol
0.00061600




trimethyl-


19.
53243-
2-Pentenenitrile, 3-methyl-5-
Citronitril
0.00061500



59-7
phenyl-, (2Z)-


20.
134123-
Benzenepropanenitrile, 4-ethyl-α,
Fleuranil
0.00057600



93-6
α-dimethyl-


21.
77-53-2
1H-3a,7-Methanoazulen-6-ol,
Cedrol Crude
0.00056900




octahydro-3,6,8,8-tetramethyl-,




(3R,3aS,6R,7R,8aS)-


22.
68155-
Ethanone, 1-(1,2,3,5,6,7,8,8a-
Iso Gamma Super
0.00056500



66-8
octahydro-2,3,8,8-tetramethyl-2-




naphthalenyl)-


23.
54464-
Ethanone, 1-(1,2,3,4,5,6,7,8-
Iso-E Super ®
0.00053800



57-2
octahydro-2,3,8,8-tetramethyl-2-




naphthalenyl)-


24.
774-55-0
Ethanone, 1-(5,6,7,8-tetrahydro-2-
Florantone
0.00053000




naphthalenyl)-


25.
141-92-4
2-Octanol, 8,8-dimethoxy-2,6-
Hydroxycitronellal
0.00052000




dimethyl-
Dimethyl Acetal


26.
20665-
Propanoic acid, 2-methyl-, 4-
Vanillin isobutyrate
0.00051200



85-4
formyl-2-methoxyphenyl ester


27.
79-78-7
1,6-Heptadien-3-one, 1-(2,6,6-
Hexalon
0.00049800




trimethyl-2-cyclohexen-1-yl)-


28.
6259-76-3
Benzoic acid, 2-hydroxy-, hexyl
Hexyl Salicylate
0.00049100




ester


29.
93-99-2
Benzoic acid, phenyl ester
Phenyl Benzoate
0.00047900


30.
153859-
Cyclohexanepropanol, 2,2,6-
Norlimbanol
0.00046900



23-5
trimethyl-α-propyl-, (1R,6S)-


31.
70788-
Cyclohexanepropanol, 2,2,6-
Timberol
0.00046900



30-6
trimethyl-α-propyl-


32.
68555-
Benzoic acid, 2-hydroxy-, 3-
Prenyl Salicylate
0.00045700



58-8
methyl-2-buten-1-yl ester


33.
950919-
2H-1,5-Benzodioxepin-3(4H)-one,
Cascalone
0.00045500



28-5
7-(1-methylethyl)-


34.
30168-
Butanal, 4-(octahydro-4,7-
Dupical
0.00044100



23-1
methano-5H-inden-5-ylidene)-


35.
1222-05-5
Cyclopenta[g]-2-benzopyran, 1,3,
Galaxolide ®
0.00041400




4,6,7,8-hexahydro-4,6,6,7,8,8-




hexamethyl-


36.
4602-84-0
2,6,10-Dodecatrien-1-ol, 3,7,11-
Farnesol
0.00037000




trimethyl-


37.
95962-
Cyclopentanone, 2-[2-(4-methyl-
Nectaryl
0.00036700



14-4
3-cyclohexen-1-yl)propyl]-


38.
4674-50-4
2(3H)-Naphthalenone, 4,4a,5,6,7,
Nootkatone
0.00035800




8-hexahydro-4,4a-dimethyl-6-(1-




methylethenyl)-, (4R,4aS,6R)-


39.
3487-99-8
2-Propenoic acid, 3-phenyl-,
Amyl Cinnamate
0.00035200




pentyl ester


40.
10522-
2-hydroxy-2-phenylethyl acetate
Styrolyl Acetate
0.00033900



41-5


41.
118-71-8
4H-Pyran-4-one, 3-hydroxy-2-
Maltol
0.00033700




methyl-


42.
128119-
1-Propanol, 2-methyl-3-[(1,7,7-
Bornafix
0.00033400



70-0
trimethylbicyclo[2.2.1]hept-2-yl)




oxy]-


43.
103614-
1-Naphthalenol, 1,2,3,4,4a,5,8,8a-
Octalynol
0.00033200



86-4
octahydro-2,2,6,8-tetramethyl-


44.
7785-33-3
2-Butenoic acid, 2-methyl-, (2E)-
Geranyl Tiglate
0.00033200




3,7-dimethyl-2,6-octadien-1-yl




ester, (2E)-


45.
117933-
1,3-Dioxane, 2-(2,4-dimethyl-3-
Karanal
0.00033100



89-8
cyclohexen-1-yl)-5-methyl-5-(1-




methylpropyl)-


46.
629-92-5
Nonadecane
Nonadecane
0.00032500


47.
67801-
4-Penten-2-ol, 3-methyl-5-(2,2,3-
Ebanol
0.00028100



20-1
trimethyl-3-cyclopenten-1-yl)-


48.
65416-
Propanoic acid, 2-methyl-, 2-
Maltol Isobutyrate
0.00028000



14-0
methyl-4-oxo-4H-pyran-3-yl ester


49.
28219-
2-Buten-1-ol, 2-ethyl-4-(2,2,3-
Laevo Trisandol
0.00028000



61-6
trimethyl-3-cyclopenten-1-yl)-


50.
5986-55-0
1,6-Methanonaphthalen-1(2H)-ol,
Healingwood
0.00027800




octahydro-4,8a,9,9-tetramethyl-,




(1R,4S,4aS,6R,8aS)-


51.
195251-
2H-1,5-Benzodioxepin-3(4H)-one,
Transluzone
0.00026500



91-3
7-(1,1-dimethylethyl)-


52.
3100-36-5
8-Cyclohexadecen-1-one
Cyclohexadecenone
0.00025300


53.
65405-
Benzoic acid, 2-hydroxy-, (3Z)-3-
cis-3-Hexenyl
0.00024600



77-8
hexen-1-yl ester
salicylate


54.
4940-11-8
4H-Pyran-4-one, 2-ethyl-3-
Ethyl Maltol
0.00022800




hydroxy-


55.
541-91-3
Cyclopentadecanone, 3-methyl-
Muskone
0.00017600


56.
118-58-1
Benzoic acid, 2-hydroxy-,
Benzyl salicylate
0.00017500




phenylmethyl ester


57.
81783-
6,8-Nonadien-3-one, 2,4,4,7-
Labienoxime
0.00017300



01-9
tetramethyl-, oxime


58.
25485-
Benzoic acid, 2-hydroxy-,
Cyclohexyl Salicylate
0.00017300



88-5
cyclohexyl ester


59.
91-87-2
Benzene, [2-(dimethoxymethyl)-1-
Amyl Cinnamic
0.00016300




hepten-1-yl]-
Aldehyde Dimethyl





Acetal


60.
104864-
3-Cyclopentene-1-butanol, β,2,2,
Firsantol
0.00016000



90-6
3-tetramethyl-δ-methylene-


61.
224031-
4-Penten-1-one, 1-spiro[4.5]dec-7-
Spirogalbanone
0.00015300



70-3
en-7-yl-


62.
134-28-1
5-Azulenemethanol,
Guaiyl Acetate
0.00013400




1,2,3,4,5,6,7,8-octahydro-α,α,3,8-




tetramethyl-, 5-acetate,




(3S,5R,8S)-


63.
236391-
Acetic acid, 2-(1-oxopropoxy)-, 1-
Romandolide ®
0.00012400



76-7
(3,3-dimethylcyclohexyl)ethyl




ester


64.
115-71-9
2-Penten-1-ol, 5-[(1R,3R,6S)-2,3-
cis-alpha-Santalol
0.00011800




dimethyltricyclo[2.2.1.02,6]hept-




3-yl]-2-methyl-, (2Z)-


65.
107898-
4-Penten-2-ol, 3,3-dimethyl-5-(2,
Polysantol ®
0.00011700



54-4
2,3-trimethyl-3-cyclopenten-1-yl)-


66.
69486-
5,8-Methano-2H-1-benzopyran-2-
Florex ®
0.00011000



14-2
one, 6-ethylideneoctahydro-


67.
84697-
Heptanal, 2-[(4-methylphenyl)
Acalea
0.00010100



09-6
methylene]-


68.
14595-
4-Cyclopentadecen-1-one, (4Z)-
Exaltenone
0.00009640



54-1


69.
32388-
Ethanone, 1-[(3R,3aR,7R,8aS)-2,3,
Vertofix ®
0.00008490



55-9
4,7,8,8a-hexahydro-3,6,8,8-




tetramethyl-1H-3a,7-




methanoazulen-5-yl]-


70.
131812-
1,3-Dioxolane, 2,4-dimethyl-2-(5,
Okoumal ®
0.00007600



67-4
6,7,8-tetrahydro-5,5,8,8-




tetramethyl-2-naphthalenyl)-


71.
106-02-5
Oxacyclohexadecan-2-one
Exaltolide ®
0.00006430


72.
141773-
1-Propanol, 2-[1-(3,3-
Helvetolide ®
0.00005790



73-1
dimethylcyclohexyl)ethoxy]-2-




methyl-, 1-propanoate


73.
63314-
5-Cyclopentadecen-1-one, 3-
Delta Muscenone
0.00005650



79-4
methyl-


74.
77-42-9
2-Penten-1-ol, 2-methyl-5-
cis-beta-Santalol
0.00004810




[(1S,2R,4R)-2-methyl-3-




methylenebicyclo[2.2.1]hept-2-




yl]-, (2Z)-


75.
362467-
2H-1,5-Benzodioxepin-3(4H)-one,
Azurone
0.00004770



67-2
7-(3-methylbutyl)-


76.
28371-
Ethanone, 1-(2,6,10-trimethyl-2,5,
Trimofix O
0.00004580



99-5
9-cyclododecatrien-1-yl)-


77.
16223-
1H-3a,6-Methanoazulene-3-
Khusimol
0.00004400



63-5
methanol, octahydro-7,7-dimethyl-




8-methylene-, (3S,3aR,6R,8aS)-


78.
10461-
Benzeneacetonitrile, α-
Peonile
0.00004290



98-0
cyclohexylidene-


79.
90-17-5
Benzenemethanol, α-
Rosacetol
0.00004240




(trichloromethyl)-, 1-acetate


80.
50607-
Benzoic acid, 2-[(2-
Mevantraal
0.00004070



64-2
methylpentylidene)amino]-,




methyl ester


81.
29895-
5-Hydroxy-2-benzyl-1,3-dioxane
Acetal CD
0.00004050



73-6


82.
94-47-3
Benzoic acid, 2-phenylethyl ester
Phenyl Ethyl Benzoate
0.00003480


83.
3100-36-5
Cyclohexadec-8-en-1-one
Globanone ®
0.00003310


84.
37609-
5-Cyclohexadecen-1-One
Ambretone
0.00003310



25-9


85.
66072-
Cyclohexanol, 4-(1,7,7-
Iso Bornyl Cyclohexanol
0.00003010



32-0
trimethylbicyclo[2.2.1]hept-2-yl)-


86.
31906-
3-Cyclohexene-1-carboxaldehyde,
Lyral ®
0.00002940



04-4
4-(4-hydroxy-4-methylpentyl)-


87.
21145-
Ethanone, 1-(5,6,7,8-tetrahydro-
Musk Plus
0.00002860



77-7
3,5,5,6,8,8-hexamethyl-2-




naphthalenyl)-


88.
21145-
Ethanone, 1-(5,6,7,8-tetrahydro-3,
Fixolide
0.00002860



77-7
5,5,6,8,8-hexamethyl-2-




naphthalenyl)-


89.
22442-
2-Cyclopentadecen-1-one, 3-
Muscenone
0.00002770



01-9
methyl-


90.
109-29-5
Oxacycloheptadecan-2-one
Silvanone Ci
0.00002600


91.
101-94-0
Benzeneacetic acid, 4-
Para Cresyl Phenyl
0.00002330




methylphenyl ester
Acetate


92.
102-20-5
Benzeneacetic acid, 2-phenylethyl
Phenyl Ethyl Phenyl
0.00002300




ester
Acetate


93.
118562-
Cyclododecaneethanol, β-methyl-
Hydroxyambran
0.00001800



73-5


94.
103-41-3
2-Propenoic acid, 3-phenyl-,
Benzyl Cinnamate
0.00001050




phenylmethyl ester


95.
4707-47-5
Benzoic acid, 2,4-dihydroxy-3,6-
Veramoss
0.00001050




dimethyl-, methyl ester


96.
183551-
Naphtho[2,1-b]furan-6(7H)-one,
Myrrhone
0.00000977



83-9
8,9-dihydro-1,5,8-trimethyl-, (8R)-


97.
102-17-0
Benzeneacetic acid, (4-
Para Anisyl Phenyl
0.00000813




methoxyphenyl)methyl ester
Acetate


98.
120-11-6
Benzene, 2-methoxy-1-
Benzyl Iso Eugenol
0.00000676




(phenylmethoxy)-4-(1-propen-1-




yl)-


99.
102-22-7
Benzeneacetic acid, (2E)-3,7-
Geranyl Phenylacetate
0.00000645




dimethyl-2,6-octadien-1-yl ester


100.
111879-
Oxacyclohexadec-12-en-2-one,
Habanolide 100%
0.00000431



80-2
(12E)-


101.
87-22-9
Benzoic acid, 2-hydroxy-, 2-
Phenyl Ethyl
0.00000299




phenylethyl ester
Salicylate


102.
78-37-5
2-Propenoic acid, 3-phenyl-, 1-
Linalyl Cinnamate
0.00000174




ethenyl-1,5-dimethyl-4-hexen-1-yl




ester


103.
28645-
Oxacycloheptadec-10-en-2-one
Ambrettolide
0.00000139



51-4


104.
123-69-3
Oxacycloheptadec-8-en-2-one,
Ambrettolide
0.00000136




(8Z)-


105.
3391-83-1
1,7-Dioxacycloheptadecan-8-one
Musk RI
0.00000057


106.
68527-
7-Octen-2-ol, 8-(1H-indol-1-yl)-
Indolene
0.000000445



79-7
2,6-dimethyl-


107.
89-43-0
Methyl 2-[(7-hydroxy-3,7-
Aurantinol
0.0000000100




dimethyloctylidene)amino]benzoate


108.
54982-
1,4-Dioxacyclohexadecane-5,16-
Zenolide
0.00000000834



83-1
dione


109.
105-95-3
1,4-Dioxacycloheptadecane-5,17-
Ethylene Brassylate
0.00000000313




dione


110.
3681-73-0
Hexadecanoic acid, (2E)-3,7-
Hexarose
0.00000000300




dimethyl-2,6-octadien-1-yl ester


111.
4159-29-9
Phenol, 4-[3-(benzoyloxy)-1-
Coniferyl benzoate
0.00000000170




propen-1-yl]-2-methoxy-


112.
144761-
Benzoic acid, 2-[(1-hydroxy-3-
Trifone DIPG
0.00000000093



91-1
phenylbutyl)amino]-, methyl ester






1Non-limiting examples of alternative qualities from various suppliers can be purchased under the following tradenames: Kharismal ® Super (IFF), Kharismal ® (IFF), Hedione ® (Firmenich), Hedione ® HC (Firmenich), Paradisone (Firmenich), Cepionate (Zenon), Super cepionate (Zenon), Claigeon ® (Zenon).



*Vapor Pressures are acquired as described in the Test Methods Section.


**Origin: The low volatile fragrance materials may be obtained from one or more of the following companies: Firmenich (Geneva, Switzerland), Symrise AG (Holzminden, Germany), Givaudan (Argenteuil, France), IFF (Hazlet, New Jersey), Bedoukian (Danbury, Connecticut), Sigma Aldrich (St. Louis, Missouri), Millennium Speciality Chemicals (Olympia Fields, Illinois), Polarone International (Jersey City, New Jersey), and Aroma & Flavor Specialities (Danbury, Connecticut).






Exemplary low volatile fragrance materials selected from the group of Table 1 Low Volatile Fragrance Materials are preferred. However, it is understood by one skilled in the art that other low volatile fragrance materials, not recited in Table 1, would also fall within the scope of the present invention, so long as they have a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C.


Preferably, the compositions of the present invention, wherein: (i)(a) the low volatile fragrance material is selected from the group of Table 1 Low Volatile Fragrance Materials 1, 4-6, 8, 12-16, 18, 22-25, 27-28, 31, 34-37, 41, 45, 47, 52-55, 57, 60, 61, 63, 65, 68, 69-74, 75, 78, 80, 83-84, 89, 94, 99, 102, 104, 106-108, and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 1-5, and mixtures thereof.


Preferably, the compositions of the present invention, wherein: (i)(a) the low volatile fragrance material is selected from the group consisting of Table 1 Low Volatile Fragrance Materials 1-6, 8-9, 12-14, 16, 18-19, 23, 25-28, 31, 34-35, 37, 41-42, 45, 47-49, 53-55, 57-60, 63, 65, 69, 71-73, 75, 78-79, 81, 84-85, 95, 100, 103, 105, 107, 109 and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 6-8, and mixtures thereof.


Preferably, the compositions of the present invention, the low volatile fragrance material is selected from the group (as described herein above), and wherein this group of low volatile fragrance material has at least about 20 wt %, at least about 30 wt %, at least about 40 wt %, at least about 50 wt %, at least about 60 wt %, or at least about 70 wt %, relative to the total weight of the low volatile fragrance material.


(ii) Moderate Volatile Fragrance Materials


Preferable examples of moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C. are provided in Table 2 Moderate Volatile Fragrance Materials. Preferably, the moderate volatile fragrance material is selected from at least 1 material, or at least 2 materials, or at least 3 materials, or at least 5 materials, or at least 7 moderate volatile fragrance materials as disclosed in Table 2.









TABLE 2







Moderate Volatile Fragrance Materials












CAS


Vapor Pressure


No.
Number
IUPAC Name
Common Name**
(Torr at 25° C.)*














1.
24168-70-5
Pyrazine, 2-methoxy-3-(1-
Methoxyisobutylpyrazine
0.09950000




methylpropyl)-


2.
89-79-2
Cyclohexanol, 5-methyl-2-
Iso-Pulegol
0.09930000




(1-methylethenyl)-, (1R,




2S,5R)-


3.
112-12-9
2-Undecanone
Methyl Nonyl Ketone
0.09780000


4.
103-05-9
Benzenepropanol, α,α-
Phenyl Ethyl Dimethyl
0.09770000




dimethyl-
Carbinol


5.
125-12-2
Bicyclo[2.2.1]heptan-2-ol,
Iso Bornyl Acetate
0.09590000




1,7,7-trimethyl-, 2-acetate,




(1R,2R,4R)-rel-


6.
78-70-6
1,6-Octadien-3-ol, 3,7-
Linalool
0.09050000




dimethyl-


7.
101-97-3
Benzeneacetic acid, ethyl
Ethyl Phenyl Acetate
0.08970000




ester


8.
100-86-7
Benzeneethanol, α,α-
Dimethyl Benzyl Carbinol
0.08880000




dimethyl-


9.
188570-78-7
Cyclopropanecarboxylic
Montaverdi
0.08640000




acid, (3Z)-3-hexen-1-yl




ester


10.
67634-25-7
3-Cyclohexene-1-
Floralate
0.08500000




methanol, 3,5-dimethyl-,




1-acetate


11.
112-44-7
Undecanal
Undecyl Aldehyde
0.08320000


12.
32669-00-4
Ethanone, 1-(3-
Tanaisone ®
0.08150000




cycloocten-1-yl)-


13.
98-53-3
Cyclohexanone, 4-(1,1-
Patchi
0.07780000




dimethylethyl)-


14.
35854-86-5
6-Nonen-1-ol, (6Z)-
cis-6-None-1-ol
0.07770000


15.
5331-14-6
Benzene, (2-butoxyethyl)-
Butyl phenethyl ether
0.07760000


16.
80-57-9
Bicyclo[3.1.1]hept-3-en-2-
Verbenone
0.07730000




one, 4,6,6-trimethyl-


17.
22471-55-2
Cyclohexanecarboxylic
Thesaron
0.07670000




acid, 2,2,6-trimethyl-,




ethyl ester, (1R,6S)-rel-


18.
60-12-8
Benzeneethanol
Phenethyl alcohol
0.07410000


19.
106-26-3
2,6-Octadienal, 3,7-
Neral
0.07120000




dimethyl-, (2Z)-


20.
5392-40-5
2,6-Octadienal, 3,7-
Citral
0.07120000




dimethyl-


21.
89-48-5
Cyclohexanol, 5-methyl-2-
Menthyl Acetate
0.07070000




(1-methylethyl)-, 1-




acetate, (1R,2S,5R)-rel-


22.
119-36-8
Benzoic acid, 2-hydroxy-,
Methyl salicylate
0.07000000




methyl ester


23.
4180-23-8
Benzene, 1-methoxy-4-
Anethol
0.06870000




(1E)-1-propen-1-yl-


24.
7549-37-3
2,6-Octadiene, 1,1-
Citral Dimethyl Acetal
0.06780000




dimethoxy-3,7-dimethyl-


25.
25225-08-5
Cyclohexanemethanol, α,
Aphermate
0.06780000




3,3-trimethyl-, 1-formate


26.
3913-81-3
2-Decenal, (2E)-
2-Decene-1-al
0.06740000


27.
15373-31-6
3-Cyclopentene-1-
Cantryl ®
0.06700000




acetonitrile, 2,2,3-




trimethyl-


28.
6485-40-1
2-Cyclohexen-1-one, 2-
Laevo carvone
0.06560000




methyl-5-(1-




methylethenyl)-, (5R)-


29.
16587-71-6
Cyclohexanone, 4-(1,1-
Orivone
0.06490000




dimethylpropyl)-


30.
62406-73-9
6,10-
Opalal CI
0.06290000




Dioxaspiro[4.5]decane,




8,8-dimethyl-7-(1-




methylethyl)-


31.
3720-16-9
2-Cyclohexen-1-one, 3-
Livescone
0.06270000




methyl-5-propyl-


32.
13816-33-6
Benzonitrile, 4-(1-
Cumin Nitrile
0.06230000




methylethyl)-


33.
67019-89-0
2,6-Nonadienenitrile
Violet Nitrile
0.06200000


34.
53398-85-9
Butanoic acid, 2-methyl-,
cis-3-Hexenyl Alpha
0.06130000




(3Z)-3-hexen-1-yl ester
Methyl Butyrate


35.
208041-98-9
n/a
Jasmonitrile
0.05920000


36.
16510-27-3
Benzene, 1-
Toscanol
0.05870000




(cyclopropylmethyl)-4-




methoxy-


37.
111-80-8
2-Nonynoic acid, methyl
Methyl Octine Carbonate
0.05680000




ester


38.
103-45-7
Acetic acid, 2-phenylethyl
Phenyl Ethyl Acetate
0.05640000




ester


39.
2550-26-7
2-Butanone, 4-phenyl-
Benzyl Acetone
0.05570000


40.
13491-79-7
Cyclohexanol, 2-(1,1-
Verdol
0.05430000




dimethylethyl)-


41.
7786-44-9
2,6-Nonadien-1-ol
2,6-Nonadien-1-ol
0.05370000


42.
103-28-6
Propanoic acid, 2-methyl-,
Benzyl Iso Butyrate
0.05130000




phenylmethyl ester


43.
104-62-1
Formic acid, 2-phenylethyl
Phenyl Ethyl Formate
0.05050000




ester


44.
28462-85-3
Bicyclo[2.2.1]heptan-2-ol,
Humus Ether
0.04870000




1,2,3,3-tetramethyl-, (1R,




2R,4S)-rel-


45.
122-03-2
Benzaldehyde, 4-(1-
Cuminic Aldehyde
0.04820000




methylethyl)-


46.
358331-95-0
2,5-Octadien-4-one, 5,6,7-
Pomarose
0.04810000




trimethyl-, (2E)-


47.
562-74-3
3-Cyclohexen-1-ol, 4-
Terpinenol-4
0.04780000




methyl-1-(1-methylethyl)-


48.
68527-77-5
3-Cyclohexene-1-
Isocyclogeraniol
0.04640000




methanol, 2,4,6-trimethyl-


49.
35852-46-1
Pentanoic acid, (3Z)-3-
Cis-3-Hexenyl Valerate
0.04580000




hexen-1-yl ester


50.
2756-56-1
Bicyclo[2.2.1]heptan-2-ol,
Iso Bornyl Propionate
0.04540000




1,7,7-trimethyl-, 2-




propanoate, (1R,2R,4R)-




rel-


51.
14374-92-6
Benzene, 1-methyl-4-(1-
Verdoracine
0.04460000




methylethyl)-2-(1-propen-




1-yl)-


52.
6784-13-0
3-Cyclohexene-1-
Limonenal
0.04380000




propanal, β,4-dimethyl-


53.
8000-41-7
2-(4-methyl-1-cyclohex-3-
Alpha Terpineol
0.04320000




enyl)propan-2-ol


54.
41884-28-0
1-Hexanol, 5-methyl-2-(1-
Tetrahydro Lavandulol
0.04230000




methylethyl)-, (2R)-


55.
22457-23-4
3-Heptanone, 5-methyl-,
Stemone ®
0.04140000




oxime


56.
104-50-7
2(3H)-Furanone, 5-
Gamma Octalactone
0.04080000




butyldihydro-


57.
143-08-8
1-Nonanol
Nonyl Alcohol
0.04070000


58.
3613-30-7
Octanal, 7-methoxy-3,7-
Methoxycitronellal
0.04020000




dimethyl-


59.
67634-00-8
Acetic acid, 2-(3-
Allyl Amyl Glycolate
0.04000000




methylbutoxy)-, 2-propen-




1-yl ester


60.
464-45-9
Bicyclo[2.2.1]heptan-2-ol,
1-Borneol
0.03980000




1,7,7-trimethyl-, (1S,2R,




4S)-


61.
124-76-5
Bicyclo[2.2.1]heptan-2-ol,
1.7.7-Trimethyl-Bicyclo-
0.03980000




1,7,7-trimethyl-, (1R,2R,
1.2.2-Heptanol-2




4R)-rel-


62.
67874-72-0
Cyclohexanol, 2-(1,1-
Coniferan
0.03980000




dimethylpropyl)-, 1-




acetate


63.
80-26-2
3-Cyclohexene-1-
Terpinyl Acetate
0.03920000




methanol, α,α,4-trimethyl-,




1-acetate


64.
498-81-7
Cyclohexanemethanol, α,
Dihydro Terpineol
0.03920000




α,4-trimethyl-


65.
112-45-8
10-Undecenal
Undecylenic aldehyde
0.03900000


66.
35044-57-6
2,4-Cyclohexadiene-1-
Ethyl Safranate
0.03880000




carboxylic acid, 2,6,6-




trimethyl-, ethyl ester


67.
106-21-8
1-Octanol, 3,7-dimethyl-
Dimethyl Octanol
0.03860000


68.
84560-00-9
Cyclopentanol, 2-pentyl-
Cyclopentol
0.03790000


69.
82461-14-1
Furan, tetrahydro-2,4-
Rhubafuran ®
0.03780000




dimethyl-4-phenyl-


70.
56011-02-0
Benzene, [2-(3-
Phenyl Ethyl Isoamyl
0.03690000




methylbutoxy)ethyl]-
Ether


71.
103-37-7
Butanoic acid,
Benzyl Butyrate
0.03660000




phenylmethyl ester


72.
6378-65-0
Hexyl hexanoate
Hexyl hexanoate
0.03490000


73.
118-61-6
Benzoic acid, 2-hydroxy-,
Ethyl salicylate
0.03480000




ethyl ester


74.
98-52-2
Cyclohexanol, 4-(1,1-
Patchon
0.03480000




dimethylethyl)-


75.
115-99-1
1,6-Octadien-3-ol, 3,7-
Linalyl Formate
0.03440000




dimethyl-, 3-formate


76.
112-54-9
Dodecanal
Laurie Aldehyde
0.03440000


77.
53046-97-2
3,6-Nonadien-1-ol, (3Z,
3,6 Nonadien-1-ol
0.03360000




6Z)-


78.
76649-25-7
3,6-Nonadien-1-ol
3,6-Nonadien-1-ol
0.03360000


79.
141-25-3
3,7-Dimethyloct-6-en-1-ol
Rhodinol
0.03290000


80.
1975-78-6
Decanenitrile
Decanonitrile
0.03250000


81.
2216-51-5
Cyclohexanol, 5-methyl-2-
L-Menthol
0.03230000




(1-methylethyl)-, (1R,2S,




5R)-


82.
3658-77-3
4-hydroxy-2,5-
Pineapple Ketone
0.03200000




dimethylfuran-3-one


83.
103-93-5
Propanoic acid, 2-methyl-,
Para Cresyl iso-Butyrate
0.03120000




4-methylphenyl ester


84.
24717-86-0
Propanoic acid, 2-methyl-,
Abierate
0.03110000




(1R,2S,4R)-1,7,7-




trimethylbicyclo[2.2.1]




hept-2-yl ester, rel-


85.
67845-46-9
Acetaldehyde, 2-(4-
Aldehyde XI
0.03090000




methylphenoxy)-


86.
67883-79-8
2-Butenoic acid, 2-methyl-,
Cis-3-Hexenyl Tiglate
0.03060000




(3Z)-3-hexen-1-yl ester,




(2E)-


87.
33885-51-7
Bicyclo[3.1.1]hept-2-ene-
Pino Acetaldehyde
0.03040000




2-propanal, 6,6-dimethyl-


88.
105-85-1
6-Octen-1-ol, 3,7-
Citronellyl Formate
0.03000000




dimethyl-, 1-formate


89.
70214-77-6
2-Nonanol, 6,8-dimethyl-
Nonadyl
0.03010000


90.
215231-33-7
Cyclohexanol, 1-methyl-3-
Rossitol
0.02990000




(2-methylpropyl)-


91.
120-72-9
1H-Indole
Indole
0.02980000


92.
2463-77-6
2-Undecenal
2-Undecene-1-al
0.02970000


93.
675-09-2
2H-Pyran-2-one, 4,6-
Levistamel
0.02940000




dimethyl-


94.
98-55-5
3-Cyclohexene-1-
Alpha-Terpineol
0.02830000




methanol, α,α,4-trimethyl-


95.
81786-73-4
3-Hepten-2-one, 3,4,5,6,6-
Koavone
0.02750000




pentamethyl-, (3Z)-


96.
122-97-4
Benzenepropanol
Phenyl Propyl Alcohol
0.02710000


97.
39212-23-2
2(3H)-Furanone, 5-
Methyl Octalactone
0.02700000




butyldihydro-4-methyl-


98.
53767-93-4
7-Octen-2-ol, 2,6-
Dihydro Terpinyl Acetate
0.02690000




dimethyl-, 2-acetate


99.
35044-59-8
1,3-Cyclohexadiene-1-
Ethyl Safranate
0.02660000




carboxylic acid, 2,6,6-




trimethyl-, ethyl ester


100.
104-55-2
2-Propenal, 3-phenyl-
Cinnamic Aldehyde
0.02650000


101.
144-39-8
1,6-Octadien-3-ol, 3,7-
Linalyl Propionate
0.02630000




dimethyl-, 3-propanoate


102.
61931-80-4
1,6-Nonadien-3-ol, 3,7-
3,7-Dimethyl-1,6-
0.02630000




dimethyl-, 3-acetate
nonadien-3-yl acetate


103.
102-13-6
Benzeneacetic acid, 2-
Iso Butyl Phenylacetate
0.02630000




methylpropyl ester


104.
65443-14-3
Cyclopentanone, 2,2,5-
Veloutone
0.02610000




trimethyl-5-pentyl-


105.
141-12-8
2,6-Octadien-1-ol, 3,7-
Neryl Acetate
0.02560000




dimethyl-, 1-acetate, (2Z)-


106.
105-87-3
2,6-Octadien-1-ol, 3,7-
Geranyl acetate
0.02560000




dimethyl-, 1-acetate, (2E)-


107.
68141-17-3
Undecane, 1,1-dimethoxy-
Methyl Nonyl
0.02550000




2-methyl-
Acetaldehyde Dimethyl





Acetal


108.
2206-94-2
Benzenemethanol, α-
Indocolore
0.02550000




methylene-, 1-acetate


109.
10528-67-3
Cyclohexanepropanol, α-
Cyclohexylmagnol
0.02550000




methyl-


110.
123-11-5
Benzaldehyde, 4-methoxy-
Anisic Aldehyde
0.02490000


111.
57576-09-7
Cyclohexanol, 5-methyl-2-
Iso Pulegol Acetate
0.02480000




(1-methylethenyl)-, 1-




acetate, (1R,2S,5R)-


112.
51566-62-2
6-Octenenitrile, 3,7-
Citronellyl Nitrile
0.02470000




dimethyl-


113.
60335-71-9
2H-Pyran, 3,6-dihydro-4-
Rosyrane Super
0.02470000




methyl-2-phenyl-


114.
30385-25-2
6-Octen-2-ol, 2,6-
Dihydromyrcenol
0.02440000




dimethyl-


115.
101-84-8
Benzene, 1,1′-oxybis-
Diphenyl Oxide
0.02230000


116.
136-60-7
Benzoic acid, butyl ester
Butyl Benzoate
0.02170000


117.
93939-86-7
5,8-Methano-2H-1-
Rhuboflor
0.02120000




benzopyran, 6-




ethylideneoctahydro-


118.
83926-73-2
Cyclohexanepropanol, α,α-
Coranol
0.02100000




dimethyl-


119.
125109-85-5
Benzenepropanal, β-
Florhydral
0.02070000




methyl-3-(1-methylethyl)-


120.
104-21-2
Benzenemethanol, 4-
Anisyl Acetate
0.02050000




methoxy-, 1-acetate


121.
1365-19-1
2-Furanmethanol, 5-
Linalool Oxide
0.02050000




ethenyltetrahydro-α,α,5-




trimethyl-


122.
137-03-1
Cyclopentanone, 2-heptyl-
Frutalone
0.02040000


123.
2563-07-7
Phenol, 2-ethoxy-4-
Ultravanil
0.02030000




methyl-


124.
1128-08-1
2-Cyclopenten-1-one, 3-
Dihydrojasmone
0.02020000




methyl-2-pentyl-


125.
7493-57-4
Benzene, [2-(1-
Acetaldehyde
0.01990000




propoxyethoxy)ethyl]-


126.
141-25-3
7-Octen-1-ol, 3,7-
Rhodinol
0.01970000




dimethyl-


127.
216970-
Bicyclo[4.3.1]decane, 3-
3-Methoxy-7,7-dimethyl-
0.01960000



21-7
methoxy-7,7-dimethyl-10-
10-methylenebicyclo[4.3.




methylene-
1]decane


128.
319002-92-1
Propanoic acid, 2-(1,1-
Sclareolate ®
0.01960000




dimethylpropoxy)-, propyl




ester, (2S)-


129.
85-91-6
Benzoic acid, 2-
Dimethyl anthranilate
0.01930000




(methylamino)-, methyl




ester


130.
13828-37-0
Cyclohexanemethanol, 4-
Mayol
0.01920000




(1-methylethyl)-, cis-


131.
26330-65-4
(E)-6-ethyl-3-methyloct-6-
Super Muguet
0.01850000




en-1-ol


132.
7540-51-4
6-Octen-1-ol, 3,7-
L-Citronellol
0.01830000




dimethyl-, (3S)-


133.
106-22-9
6-Octen-1-ol, 3,7-
Citronellol
0.01830000




dimethyl-


134.
543-39-5
7-Octen-2-ol, 2-methyl-6-
Myrcenol
0.01820000




methylene-


135.
7775-00-0
Benzenepropanal, 4-(1-
Cyclemax
0.01820000




methylethyl)-


136.
18479-54-4
4,6-Octadien-3-ol, 3,7-
Muguol
0.01800000




dimethyl-


137.
29214-60-6
Octanoic acid, 2-acetyl-,
Gelsone
0.01790000




ethyl ester


138.
1209-61-6
5-Oxatricyclo[8.2.0.04,6]
Tobacarol
0.01730000




dodecane, 4,9,12,12-




tetramethyl-


139.
57934-97-1
2-Cyclohexene-1-
Givescone
0.01710000




carboxylic acid, 2-ethyl-6,




6-dimethyl-, ethyl ester


140.
14901-07-6
3-Buten-2-one, 4-(2,6,6-
Beta-Ionone
0.01690000




trimethyl-1-cyclohexen-1-




yl)-, (3E)-


141.
64001-15-6
4,7-Methano-1H-inden-5-
Dihydro Cyclacet
0.01630000




ol, octahydro-, 5-acetate


142.
95-41-0
2-Cyclopenten-1-one, 2-
Iso Jasmone T
0.01600000




hexyl-


143.
134-20-3
Benzoic acid, 2-amino-,
Methyl Anthranilate
0.01580000




methyl ester


144.
100-06-1
Ethanone, 1-(4-
Para Methoxy
0.01550000




methoxyphenyl)-
Acetophenone


145.
105-86-2
2,6-Octadien-1-ol, 3,7-
Geranyl Formate
0.01540000




dimethyl-, 1-formate, (2E)-


146.
154171-77-4
Spiro[1,3-dioxolane-2,
Ysamber K ®
0.01470000




8′(5′H)-[2H-2,4a]




methanonaphthalene],




hexahydro-1′,1′,5′,5′-




tetramethyl-, (2′S,4′aS,




8′aS)-(9CI)


147.
154171-76-3
Spiro[1,3-dioxolane-
Ysamber
0.01470000




2,8′(5′H)-[2H-




2,4a]methanonaphthalene],




hexahydro-1′,1′,5′,5′-




tetramethyl-


148.
127-41-3
3-Buten-2-one, 4-(2,6,6-
Alpha-Ionone
0.01440000




trimethyl-2-cyclohexen-1-




yl)-, (3E)-


149.
151-05-3
Benzeneethanol, α,α-
Dimethyl Benzyl Carbinyl
0.01390000




dimethyl-, 1-acetate
Acetate


150.
2500-83-6
4,7-Methano-1H-inden-5-
Flor Acetate
0.01370000




ol, 3a,4,5,6,7,7a-




hexahydro-, 5-acetate


151.
150-84-5
6-Octen-1-ol, 3,7-
Citronellyl acetate
0.01370000




dimethyl-, 1-acetate


152.
30310-41-9
2H-Pyran, tetrahydro-2-
Pelargene
0.01350000




methyl-4-methylene-6-




phenyl-


153.
68845-00-1
Bicyclo[3.3.1]nonane, 2-
Boisiris
0.01350000




ethoxy-2,6,6-trimethyl-9-




methylene-


154.
106-24-1
2,6-Octadien-1-ol, 3,7-
Geraniol
0.01330000




dimethyl-, (2E)-


155.
106-25-2
2,6-Octadien-1-ol, 3,7-
Nerol
0.01330000




dimethyl-, (2Z)-


156.
75975-83-6
Bicyclo[7.2.0]undec-4-
Vetyvenal
0.01280000




ene, 4,11,11-trimethyl-8-




methylene-, (1R,4E,9S)-


157.
19870-74-7
1H-3a,7-Methanoazulene,
Cedryl methyl ether
0.01280000




octahydro-6-methoxy-3,6,




8,8-tetramethyl-, (3R,3aS,




6S,7R,8aS)-


158.
87-44-5
Bicyclo[7.2.0]undec-4-
Caryophyllene Extra
0.01280000




ene, 4,11,11-trimethyl-8-




methylene-, (1R,4E,9S)-


159.
54440-17-4
1H-Inden-1-one, 2,3-
Safraleine
0.01260000




dihydro-2,3,3-trimethyl-


160.
110-98-5
2-Propanol, 1,1′-oxybis-
Dipropylene Glycol
0.01250000


161.
41890-92-0
2-Octanol, 7-methoxy-3,7-
Osyrol ®
0.01250000




dimethyl-


162.
71077-31-1
4,9-Decadienal, 4,8-
Floral Super
0.01230000




dimethyl-


163.
65-85-0
Benzoic Acid
Benzoic Acid
0.01220000


164.
61444-38-0
3-Hexenoic acid, (3Z)-3-
cis-3-hexenyl-cis-3-
0.01220000




hexen-1-yl ester, (3Z)-
hexenoate


165.
116044-44-1
Bicyclo[2.2.1]hept-5-ene-
Herbanate
0.01210000




2-carboxylic acid, 3-(1-




methylethyl)-, ethyl ester,




(1R,2S,3S,4S)-rel-


166.
104-54-1
2-Propen-1-ol, 3-phenyl-
Cinnamic Alcohol
0.01170000


167.
78-35-3
Propanoic acid, 2-methyl-,
Linalyl Isobutyrate
0.01170000




1-ethenyl-1,5-dimethyl-4-




hexen-1-yl ester


168.
23495-12-7
Ethanol, 2-phenoxy-, 1-
Phenoxy Ethyl Propionate
0.01130000




propanoate


169.
103-26-4
2-Propenoic acid, 3-
Methyl Cinnamate
0.01120000




phenyl-, methyl ester


170.
67634-14-4
Benzenepropanal, 2-ethyl-
Florazon (ortho-isomer)
0.01110000




α,α-dimethyl-


171.
5454-19-3
Propanoic acid, decyl ester
N-Decyl Propionate
0.01100000


172.
93-16-3
Benzene, 1,2-dimethoxy-
Methyl Iso Eugenol
0.01100000




4-(1-propen-1-yl)-


173.
81782-77-6
3-Decen-5-ol, 4-methyl-
4-Methyl-3-decen-5-ol
0.01070000


174.
67845-30-1
Bicyclo[2.2.2]oct-5-ene-2-
Maceal
0.01060000




carboxaldehyde, 6-methyl-




8-(1-methylethyl)-


175.
97-53-0
Phenol, 2-methoxy-4-(2-
Eugenol
0.01040000




propen-1-yl)-


176.
120-57-0
1,3-Benzodioxole-5-
Heliotropin
0.01040000




carboxaldehyde


177.
93-04-9
Naphthalene, 2-methoxy-
Beta Naphthyl Methyl
0.01040000





Ether Extra 99


178.
4826-62-4
2-Dodecenal
2 Dodecene-1-al
0.01020000


179.
20407-84-5
2-Dodecenal, (2E)-
Aldehyde Mandarin
0.01020000


180.
5462-06-6
Benzenepropanal, 4-
Canthoxal
0.01020000




methoxy-α-methyl-


181.
94-60-0
1,4-Cyclohexanedicarboxylic
Dimethyl 1,4-
0.01020000




acid, 1,4-dimethyl ester
cyclohexanedicarboxylate


182.
57378-68-4
2-Buten-1-one, 1-(2,6,6-
delta-Damascone
0.01020000




trimethyl-3-cyclohexen-1-




yl)-


183.
17283-81-7
2-Butanone, 4-(2,6,6-
Dihydro Beta Ionone
0.01020000




trimethyl-1-cyclohexen-1-




yl)-


184.
1885-38-7
2-Propenenitrile, 3-phenyl-,
Cinnamalva
0.01010000




(2E)-


185.
103-48-0
Propanoic acid, 2-methyl-,
Phenyl Ethyl Iso Butyrate
0.00994000




2-phenylethyl ester


186.
488-10-8
2-Cyclopenten-1-one, 3-
Cis Jasmone
0.00982000




methyl-2-(2Z)-2-penten-1-




yl-


187.
7492-67-3
Acetaldehyde, 2-[(3,7-
Citronellyloxyacetaldehyde
0.00967000




dimethyl-6-octen-1-yl)




oxy]-


188.
68683-20-5
1-Cyclohexene-1-ethanol,
Iso Bergamate
0.00965000




4-(1-methylethyl)-, 1-




formate


189.
3025-30-7
2,4-Decadienoic acid,
Ethyl 2,4-Decadienoate
0.00954000




ethyl ester, (2E,4Z)-


190.
103-54-8
2-Propen-1-ol, 3-phenyl-,
Cinnamyl Acetate
0.00940000




1-acetate


191.
18127-01-0
Benzenepropanal, 4-(1,1-
Bourgeonal
0.00934000




dimethylethyl)-


192.
3738-00-9
Naphtho[2,1-b]furan,
Ambrox ® or Cetalox ® or
0.00934000




dodecahydro-3a,6,6,9a-
Synambran




tetramethyl-


193.
51519-65-4
1,4-Methanonaphthalen-
Tamisone
0.00932000




5(1H)-one, 4,4a,6,7,8,8a-




hexahydro-


194.
148-05-1
Dodecanoic acid, 12-
Dodecalactone
0.00931000




hydroxy-, λ-lactone (6CI,




7CI); 1,12-


195.
6790-58-5
(3aR,5aS,9aS,9bR)-
Ambronat ® or Ambroxan ®
0.00930000




3a,6,6,9a-tetramethyl-




2,4,5,5a,7,8,9,9b-




octahydro-1H-




benzole[e][1]benzofuran


196.
86-26-0
1,1′-Biphenyl, 2-methoxy-
Methyl Diphenyl Ether
0.00928000


197.
68738-94-3
2-
Cyclomyral ®
0.00920000




Naphthalenecarboxaldehyde,




octahydro-8,8-




dimethyl


198.
2705-87-5
Cyclohexanepropanoic
Allyl Cyclohexane
0.00925000




acid, 2-propen-1-yl ester
Propionate


199.
7011-83-8
2(3H)-Furanone, 5-
Lactojasmone ®
0.00885000




hexyldihydro-5-methyl-


200.
61792-11-8
2,6-Nonadienenitrile, 3,7-
Lemonile ®
0.00884000




dimethyl-


201.
692-86-4
10-Undecenoic acid, ethyl
Ethyl Undecylenate
0.00882000




ester


202.
103-95-7
Benzenepropanal, α-
Cymal
0.00881000




methyl-4-(1-methylethyl)-


203.
13019-22-2
9-Decen-1-ol
Rosalva
0.00879000


204.
94201-19-1
1-Oxaspiro[4.5]decan-2-
Methyl Laitone 10% TEC
0.00872000




one, 8-methyl-


205.
104-61-0
2(3H)-Furanone, dihydro-
γ-Nonalactone
0.00858000




5-pentyl-


206.
706-14-9
2(3H)-Furanone, 5-
γ-Decalactone
0.00852000




hexyldihydro-


207.
24720-09-0
2-Buten-1-one, 1-(2,6,6-
α-Damascone
0.00830000




trimethyl-2-cyclohexen-1-




yl)-, (2E)-


208.
39872-57-6
2-Buten-1-one, 1-(2,4,4-
Isodamascone
0.00830000




trimethyl-2-cyclohexen-1-




yl)-, (2E)-


209.
705-86-2
2H-Pyran-2-one,
Decalactone
0.00825000




tetrahydro-6-pentyl-


210.
67634-15-5
Benzenepropanal, 4-ethyl-
Floralozone
0.00808000




α,α-dimethyl-


211.
40527-42-2
1,3-Benzodioxole, 5-
Heliotropin Diethyl Acetal
0.00796000




(diethoxymethyl)-


212.
56973-85-4
4-Penten-1-one, 1-(5,5-
Neobutenone α
0.00763000




dimethyl-1-cyclohexen-1-




yl)-


213.
128-51-8
Bicyclo[3.1.1]hept-2-ene-
Nopyl Acetate
0.00751000




2-ethanol, 6,6-dimethyl-,




2-acetate


214.
103-36-6
2-Propenoic acid, 3-
Ethyl Cinnamate
0.00729000




phenyl-, ethyl ester


215.
5182-36-5
1,3-Dioxane, 2,4,6-
Floropal ®
0.00709000




trimethyl-4-phenyl-


216.
42604-12-6
Cyclododecane,
Boisambrene
0.00686000




(methoxymethoxy)-


217.
33885-52-8
Bicyclo[3.1.1]hept-2-ene-
Pinyl Iso Butyrate Alpha
0.00685000




2-propanal, α,α,6,6-




tetramethyl-


218.
92015-65-1
2(3H)-Benzofuranone,
Natactone
0.00680000




hexahydro-3,6-dimethyl-


219.
63767-86-2
Cyclohexanemethanol, α-
Mugetanol
0.00678000




methyl-4-(1-methylethyl)-


220.
3288-99-1
Benzeneacetonitrile, 4-(1,
Marenil CI
0.00665000




1-dimethylethyl)-


221.
35044-68-9
2-Buten-1-one, 1-(2,6,6-
beta-Damascone
0.00655000




trimethyl-1-cyclohexen-1-




yl)-


222.
41724-19-0
1,4-Methanonaphthalen-
Plicatone
0.00652000




6(2H)-one, octahydro-7-




methyl-


223.
75147-23-8
Bicyclo[3.2.1]octan-8-one,
Buccoxime ®
0.00647000




1,5-dimethyl-, oxime


224.
25634-93-9
2-Methyl-5-phenylpentan-
Rosaphen ® 600064
0.00637000




1-ol


225.
55066-48-3
3-Methyl-5-
Phenyl Hexanol
0.00637000




phenylpentanol


226.
495-62-5
Cyclohexene, 4-(1,5-
Bisabolene
0.00630000




dimethyl-4-hexen-1-




ylidene)-1-methyl-


227.
2785-87-7
Phenol, 2-methoxy-4-
Dihydro Eugenol
0.00624000




propyl-


228.
87-19-4
Benzoic acid, 2-hydroxy-,
Iso Butyl Salicylate
0.00613000




2-methylpropyl ester


229.
4430-31-3
2H-1-Benzopyran-2-one,
Octahydro Coumarin
0.00586000




octahydro-


230.
38462-22-5
Cyclohexanone, 2-(1-
Ringonol 50 TEC
0.00585000




mercapto-1-methylethyl)-




5-methyl-


231.
77-83-8
2-Oxiranecarboxylic acid,
Ethyl Methyl
0.00571000




3-methyl-3-phenyl-, ethyl
Phenyl Glycidate




ester


232.
37677-14-8
3-Cyclohexene-1-
Iso Hexenyl Cyclohexenyl
0.00565000




carboxaldehyde, 4-(4-
Carboxaldehyde




methyl-3-penten-1-yl)-


233.
103-60-6
Propanoic acid, 2-methyl-,
Phenoxy Ethyl iso-
0.00562000




2-phenoxyethyl ester
Butyrate


234.
18096-62-3
Indeno[1,2-d]-1,3-dioxin,
Indoflor ®
0.00557000




4,4a,5,9b-tetrahydro-


235.
63500-71-0
2H-Pyran-4-ol, tetrahydro-
Florosa Q/Florol
0.00557000




4-methyl-2-(2-




methylpropyl)-


236.
65405-84-7
Cyclohexanebutanal, α,2,
Cetonal ®
0.00533000




6,6-tetramethyl-


237.
171102-41-3
4,7-Methano-1H-inden-6-
Flor Acetate
0.00530000




ol, 3a,4,5,6,7,7a-




hexahydro-8,8-dimethyl-,




6-acetate


238.
10339-55-6
1,6-Nonadien-3-ol, 3,7-
Ethyl linalool
0.00520000




dimethyl-


239.
23267-57-4
3-Buten-2-one, 4-(2,2,6-
Ionone Epoxide Beta
0.00520000




trimethyl-7-




oxabicyclo[4.1.0]hept-1-




yl)-


240.
97-54-1
Phenol, 2-methoxy-4-(1-
Isoeugenol
0.00519000




propen-1-yl)-


241.
67663-01-8
2(3H)-Furanone, 5-
Peacholide
0.00512000




hexyldihydro-4-methyl-


242.
33885-52-8
Bicyclo[3.1.1]hept-2-ene-
Pinyl Iso Butyrate Alpha
0.00512000




2-propanal, α,α,6,6-




tetramethyl-


243.
23696-85-7
2-Buten-1-one, 1-(2,6,6-
Damascenone
0.00503000




trimethyl-1,3-




cyclohexadien-1-yl)-


244.
80-71-7
2-Cyclopenten-1-one, 2-
Maple Lactone
0.00484000




hydroxy-3-methyl-


245.
67662-96-8
Propanoic acid, 2,2-
Pivarose Q
0.00484000




dimethyl-, 2-phenylethyl




ester


246.
2437-25-4
Dodecanenitrile
Clonal
0.00480000


247.
141-14-0
6-Octen-1-ol, 3,7-
Citronellyl Propionate
0.00469000




dimethyl-, 1-propanoate


248.
54992-90-4
3-Buten-2-one, 4-(2,2,3,6-
Myrrhone
0.00460000




tetramethylcyclohexyl)-


249.
55066-49-4
Benzenepentanal, β-
Mefranal
0.00455000




methyl-


250.
7493-74-5
Acetic acid, 2-phenoxy-,
Allyl Phenoxy Acetate
0.00454000




2-propen-1-yl ester


251.
80-54-6
Benzenepropanal, 4-(1,1-
Lilial ®
0.00444000




dimethylethyl)-α-methyl-


252.
86803-90-9
4,7-Methano-1H-indene-2-
Scentenal ®
0.00439000




carboxaldehyde,




octahydro-5-methoxy-


253.
68991-97-9
2-Naphthalenecarboxaldehyde,
Melafleur
0.00436000




1,2,3,4,5,6,7,8-




octahydro-8,8-dimethyl-


254.
18871-14-2
Pentitol, 1,5-anhydro-2,4-
Jasmal
0.00434000




dideoxy-2-pentyl-, 3-




acetate


255.
58567-11-6
Cyclododecane,
Boisambren Forte
0.00433000




(ethoxymethoxy)-


256.
94400-98-3
Naphth[2,3-b]oxirene,
Molaxone
0.00425000




1a,2,3,4,5,6,7,7a-




octahydro-1a,3,3,4,6,6-




hexamethyl-,




(1aR,4S,7aS)-rel-


257.
79-69-6
3-Buten-2-one, 4-(2,5,6,6-
alpha-Irone
0.00419000




tetramethyl-2-cyclohexen-




1-yl)-


258.
65442-31-1
Quinoline, 6-(1-
Iso Butyl Quinoline
0.00408000




methylpropyl)-


259.
87731-18-8
Carbonic acid, 4-
Violiff
0.00401000




cycloocten-1-yl methyl




ester


260.
173445-65-3
1H-Indene-5-propanal, 2,
Hivernal (A-isomer)
0.00392000




3-dihydro-3,3-dimethyl-


261.
23911-56-0
Ethanone, 1-(3-methyl-2-
Nerolione
0.00383000




benzofuranyl)-


262.
52474-60-9
3-Cyclohexene-1-
Precyclemone B
0.00381000




carboxaldehyde, 1-methyl-




3-(4-methyl-3-penten-1-yl)-


263.
139539-66-5
6-Oxabicyclo[3.2.1]
Cassifix
0.00381000




octane, 5-methyl-1-(2,2,3-




trimethyl-3-cyclopenten-1-




yl)-


264.
80858-47-5
Benzene, [2-
Phenafleur
0.00380000




(cyclohexyloxy)ethyl]-


265.
32764-98-0
2H-Pyran-2-one,
Jasmolactone
0.00355000




tetrahydro-6-(3-penten-1-




yl)-


266.
78417-28-4
2,4,7-Decatrienoic acid
Ethyl 2,4,7-decatrienoate
0.00353000




ethyl ester


267.
140-26-1
Butanoic acid, 3-methyl-,
Beta Phenyl Ethyl
0.00347000




2-phenylethyl ester
Isovalerate


268.
105-90-8
2,6-Octadien-1-ol, 3,7-
Geranyl Propionate
0.003360000




dimethyl-, 1-propanoate,




(2E)-


269.
41816-03-9
Spiro[1,4-
Rhubofix ®
0.00332000




methanonaphthalene-




2(1H),2′-oxirane], 3,4,4a,




5,8,8a-hexahydro-3′,7-




dimethyl-


270.
7070-15-7
Ethanol, 2-[[(1R,2R,4R)-1,
Arbanol
0.00326000




7,7-trimethylbicyclo[2.2.1]




hept-2-yl]oxy]-, rel-


271.
93-29-8
Phenol, 2-methoxy-4-(1-
Iso Eugenol Acetate
0.00324000




propen-1-yl)-, 1-acetate


272.
476332-65-7
2H-Indeno[4,5-b]furan,
Amber Xtreme Compound 1
0.00323000




decahydro-2,2,6,6,7,8,8-




heptamethyl-


273.
68901-15-5
Acetic acid, 2-
Cyclogalbanate
0.00323000




(cyclohexyloxy)-, 2-




propen-1-yl ester


274.
107-75-5
Octanal, 7-hydroxy-3,7-
Hydroxycitronellal
0.00318000




dimethyl-


275.
68611-23-4
Naphtho[2,1-b]furan, 9b-
Grisalva
0.00305000




ethyldodecahydro-3a,7,7-




trimethyl-


276.
313973-37-4
1,6-Heptadien-3-one, 2-
Pharaone
0.00298000




cyclohexyl-


277.
137-00-8
5-Thiazoleethanol, 4-
Sulfurol
0.00297000




methyl-


278.
7779-30-8
1-Penten-3-one, 1-(2,6,6-
Methyl Ionone
0.00286000




trimethyl-2-cyclohexen-1-




yl)-


279.
127-51-5
3-Buten-2-one, 3-methyl-
Isoraldeine Pure
0.00282000




4-(2,6,6-trimethyl-2-




cyclohexen-1-yl)-


280.
72903-27-6
1,4-Cyclohexanedicarboxylic
Fructalate ™
0.00274000




acid, 1,4-diethyl ester


281.
7388-22-9
3-Buten-2-one, 4-(2,2-
Ionone Gamma Methyl
0.00272000




dimethyl-6-




methylenecyclohexyl)-3-




methyl-


282.
104-67-6
2(3H)-Furanone, 5-
gamma-Undecalactone
0.00271000




heptyldihydro-
(racemic)


283.
1205-17-0
1,3-Benzodioxole-5-
Helional
0.00270000




propanal, α-methyl-


284.
33704-61-9
4H-Inden-4-one, 1,2,3,5,6,
Cashmeran
0.00269000




7-hexahydro-1,1,2,3,3-




pentamethyl-


285.
36306-87-3
Cyclohexanone, 4-(1-
Kephalis
0.00269000




ethoxyethenyl)-3,3,5,5-




tetramethyl-


286.
97384-48-0
Benzenepropanenitrile, α-
Citrowanil ® B
0.00265000




ethenyl-α-methyl-


287.
141-13-9
9-Undecenal, 2,6,10-
Adoxal
0.00257000




trimethyl-


288.
2110-18-1
Pyridine, 2-(3-
Corps Racine VS
0.00257000




phenylpropyl)-


289.
27606-09-3
Indeno[1,2-d]-1,3-dioxin,
Magnolan
0.00251000




4,4a,5,9b-tetrahydro-2,4-




dimethyl-


290.
67634-20-2
Propanoic acid, 2-methyl-,
Cyclabute
0.00244000




3a,4,5,6,7,7a-hexahydro-4,




7-methano-1H-inden-5-yl




ester


291.
65405-72-3
1-Naphthalenol, 1,2,3,4,
Oxyoctaline Formate
0.00236000




4a,7,8,8a-octahydro-2,4a,




5,8a-tetramethyl-, 1-




formate


292.
122-40-7
Heptanal, 2-
Amyl Cinnamic Aldehyde
0.00233000




(phenylmethylene)-


293.
103694-68-4
Benzenepropanol, β,β,3-
Majantol ®
0.00224000




trimethyl-


294.
13215-88-8
2-Cyclohexen-1-one, 4-(2-
Tabanone Coeur
0.00223000




buten-1-ylidene)-3,5,5-




trimethyl-


295.
25152-85-6
3-Hexen-1-ol, 1-benzoate,.
Cis-3-Hexenyl Benzoate
0.00203000




(3Z)-


296.
406488-30-0
2-Ethyl-N-methyl-N-(m-
Paradisamide
0.00200000




tolyl)butanamide


297.
121-33-5
Benzaldehyde, 4-hydroxy-
Vanillin
0.00194000




3-methoxy-


298.
77-54-3
1H-3a,7-Methanoazulen-
Cedac
0.00192000




6-ol, octahydro-3,6,8,8-




tetramethyl-, 6-acetate,




(3R,3aS,6R,7R,8aS)-


299.
76842-49-4
4,7-Methano-1H-inden-6-
Frutene
0.00184000




ol, 3a,4,5,6,7,7a-




hexahydro-8,8-dimethyl-,




6-propanoate


300.
121-39-1
2-Oxiranecarboxylic acid,
Ethyl Phenyl Glycidate
0.00184000




3-phenyl-, ethyl ester


301.
211299-54-6
4H-4a,9-
Ambrocenide ®
0.00182000




Methanoazuleno[5,6-d]-1,




3-dioxole, octahydro-2,2,




5,8,8,9a-hexamethyl-,




(4aR,5R,7aS,9R)-


302.
285977-85-7
(2,5-Dimethyl-1,3-
Lilyflore
0.00180000




dihydroinden-2-




yl)methanol


303.
10094-34-5
Butanoic acid, 1,1-
Dimethyl Benzyl Carbinyl
0.00168000




dimethyl-2-phenylethyl
Butyrate




ester


304.
40785-62-4
Cyclododeca[c]furan, 1,3,
Muscogene
0.00163000




3a,4,5,6,7,8,9,10,11,13a-




dodecahydro-


305.
75490-39-0
Benzenebutanenitrile, α,α,
Khusinil
0.00162000




γ-trimethyl-


306.
55418-52-5
2-Butanone, 4-(1,3-
Dulcinyl
0.00161000




benzodioxol-5-yl)-


307.
3943-74-6
Benzoic acid, 4-hydroxy-
Carnaline
0.00157000




3-methoxy-, methyl ester


308.
72089-08-8
3-Cyclopentene-1-butanol,
Brahmanol ®
0.00154000




β,2,2,3-tetramethyl-




2-Methyl-4-(2,2,3-




trimethyl-3-cyclopenten-1-




yl)butanol


309.
3155-71-3
2-Butenal, 2-methyl-4-(2,
Boronal
0.00147000




6,6-trimethyl-1-




cyclohexen-1-yl)-


310.
2050-08-0
Benzoic acid, 2-hydroxy-,
Amyl Salicylate
0.00144000




pentyl ester


311.
41199-20-6
2-Naphthalenol,
Ambrinol
0.00140000




decahydro-2,5,5-trimethyl-


312.
12262-03-2
ndecanoic acid, 3-
Iso Amyl Undecylenate
0.00140000




methylbutyl ester


313.
107-74-4
1,7-Octanediol, 3,7-
Hydroxyol
0.00139000




dimethyl-


314.
91-64-5
2H-1-Benzopyran-2-one
Coumarin
0.00130000


315.
68901-32-6
1,3-Dioxolane, 2-[6-
Glycolierral
0.00121000




methyl-8-(1-methylethyl)




bicyclo[2.2.2]oct-5-en-2-




yl]-


316.
68039-44-1
Propanoic acid, 2,2-
Pivacyclene
0.00119000




dimethyl-, 3a,4,5,6,7,7a-




hexahydro-4,7-methano-




1H-inden-6-yl ester


317.
106-29-6
Butanoic acid, (2E)-3,7-
Geranyl Butyrate
0.00116000




dimethyl-2,6-octadien-1-yl




ester


318.
5471-51-2
2-Butanone, 4-(4-
Raspberry ketone
0.00106000




hydroxyphenyl)-


319.
109-42-2
10-Undecenoic acid, butyl
Butyl Undecylenate
0.00104000




ester





*Vapor Pressures are acquired as described in the Test Methods Section.


**Origin: Same as for Table 1 hereinabove.






Exemplary moderate volatile fragrance materials selected from the group of Table 2 Moderate Volatile Fragrance Materials are preferred. However, it is understood by one skilled in the art that other moderate volatile fragrance materials, not recited in Table 2, would also fall within the scope of the present invention, so long as they have a vapor pressure of 0.1 to 0.001 Torr at 25° C.


Preferably, the compositions of the present invention, wherein: (i)(b) the moderate volatile fragrance material is selected from the group of Table 2 Moderate Volatile Fragrance Materials 1-9, 11-12, 14-15, 17-18, 20-25, 27-35, 37-38, 39-43, 45-46, 48-53, 55-61, 63, 65, 67-71, 73-77, 79, 81-84, 86-91, 93-122, 124-125, 130-131, 133-135, 137, 139-145, 147-149, 151, 153-155, 157, 161-162, 164-169, 171-191, 193, 195-198, 200-203, 205-215, 218-219, 221, 223-241, 243, 245-250, 252-255, 257-262, 264-265, 267-268, 272, 273-276, 279-300, 302-304, 306, 308-310, 312-319, and mixtures thereof, and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 1-5, and mixtures thereof.


Preferably, the compositions of the present invention, wherein: (i)(a) the moderate volatile fragrance material is selected from the group consisting of Table 2 Moderate Volatile Fragrance Materials 1, 3, 4, 6, 7, 9, 11-12, 14, 15, 17-18, 20-25, 30-31, 34-35, 37-38, 41-42, 45-46, 49, 51-53, 55, 57-59, 65-70, 73, 75-77, 79-80, 82, 86-89, 91-94, 98, 101-107, 111-113, 115-122, 124-125, 130-133, 135, 137, 139-143, 145, 147-149, 151, 153-155, 157-159, 161-162, 164-168, 171-180, 182-183, 187-191, 193, 195-198, 200-203, 205-213, 218-219, 221-222, 224-229, 231-241, 243, 245-250, 252, 253, 254-255, 257-263, 264-265, 267-269, 271, 273-276, 279-300, 302-304, 306, 308-310, 312, 314-319, and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 6-8, and mixtures thereof.


Preferably, the compositions of the present invention, the low volatile fragrance material is selected from the group (as described herein above), and wherein this group of low volatile fragrance material has at least about 20 wt %, at least about 30 wt %, at least about 40 wt %, at least about 50 wt %, at least about 60 wt %, or at least about 70 wt %, relative to the total weight of the low volatile fragrance material.


(iii) High Volatile Fragrance Materials


Preferable examples of high volatile fragrance materials having a vapor pressure greater than 0.1 (0.0133 kPa) Torr at 25° C. are provided in Table 3 High Volatile Fragrance Materials. Preferably, the high volatile fragrance material is selected from at least 1 material, or at least 2 materials, or at least 3 materials, or at least 5 materials, or at least 7 high volatile fragrance materials as disclosed in Table 3.









TABLE 3







High Volatile Fragrance Materials












CAS


Vapor Pressure


No.
Number
IUPAC Name
Common Name**
(Torr at 25° C.)*














1.
107-31-3
Formic acid, methyl ester
Methyl Formate
732.00000000


2.
75-18-3
Methane, 1,1′-thiobis-
Dimethyl Sulfide 1.0% In
647.00000000





DEP


3.
141-78-6
Acetic acid ethyl ester
Ethyl Acetate
112.00000000


4.
105-37-3
Propanoic acid, ethyl ester
Ethyl Propionate
44.50000000


5.
110-19-0
Acetic acid, 2-
Isobutyl Acetate
18.00000000




methylpropyl ester


6.
105-54-4
Butanoic acid, ethyl ester
Ethyl Butyrate
13.90000000


7.
14765-30-1
1-Butanol
Butyl Alcohol
8.52000000


8.
7452-79-1
Butanoic acid, 2-methyl-,
Ethyl-2-Methyl Butyrate
7.85000000




ethyl ester


9.
123-92-2
1-Butanol, 3-methyl-, 1-
Iso Amyl Acetate
5.68000000




acetate


10.
66576-71-4
Butanoic acid, 2-methyl-,
Iso Propyl 2-
5.10000000




1-methylethyl ester
Methylbutyrate


11.
110-43-0
2-Heptanone
Methyl Amyl Ketone
4.73000000


12.
6728-26-3
2-Hexenal, (2E)-
Trans-2 Hexenal
4.62000000


13.
123-51-3
1-Butanol, 3-methyl-
Isoamyl Alcohol
4.16000000


14.
1191-16-8
2-Buten-1-ol, 3-methyl-,
Prenyl acetate
3.99000000




1-acetate


15.
57366-77-5
1,3-Dioxolane-2-
Methyl Dioxolan
3.88000000




methanamine, N-methyl-


16.
7785-70-8
Bicyclo[3.1.1]hept-2-ene,
Alpha Pinene
3.49000000




2,6,6-trimethyl-, (1R,5R)-


17.
79-92-5
Bicyclo[2.2.1]heptane, 2,
Camphene
3.38000000




2-dimethyl-3-methylene-


18.
94087-83-9
2-Butanethiol, 4-methoxy-
4-Methoxy-2-Methyl-2-
3.31000000




2-methyl-
Butanenthiol


19.
39255-32-8
Pentanoic acid, 2-methyl-,
Manzanate
2.91000000




ethyl ester


20.
3387-41-5
Bicyclo[3.1.0]hexane, 4-
Sabinene
2.63000000




methylene-1-(1-




methylethyl)-


21.
127-91-3
Bicyclo[3.1.1]heptane, 6,
Beta Pinene
2.40000000




6-dimethyl-2-methylene-


22.
105-68-0
1-Butanol, 3-methyl-, 1-
Amyl Propionate
2.36000000




propanoate


23.
123-35-3
1,6-Octadiene, 7-methyl-
Myrcene
2.29000000




3-methylene-


24.
124-13-0
Octanal
Octyl Aldehyde
2.07000000


25.
7392-19-0
2H-Pyran, 2-
Limetol
1.90000000




ethenyltetrahydro-2,6,6-




trimethyl-


26.
111-13-7
2-Octanone
Methyl Hexyl Ketone
1.72000000


27.
123-66-0
Hexanoic acid, ethyl ester
Ethyl Caproate
1.66000000


28.
470-82-6
2-Oxabicyclo[2.2.2]
Eucalyptol
1.65000000




octane, 1,3,3-trimethyl-


29.
99-87-6
Benzene, 1-methyl-4-(1-
Para Cymene
1.65000000




methylethyl)-


30.
104-93-8
Benzene, 1-methoxy-4-
Para Cresyl Methyl Ether
1.65000000




methyl-


31.
13877-91-3
1,3,6-Octatriene, 3,7-
Ocimene
1.56000000




dimethyl-


32.
138-86-3
Cyclohexene, 1-methyl-4-
dl-Limonene
1.54000000




(1-methylethenyl)-


33.
5989-27-5
Cyclohexene, 1-methyl-4-
d-limonene
1.54000000




(1-methylethenyl)-, (4R)-


34.
106-68-3
3-Octanone
Ethyl Amyl Ketone
1.50000000


35.
110-41-8
Undecanal, 2-methyl-
Methyl Nonyl
1.43000000





Acetaldehyde


36.
142-92-7
Acetic acid, hexyl ester
Hexyl acetate
1.39000000


37.
110-93-0
5-Hepten-2-one, 6-methyl-
Methyl Heptenone
1.28000000


38.
81925-81-7
2-Hepten-4-one, 5-methyl-
Filbertone 1% in TEC
1.25000000


39.
3681-71-8
3-Hexen-1-ol, 1-acetate,
cis-3-Hexenyl acetate
1.22000000




(3Z)-


40.
97-64-3
Propanoic acid, 2-
Ethyl Lactate
1.16000000




hydroxy-, ethyl ester


41.
586-62-9
Cyclohexene, 1-methyl-4-
Terpineolene
1.13000000




(1-methylethylidene)-


42.
51115-64-1
Butanoic acid, 2-
Amyl butyrate
1.09000000




methylbutyl ester


43.
106-27-4
Butanoic acid, 3-
Amyl Butyrate
1.09000000




methylbutyl ester


44.
99-85-4
1,4-Cyclohexadiene, 1-
Gamma Terpinene
1.08000000




methyl-4-(1-methylethyl)-


45.
18640-74-9
Thiazole, 2-(2-
2-Isobutylthiazole
1.07000000




methylpropyl)-


46.
928-96-1
3-Hexen-1-ol, (3Z)-
cis-3-Hexenol
1.04000000


47.
100-52-7
Benzaldehyde
Benzaldehyde
0.97400000


48.
141-97-9
Butanoic acid, 3-oxo-,
Ethyl Acetoacetate
0.89000000




ethyl ester


49.
928-95-0
2-Hexen-1-ol, (2E)-
Trans-2-Hexenol
0.87300000


50.
928-94-9
2-Hexen-1-ol, (2Z)-
Beta Gamma Hexenol
0.87300000


51.
24691-15-4
Cyclohexane, 3-ethoxy-1,
Herbavert
0.85200000




1,5-trimethyl-, cis-(9CI)


52.
19872-52-7
2-Pentanone, 4-mercapto-
4-Methyl-4-
0.84300000




4-methyl-
Mercaptopentan-2-one





1 ppm TEC


53.
3016-19-1
2,4,6-Octatriene, 2,6-
Allo-Ocimene
0.81600000




dimethyl-, (4E,6E)-


54.
69103-20-4
Oxirane, 2,2-dimethyl-3-
Myroxide
0.80600000




(3-methyl-2,4-pentadien-




1-yl)-


55.
189440-77-5
4,7-Octadienoic acid,
Anapear
0.77700000




methyl ester, (4E)-


56.
67633-96-9
Carbonic acid, (3Z)-3-
Liffarome ™
0.72100000




hexen-1-yl methyl ester


57.
123-68-2
Hexanoic acid, 2-propen-
Allyl Caproate
0.67800000




1-yl ester


58.
106-72-9
5-Heptenal, 2,6-dimethyl-
Melonal
0.62200000


59.
106-30-9
Heptanoic acid, ethyl ester
Ethyl Oenanthate
0.60200000


60.
68039-49-6
3-Cyclohexene-1-
Ligustral or Triplal
0.57800000




carboxaldehyde, 2,4-




dimethyl-


61.
101-48-4
Benzene, (2,2-
Phenyl Acetaldehyde
0.55600000




dimethoxyethyl)-
Dimethyl Acetal


62.
16409-43-1
2H-Pyran, tetrahydro-4-
Rose Oxide
0.55100000




methyl-2-(2-methyl-1-




propen-1-yl)-


63.
925-78-0
3-Nonanone
Ethyl Hexyl Ketone
0.55100000


64.
100-47-0
Benzonitrile
Benzyl Nitrile
0.52400000


65.
589-98-0
3-Octanol
Octanol-3
0.51200000


66.
58430-94-7
1-Hexanol, 3,5,5-
Iso Nonyl Acetate
0.47000000




trimethyl-, 1-acetate


67.
10250-45-0
4-Heptanol, 2,6-dimethyl-,
Alicate
0.45400000




4-acetate


68.
105-79-3
Hexanoic acid, 2-
Iso Butyl Caproate
0.41300000




methylpropyl ester


69.
2349-07-7
Propanoic acid, 2-methyl-,
Hexyl isobutyrate
0.41300000




hexyl ester


70.
23250-42-2
Cyclohexanecarboxylic
Cyprissate
0.40500000




acid, 1,4-dimethyl-,




methyl ester, trans-


71.
122-78-1
Benzeneacetaldehyde
Phenyl acetaldehyde
0.36800000


72.
5405-41-4
Butanoic acid, 3-hydroxy-,
Ethyl-3-Hydroxy Butyrate
0.36200000




ethyl ester


73.
105-53-3
Propanedioic acid, 1,3-
Diethyl Malonate
0.34400000




diethyl ester


74.
93-58-3
Benzoic acid, methyl ester
Methyl Benzoate
0.34000000


75.
16356-11-9
1,3,5-Undecatriene
Undecatriene
0.33600000


76.
65405-70-1
4-Decenal, (4E)-
Decenal (Trans-4)
0.33100000


77.
54546-26-8
1,3-Dioxane, 2-butyl-4,4,
Herboxane
0.33000000




6-trimethyl-


78.
13254-34-7
2-Heptanol, 2,6-dimethyl-
Dimethyl-2 6-Heptan-2-ol
0.33000000


79.
98-86-2
Ethanone, 1-phenyl-
Acetophenone
0.29900000


80.
93-53-8
Benzeneacetaldehyde, α-
Hydratropic aldehyde
0.29400000




methyl-


81.
80118-06-5
Propanoic acid, 2-methyl-,
Iso Pentyrate
0.28500000




1,3-dimethyl-3-buten-1-yl




ester


82.
557-48-2
2,6-Nonadienal, (2E,6Z)-
EZ-2,6-Nonadien-1-al
0.28000000


83.
24683-00-9
Pyrazine, 2-methoxy-3-(2-
2-Methoxy-3-Isobutyl
0.27300000




methylpropyl)-
Pyrazine


84.
104-57-4
Formic acid, phenylmethyl
Benzyl Formate
0.27300000




ester


85.
104-45-0
Benzene, 1-methoxy-4-
Dihydroanethole
0.26600000




propyl-


86.
491-07-6
Cyclohexanone, 5-methyl-
Iso Menthone
0.25600000




2-(1-methylethyl)-, (2R,




5R)-rel-


87.
89-80-5
Cyclohexanone, 5-methyl-
Menthone Racemic
0.25600000




2-(1-methylethyl)-, (2R,




5S)-rel-


88.
2463-53-8
2-Nonenal
2 Nonen-1-al
0.25600000


89.
55739-89-4
Cyclohexanone, 2-ethyl-4,
Thuyacetone
0.25000000




4-dimethyl-


90.
150-78-7
Benzene, 1,4-dimethoxy-
Hydroquinone Dimethyl
0.25000000





Ether


91.
64988-06-3
Benzene, 1-
Rosacene
0.24600000




(ethoxymethyl)-2-




methoxy-


92.
76-22-2
Bicyclo[2.2.1]heptan-2-
Camphor gum
0.22500000




one, 1,7,7-trimethyl-


93.
67674-46-8
2-Hexene, 6,6-dimethoxy-
Methyl Pamplemousse
0.21400000




2,5,5-trimethyl-


94.
112-31-2
Decanal
Decyl Aldehyde
0.20700000


95.
16251-77-7
Benzenepropanal, β-
Trifernal
0.20600000




methyl-


96.
93-92-5
Benzenemethanol, α-
Methylphenylcarbinol
0.20300000




methyl-, 1-acetate
Acetate


97.
143-13-5
Acetic acid, nonyl ester
Nonyl Acetate
0.19700000


98.
122-00-9
Ethanone, 1-(4-
Para Methyl Acetophenone
0.18700000




methylphenyl)-


99.
24237-00-1
2H-Pyran, 6-butyl-3,6-
Gyrane
0.18600000




dihydro-2,4-dimethyl-


100.
41519-23-7
Propanoic acid, 2-methyl-,
Hexenyl Isobutyrate
0.18200000




(3Z)-3-hexen-1-yl ester


101.
93-89-0
Benzoic acid, ethyl ester
Ethyl Benzoate
0.18000000


102.
20780-48-7
3-Octanol, 3,7-dimethyl-
Tetrahydro Linalyl Acetate
0.18000000




3-acetate


103.
101-41-7
Methyl 2-phenylacetate
Methylphenyl acetate
0.17600000


104.
40853-55-2
1-Hexanol, 5-methyl-2-(1-
Tetrahydro Lavandulyl
0.17300000




methylethyl)-, 1-acetate
Acetate


105.
933-48-2
Cyclohexanol, 3,3,5-
Trimethylcyclohexanol
0.17300000




trimethyl-, (1R,5R)-rel-


106.
35158-25-9
2-Hexenal, 5-methyl-2-(1-
Lactone of Cis Jasmone
0.17200000




methylethyl)-


107.
18479-58-8
7-Octen-2-ol, 2,6-
Dihydromyrcenol
0.16600000




dimethyl-


108.
140-11-4
Acetic acid, phenylmethyl
Benzyl acetate
0.16400000




ester


109.
14765-30-1
Cyclohexanone, 2-(1-
2-sec-Butyl Cyclo
0.16300000




methylpropyl)-
Hexanone


110.
20125-84-2
3-Octen-1-ol, (3Z)-
Octenol
0.16000000


111.
142-19-8
Heptanoic acid, 2-propen-
Allyl Heptoate
0.16000000




1-yl ester


112.
100-51-6
Benzenemethanol
Benzyl Alcohol
0.15800000


113.
10032-15-2
Butanoic acid, 2-methyl-,
Hexyl-2-Methyl Butyrate
0.15800000




hexyl ester


114.
695-06-7
2(3H)-Furanone, 5-
Gamma Hexalactone
0.15200000




ethyldihydro-


115.
21722-83-8
Cyclohexaneethanol, 1-
Cyclohexyl Ethyl Acetate
0.15200000




acetate


116.
111-79-5
2-Nonenoic acid, methyl
Methyl-2-Nonenoate
0.14600000




ester


117.
16491-36-4
Butanoic acid, (3Z)-3-
Cis 3 Hexenyl Butyrate
0.13500000




hexen-1-yl ester


118.
111-12-6
2-Octynoic acid, methyl
Methyl Heptine Carbonate
0.12500000




ester


119.
59323-76-1
1,3-Oxathiane, 2-methyl-
Oxane
0.12300000




4-propyl-, (2R,4S)-rel-


120.
62439-41-2
Heptanal, 6-methoxy-2,6-
Methoxy Melonal
0.11900000




dimethyl-


121.
13851-11-1
Bicyclo[2.2.1]heptan-2-ol,
Fenchyl Acetate
0.11700000




1,3,3-trimethyl-, 2-acetate


122.
115-95-7
1,6-Octadien-3-ol, 3,7-
Linalyl acetate
0.11600000




dimethyl-, 3-acetate


123.
18479-57-7
2-Octanol, 2,6-dimethyl-
Tetra-Hydro Myrcenol
0.11500000


124.
78-69-3
3,7-dimethyloctan-3-ol
Tetra Hydro Linalool
0.11500000


125.
111-87-5
1-Octanol
Octyl Alcohol
0.11400000


126.
71159-90-5
3-Cyclohexene-1-
Grapefruit mercaptan
0.10500000




methanethiol, α,α,4-




trimethyl-


127.
80-25-1
Cyclohexanemethanol, α,
Menthanyl Acetate
0.10300000




α,4-trimethyl-, 1-acetate


128.
88-41-5
Cyclohexanol, 2-(1,1-
Verdox ™
0.10300000




dimethylethyl)-, 1-acetate


129.
32210-23-4
Cyclohexanol, 4-(1,1-
Vertenex
0.10300000




dimethylethyl)-, 1-acetate


130.
112-44-7
Undecanal
n-Undecanal
0.10200000


131.
124-19-6
Nonanal
Nonanal Aldehyde C-9
0.53200000


132.
929253-05-4
6-methoxy-2,6-
6-methoxy-2,6-dimethyl
0.04020000




dimethyloctanal
octanal


133.
68039-47-4
2-propan-2-
Phenethyl Isopropyl Ether
0.24900000




yloxyethylbenzene


134.
6413-10-1
ethyl 2-(2-methyl-1,3-
Apple Ketal
0.21900000




dioxolan-2-yl)acetate


135.
106-23-0
3,7-dimethyloct-6-enal
citronellal
0.21500000





*Vapor Pressures are acquired as described in the Test Methods Section.


**Origin: Same as for Table 1 hereinabove.






Exemplary high volatile fragrance materials selected from the group of Table 3 High Volatile Fragrance Materials are preferred. However, it is understood by one skilled in the art that other high volatile fragrance materials, not recited in Table 3, would also fall within the scope of the present invention, so long as they have a vapor pressure of greater than 0.1 Torr (0.0133 kPa) at 25° C.


Preferably, the compositions of the present invention, wherein: (i)(c) the high volatile fragrance material is selected from the group of Table 3 High Volatile Fragrance Materials 1, 2, 6, 8, 9, 12, 14, 19, 36, 39, 46, 47, 56, 57, 58, 60, 62, 74, 78, 93, 94, 96, 100, 106, 111, 117, 119, 120, 128, 129, 131-135 and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 1-5, and mixtures thereof.


Preferably, the compositions of the present invention, wherein: (i)(c) the high volatile fragrance material is selected from the group consisting of Table 3 high Volatile Fragrance Materials 1, 2, 6, 8, 9, 12, 14, 19, 36, 39, 46, 47, 56, 57, 58, 60, 62, 74, 78, 93, 94, 96, 100, 106, 111, 117, 119, 120, 128, 129, 131-135, and mixtures thereof; and (ii) the substantially non-odorous fragrance modulator is selected from the group of Table 4(a) Substantially Non-Odorous Fragrance Modulators 6-8, and mixtures thereof.


Preferably, the compositions of the present invention, the high volatile fragrance material is selected from the group (as described herein above), and wherein this group of high volatile fragrance material has at least about 20 wt %, at least about 30 wt %, at least about 40 wt %, at least about 50 wt %, at least about 60 wt %, or at least about 70 wt %, relative to the total weight of the high volatile fragrance material.


Fragrance Modulators


In one aspect, compositions of the present invention comprise at least one substantially non-odorous modulator selected from the group consisting of:

    • (a) Methyl Glucoside Polyol; Ethyl Glucoside Polyol; Propyl Glucoside Polyol; and their mixtures;
    • (b) Isocetyl Alcohol;
    • (c) PPG-3 Myristyl Ether; Neopentyl Glycol Diethylhexanoate; and their mixtures;
    • (d) Sucrose Laurate, Sucrose Dilaurate, Sucrose Myristate, Sucrose Palmitate, Sucrose Stearate, Sucrose Distearate, Sucrose Tristearate, and mixtures thereof;
    • (e) Trimethylcyclohexane derivatives having the formula (I):




embedded image






      • wherein:
        • n is 0, 1 or 2;
        • A is C═O or CH—OH;
        • R1a is hydrogen or methyl;
        • R2a is a C2-C10 hydrocarbon group; and
        • custom character is a saturated or unsaturated carbon-carbon bond;



    • (f) L-menthoxy ether derivatives having the formula (II):







embedded image






      • wherein:
        • m is 0, 1 or 2;
        • B is hydrogen or OH; and
        • C is hydrogen or methyl;



    • (g) Tetra-hydronaphthalene derivatives having the formula (III):







embedded image






      • wherein:
        • R1b is hydrogen or methyl; and
        • R2b is alkyl;



    • (h) Hyaluronic acid disaccharide sodium salt, sodium hyaluronate and their mixtures;

    • (i) Ether derivatives having the formula (IV) or formula (V):

      C5HlOm—(OR1c)n  (IV)
      • wherein:
        • C5HlOm is a pentose residue, wherein l is an integer from 6 to 9, and m is an integer from 1 to 4;
        • n is an integer from 1 to 4; and
        • R1c is C4-C20 hydrocarbon group; and

          C6HxOy—(OR1d)z  (V)
      • wherein:
        • C6HxOy is a hexose residue, wherein x is an integer from 7 to 11, and y is an integer from 1 to 5;
        • z is an integer from 1 to 5; and
        • R1d is C4-C20 hydrocarbon group; and

    • (j) Diethylene Glycol Ether derivatives having the formula (VI) or formula (VII):

      C5HcOd—(OCH2CH2—O—CH2CH2—O—R1e)e  (VI)
      • wherein:
        • C5HcOd is a pentose residue, wherein c is an integer from 6 to 8, and d is an integer from 1 to 3;
        • e is an integer from 2 to 4; and
        • R1c is C1-C6 alkyl group; and

          C6HfOg—(OCH2CH2—O—CH2CH2—O—R1f)h   (VII)
      • wherein:
        • C6HfOg is a hexose residue, wherein f is an integer from 7 to 10, and g is an integer from 1 to 4;
        • h is an integer from 2 to 5; and
        • R1f is C1-C6 alkyl group;

    • (k) Hydroquinone Glycoside derivatives having the formula (VIII):







embedded image






      • wherein:
        • R1g is selected from the group consisting of: (i) pentose residue, hexose residue, aminosaccharide residue, uronic acid residue and their mixtures; (ii) methylated versions of group (i); and (iii) mixtures of groups (i) and (ii); and



    • (l) Propylene Glycol Propyl Ether; Dicetyl Ether; Polyglycerin-4 Ethers; Isoceteth-5; Isoceteth-7, Isoceteth-10; Isoceteth-12; Isoceteth-15; Isoceteth-20; Isoceteth-25; Isoceteth-30; Disodium Lauroamphodipropionate; Hexaethylene glycol monododecyl ether; and their mixtures;

    • (m) Neopentyl Glycol Diisononanoate; Cetearyl Ethylhexanoate; and their mixtures;

    • (n) Glyceryl Ether derivatives having the formula (IX):







embedded image






      • wherein:
        • R1h is C4-C12 aliphatic hydrocarbon group;



    • (o) Panthenol Ethyl Ether, DL-Panthenol and their mixtures;

    • (p) Aliphatic Dibasic Acid Diester derivatives having the formula (X):

      R1iOCOR2iCOOR3i  (X)
      • wherein:
        • R1i is C4-C5 alkyl;
        • R2i is C4 alkylene; and
        • R3i is C4-C5 alkyl; and

    • (q) Aliphatic Ether derivatives having the formula (XI):

      R4i—O—(CH(CH3)—CH2O)a—(CH2—CH2O)b—H  (XI)
      • wherein:
        • a and b are integers such that the sum of a and b is from 1 to 4; and
        • R4i is an aliphatic chain comprising from 8 to 18 carbons;

    • (r) N-hexadecyl n-nonanoate, Noctadecyl n-nonanoate and their mixtures;

    • (s) Tricyclodecane Amide derivatives selected from the group consisting of:
      • (i) the compounds of formula (XII):







embedded image








        • wherein:
          • X is selected from:











embedded image










          • t is 1 to 8;

          • Y is hydrogen,













embedded image










          •  or a halogen; and

          • each R1j is independently selected from a hydrogen, or C1-C4 alkyl;





      • (ii) the compounds of formula (XIII):









embedded image








        • wherein:
          • each R2j is independently selected from a hydrogen, methyl, ethyl or C3-C18 alkyl, cycloalkyl or cycloheteroalkyl, with the proviso that both R2e groups are not hydrogen; and



      • (iii) mixtures of the compounds of formulae (XII) and (XIII); and



    • (t) mixtures thereof.





Preferably, the substantially non-odorous fragrance modulator is selected from the group of materials disclosed in Table 4(a).









TABLE 4(a)







Substantially Non-Odorous Fragrance Modulators














CAS



No.
Group
Chemical Name
Number
Supplier














1.
(a)
PPG-10 Methyl Glucose Ether
61849-72-7
Lubrizol


2.

PPG-20 Methyl Glucose Ether1
61849-72-7


3.

Ethoxylated Methyl Glucose Ether2
68239-42-9


4.

Caprylyl/Capryl Glucoside3
68515-73-1
BASF


5.

Undecyl Glucoside3a

SEPPIC






(France)


6.
(b)
Isocetyl Alcohol4
36653-82-4
Ashland






Speciality






Ingredients


7.
(c)
PPG-3 Myristyl Ether5

Evonik


8.

Neopentyl Glycol Diethylhexanoate6
28510-23-8
Lubrizol


9.
(d)
Sucrose Laurate
25339-99-5
Alfa Chemicals






Ltd. (UK)


10.

Sucrose dilaurate
25915-57-5
Alfa Chemicals






Ltd. (UK)


11.

Sucrose Myristate
27216-47-3
Mitsubishi






Chemicals


12.

Sucrose Palmitate
26446-38-8
Alfa Chemicals


13.

Sucrose Stearate
25168-73-4
Ltd. (UK)


14.

Sucrose Distearate
27195-16-0
Mitsubishi






Chemicals (JP)


15.

Sucrose Tristearate
27923063-3
Mitsubishi






Chemicals (JP)


16.
(e)
(E)-1-(2,2,6-trimethylcyclohexyl)oct-1-en-3-

Takasago




one8

(Japan)


17.
(f)
2-(1-menthoxy)ethane-1-ol9

Takasago


18.

1-(1-menthoxy)propane-2-ol9

(Japan)


19.

3-(1-menthoxy)propane-1-ol9



20.

3-(1-menthoxy)propane-1,2-diol9



21.

2-methyl-3-(1-menthoxy)propane-1,2-diol9



22.

4-(1-menthoxy) butane-1-ol9



23.
(g)
1,1,4,4-tetramethyl-6-acetyl-7-formyl-1,2,3,4-

Givaudan




tetrahydronaphthalene10

(Switzerland)


24.

1,1,2,4,4-pentamethyl-6-acetyl-7-formyl-





1,2,3,4-tetrahydronaphthalene10


25.
(h)
Hyaluronic acid disaccharide sodium salt11
9004-61-9
Sigma Aldrich


26.

Sodium Hyaluronate11
9067-32-7
(UK)


27.
(i)
Mono-o-(linalyl)-glucopyranose12

Kanebo (Japan)


28.

Di-o-(linalyl)-glucopyranose12



29.

Tri-o-(linalyl)-glucopyranose12



30.

Tetra-o-(linalyl)-glucopyranose12



31.

Penta-o-(linalyl)-glucopyranose12



32.

Mono-o-(cis-3-hexenyl)-glactopyranose12



33.

Di-o-(cis-3-hexenyl)-glactopyranose12



34.

Tri-o-(cis-3-hexenyl)-glactopyranose12



35.

Tetra-o-(cis-3-hexenyl)-glactopyranose12



36.

Penta-o-(cis-3-hexenyl)-glactopyranose12



37.
(j)
Bis-O-(3,6-dioxadecanyl)-glucopyranose13



38.

Tris-O-(3,6-dioxadecanyl)-glucopyranose13



39.

Tetrakis-O-(3,6-dioxadecanyl)-glucopyranose13



40.

Pentakis-O-(3,6-dioxadecanyl)-glucopyranose13



41.

Bis-O-(3,6-dioxaoctanyl)-galactopyranose13



42.

Tris-O-(3,6-dioxaoctanyl)-galactopyranose13



43.

Tetrakis-O-(3,6-dioxaoctanyl)-galactopyranose13



44.

Pentakis-O-(3,6-dioxaoctanyl)-galactopyranose13



45.

Bis-O-(3,6-dioxaheptanyl)-xylopyranose13



46.

Tris-O-(3,6-dioxaheptanyl)-xylopyranose13



47.

Tetrakis-O-(3,6-dioxaheptanyl)-xylopyranose13



48.

Bis-O-(3,6-dioxadodecanyl)-glucopyranose13



49.

Tris-O-(3,6-dioxadodecanyl)-glucopyranose13



50.

Tetrakis-O-(3,6-dioxadodecanyl)-glucopyranose13



51.

Pentakis-O-(3,6-dioxadodecanyl)-





glucopyranose13


52.
(k)
Hydroquinone beta-D-glycoside14
497-76-7
Shiseido


53.
(l)
Propylene Glycol Propyl Ether
1569-01-3
Sigma Aldrich


54.

Dicetyl Ether
4113-12-6
(UK)


55.

Polyglycerin-4 Ethers
25618-55-7
Solvay






Chemicals


56.

Isoceteth-5
69364-63-2
Nihon


57.

Isoceteth-7
69364-63-2
Emulsion


58.

Isoceteth-10
69364-63-2
Company Ltd.


59.

Isoceteth-12
69364-63-2


60.

Isoceteth-15
69364-63-2


61.

Isoceteth-20
69364-63-2


62.

Isoceteth-25
69364-63-2


63.

Isoceteth-30
69364-63-2


64.

Disodium Lauroamphodipropionate
68929-04-4
Rhodia


65.

Hexaethylene glycol monododecyl ether14b
3055-96-7
Sigma Aldrich






(UK)


66.
(m)
Neopentyl Glycol Diisononanoate15
27841-07-2
Symrise


67.

Cetearyl Ethylhexnoate16
90411-68-0
(Germany)


68.
(n)
2-ethylhexyloxypropanediol17
70455-33-9
Takasago (JP)


69.
(o)
Panthenol Ethyl Ether18
667-83-4
DSM






Nutritional






Products, Inc.






(USA)


70.

DL-Panthenol
16485-10-2
Roche Inc.






(USA)


71.
(p)
Diisobutyl Adipate19
141-04-8
Sigma Aldrich


72.

Diisoamyl Adipate19
6624-70-0
(UK)


73.
(q)
PPG-11 Stearyl Ether19a
25231-21-4
Kao (JP)


74.
(r)
N-hexadecyl n-nonanoate19b
72934-15-7
Symrise




(i.e., cetyl nonanoate)

(Germany)


75.

Noctadecyl n-nonanoate19b
107647-




(i.e., stearyl nonanoate)
13-2


76.
(s)
methanone, (morphonyl)tricyclo[3.3.1.13,7]dec-

Unilever (UK)




1-yl-20


77.

methanone, (piperidinyl)tricyclo[3.3.1.13,7]dec-





1-yl-20


78.

methanone, (pyrrolidinyl)tricyclo[3.3.1.13,7]dec-





1-yl20


79.

methanone, (azetidinyl)tricyclo[3.3.1.13,7]dec-1-





yl-20


80.

methanone,





(hexahydroazepinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


81.

methanone, (4-cyano-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


82.

methanone, (4-amido-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


83.

methanone, (Tricyclo[3.3.1.13,7]decanyl)-N-





tricyclo[3.3.1.13,7]dec-1-yl-20


84.

methanone,





(decahydroisoquinolinyl)tricyclo[3.3.1.13,7]dec-




1-yl-20


85.

methanone,





(decahydroisoquinolinyl)tricyclo[3.3.1.13,7]dec-




1-yl-20


86.

methanone,





(decahydroquinolinyl)tricyclo[3.3.1.13,7]dec-1-




yl-20


87.

methanone, (3,3-dimethyl-1-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


88.

methanone, (2-methyl-1-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


89.

methanone, (4-methyl-1-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


90.

methanone, (3-methyl-1-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


91.

methanone, (3,5-dimethyl-1-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


92.

methanone, (4-methyl-4-ethy-





piperidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


93.

methanone, (3,3-diethyl-1-





pyrrolidinyl)tricyclo[3.3.1.13,7]dec-1-yl-20


94.

methanone, (N,N-diisopropyl)





tricyclo[3.3.1.13,7]dec-1-yl-20


95.

methanone, (3,3-dimethylbutylaminyl)





tricyclo[3.3.1.13,7]dec-1-yl-20


96.

methanone, (2,2-dimethylpropylaminyl)





tricyclo[3.3.1.13,7]dec-1-yl-20


97.

methanone, (1,1-dimethyl-3,3-





dimethylbutylaminyl) tricyclo[3.3.1.13,7]dec-1-




yl-20


98.

methanone, (1,3-dimethyl-butylaminyl)





tricycle[3.3.1.13,7]dec-1-yl-20


99.
(t)
Bis-methoxy PEG-13
936645-
PolymerExpert




PEG-438/PPG-110 SMDI Copolymer21
35-1
S.A. (Pessac,






France)


100.
(u)
propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-
61791-12-6
Sigma Aldrich




methoxyphenyl}acetate22

(US)


101.
(v)
3-((2-ethylhexyl)oxy)propane-1,2-diol23
70445-33-9



102.

3-((2-propylheptyl)oxy)propane-1,2-diol23




103.

1-amino-3-((2-ethylhexyl)oxy)propan-2-ol23
99509-00-9







1available as GLUCAM ™ P-20.




2available as Glucam ™ E-20.




3available as Plantacare ® 810 UP.




3aavailable as Simulsol ® SL 11W.




4available as CERAPHYL ® ICA.




5available as Tegosoft ® APM.




6available as Schercemol ™ NGDO.




7disclosed in U.S. Pat. No. 6,737,396B2 (Firmenich), column 1, lines 43-47.




8diclosed as compound 1′i in U.S. Pat. No. 6,440,400B1 (Takasago Int. Corp.), col. 5.




8adiclosed in U.S. Pat. No. 4,313,855 (Dragoco Gerberding & Co. GmbH), col. 1, lines 12-13.




9disclosed in U.S. Pat. No. 7,538,081B2 (Takasago Int. Corp.), column 7, lines 50-53.




10disclosed in U.S. Pat. No. 6,147,049 (Givaudan Roure), col. 5, line 24, to col. 6, line 17.




11disclosed in PCT Publication No. WO85/04803 (Diagnostic), pg. 2, line 1 to pg. 4, line 2.




12disclosed in JP Patent No. 61-083114 (Kanebo).




13disclosed in JP Patent No. 61-063612 (Kanebo).




14disclosed in JP Patent No. 62-084010 (Shiseido).




14bavailable as: Laureth-6.




15disclosed in U.S. Patent Publication No. 2011/0104089A1 (Symrise), para. [0001].




16available as PCL-Liquid ® 100.




17disclosed in U.S. Pat. No. 7,196,052 (Takasago Int. Corp.), col. 4, lines 34-35.




18disclosed in EP Patent Publication No. 616800A2 (Givaudan), pg. 2, lines 12-25.




19disclosed in U.S. Pat. No. 4,110,626 (Shiseido), column 3, lines 54-56.




19adisclosed in PCT Publication No. WO2014/155019 (LVMH).




19bdisclosed in U.S. Pat. No. 9,050,261 (Symrise).




20disclosed as compounds C1-C22 in WO2014/139952 (Unilever).




21available as Expert Gel ® EG56.




22available as Kolliphor ® EL.




23disclosed in U.S. Pat. No. 9,050,261 (Symrise).







Preferably, the substantially non-odorous fragrance modulator is selected from the group of materials disclosed in Table 4(b).









TABLE 4(b)







Substantially Non-Odorous Fragrance Modulators














CAS



No.
Chemical or INCI Name
Trade Name
Number
Supplier














1.
C12-14 Sec-Pareth-3
Tergitol ® 15-S-7
68131-
Sigma Aldrich





40-8
(UK)


2.
Poly(ethylene glycol-ran-
PPG-7-Buteth-10
9038-
Sigma Aldrich



propylene glycol) monobutyl

95-3
(UK)



ether


3.
PPG-4-Ceteth-10
Nikkol PBC-33
37311-
Chemical





01-6
Navi


4.
Deceth-4
Ethal DA-4
5703-
Ethox





94-6
Chemicals,






Inc.


5.
PPG-5-Ceteth-20
AEC PPG-5-Ceteth-20
9087-
A & E





53-0
Connock






(Perfumery &






Cosmetics)






Ltd.


6.
C14-15 Pareth-7
Neodol 45-7 alcohol
68951-
Shell




ethoxylate
67-7
Chemical






Company


7.
Linear alcohol (C12-15) Pareth-
Bio-soft N25-7
68131-
Stephan



3ethoxylate, POE-7

39-5
Company


8.
Linear alcohol (C12-13) Pareth-
Bio-soft N23-6.5
66455-
(USA)



3ethoxylated, POE-6.5)

14-9


9.
Polyethylene glycol 1100
Cremophor ® A 25
68439-
Sigma Aldrich



mono(hexadecyl/octadecyl)

49-6
(UK)



ether


10.
Linear alcohol (C9-11)
Bio-soft N91-8
68439-
Stephan



ethoxylated POE-8 Pareth-3

46-3
Company






(USA)


11.
Coceth-10 or
Genapol ® C-100
61791-
Sigma Aldrich



Polyoxyethylene (10) dodecyl

13-7
(UK)



ether


12.
Alcohols, C12-14, ethoxylated
Rhodasurf ® LA 30
68439-
Solvay





50-9
Solutions






Italia S.p.A.


13.
Poly(ethylene glycol) methyl
Poly(ethylene glycol)
9004-
Sigma Aldrich



ether
methyl ether
74-4
(UK)


14.
C10-16 Pareth-1
Neodol ® PC 110
68002-
Shell





97-1
Chemical






Company


15.
PPG-11 Stearyl Ether
Arlamol ™ PS11E
25231-
Croda (UK)





21-4


16.
Steareth-100
Brij ® S100
9005-
Sigma Aldrich





00-9
(UK)


17.
Polyethylene glycol hexadecyl
Brij ® C-58
9004-
Sigma Aldrich



ether

95-9
(UK)


18.
Pluronic ® F-127
Pluronic ® F-127
9003-
Sigma Aldrich





11-6
(UK)


19.
Linear Alcohol (C11)
Bio-soft N1-5
34398-
Stepan



Ethoxylate, POE-5

01-1
Canada Inc.


20.
Laureth-10
Intrasol FA 12/18/10
6540-
Evonik





99-4
Industries AG


21.
Decaethylene glycol
Polyoxyethylene (10)
9002-
Sigma Aldrich



mono-dodecyl ether
lauryl ether
92-0
(UK)


22.
Ethylene glycol monomethyl
2-Methoxyethanol
109-86-4
Sigma Aldrich



ether


(UK)


23.
Myreth-4
Homulgator 920 G
27306-
Grau





79-2
Aromatics






GmbH &






Company KG


24.
Oleth-16
Pegnol O-16A
25190-
Toho



Alkoxylated Alcohols

05-0
Chemical






Industry Co.,






Ltd.


25.
Isosteareth-5
Emalex 1805
52292-
Nihon





17-8
Emulsion






Company,






Ltd.


26.
PPG-10 Cetyl Ether
Arlamol ™ PC10
9035-
Croda (UK)





85-2


27.
Polyoxy(ethylene glycol) (18)
Poly(ethylene glycol)
24938-
Sigma-



tridecyl ether
(18) tridecyl ether
91-8
Aldrich (UK)


28.
Poly(oxy-1,2-ethanediyl), a-
ALFONIC ® 10-8
26183-
Sasol



decyl-w-hydroxy-
Ethoxylate
52-8
Chemicals






(USA) LLC


29.
Laureth-1
Mackam ™ 2LSF
4536-
Rhodia (DE)





30-5


30.
PEG-5 Hydrogenated Tallow
Ethox HTAM-5
61791-
Ethox



Amine

26-2
Chemicals,






Inc.


31.
PEG-15 Oleamine
Nikkol TAMNO-15
26635-
Nikko





93-8
Chemicals






Co., Ltd.


32.
Polyoxyethylene (20) oleyl ether
Brij ® O20-SS
9004-
Sigma Aldrich





98-2
(UK)


33.
Cetoleth-10
Brij ® CO10
8065-
Croda, Inc.





81-4


34.
Talloweth-7
Emulmin 70
61791-
Sanyo





28-4
Chemical






Industries Ltd.


35.
Isobutoxypropanol
Isobutoxypropanol
34150-
MolPort



Alcohols

35-1


36.
Isobutoxypropanol
Isobutoxypropanol
23436-
AKos



Alcohols

19-3
Consulting &






Solutions


37.
Diethylene Glycol
Twincide EDG
111-46-6
Roda


38.
Methoxyethanol
Hisolve MC
109-86-4
Toho






Chemical






Industry Co.,






Ltd.


39.
Ethoxyethanol
2-Ethoxyethanol
110-80-5
Sigma-



Alcohols


Aldrich (UK)


40.
Methoxyisopropanol
Dowanol ™ PM
107-98-2
The Dow



Alcohols


Chemical






Company


41.
Methoxyethanol
Hisolve MC
32718-
Toho





54-0
Chemical






Industry Co.,






Ltd.


42.
Methylal
Dimethoxymethane
109-87-5
Sigma-



Ethers


Aldrich (UK)


43.
3-Methoxybutanol
Methoxybutanol
2517-
Hans





43-3
Schwarzkopf






GmbH/Co.






KG


44.
Butoxyethanol
Butyl OXITOL
111-76-2
Shell






Chemical






Company


45.
Propylene Glycol n-Butyl Ether
Dowanol ™ PnB
5131-
The Dow





66-
Chemical





8/29387-
Company





86-8


46.
Propylene Glycol Butyl Ether
Propylene Glycol Butyl
15821-
Sigma Aldrich




Ether
83-7
(UK)


47.
2-(2-butoxyethoxy)ethanol
Diethylene glycol butyl
112-34-5
Sigma Aldrich




ether

(UK)


48.
Deceth-4 Phosphate
Crodafos ™ D4A
52019-
Croda, Inc.





36-0


49.
2-(Hexadecyloxy)ethanol
Ethylene glycol
2136-
Sigma-




monohexadecyl ether
71-2
Aldrich (UK)


50.
Poly(propylene glycol)
Poly(propylene glycol)
9003-
Sigma-



monobutyl ether
monobutyl ether
13-8
Aldrich (UK)


51.
Propylene Glycol Propyl Ether
Dowanol ™ PnP
30136-
The Dow





13-1
Chemical






Company


52.
Propylene Glycol n-Butyl Ether
Dowanol ™ PnB
29387-
The Dow





86-
Chemical





8/5131-
Company





66-8


53.
Dipropylene glycol monomethyl
Di(propylene glycol)
34590-
Sigma Aldrich



ether
methyl ether, mixture of
94-8
(UK)




isomers


54.
Dipropylene Glycol Dimethyl
Proglyde ™ DMM
111109-
The Dow



Ether

77-4
Chemical






Company


55.
PPG-2 Methyl Ether
Dowanol ™ DPM
13429-
The Dow





07-7
Chemical






Company


56.
Methoxydiglycol
OriStar DEGME
111-77-3
Orient Stars



Ethers


LLC


57.
Diethylene glycol ethyl ether
Di(ethylene glycol) ethyl
111-90-0
Sigma Aldrich




ether

(UK)


58.
Dimethoxydiglycol
Dimethyldiglycol
111-96-6
H&V



Ethers


Chemicals


59.
PPG-3 Methyl Ether
Dowanol ™ TPM
37286-
The Dow





64-9
Chemical






Company


60.
Methyl Morpholine Oxide
224286 ALDRICH
7529-
Sigma-



Amine Oxides
4-Methylmorpholine N-
22-8
Aldrich (UK)




oxide


61.
Oleth-3
Brij ® O3
5274-
Croda Europe,





66-8
Ltd.


62.
Tri(propylene glycol) n-butyl
Dowanol ™ TPnB
55934-
Sigma-



ether

93-5
Aldrich (UK)


63.
Tripropylene Glycol
Tripropylene Glycol
24800-
Sigma-





44-0
Aldrich (UK)


64.
PPG-3 Methyl Ether
Dowanol ™ TPM
25498-
The Dow



Alkoxylated Alcohols

49-1
Chemical






Company


65.
Triethylene glycol
Triglycol
112-27-6
Sigma Aldrich






(UK)


66.
PEG-3 Methyl Ether
Hymol ™
112-35-6
Toho






Chemical






Industry Co.,






Ltd.


67.
Laureth-3
AEC Laureth-3
3055-
A&E





94-5
Connock






(Perfumery &






Cosmetics)






Ltd.


68.
Ethylhexylglycerin
AG-G-75008
70445-
Angene





33-9
Chemical


69.
Tetra(ethylene glycol)
Tetraethylene glycol
112-60-7
Sigma Aldrich






(UK)


70.
Steareth-3
Isoxal 5
4439-
Vevy Europe





32-1
SpA


71.
Ceteth-3
Emalex 103
4484-
Nihon





59-7
Emulsion






Company,






Ltd.


72.
Myreth-3
Isoxal 5
26826-
Vevy Europe





30-2
SpA


73.
Trideceth-3
Alfonic ® TDA-3

Sasol North




Ethoxylate

America, Inc.


74.
Ceteth-2
Brij ® C2
5274-
Croda Europe,





61-3
Ltd.


75.
Oleth-2
Brij ® O2
5274-
Croda, Inc.





65-7


76.
Steareth-2
Brij ® S2
16057-
Croda, Inc.





43-5


77.
Cetoleth-10
Brij ® CO10
8065-
Croda, Inc.





81-4


78.
Trimethyl Pentanol
Trimethyl Pentanol
68959-
Angene



Hydroxyethyl Ether
Hydroxyethyl Ether
25-1
Chemical



Alcohols


79.
Steareth-10 Allyl Ether
Salcare ® SC80
109292-
BASF





17-3


80.
TEA-Lauryl Ether
material ID-AG-J-99109
1733-
Angene





93-3
Chemical


81.
Polyglyceryl-2 Oleyl Ether
Chimexane NB
71032-
Chimex





90-1


82.
Batyl Alcohol
B402 ALDRICH
544-62-7
Sigma-






Aldrich (UK)


83.
Octaethylene Glycol
15879 ALDRICH
5117-
Sigma-





19-1
Aldrich (UK)


84.
Triglycerol diisostearate
Cithrol ™
66082-
Croda (UK)





42-6


85.
Diglycerin
Diglycerin 801
59113-
Sakamoto





36-9
Yakuhin






Kogyo Co.,






Ltd.


86.
Polyglycerin #310
Polyglycerin #310
25618-
Sakamoto





55-7
Yakuhin






Kogyo Co.,






Ltd.


87.
Distearyl Ether
Cosmacol ® SE
6297-
Sasol





03-6
Germany






GmbH


88.
Caprylyl Glyceryl Ether
Caprylyl Glyceryl Ether
10438-
AKos





94-5
Consulting &






Solutions


89.
Chimyl Alcohol
Chimyl Alcohol
506-03-6
Nikko






Chemicals






Co., Ltd.


90.
Dipentaerythrityl
Liponate ® DPC-6
68130-
Lipo



Hexacaprylate/Hexacaprate

24-5
Chemicals,






Inc.


91.
Morpholine
394467 ALDRICH
110-91-8
Sigma-






Aldrich (UK)


92.
Dimethyl Oxazolidine
OXABAN ™-A
51200-
The Dow





87-4
Chemical






Company


93.
Ethyl Hydroxymethyl Oleyl
4-Oxazolemethanol
68140-
Angene



Oxazoline

98-7
Chemical


94.
Methyl Hydroxymethyl Oleyl
Adeka Nol GE-RF
14408-
Adeka



Oxazoline

42-5
Corporation


95.
Pramoxine HCl
OriStar PMHCL
637-58-1
Orient Stars






LLC


96.
Allantoin Ascorbate
Allantoin Ascorbate
57448-
ABI Chem





83-6


97.
Stearamidopropyl Morpholine
Mackalene ™ 326
55852-
Rhodia Inc.



Lactate

14-7


98.
Dioxolane
Elcotal DX
646-06-0
Lambiotte &






CIE S.A.


99.
Glycerol Formal
Glycerol Formal
5464-
Sigma Aldrich





28-8
(UK)


100.
Stearamidopropyl Morpholine
Mackine 321
55852-
Rhodia Inc.





13-6


101.
2,4,6-
Poly(melamine-co-
68002-
Sigma-



Tris[bis(methoxymethyl)amino]-
formaldehyde)
20-0
Aldrich (UK)



1,3,5-triazine
methylated


102.
Poloxamine 1307
Pluracare ® 1307
11111-
BASF





34-5


103.
Nonoxynol-8
Igepal ® CO-610
27177-
Rhodia Inc.





05-5


104.
Nonoxynol-10
Igepal ® CO-710
27177-
Rhodia Inc.





08-8


105.
Octoxynol-10
Nikkol OP-10
2315-
Nikko





66-4
Chemicals






Co., Ltd.


106.
Nonoxynol-9
Igepal ® CO-630
68987-
Rhodia Inc.





90-6


107.
Nonoxynol-9 Iodine
Nonoxynol-9 iodine
94349-
Angene





40-3
Chemical


108.
Octylphenoxy
Igepal ® CA-630
68987-
Rhodia Inc.



poly(ethyleneoxy)ethanol,

90-6



branched


109.
Sodium Octoxynol-2 Ethane
Triton ™ X-200
55837-
The Dow



Sulfonate

16-6
Chemical






Company


110.
Benzylhemiformal
Preventol D2
14548-
Lanxess





60-8
Corporation


111.
Nonoxynol-2
Igepal ® CO-210
27176-
Rhodia Inc.





93-8


112.
Octoxynol-3
Igepal ® CA-420
2315-
The Dow





62-0
Chemical






Company


113.
Nonoxynol-3
Marlophen NP 3
27176-
Sasol





95-0
Germany






GmbH


114.
Alkoxylated Alcohols
Alkasurf NP-4
7311-
Rhodia Inc.





27-5


115.
Nonoxynol-3
Triethylene Glycol
51437-
Santa Cruz




Mono(p-nonylphenyl)
95-7
Biotechnology




Ether


116.
Nonoxynol-7
Lowenol 2689
27177-
Jos. H.





03-3
Lowenstein &






Sons, Inc.


117.
Nonoxynol-6
Igepal ® CO-530
27177-
Rhodia Inc.





01-1


118.
Nonoxynol-5
Igepal ® CO-520
20636-
Rhodia Inc.





48-0


119.
Nonoxynol-5
Igepal ® CO-520
26264-
Rhodia Inc.





02-8


120.
Nonoxynol-4
Alkasurf NP-4
27176-
Rhodia Inc.





97-2


121.
Polyglyceryl-10 Trioleate
Nikkol Decaglyn 3-OV
102051-
Nikko





00-3
Chemicals






Co., Ltd.


122.
Polyglyceryl-10 Dioleate
Nikkol Decaglyn 2-O
33940-
Nikko





99-7
Chemicals






Co., Ltd.


123.
Polyglyceryl-10 Tetraoleate
Caprol 10G40
34424-
Abitec





98-1
Corporation


124.
Polyglyceryl-10 Stearate
Nikkol Decaglyn 1-SV
79777-
Nikko




EX
30-3
Chemicals






Co., Ltd.


125.
Polyglyceryl-10 Oleate
S-Face O-1001 P
79665-
Sakamoto





93-3
Yakuhin






Kogyo Co.,






Ltd.


126.
Polyglyceryl-10 Myristate
Nikkol Decaglyn 1-MV
87390-
Nikko




EX
32-7
Chemicals






Co., Ltd.


127.
Dermofeel ® G 10 L
Dermofeel ® G 10 L
34406-
Dr.





66-1
Straetmans


128.
Polyglyceryl-6 Laurate
NIKKOL Hexaglyn 1-L
51033-
Chemical





38-6
Navi


129.
Polyglyceryl-6 Isostearate
S-Face IS-601 P
126928-
Sakamoto





07-2
Yakuhin






Kogyo Co.,






Ltd.


130.
Choleth-10
Emalex CS-10
27321-
Nihon





96-6
Emulsion






Company,






Ltd.


131.
Steareth-10 Allyl
Salcare ® SC80
109292-
BASF



Ether/Acrylates Copolymer

17-3


132.
Polyvinyl Stearyl Ether
Giovarez ®1800
9003-
Phoenix





96-7
Chemical, Inc.


133.
Dicetyl Ether
Cosmacol Ether 16

Sasol






Germany






GmbH


134.
PPG-23-Steareth-34
Unisafe 34S-23
9038-
Pola Chemical





43-1
Industries,






Inc.


135.
Stearoxypropyl Dimethylamine
Farmin DM E-80
17517-
Kao Corp.





01-0


136.
Distearyl Ether
Cosmacol SE
6297-
Sasol





03-6
Germany






GmbH


137.
Polyquatemium-10
AEC Polyquatemium-10
55353-
A & E





19-0
Connock






(Perfumery &






Cosmetics)






Ltd.


138.
Octyl ether
Dioctyl ether
629-82-3
Sigma Adlrich






(UK)


139.
Ethyl Ether
Diethyl Ether
60-29-7
EMD






Chemicals


140.
Methyl Hexyl Ether
methyl hexyl ether
4747-
TCI



Ethers

07-3
AMERICA


141.
Ceteth-12
Emalex 112
94159-
Nihon





75-8
Emulsion






Company,






Ltd.


142.
Ceteth-10 or cetyl alcohol POE-
Jeecol CA-10
14529-
Jeen



10

40-9
International


143.
Steareth-10
Jeecol SA-10
13149-
Jeen





86-5
International


144.
Nonaethylene glycol
Nonaethylene glycol
3055-
Sigma Aldrich



monododecyl ether
monododecyl ether
99-0
(UK)


145.
Oleth-10
Brij ® O10
71976-
Croda, Inc.





00-6


146.
Oleth-10
Brij ® O10
24871-
Croda, Inc.





34-9


147.
PEG-12
Carbowax ™ PEG 600
6790-
The Dow





09-6
Chemical






Company


148.
PEG-9
Sabopeg 400
3386-
Sabo s.p.a.





18-3


149.
PEG-10
DECAETHYLENE
5579-
MolPort




GLYCOL
66-8


150.
PEG-6
Carbowax ™ PEG 300
2615-
The Dow





15-8
Chemical






Company


151.
Glycerol propoxylate
Glycerol propoxylate
25791-
Sigma Aldrich





96-2
(UK)


152.
Glycerol ethoxylate
Glycerol ethoxylate
31694-
Sigma Aldrich





55-0
(UK)


153.
Laureth-8
AEC Laureth-8
3055-
A & E





98-9
Connock






(Perfumery &






Cosmetics)






Ltd.


154.
Oleth-8
Emalex 508
27040-
Nihon





03-5
Emulsion






Company,






Ltd.


155.
Laureth-7
Alfonic 1216CO-7
3055-
Sasol North




Ethoxylate
97-8
America, Inc.


156.
Steareth-7
Polyoxyethylene (7)
66146-
Sigma Aldrich




stearyl ether
84-7


157.
Deceth-6
Alfonic 1012-6.0
5168-
Sasol North




Ethoxylate
89-8
America, Inc.


158.
Steareth-6
Emalex 606
2420-
Nihon





29-3
Emulsion






Company,






Ltd.


159.
Hexaethylene glycol
Hexaethylene glycol
3055-
Sigma-



monododecyl ether
monododecyl ether
96-7
Aldrich (UK)


160.
Hexaethylene glycol
Hexaethylene glycol
5168-
Sigma-



monohexadecyl ether
monohexadecyl ether
91-2
Aldrich (UK)


161.
Beheneth-5
Nikkol BB-5
136207-
Nikko





49-3
Chemicals






Co., Ltd.


162.
Myreth-5
Isoxal 12
92669-
Vevy Europe





01-7
SpA


163.
Steareth-5
Jeecol SA-5
71093-
Jeen





13-5
International






Corporation


164.
Ceteth-5
Emalex 105
4478-
Nihon





97-1
Emulsion






Company,






Ltd.


165.
Oleth-5
Brij ® O5
5353-
Croda, Inc.





27-5


166.
Laureth-5
Safol ® 23E5 Ethoxylate
3055-
Sasol North





95-6
America, Inc.


167.
Steareth-4
Jeecol SA-4
59970-
Jeen





10-4
International






Corporation


168.
Laureth-4
Brij ® L4
5274-
Croda, Inc.





68-0


169.
Myreth-4
Homulgator 920 G
39034-
Grau





24-7
Aromatics






GmbH &






Company KG


170.
Ceteth-4
Procol CA-4
5274-
Protameen





63-5
Chemicals


171.
Oleth-4
Chemal OA-4
5353-
Chemax, Inc.





26-4


172.
Oleth-4
Chemal OA-4
103622-
Chemax, Inc.





85-1


173.
Polyimide-1
Aquaflex ™ XL-30
497926-
Chemwill





97-3


174.
Polymethoxy Bicyclic
Caswell No. 494CA
56709-
Angene



Oxazolidine

13-8
Chemical


175.
Hydroxymethyl
Zoldine ™ ZT
6542-
Angus



Dioxoazabicyclooctane

37-6
Chemical






Company


176.
Dihydro-7a-ethyloxazolo[3,4-
5-Ethyl-1-aza-3,7-
7747-
Sigma Aldrich



c]oxazole
dioxabicyclo[3.3.0]octane
35-5
(UK)


177.
Dibenzylidene Sorbitol
Disorbene ®
32647-
Roquette





67-9
America, Inc.


178.
Dimethyldibenzylidene Sorbitol
Millad ® 3988
135861-
Milliken





56-2
Chemicals


179.
Laureth-2
Alfonic 1216CO-2
3055-
Sasol North




Ethoxylate
93-4
America, Inc.


180.
2-(2-Butoxyethoxy)ethyl (6-
Piperonyl Butoxide
51-03-6
Sigma-



propylpiperonyl) ether


Aldrich (UK)


181.
Menthone Glycerin Acetal
Frescolat ® MGA
63187-
Symrise





91-7


182.
Propylene Glycol Caprylate
Mackaderm PGC
68332-
Rhodia Inc.





79-6


183.
Diethoxynonadiene
SBB016951
67674-
Ambinter





36-6


184.
Menthoxypropanediol
Coolact ® 10
87061-
Takasago



Alcohols

04-9
International






Corporation


185.
2-Diphenylmethoxy-N,N-
Diphenhydramine HCl
147-24-0
Sigma-



dimethylethylamine


Aldrich (UK)



hydrochloride


186.
3-((2-ethylhexyl)oxy)propane-

70445-




1,2-diol

33-9


187.
3-((2-propylheptyl)oxy)propane-






1,2-diol


188.
1-amino-3-((2-

99509-




ethylhexyl)oxy)propan-2-ol

00-9


189.
1-(1-Methyl-2-propoxyethoxy)-
Di(propylene glycol)
29911-
Sigma Aldrich



2-propanol
propyl ether
27-1
(UK)









The compounds, as described above in Tables 4(a) and 4(b), act as a substantially non-odorous fragrance modulator of the perceived fidelity and/or longevity of the fragrance profile of the composition of the present invention. For example, the substantially non-odorous fragrance modulators, with a fragrance component having a diamond construction, act to prolong the duration during which the fragrance profile, preferably the characters attributable from the moderate and high volatile fragrance materials, can be perceived as compared to a control composition in the absence of the modulators or having the classical fragrance pyramid three-tiered structure. As another example, the substantially non-odorous fragrance modulators, with a fragrance component having a diamond construction, can improve the fidelity of the fragrance profile, preferably the characters attributable from the moderate and high volatile fragrance materials, such that it remains significantly the same from initial impression to the end as compared to a control composition in the absence of the modulators or having the classical fragrance pyramid three-tiered structure. While not wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulators associate to the fragrance materials and retard evaporation.


Test Methods

The following assays set forth must be used in order that the invention described and claimed herein may be more fully understood.


Test Method 1: Determining Vapor Pressure


In order to determine the vapor pressure for the fragrance materials, go to the website https://scifinder.cas.org/scifindedview/scifinder/scifinderExplorejsf and follow these steps to acquire the vapor pressure.


1. Input the CAS registry number for the particular fragrance material.


2. Select the vapor pressure from the search results.


3. Record the vapor pressure (given in Torr at 25° C.).


SciFinder uses Advanced Chemistry Development (ACD/Labs) Software Version 11.02. (© 1994-2013). If the CAS number for the particular fragrance material is unknown or does not exist, you can utilize the ACD/Labs reference program to directly determine the vapor pressure. Vapor Pressure is expressed in 1 Torr, which is equal to 0.133 kilopascal (kPa).


Test Method 2: Olfactory Tests


In order to show the effect of the substantially non-odorous fragrance modulators and fragrance component having a diamond construction on the perception of fragrance profile in a composition of the present invention, test compositions are made, as described in the Example section, and given to panelists to evaluate.


At the testing facility, 50 μL samples of the compositions and the controls are applied to glass slides and placed on a hot plate at 32° C. to represent skin temperature for varying durations. It is important that glass slides of samples that are to be later compared are prepared at the same time. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) of each glass slide sample at a given time point. Slides are presented coded so that their identity is not known by the panelists. Within a given time point panelists evaluate the slides in a random order and are able to revisit their assessment as they work through the slides at that time point. Their assessments are recorded. In the subsequent analysis, the data for strength and character comparisons are drawn from the independent assessments carried out at a given time point. Only when using the character difference scale below are any 2 products physically directly compared to each other. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry. Typically, around 6-10 panellists are used to evaluate a given product and its control.


(a) Fragrance Intensity:


The panelists are asked to give a score on a scale of 0 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 4 herein below.









TABLE 4







Odour Intensity Scale








Score
Fragrance Intensity





0
None


1
Very Weak


2
Weak


3
Moderate


4
Strong


5
Very Strong









(b) Fragrance Character:


The panelists are asked to assess the fragrance character in one of 2 ways:

    • i) a score on a scale of 0 to 3 for the dominance of particular characters that are relevant to that particular fragrance, e.g.: fresh, green, watery, floral, rose, muguet, fruity, apple, berry, citrus, creamy, woody, balsamic, amber, musk just to name a few, according to the odour grading scale set out in Table 5(i) herein below;
    • ii) a score on a scale of 1 to 5 for changes in the perceived fragrance profile change for the test compositions versus the controls according to the odour grading scale set out in Table 5(ii) herein below.









TABLE 5(i)







Character Dominance Odour Grading Scale








Score
Fragrance Character Dominance





0
Not noticeable


1
Slight presence of the character


2
Moderate presence of the character


3
Dominance of the character
















TABLE 5(ii)







Character Difference Odour Grading Scale








Score
Fragrance Profile Change





1
Frargrance profile is unchanged, i.e., no difference between



the sample vs. the control.


2
Slight fragrance profile change when compared directly with



the control.


3
Moderate fragrance profile but similar character to the control,


4
Large difference in fragrance profile from the control.


5
Total difference in the fragrance profile from the control.









The results of the panelists are averaged and then analysed using Analysis of Variance methods. The model treats the subject as a random effect and looks at the impact of product, time and the interaction between product and time. From the analysis the least square means for the product and time interaction are obtained. These means (as well as their confidence intervals) are then plotted to enable comparisons between products at each time point. It should be noted that the confidence levels plotted are intended as a guide, and not as a statistical comparison, as they do not take into account that multiple testing has been performed. As well as a graphical assessment, statistical comparisons between the two products at each of the time points are performed with a Sidak correction for multiple comparisons. The p-values for the product differences are obtained, with p-values <0.05 indicating a statistical difference between the two products at 5% significance (or 95% confidence).


Test Method 3: Analytical Evaporation Tests


The following test is carried out to demonstrate the improved or enhanced longevity of a fragrance profile of a composition of the present invention vs. a control. In particular, the test measures the effect of a substantially non-odorous fragrance modulator on the evaporation rate of one or more fragrance materials (e.g., 10 PRMs) formulated in a composition. The evaporation response of the fragrance materials to the modulator, as a function of time, is measured through the use of gas chromatography (“GC”).

    • 1. A test composition may comprise a substantially non-odorous fragrance modulator (any one of the modulators as disclosed in Tables 4(a) and 4(b)) with either: (i) a fragrance material (any one of the moderate volatile fragrance materials as disclosed in Table 2 and high volatile fragrance materials as disclosed in Table 3), or (ii) a blend of fragrance materials from Tables 2 and 3 (as disclosed as Fragrance Example 6 in Table 11). The test compositions also contain high purity ethanol, such as Hayman 100% EP/BP grade, and deionized water. Samples test compositions are provided in Tables 19(a)-19(b). All of the ingredients are admixed until evenly distributed in the test compositions.
    • 2. A control composition to the test composition described in 1 above, without the substantially non-odorous fragrance modulator is made in a similar manner to Step 1, except that the missing substantially non-odorous modulator is replaced by deionized water. Sample control compositions are provided in Tables 19(a)-19(b).
    • 3. An internal standard is needed to correct for variations of the amount of composition dispensed in the evaporation test as well as loss during the GC analysis. The internal standard has a vapor pressure of less than 0.001 Torr (0.000133 kPa) at 25° C. and is soluble in the composition and fragrance material. A suitable non-limiting example of an internal standard is triethyl citrate. The internal standard and fragrance material are admixed until evenly distributed at a level of 90 to 95 parts by weight of fragrance material and the required amount of internal standard to reach 100 parts. This mixture is then use to prepare the sample compositions in Step 1 and 2. Alternatively, the internal standard and test or control composition are admixed until evenly distributed at a level of 99 to 99.75 parts by weight of composition and the required amount of internal standard to reach 100 parts. This resultant solution is used in subsequent steps.
    • 4. A hotplate is set to a temperature of 32° C. An aluminum container, such as TA Instruments T-Zero™ pan, is placed on the hotplate. 20 μL of the test or control composition is introduced in the aluminum container using a micropipette. Alternatively, the aluminum container may be filled with the test or control composition to its full capacity. The time at which this takes place is determined to be time zero (i.e., T=0). Multiple aluminum containers are prepared and left at the set temperature for pre-determined periods of time, such as for example 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs, 8 hrs and up to 12 hrs.
    • 5. The aluminum container is removed from the hotplate at the end of the pre-determined time period and transferred by being inserted into a 4 mL glass vial already containing at least 2 mL of highly volatile solvent, such as high purity ethanol or hexane.
    • 6. The glass vial is mixed using a Heidolph multi REAX shaker, or equivalent, for 5 to 10 mins to extract the fragrance materials into the solvent phase. 1.5 mL of the resultant solution is transferred to a 2 mL GC vial.
    • 7. The GC vial is analysed on an Agilent GC system 6890 equipped with an autosampler, or equivalent. A GC column such as a DB-5MS, Rxi-5 SilMS model or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 μm is used. The GC parameters are set to the values indicated as follows:









TABLE 5(iii)





GC Parameters
















Injector temperature:
270° C.


Initial gas velocity:
25 to 40 cm/sec (for Helium as the carrier gas)


Initial oven temperature:
 50° C.


Temperature ramp:
 8° C./min


Final oven temperature:
310° C.











    •  Gas chromatography with flame ionization detection (“FID”) or with mass spectrometry (“MS”) can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material and internal standard being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and quantification of the analytes of interest.

    • 8. The peak area of the fragrance material and internal standard are recorded. The peak area ratio of the fragrance material and the internal standard is calculated at each time point for each sample composition. The % of non-evaporated fragrance material remaining from T=0 is calculated at each time point for each sample composition. The % fragrance material remaining in each composition is plotted to give an evaporation profile over time. This is done for both the test and control compositions. Significance is determined by comparison of the evaporation profile for the same fragrance material or same fragrance mixture in the test and control compositions.


      Test Method 4: Analytical Headspace Tests





The following test is carried out to demonstrate the character retention over time of a fragrance composition of the present invention vs. a control. It is necessary for the test and control samples to be run at approximately the same time to ensure that ambient conditions are the same. The test measures the presence of one or more fragrance materials in the headspace formed in a sealed vial by the test composition, after set evaporation times. The fragrance profile in the headspace is measured at specific time points through the use of headspace (“HS”) gas chromatography (“GC”).

    • 1. The test and control compositions as described in the Example section are used for the evaluation.
    • 2. Capillaries of about 2 cm to 3.5 cm, with one sealed end are cut from a Sigma Aldrich “Stuart™ melting point tube” product code Z673269, or equivalent. A suitable fixed volume chosen between 50 and 200 μL of the composition is pipetted into the well of a VWR Tissue Culture 96 F well plate, or equivalent. The sealed end of the glass capillary is dipped into the filled well and left for at least 15 secs to wet the surface of the glass. Care must be taken not to contact the glass capillary with the sides of the well by maintaining it straight and approximately in the center of the well.
    • 3. The glass capillary is then removed from the well and inverted or transferred onto a stable surface or into a holder and allowed to evaporate at ambient conditions for a set period of time. A windshield may be used to reduce high air turbulence.
    • 4. The glass capillary is then introduced into an empty 20 mL HS vial, which is immediately closed with a PTFE cap. The time at which this takes place is determined to be time T=initial (i.e., T=10 mins)
    • 5. Multiple glass capillaries are prepared in the same way and left to evaporate at ambient temperature for pre-determined periods of time, such as for example 10, 15, 30 mins, 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, and up to 6 hrs, before being introduced to the headspace vial and sealed.
    • 6. The HS vial is then analysed on an Agilent GC system 6890 equipped with a Gerstel MPS 2 autosampler, or equivalent, capable of performing SPME injections. A SPME fiber assembly DVB/CAR/PDMS (50/30 μm, 1 cm length) is required. A GC column such as a DB-5MS, ZB-SMSi models, or equivalent phase, with a length of 30 m, an inner diameter of 0.25 mm and a film thickness of 1 μm is used.
    • 7. The SPME HS parameters are set to the values indicated as follows:









TABLE 5(iv)





SPME Parameters



















Incubation chamber temperature:
40°
C.



Incubation time:
20
mins



Agitation of sample
250
RPM



Extraction time
5
mins



Desorption time
2
mins












    • 8. The GC parameters are set to the values indicated as follows:












TABLE 5(v)





GC Parameters
















Injector temperature:
270° C.


Initial gas velocity:
20 to 40 cm/sec (for Helium as the carrier gas)


Initial oven temperature:
45° C. with 2 mins Hold Time


Temperature ramp 1:
 30° C./min


Temperature 1:
 80° C.


Temperature ramp 2:
 8° C./min


Final temperature:
300° C.











    •  Gas chromatography with flame ionization detection (“FID”) or with mass spectrometry (“MS”) can be used for the identification and quantification of fragrance material in the compositions. Either detection system can be used in conjunction with GC. The column dimensions as well as GC settings described in this method, such as injector temperature, carrier gas velocity, temperature ramp and final oven temperature can be adjusted to optimize the response of the fragrance material being monitored. The detection system settings, such as FID gas flows and temperature or MS parameters, should be optimized by a trained analyst to enable the precise detection and identification of the analytes of interest.

    • 9. A qualitative assessment of the chromatograms obtained is performed by comparing the peak height of the fragrance materials and overall chromatogram at time T=10 mins to other time points. A dotted line is drawn around an estimated retention time where fragrance materials with a vapour pressure of 0.001 Torr or less (0.000133 kPa or less) elute during the analysis. The difference between the peaks present at each measured time point for the test and control compositions provides evidence of the retention of the character of the fragrance over time.

    • 10. This test set-up is designed to enable the collection of the headspace in a manner that does not saturate the SPME fiber. If the fiber is saturated it does not provide an accurate analysis of the headspace composition. Therefore the quantity of liquid and the evaporation surface area are very different from those in the olfactive evaluation of the same samples. For this reason it is not possible to compare directly the evaporation time frames used in the 2 experiments. It is expected that the evaporation profile is much faster in this headspace experiments compared to the olfactive evaluations.





EXAMPLES

The following examples are provided to further illustrate the present invention and are not to be construed as limitations of the present invention, as many variations of the present invention are possible without departing from its spirit or scope.


Example 1—Fragrance Oils

Fragrance examples 1, 2, 3, 4b and 5b are provided below in Tables 6, 7, 8, 9 and 10, respectively, as non-limiting examples of formulations of fragrance materials intended to form the fragrance component of the compositions of the present invention. The exemplary formulations of the fragrance materials span the range from “simple accords” (less than 10 fragrance materials) to “complex fragrances” (greater than 30 fragrance materials). Typically, full bodied fragrance compositions do not comprise less than about 30 fragrance materials.


Fragrance examples 4a and 5a provided in Table 9 and 10, respectively, below are examples of traditional formulations of fragrance materials that fall outside the scope of the present invention.


Fragrance example 6 provided in Table 11 below as an example of a formulation of volatile fragrance materials.


Fragrance examples 7 and 8 are provided in Tables 12 and 13 below as examples of a formulation of fragrance materials intended to form the fragrance component that fall outside the scope of the present invention.


Fragrance examples 9 to 16 are provided in Tables 14 and 15 below as examples of formulations of fragrance materials containing higher than 30 wt % of the low volatile fragrance materials.


Fragrance examples 17 and 18 are provided in Tables 16 and 17 below as comparative samples of formulations of fragrance materials intended to form the fragrance component.


The following fragrance formulations are made by mixing the listed ingredients in the listed proportions (wt %) at room temperature, wherein the wt % is relative to the total weight of the fragrance component.









TABLE 6







Fragrance Example 1 (Fresh Floral Accord - 10 wt % of


Low Volatile Fragrance Materials)












Vapor Pressure
Parts


Ingredients
CAS Number
(Torr at 25° C.)
(wt %)













Benzyl acetate
140-11-4
0.1640
10.8


Linalool
78-70-6
0.0905
9.8


Phenethyl alcohol
60-12-8
0.0741
15.7


Indole
120-72-9
0.0298
1.0


α-Terpineol
98-55-5
0.0283
2.9


Geranyl acetate
105-87-3
0.0256
4.9


Cymal
103-95-7
0.00881
5.9


Hydroxycitronellal
107-75-5
0.00318
22.4


Majantol
103694-68-4
0.00224
16.6


Hexyl cinnamic
101-86-0
0.000697
10.0


aldehyde











Total
100.00
















TABLE 7







Fragrance Example 2 (Fresh Male Accord - 13.51 wt % of


Low Volatile Fragrance Materials)












Vapor Pressure
Parts


Ingredients
CAS Number
(Torr at 25° C.)
(wt %)













d-Limonene
5989-27-5
1.540000
10.0


Dihydromyrcenol
18479-58-8
0.166000
10.0


Boisiris
68845-00-1
0.013500
6.5


Canthoxal
5462-06-6
0.010200
8.0


Helional
1205-17-0
0.002700
10.0


Kephalis
36306-87-3
0.002690
20.0


Majantol
103694-68-4
0.002240
15.5


Javanol ®
198404-98-7
0.000902
5.0


Galaxolide ®*
1222-05-5
0.000414
7.5


Isopropyl
110-27-0

7.5


Myristate











Total
100.00





*Supplied at 50% in Isopropyl myristate.













TABLE 8







Fragrance Example 3 (Sweet Dream 18 Fragrance - 11.15 wt %


of Low Volatile Fragrance Materials)












Vapor Pressure
Parts


Ingredients
CAS Number
(Torr at 25° C.)
(wt %)













Prenyl acetate
1191-16-8
3.99000000
0.100


Manzanate
39255-32-8
2.91000000
0.200


Hexyl acetate
142-92-7
1.39000000
0.700


cis-3-Hexenyl
3681-71-8
1.22000000
0.200


acetate


Benzaldehyde
100-52-7
0.97400000
0.200


Liffarome
67633-96-9
0.72100000
0.150


Hexyl isobutyrate
2349-07-7
0.41300000
0.055


Dihydromyrcenol
18479-58-8
0.16600000
2.500


Benzyl acetate
140-11-4
0.16400000
0.700


Linalyl acetate
115-95-7
0.11600000
2.500


Verdox
88-41-5
0.10300000
4.000


Phenethyl alcohol
60-12-8
0.07410000
8.000


Rossitol
215231-33-7
0.02990000
1.500


alpha-Terpineol
98-55-5
0.02830000
1.500


Geranyl acetate
105-87-3
0.02560000
1.500


Rhodinol
141-25-3
0.01970000
0.700


Givescone
57934-97-1
0.01710000
0.700


Methyl anthranilate
134-20-3
0.01580000
0.050


Ysamber K
154171-77-4
0.01470000
1.000


alpha-Ionone
127-41-3
0.01440000
3.000


Citronellyl acetate
150-84-5
0.01370000
0.500


cis-3-hexenyl-cis-3-
61444-38-0
0.01220000
0.200


hexenoate


Cinnamic alcohol
104-54-1
0.01170000
0.100


delta-damascone
57378-68-4
0.01020000
0.200


Citronellyloxyacetal
7492-67-3
0.00967000
0.100


dehyde


Cymal
103-95-7
0.00881000
0.500


Floralozone
67634-15-5
0.00808000
0.100


Ethylmethylphenylglycidate
77-83-8
0.00571000
0.200


Florosa Q
63500-71-0
0.00557000
3.000


Ethyl linalool
10339-55-6
0.00520000
6.400


Pivarose
67662-96-8
0.00484000
2.500


Hydroxycitronellal
107-75-5
0.00318000
7.500


Methyl Ionone
7779-30-8
0.00286000
4.000


gamma-
104-67-6
0.00271000
0.500


Undecalactone


Kephalis
36306-87-3
0.00269000
5.000


Cashmeran
33704-61-9
0.00269000
1.000


Magnolan
27606-09-3
0.00251000
3.000


Majantol
103694-68-4
0.00224000
6.900


Brahmanol
72089-08-8
0.00154000
3.000


Coumarin
91-64-5
0.00130000
0.500


Glycolierral
68901-32-6
0.00121000
0.100


Raspberry ketone
5471-51-2
0.00106000
0.100


Top Mango base3


0.500


Cherry base3


0.200


Cassis base3


0.300


Bergamot Oil4


6.000


Prunella base3


0.500


Hexyl cinnamic
101-86-0
0.00069700
1.500


aldehyde


Sandalore
65113-99-7
0.00062500
3.000


Dupical
30168-23-1
0.00044100
0.005


Galaxolide ®1
1222-05-5
0.00041400
1.500


Ebanol
67801-20-1
0.00028100
2.000


Helvetolide
141773-73-1
0.00005790
2.000


Warm Milk base5


0.200


Vanilla Absolute2, 6


0.100


Isopropyl Myristate


1.500


Dipropylene Glycol


6.040








Total
100.00






1Supplied at 50% in IPM.




2Supplied at 50% in DiPG.




3Proprietary bases that contain a mixture of perfume raw materials, judged to be of high volatility for the purposes of calculating % of low volatility PRMs.




4Natural oils or extracts that contain a mixture of perfume raw materials, judged to be of high volatility for the purposes of calculating % of low volatility PRMs.




5Proprietary bases that contain a mixture of perfume raw materials, judged to be of low volatility for the purposes of calculating % of low volatility PRMs.




6Natural oils or extracts that contain a mixture of perfume raw materials, judged to be of low volatility for the purposes of calculating % of low volatility PRMs.














TABLE 9







Fragrance Examples 4a and 4b (“Traditional Floral Magnifica”


Example 4a - 37 wt % of Low Volatile Fragrance Materials; 55 wt % of


Moderate Volatile Fragrance Materials; 7 wt % of High Volatile Fragrance


Materials; and “Diamond Floral Magnifica” Example 4b - 13 wt % of


Low Volatile Fragrance Materials; 80 wt % of Moderate Volatile Fragrance


Materials; 7 wt % of High Volatile Fragrance Materials)









Parts (wt %)













Vapor Pressure
Example 4a
Example 4b


Ingredients
CAS Number
(Torr at 25° C.)
(Traditional)
(Diamond)














Beta Gamma
928-96-1
2.126000
0.20
0.20


Hexenol


Cis 3 Hexenyl
3681-71-8
1.219000
0.30
0.30


Acetate


Benzyl Acetate
140-11-4
0.16400000
3.01
3.01


Liffarome
67633-96-9
0.721000
0.20
0.20


Ligustral Or
68039-49-6
0.578000
0.10
0.10


Triplal


Methyl
67674-46-8
0.214000
0.40
0.40


Pamplemousse


d-Limonene
5989-27-5
1.54000000
3.01
3.01


Phenyl

0.368000
0.0002
0.0002


Acetaldehyde1













Total High Volatile Fragrance Materials
7.2%
7.2%











Alpha Damascone
24720-09-0
0.008300
0.04
0.06


Ethyl 2 4-
3025-30-7
0.009540
0.20
0.20


Decadienoate


Ambronat
6790-58-5
0.009340
2.00
2.01


cis-3-Hexenyl cis-
61444-38-0
0.012200
0.10
0.10


3-Hexenoate


Citronellol
106-22-9
0.032900
4.01
4.01


Cyclemax
7775-00-0
0.018200
0.40
0.40


Cyclo Galbanate
68901-15-5
0.003230
0.10
0.10


Cymal
103-95-7
0.008810
0.90
1.51


Dimethyl Benzyl
10094-34-5
0.001680
0.50
0.50


Carbinyl Butyrate


Ethyl 2,4-
3025-30-7
0.00954000
0.20
0.20


Decadienoate


Ethyl Linalool
10339-55-6
0.005200
7.23
12.04


Florol
63500-71-0
0.005570
6.43
10.71


Gamma
706-14-9
0.008520
0.20
0.20


Decalactone


Geraniol
106-24-1
0.013300
3.01
5.02


Geranyl Acetate
105-87-3
0.009760
2.01
2.01


Helional
1205-17-0
0.002700
2.41
4.01


Heliotropin
120-57-0
0.010400
0.20
0.20


Hivernal
173445-65-3
0.00392000
0.20
0.20


Hydroxycitronellal
107-75-5
0.003180
2.41
4.01


Ionone Beta
14901-07-6
0.003080
0.24
0.40


Ionone Gamma
127-51-5
0.002820
1.81
3.01


Methyl


Jasmal
18871-14-2
0.004340
5.02
5.02


Jasmolactone
32764-98-0
0.003550
0.20
0.20


Linalyl Propionate
144-39-8
0.026300
1.20
1.20


Magnolan 690304
27606-09-3
0.002510
3.01
5.02


Majantol
103694-68-4
0.002240
2.41
4.01


Para Hydroxy
5471-51-2
0.001060
0.20
0.20


Phenyl Butanone


Phenyl Ethyl
60-12-8
0.074100
3.01
5.02


Alcohol


Phenyl Hexanol
55066-48-3
0.006370
3.61
6.02


Undecavertol
81782-77-6
0.010700
2.01
2.01


Vanillin
121-33-5
0.001940
0.10
0.10









Total Moderate Volatile Fragrance Materials
55.4%
79.7%











Ambretone
37609-25-9
0.00003310
1.00
1.00


Ambrettolide
28645-51-4
0.00000139
1.00
1.00


Cis 3-Hexenyl
65405-77-8
0.000246
1.51
0.50


Salicylate


Benzyl salicylate
118-58-1
0.00017500
10.79
1.51


Delta Muscenone
63314-79-4
0.00005650
1.00
1.00


Hedione HC
24851-98-7
0.000710
10.54
3.51


Iso-E Super ®
54464-57-2
0.00053800
10.54
3.51


Polysantol ®
107898-54-4
0.00011700
0.50
0.50









Total Low Volatile Fragrance Materials
36.9%
12.5%


Total
100
100






1delivered as 1% in DPG.














TABLE 10







Fragrance Examples 5a and 5b (“Traditional Muguesia Magnifica”


Example 5a - 37 wt % of Low Volatile Fragrance Materials; 54 wt %


of Moderate Volatile Fragrance Materials; 9 wt % of High Volatile


Fragrance Materials; and “Diamond Muguesia Magnifica” Example


5b - 13 wt % of Low Volatile Fragrance Materials; 76 wt %


of Moderate Volatile Fragrance Materials; 11 wt %


of High Volatile Fragrance Materials)










Vapor
Parts (wt %)













Pressure
Example
Example



CAS
(Torr at
5a (Tra-
5b


Ingredients
Number
25° C.)
ditional)
(Diamond)














Benzyl Acetate
140-11-4
0.304000
5.86
7.32


Benzyl Alcohol
100-51-6
0.158000
0.10
0.10


Beta Gamma
928-96-1
2.126000
0.40
0.40


Hexenol






Cis 3 Hexenyl
3681-71-8
1.219000
0.20
0.20


Acetate






Linalyl Acetate
115-95-7
0.077400
1.00
1.00


Methyl Phenyl
93-92-5
0.203000
0.32
0.40


Carbinyl Acetate






d-Limonene
5989-27-5
1.54000000
1.00
1.00


Phenyl
101-48-4
0.000538
0.20
0.10


Acetaldehyde






Dimethyl Acetal













Total High Volatile Fragrance Materials
9.1%
10.5%











Cis Jasmone
488-10-8
0.020100
0.50
0.50


Cinnamic Alcohol
104-54-1
0.005720
0.20
0.20


Cinnamic
104-55-2
0.02650000
0.06
0.06


Aldehyde






Citronellol
106-22-9
0.032900
4.01
5.01


Citronellyl
150-84-5
0.013700
3.21
4.01


Acetate






Citronellyl
7492-67-3
0.009670
0.10
0.10


Oxyacetaldehyde






Cyclemax
7775-00-0
0.018200
0.32
0.40


Cyclo Galbanate
68901-15-5
0.003230
0.20
0.20


Cymal
103-95-7
0.008810
1.61
2.01


Ethyl Linalool
10339-55-6
0.005200
8.03
10.03


Florhydral
125109-85-5
0.020700
0.16
0.20


Geraniol
106-24-1
0.013300
4.01
5.02


Geranyl Acetate
105-87-3
0.009760
3.21
4.01


Helional
1205-17-0
0.002700
4.01
5.02


Hydroxycitronellal
107-75-5
0.003180
3.21
4.01


Indol
120-72-9
0.029800
0.10
0.10


Jasmal
18871-14-2
0.004340
3.21
4.01


Majantol
103694-68-4
0.002240
3.21
4.01


Phenyl Ethyl
103-45-7
0.056400
0.40
0.40


Acetate






Phenyl Ethyl
60-12-8
0.074100
14.45
18.06


Alcohol






Florosa Q
63500-71-0
0.005570
0
9.03









Total Moderate Volatility Fragrance Materials
54.2%
76.4%











Ambrettolide
28645-51-4
0.000001
1.00
1.00


Cis-3-Hexenyl
65405-77-8
0.000246
1.00
0.50


Salicylate






Benzyl Salicylate
118-58-1
0.00017500
16.61
2.51


Hedione ® Hc
24851-98-7
0.000710
8.03
4.01


Iso-E Super ®
54464-57-2
0.000538
10.03
5.02









Total Low Volatile Fragrance Materials
36.7%
13.0%


Total
100
100
















TABLE 11







Fragrance Example 6 (10 Volatile Fragrance Materials)













CAS
Vapor Pressure
Parts



Ingredients
Number
(Torr at 25° C.)
(wt %)















Tetra-Hydro
78-69-3
0.115
9.85



Linalool






Terpinyl acetate
80-26-2
0.0392
12.21



Dimethyl Benzyl
151-05-3
0.0139
11.96



Carbinyl Acetate






Dimethyl Benzyl
100-86-7
0.0888
9.35



Carbinol






Phenyl Ethyl
60-12-8
0.074100
7.60



alcohol






Laevo Carvone
6485-40-1
0.0656
9.35



Indole
120-72-9
0.0298
7.29



Ethyl Safranate
35044-59-8
0.0266
12.09



Indocolore
2206-94-2
0.0255
10.09



Eugenol
97-53-0
0.0104
10.21










Total
100.00
















TABLE 12







Fragrance Example 7 (Fresh Floral GF 6-7 Accord - 40.14 wt %


of Low Volatile Fragrance Materials)













CAS
Vapor Pressure
Parts



Ingredients
Number
(Torr at 25° C.)
(wt %)















Ligustral or
68039-49-6
0.578000
0.15



Triplal






Benzyl acetate
140-11-4
0.164000
0.31



Verdox
88-41-5
0.103000
5.38



Phenethyl alcohol
60-12-8
0.074100
1.54



Indole
120-72-9
0.029800
0.02



Heliotropin
120-57-0
0.010400
1.23



gamma-
706-14-9
0.008520
0.38



Decalactone






Florol
63500-71-0
0.005570
15.38



Ethyl linalool
10339-55-6
0.005200
26.15



Isoeugenol
97-54-1
0.005190
0.08



alpha-Irone
79-69-6
0.004190
1.54



Vanillin
121-33-5
0.001940
6.15



Dimethyl benzyl
10094-34-5
0.001680
1.54



carbinyl butyrate






Methyl beta-
93-08-3
0.000957
0.77



naphthyl ketone






Methyl
24851-98-7
0.000710
30.60



dihydrojasmonate






Benzyl salicylate
118-58-1
0.000175
7.69



Polysantol
107898-54-4
0.000117
0.77



Lrg 201
4707-47-5
0.000029
0.31










Total
100.00
















TABLE 13







Fragrance Example 8 (Traditional Floral Accord - 54.00 wt %


of Low Volatile Fragrance Materials)













CAS
Vapor Pressure
Parts



Ingredients
Number
(Torr at 25° C.)
(wt %)















Benzyl acetate
140-11-4
0.1640
5.5



Linalool
78-70-6
0.0905
5.0



Phenethyl alcohol
60-12-8
0.0741
8.0



Indole
120-72-9
0.0298
0.5



α-Terpineol
98-55-5
0.0283
1.5



Geranyl acetate
105-87-3
0.0256
2.5



Cymal
103-95-7
0.00881
3.0



Hydroxycitronellal
107-75-5
0.00318
11.5



Majantol
103694-68-4
0.00224
8.5



Hexyl cinnamic
101-86-0
0.000697
4.0



aldehyde






iso gamma super
68155-66-8
0.000565
12.50



Sandalore
65113-99-7
0.000625
18.75



Habanolide
111879-80-2
0.00000431
18.75










Total
100.00
















TABLE 14







Fragrance Examples 9, 10, 11 and 12 (Traditional Flora Magnifica -


Greater than 30 wt % of Low Volatile Fragrance Materials)












Fragrance
Fragrance
Fragrance
Fragrance



Example
Example
Example
Example



9
10
11
12


Ingredients
Weight %
Weight %
Weight %
Weight %














Traditional Flora
86.96
83.33
74.07
68.97


Magnifica 1






Ethylene Brassylate
4.35
4.167
3.704
6.90


Methyl Dihydro
4.35
8.33
14.82
13.79


Jasmonate






Iso E super
4.35
4.167
7.407
10.35


Total
100
100
100
100.00


Wt % Low Volatile
44.33
46.66
52.60
55.87


Fragrance Materials






Wt % Moderate Volatile
49.57
47.50
42.22
39.31


Fragrance Materials






Wt % High Volatile
6.09
5.83
5.18
4.83


Fragrance Materials






1 Fragrance Example 4a.














TABLE 15







Fragrance Examples 13, 14, 15 and 16 (Traditional Muguesia Magnifica -


Greater than 30 wt % of Low Volatile Fragrance Materials)












Fragrance
Fragrance
Fragrance
Fragrance



Example
Example
Example
Example



13
14
15
16


Ingredients
Weight %
Weight %
Weight %
Weight %














Traditional Muguesia
86.96
83.33
74.07
68.97


Magnifica 1






Ethylene Brassylate
4.35
4.17
3.70
6.90


Methyl Dihydro
4.35
8.33
14.82
13.79


Jasmonate






Iso E super
4.35
4.17
7.41
10.35


Total
100.00
100.00
100.00
100.00


Wt % Low Volatile
45.23
47.50
53.34
49.08


Fragrance Materials






Wt % Moderate Volatile
46.96
45.00
40.00
37.24


Fragrance Materials






Wt % High Volatile
7.83
7.50
6.67
6.21


Fragrance Materials






1 Fragrance Example 5a.







Fragrance example 17 (as disclosed in Table 16) is composed of 30.28 wt % of high volatile fragrance materials, 38.21 wt % of moderate volatile fragrance materials and 31.48 wt % of low volatile fragrance materials, wherein the wt % is relative to the total weight of the fragrance component.









TABLE 16







Fragrance Example 17 (Comparative Fragrance 1 - 31.48 wt % of Low


Volatile Fragance Materials)










Vapor
Amount












CAS
Pressure
Parts by
Parts


Ingredients
Number
(Torr at 25° C.)
Weight
(wt %)















Limonene
5989-27-5
1.541
2576
30.04



Cis-3-Hexenol
928-96-1
1.039
21
0.24



Zestover 6
78-70-6
0.578
1
0.01



Linalol
78-70-6
0.0905
553
6.45



Aphermate 4 (10% DIPG) 7
25225-08-5
0.0678
7
0.08



Cyclosal
535-86-4
0.0311
35
0.41



Coranol
83926-73-2
0.0210
371
4.33



Sclareolate ®* 1
319002-92-1
0.0196
630
7.35



3-Methoxy-7,7-dimethyl-10-
216970-21-7
0.0196
371
4.33



methylene-bicyclo[4.3.1]decane







Cedramber 2
19870-74-8
0.0128
1050
12.24



Ambrox ®*
3738-00-9
0.00934
1
0.01



Decal
706-14-9
0.00852
21
0.24



Damascone Alpha* (10% DIPG) 7
24720-09-0
0.00830
9.1
0.11



(Methoxymethoxy)Cyclododecane
42604-12-6
0.00686
182
2.12



Lilial ®
80-54-6
0.00444
26
0.30



γ-Undecalactone*
104-67-6
0.00271
21
0.24



Calone ®* 3
28940-11-6
0.000831
50
0.58



Paradisone 5 ®*
24851-98-7
0.000710
1000
11.66



Galaxolide ® (70% MIP Extra) 7
1222-05-5
0.000414
700
8.16



Exaltenone
14595-54-1
0.0000964
950
11.08











Total
8575.10
100
wt %





*origin: Firmenich SA (Geneva, Switzerland).



1 Propyl (S)-2-(1,1-dimethylpropxy)propanoate.




2 8-Methoxy-2,6,6,8-tetramethyl-tricyclo[5.3.1.0(1,5)]undecane.




3 7-Methyl-2H,4H-1,5-benzodioxepin-3-one.




4 1-(3,3-dimethyl-1-cyclohexyl)ethyl formate; origin: International Flavors & Fragrances.




5 Methyl dihydrojasmonate.




6 Linalool.




7 Fragrance materials added as dilutions in a non-volatile solvent. For the purposes of calculating the fragrance oil composition actual fragrance materials levels added are used.







Fragrance example 18 (as disclosed in Table 17) is composed of 26.71 wt % of high volatile fragrance materials, 63.88 wt % of moderate volatile fragrance materials and 9.37 wt % of low volatile fragrance materials, wherein the wt % is relative to the total weight of the fragrance component.









TABLE 17







Fragrance Example 18 (Comparative Fragrance 2 - 9.37 wt % of Low Volatile


Fragance Materials)










Vapor
Amount












CAS
Pressure
Parts by
Parts


Ingredients
Number
(Torr at 25° C.)
Weight
(wt %)















D-Limonene
5989-27-5
1.540
50.00
5.21



cis-3-Hexenol (10% in DPG) 4
928-96-1
1.040
0.5
0.05



Acetophenone (10% in DPG) 4
98-86-2
0.299
1.00
0.10



Methylphenyl Acetate
101-41-7
0.176
10.00
1.04



Dihydromyrcenol
18479-58-8
0.166
50.00
5.21



Benzyl acetate
140-11-4
0.164
60.00
6.25



Tetra-Hydro Linalool
n/a
0.115
50.00
5.21



n-Undecanal
n/a
0.102
5.00
0.52



Linalool
78-70-6
0.0905
40.00
4.17



Phenylethyl Alcohol
60-12-8
0.0741
245.00
25.53



Allyl amyl glycolate (10% in
67634-00-8
0.04000
2.00
0.21



DPG) 4







Indole (10% in DPG) 4
120-72-9
0.02980
1.00
0.10



Alpha-Terpineol
98-55-5
0.02830
30.00
3.13



Diphenyl Oxide
101-84-8
0.02230
5.00
0.52



L-Citronellol
7540-51-4
0.01830
80.00
8.34



Beta-Ionone
14901-07-6
0.01690
5.00
0.52



Alpha-Ionone
127-41-3
0.01440
15.00
1.56



Dimethyl benzyl carbinyl acetate
151-05-3
0.01390
30.00
3.13



Geraniol
106-24-1
0.01330
40.00
4.17



Nerol
n/a
0.01330
20.00
2.08



Lilial ® 1
80-54-6
0.00444
60.00
6.25



Gamma-Undecalactone
104-67-6
0.00271
15.00
1.56



Amyl salicylate
2050-08-0
0.00144
25.00
2.61



Galaxolide ®
1222-05-5
0.000414
20.00
2.08



cis-3-Hexenyl salicylate
65405-77-8
0.000246
20.00
2.08



Ethylene Brassylate
105-95-3
0.00000000313
30.00
3.13



Styrolyl Acetate5
n/a
n/a
20.00
2.08



Decenol trans-9 3
n/a
n/a
15.00
1.56



Geranium oil 2
n/a
n/a
15.00
1.56











Total
959.5
100
wt %






1 Benzenepropanal, 4-(1,1-dimethylethyl)-α-methyl-.




2 Natural oil that is judged to be volatile for the purposes of calculating levels of the volatile fragrance materials.




3 Proprietary oil that is judged to be volatile for the purposes of calculating levels of the volatile fragrance materials.




4 Fragrance materials added as dilutions in a non-volatilee solvent. For the purposes of calculating the fragrance oil composition actual fragrance materials levels added are used.




5Unknown oil that is judged to be of low volatility for the purposes of calculating levels of the volatile fragrance materials.







Example 2—Compositions Comprising Fragrance Oils and Substantially Non-Odorous Fragrance Modulators

Compositions A1, D1, G1, J1 and M1 are examples of fragrance compositions according to the present invention, made with any one of fragrance examples 1-3, 4b, 5b and 18, respectively. Compositions B, E, H, K and N are examples of fragrance compositions containing any one of the following fragrance examples 4a, 5a, and 7-17, and which are outside the scope of the present invention. In parallel, control compositions C1, F1, I1, L1 and 01 are prepared by replacing the different substantially non-odorous fragrance modulators by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(a), in the proportions indicated.









TABLE 18(a)







Fragrance Compositions









Fragrance Composition (wt %)1






















Ingredients
A1
B1
C1
D1
E1
F1
G1
H1
I1
J1
K1
L1
M1
N1
O1





Fragrance
5-10


0.01-2


3-10


5-10


0.1-5




A12


Fragrance

5-10


0.01-2


3-10


5-10


0.1-5



B3


Fragrance


5-10


0.01-2


3-10


5-10


0.1-5


A1 or B








Ethanol
60-99.99


Butylated
0-0.07


Hydroxy


Toluene






















Modulator
2-20
2-20















A4


Modulator



0.1
0.1












B5


Modulator






0.1-5  
0.1-5  









C6


Modulator









2-10
2-10






D7


Modulator












0.1-3
0.1-3



E8








Deionized
to 100.00


water






1Wt % is relative to the total weight of the composition.




2Can be any one of fragrance examples 1-3, 4b, 5b, and 18.




3Can be any one of fragrance examples 4a, 5a, and 7-17.




4Can be any one of the substantially non-odorous fragrance modulators examples: sucrose laurate; sucrose dilaurate, sucrose myristate, sucrose palmitate, sucrose sterate; sucrose distearate; or sucrose tristearate.




5Substantially non-odorous fragrance modulator is (E)-1-(2,2,6-trimethylcyclohexyl)oct-1-en-3-one.




6Can be any one of the substantially non-odorous fragrance modulators examples: 2-(1-menthoxy) ethane-1-ol; 1-(1-menthoxy) propane-2-ol; 3-(1-menthoxy) propane-1-ol; 3-(1-menthoxy) propane-1,2-diol; 2-methyl-3-(1-menthoxy)propane-1,2-diol; or 4-(1-menthoxy) butane-1-ol.




7Substantially non-odorous fragrance modulator is Hydroquinone beta-D-glycoside.




8Substantially non-odorous fragrance modulator is Hyaluronic acid disaccharide sodium salt or Sodium Hyaluronate (20-50 kDa).







Compositions A2, D2, G2, J2 and M2 are examples of fine fragrance compositions according to the present invention, made with any of the fragrance examples 1 to 3, 4b, 5b, and 18 respectively. Compositions B2, E2, H2, K2 and N2 are examples of fragrance compositions containing traditional or higher levels of low volatile fragrance materials, made with any of the fragrance examples 4a, 5a, and 7-17, respectively. In parallel, control compositions C2, F2, I2, L2 and O2 are prepared by replacing the different substantially non-odorous fragrance modulators by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(b), in the proportions indicated.









TABLE 18(b)







Fragrance Compositions









Fragrance Composition (wt %)1






















Ingredients
A2
B2
C2
D2
E2
F2
G2
H2
I2
J2
K2
L2
M2
N2
O2





Fragrance A12
5-10


5-15


2.5-10 


  5-20


0.1-20




Fragrance B3

5-10


5-15


2.5-10 


  5-20


0.1-20



Fragrance


5-10


5-15


2.5-10


5-20


0.1-20


A1 or B








Ethanol
60-99.9


Butylated
 0-0.07


Hydroxy


Toluene






















Modulator A4
5-20
5-20
0














Modulator B5



0.5-5  
0.5-5  
0











Modulator C6






0.1-3.0
0.1-3.0
0








Modulator D7









2.5-15
2.5-15
0





Modulator E8












0.1-20
0.1-20
0








Deionized
to 100.00


water






1Wt % is relative to the total weight of the composition.




2Can be any one of fragrance examples 1-3, 4b, 5b, and 18.




3Can be any one of fragrance examples 4a, 5a, and 7-17.




4Can be any one of the substantially non-odorous fragrance modulators examples: Propylene Glycol Propyl Ether, Hexaethylene glycol monododecyl ether, Panthenol Ethyl Ether, DL-Panthenol, Diisobutyl Adipate, or Diisoamyl Adipate.




5Neopentyl Glycol Diisononanoate.




62-ethylhexyloxypropanediol.




7PPG-11 Stearyl Ether.




8Can be any one of the substantially non-odorous fragrance modulators examples: Dicetyl Ether; Polyglycerin-4 Ethers; Isoceteth-5; Isoceteth-7, Isoceteth-10; Iscoeteth-12; Isoceteth-15; Isoceteth-20; Isoceteth-25; Isoceteth-30; Disodium Lauroamphodipropionate; Hexaethylene glycol monododecyl ether; or Cetearyl Ethylhexnoate.







Composition A3 is an example of a fragrance composition according to the present invention, made with any of the fragrance examples 1-3, 4b, 5b and 18, respectively. Composition B3 is an example of a fragrance composition containing traditional or higher levels of low volatile fragrance materials, made with any of the fragrance examples 4a, 5a, and 7-17, respectively. In parallel, a control composition C3 is prepared by replacing the different substantially non-odorous fragrance fixative by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(c) in the proportions indicated.









TABLE 18(c)







Fragrance Composition









Fragrance Composition



(wt %) 1












Ingredients
A3
B3
C3






Fragrance A1 2
  2-15





Fragrance B 3

  2-15




Fragrance A1 or B


2-15










Ethanol
60-99.99



Butylated Hydroxy
0-0.07



Toluene













Modulator A 4
0.1-20
0.1-20











Deionized water
to 100.00






1 Wt % is relative to the total weight of the composition.




2 Can be any one of fragrance examples 1-3, 4b, 5b, and 18.




3 Can be any one of fragrance examples 4a, 5a, and 7-17.




4 Can be any one of the substantially non-odorous fragrance modulator as disclosed in Table 4(b).







Compositions A4, D4, G4, and J4 are examples of fragrance compositions according to the present invention, made with any one of fragrance examples 1-3, 4b, 5b, and 18, respectively. Compositions B4, E4, H4, and K4 are examples of fragrance compositions containing any one of the following fragrance examples 4a, 5a, and 7-17, and which are outside the scope of the present invention. In parallel, control compositions C4, F4, 14, and L4 are prepared by replacing the different substantially non-odorous fragrance modulators by the same amount of deionized water or ethanol. All of the compositions are prepared by admixture of the components described in Table 18(d), in the proportions indicated.









TABLE 18(d)







Fragrance Compositions









Fragrance Composition (wt %)1



















Ingredients
A4
B4
C4
D4
E4
F4
G4
H4
I4
J4
K4
L4





Fragrance
 7


 7


 7


 7




A12


Fragrance B3

 7


 7


 7


 7



Fragrance


7


7


7


7


A1 or B








Ethanol
75


Butylated
0-0.07


Hydroxy


Toluene



















PPG-20
15
15
0











Methyl


Glucose


Ether4


Caprylyl/



15
15
0








Capryl


Glucoside5


Undecyl






15
15
0





Glucoside6


Isocetyl









15
15
0


Aclohol7








Deionized
to 100.00


water






1Wt % is relative to the total weight of the composition.




2Can be any one of fragrance examples 1-3, 4b, 5b, and 18.




3Can be any one of fragrance examples 4a, 5a, and 7-17.




4Available as GLUCAM ™ P-20.




5Available as Plantacare ® 810 UP.




6Available as Simulsol ® SL 11W.




7Available as Ceraphyl ® ICA.







Compositions A5 is an example of a fragrance composition according to the present invention, made with any one of fragrance examples 1-3, 4b, 5b, and 18, respectively. Compositions C5 is an example of a fragrance composition containing traditional or higher levels of low volatile fragrance materials, made with any one of the following fragrance examples 4a, 5a, and 7-17, respectively. In parallel, control compositions C5 is prepared by replacing the different substantially non-odorous fragrance modulator by the same amount of deionized water. All of the compositions are prepared by admixture of the components described in Table 18(e), in the proportions indicated.









TABLE 18(e)







Fragrance Composition









Fragrance Composition



(wt %) 1












Ingredients
A5
B5
C5






Fragrance A1 2
  2-15





Fragrance B 3

  2-15




Fragrance A1 or B


2-15










Ethanol
60-99.99



Butylated Hydroxy
0-0.07



Toluene













Modulator A 4
0.1-20
0.1-20











Deionized water
to 100.00






1 Wt % is relative to the total weight of the composition.




2 Can be any one of fragrance examples 1-3, 4b, 5b, and 18.




3 Can be any one of fragrance examples 4a, 5a, and 7-17.




4 Can be any one of the substantially non-odorous fragrance modulators nos. 1, 3, 7, 8, 99, 100, and 101-103 as disclosed in Table 4(a).







Tables 19(a) provides test compositions (MOD1 to MOD3) comprising the volatile fragrance formulation of fragrance example 6 (as disclosed in Table 11) with a substantially non-odorous fragrance modulator (as disclosed in Tables 4(a) and 4(b)) that are particularly suited to analytical measurements. All of the compositions are prepared by admixture of the components described in Table 19(a) in the proportions indicated.









TABLE 19(a)







Fragrance Example (Compositions Comprising


10 Volatile Fragrance Materials)












Test composition
Reference composition




(wt % 1)
(wt % 1)



Ingredients
MOD 1 to 3
REF














Fragrance A 2
7.0
7.0



Triethyl citrate
0.25 to 1.0
0.25 to 1.0



Ethanol
75.0
75.0



Modulator 3
15.0
0.0



Water
qsp
qsp



Total
100.0
100.0






1 Wt % is relative to the total weight of the composition.




2 Fragrance Example 6 (as disclosed in Table 11).




3 Can be any one of the substantially non-odorous fragrance modulator nos. 7, 8 and 100 as disclosed in Table 4(a).







Tables 19(b) provides test compositions comprising the volatile fragrance formulation of fragrance example 6 (as disclosed in Table 11) with a substantially non-odorous fragrance modulator (as disclosed in Tables 4(a) and 4(b)) that are particularly suited to analytical measurements. All of the compositions are prepared by admixture of the components described in Table 19(b) in the proportions indicated.









TABLE 19(b)







Compositions comprising fragrance with


10 Volatile Fragrance Materials












Test composition
Reference composition



Ingredients
(wt % 1)
(wt % 1)














Fragrance A 2
7.0
7.0



Triethyl citrate
0.25 to 1.0
0.25 to 1.0



Ethanol
75.0
75.0



Modulator 3
1-15.0
0.0



Water
qsp
qsp



Total
100.0
100.0






1 Wt % is relative to the total weight of the composition.




2 Fragrance Example 6 (as disclosed in Table 11).




3 Can be any one of the substantially non-odorous fragrance modulator nos. 1-6, 9-99, and 101-103 as disclosed in Table 4(a) and substantially non-odorous fragrance modulator nos. 1-189 as disclosed in Table 4(b).







Example 3—Single Fragrance Material Compositions Containing Substantially Non-Odorous Fragrance Modulators

Compositions A6, C6, E6, and G6-L6 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance modulators, respectively. In parallel, control Compositions B6, D6, F6 and M6 are prepared without a substantially non-odorous fragrance modulator as a control. All the compositions are prepared by admixture of the components in Table 20, in the proportions indicated.









TABLE 20







Single Fragrance Material Compositions









Single PRM Composition (wt %)1




















Ingredients
A6
B6
C6
D6
E6
F6
G6
H6
I6
J6
K6
L6
M6





Dimethyl
1  
1













Benzyl


Carbinol


Ethyl Safranate


1  
1











Phenylethyl




1  
1









alcohol


Eugenol











1  
1


Fragrance C6






0.5-1  
0.5-1
0.5-1
0.5-1  
0.5-1




Sucrose
3.8
0
3.0
0
4.6
0









Myristate


Modulator A22






1-5








Modulator B3







0.1







Modulator C4








0.1-5






Modulator D5









1-4

1.6
0


Modulator E7










0.1-3










Ethanol
to 100






1Wt % is relative to the total weight of the composition.




2Can be any one of the substantially non-odorous modulators examples: sucrose laurate, sucrose dilaurate, sucrose palmitate, sucrose stearate, sucrose distearate, or sucrose tristearate.




3Can be any one of the substantially non-odorous modulators examples: (E)-1-(2,2,6-trimethylcyclohexyl)oct-1-en-3-one.




4Can be any one of the substantially non-odorous modulators examples: 2-(l-menthoxy) ethane-1-ol; 1-(l-menthoxy) propane-2-ol; 3-(l-menthoxy) propane-1-ol; 3-(l-menthoxy) propane-1,2-diol; 2-methyl-3-(l-menthoxy)propane-1,2-diol; or 4-(l-menthoxy) butane-1-ol.




5Substantially non-odorous fragrance modulator is Hydroquinone beta-D-glycoside (available as Arbutin from Sigma-Aldrich).




6Can be any one of the single fragrance materials: Dimethyl Benzyl Carbinol; Ethyl Safranate, Phenyl ethyl alcohol or Eugenol.




7Substantially non-odorous fragrance modulator is Hyaluronic acid disaccharide sodium salt or Sodium Hyaluronate (20-50 kDa).







Compositions A7, C7 and E7-17 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance modulators, respectively. In parallel, control Compositions B7, D7 and J7 are prepared without a substantially non-odorous fragrance modulator as a control. All the compositions are prepared by admixture of the components in Table 21, in the proportions indicated.









TABLE 21







Single Fragrance Material Compositions








Ingre-
Single PRM Composition (wt %)1

















dients
A7
B7
C7
D7
E7
F7
G7
H7
I7
J7





Dimethyl


1.0
1.0








Benzyl


Carbinyl


Acetate


Eugenol
1.0
1.0










Fragrance




0.1-1
0.1-1
0.1-1
0.1-1
0.1-1
0.1-1


C6


Propylene
0.8
0.0










Glycol


Propyl


Ether


Diisobutyl


1.4
0.0








adipate


Modulator




0.1-5




0


A22


Modulator





0.1-5



0


B3


Modulator






0.1-5


0


C4


Modulator







0.1-5

0


D5


Modulator








0.1-5
0


E7








Ethanol
to 100






1Wt % is relative to the total weight of the composition.




2Can be any one of the substantially non-odorous modulators examples: Hexaethylene glycol monododecyl ether, Panthenol Ethyl Ether, DL-Panthenol, or Diisoamyl Adipate.




3Neopentyl Glycol Diisononanoate.




42-ethylhexyloxypropanediol.




5PPG-11 Stearyl Ether.




6Can be any one of the single fragrance materials examples: Dimethyl Benzyl Carbinyl Acetate or Eugenol.




7Can be any one of the substantially non-odorous modulators examples: Dicetyl Ether; Polyglycerin-4 Ethers; Isoceteth-5; Isoceteth-7, Isoceteth-10; Isoceteth-12; Isoceteth-15; Isoceteth-20; Isoceteth-25; Isoceteth-30; Disodium Lauroamphodipropionate; Hexaethylene glycol monododecyl ether or Cetearyl Ethylhexnoate.







Compositions A8, C8, E8, G8, 18, K8, M8, Q8, S8, U8, W8, Y8, AA8, and CC8 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance fixatives, respectively. In parallel, control Compositions B8, D8, F8, H8, J8, L8, N8, P8, R8, T8, V8, X8, Z8, BB8, and DD8 are prepared without a substantially non-odorous fragrance fixative as a control. All of the compositions are prepared by admixture of the components in Tables 22(a) and 22(b), in the proportions indicated.









TABLE 22(a)







Single Fragrance Material Compositions









Single Fragrance Material Composition (wt %1)























Ingredients
A8
B8
C8
D8
E8
F8
G8
H8
I8
J8
K8
L8
M8
N8
O8
P8





Dimethyl Benzyl
1
1






1
1








Carbinol


Eugenol


1
1






1
1






Phenylethyl




1
1






1
1




Alchol


Fragrance A2






1
1






1
1


Piperonyl
  2.2
0
  2.0
0
  2.2
0
0.5-5
0










butoxide


Poly(PG)monobutyl








  2.2
0
  2.0
0
  1.8
0
0.5-5
0


ether








Ethanol
to 100






1Wt % is relative to the total weight of the composition.




2Can be any one of the single fragrance materials of Table 2 or 3.














TABLE 22(b)







Single Fragrance Material Compositions









Single Fragrance Material Composition (wt %1)





















Ingredients
Q8
R8
S8
T8
U8
V8
W8
X8
Y8
Z8
AA8
BB8
CC8
DD8





Indole
1
1






1
1






Eugenol


1
1






1
1




Dimethyl




1
1






1
1


Benzyl


Carbinol


Phenylethyl






1
1








Alchol


Triglycol
  1.3

  0.9

  1.0

  1.2















Ethanol
To 100






1Wt % is relative to the total weight of the composition.







Compositions A9, C9, E9, G9 and 19 are examples of compositions according to the present invention, made with single fragrance materials and the substantially non-odorous fragrance modulators, respectively. In parallel, control Compositions B9, D9, F9, H9 and J9 are prepared without a substantially non-odorous fragrance modulator as a control. All the compositions are prepared by admixture of the components in Table 22(c), in the proportions indicated.









TABLE 22(c)







Single Fragrance Material Compositions









Single Fragrance Material Composition (wt %)1

















Ingredients
A9
B9
C9
D9
E9
F9
G9
H9
I9
J9





Indocolore
1.0
1.0










Dimethyl


1.0
1.0








Benzyl


Carbinol


Eugenol




1.0
1.0






Phenylethyl






1.0
1.0




alcohol


Fragrance C2








1.0
1.0


Expert
5.0
0.0










Gel ®


EG563


Kolliphor ®


16.6 
0.0
15.2 
0.0
13.0 
0.0




EL4


Glycerol








0.1-20
0.0


Alkxoylates5








Ethanol
to 100






1Wt % is relative to the total weight of the composition.




2Can be any one of the single fragrance materials examples: Indocolore, Dimethyl Benzyl Carbinol, Eugenol or Phenethyl alcohol.




3Chemical name is Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer and listed as a substantially non-odorous modulator no. 99 as disclosed in Table 4(a).




4Chemical name is propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate and listed as a substantially non-odorous modulator no. 100 as disclosed in Table 4(a).




5Can be any one of the substantially non-odorous modulators examples: 3-((2-ethylhexyl)oxy)propane-1,2-diol (modulator no. 101 as disclosed in Table 4(a)); 3-((2-propylheptyl)oxy)propane-1,2-diol (modulator no. 102 as disclosed in Table 4(a)); or 1-amino-3-((2-ethylhexyl)oxy)propan-2-ol (modulator no. 103 as disclosed in Table 4(a)).







Composition A10 is an example of a composition according to the present invention, made with single fragrance material and the substantially non-odorous fragrance modulator, respectively. In parallel, control Composition B10 is prepared without a substantially non-odorous fragrance modulator. All the compositions are prepared by admixture of the components in Table 22(d), in the proportions indicated.









TABLE 22(d)







Single Fragrance Material Compositions










Single Fragrance Material Composition (wt %) 1












Ingredients
A10
B10






Fragrance A 2
1-7  
1-7



Modulator 3
1-15.0
0.0











Ethanol
to 100







1 Wt % is relative to the total weight of the composition.




2 Can be any one of the fragrance materials disclosed in Tables 2 and 3.




3 Can be any one of the substantially non-odorous fragrance modulator not already disclosed in Tables 20, 21, and 22(a)-22(c) above.







Example 4—Exemplary Product Compositions

Compositions I, II, III and IV are examples of body spray compositions according to the present invention. They are prepared by admixture of the components described in Table 23, in the proportions indicated.









TABLE 23







Body Spray Compositions









Composition (wt % 1)












Ingredients
CAS Number
I
II
III
IV















Denatured Ethanol
64-17-5
39.70
59.45
39.70
39.70


Water
7732-18-5

0.75




Dipropylene Glycol
25265-71-8
15.00

15.00
15.00


Isopropyl Myristate
110-27-0
1.00

1.00
1.00


Zinc Phenosulphonate
127-82-2
0.50

0.50
0.50


Cavasol ® W7 methylated
128446-36-6

1.00




Beta-cyclodextrin







Fragrance 2

1.20
1.20
1.20
1.20


Fragrance Modulator 3

2.60
2.60
2.60
2.60


Propane
74-98-6
4.86

4.86
4.86


Isobutane
72-28-5
27.14

27.14
27.14


1,1-Difluoroethane (HFC-
75-37-6
8.00
35.00
8.00
8.00


152a)
















Total
100.00
100.00
100.00
100.00






1 Wt % relative to the total weight of the composition.




2 Can be any one of Fragrances Examples 1, 2, 3, 4b, 5b or 18.




3 Can be any one of the substantially non-odorous fragrance modulators disclosed in Tables 4(a) and 4(b).







Composition V, VI and VII are examples of body lotion compositions according to the present invention. They are prepared by admixture of the components as described in Table 24, in the proportions indicated.









TABLE 24







Body Lotion Composition









Composition (wt % 1)











Ingredients
CAS Number
V
VI
VII





Water
7732-18-5
qsp 100%
qsp 100%
qsp 100%


Trilon ® B
64-02-8
0.05
0.05
0.05


Carbopol ® ETD
9003-01-4
0.2
0.2
0.2


2050






Pemulen ™ TR1
9063-87-0
0.2
0.2
0.2


Nexbase ® 2008
68037-01-4
8
8
8


Silicone V100
63148-62-9
6
6
6


Fragrance

3
3
3


Modulator 3






Tris Amino ™ Ultra
102-71-6
0.4
0.4
0.4


Pur






Fragrance 2

3
3
3


Preservatives

qs
qs
qs










Total
100.00
100.00
100.00






1 Wt % relative to the total weight of the composition.




2 Can be any one of the Fragrances Examples 1, 2, 3, 4b, 5b or 18.




3 Can be any one of the substantially non-odorous fragrance modulators disclosed in Tables 4(a) and 4(b).







Example 5—Olfactive Test Results

Compositions disclosed in Tables 18(a)-18(d), 20, 21, and 22(a)-22(d) are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 6-10 experienced panelists evaluate the perceived fragrance profile at initial time 0, then at various time points, typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application. Panelists are asked to score the compositions for the longevity and/or fidelity of the fragrance profile on a scale of 0 to 5, wherein 0 represents a no fragrance is detected and 5 represents a very strong fragrance intensity is detected. The results of the panelists are then averaged and discussed below.


(a) Effects of the Substantially Non-Odorous Fragrance Modulators on Single Fragrance Material Compositions



FIG. 2 shows the fragrance intensity profile of Composition A9 (as disclosed in Table 22(c)) as evaluated by 10 panelists, which comprises the substantially non-odorous fragrance modulator Bis-methoxy PEG-13 PEG-438/PPG-110 SMDI Copolymer (i.e., Expert Gel® 56) and the single fragrance material Indocolore. Addition of the substantially non-odorous fragrance modulator (Expert Gel® 56) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition B9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the continued initial evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1, 3 and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all these time points.



FIG. 3 shows the fragrance intensity profile of Composition C9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor® EL) and the single fragrance material Dimethyl Benzyl Carbinol. Addition of the substantially non-odorous fragrance modulator (Kolliphor® EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition D9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001), 3 hours (p=0.0265) and 6 hours (p=0.0388) at 95% significance level (i.e., p<0.05) at all these time points.



FIG. 4 shows the fragrance intensity profile of Composition E9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor® EL) and the single fragrance material Eugenol. Addition of the substantially non-odorous fragrance modulator (Kolliphor® EL) maintains the intensity of the fragrance material for up to at least 6 hours whilst the control, Composition F9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile much more over this time. The substantially non-odorous fragrance modulator acts to suppress the initial display of Eugenol and then maintains that continued initial evaporation over time. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 0 hours (p=0.0025), 1 hour (p<0.0001), 3 hours (p<0.0001) and 6 hours (p<0.0001) at 95% significance level (i.e., p<0.05) at all time points.



FIG. 5 shows the fragrance intensity profile of Composition G9 (as disclosed in Table 22(c)) as evaluated by 9 panelists, which comprises the substantially non-odorous fragrance modulator propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate (i.e., Kolliphor® EL) and the single fragrance material Phenethyl alcohol (PEA). Addition of the substantially non-odorous fragrance modulator (Kolliphor® EL) maintains the intensity of the fragrance material from 1 hour to 3 hours whilst the control, Composition H9, in the absence of the substantially non-odorous fragrance modulator, drops in fragrance intensity profile over this time. The substantially non-odorous fragrance modulator acts to maintain the reduced rate of evaporation over time of the fragrance material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 1 hour (p<0.0001) at 95% significance level (i.e., p<0.05) and at 3 hours (p=0.0876) at 90% significance level (i.e., p<0.1).


(b) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Longevity of Compositions Having Diamond Construction of Fragrance Component Vs. Compositions Having Traditional Levels of Fragrance Component (Greater than 30 wt % Relative to the Total Weight of the Fragrance Component) and No Substantially Non-Odorous Fragrance Modulator


Panelists are asked to score the compositions for the intensity of the fragrance on a scale of 0 to 5, wherein 0 represents a no fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus control Compositions C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond constructed fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile longevity, particularly intensity of the characters attributable to the volatile fragrance materials are maintained for up to at least 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator.



FIG. 6 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam™ P-20, and comprising the Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.



FIG. 7 provides the fragrance intensity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C4, in the absence of the substantially non-odorous fragrance modulator Glucam™ P-20, and comprising the Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.



FIG. 8 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a drops in fragrance intensity over the 6 hours.



FIG. 9 provides the fragrance intensity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the intensity of the fragrance material for up to 6 hours. As compared to the control Composition C2, in the absence of the substantially non-odorous fragrance modulator Diisobutyl Adipate, and comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a drops in fragrance intensity over the 6 hours.


Panelists are also asked to score the Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 for the intensity of the fragrance profile. The results show the effect of the substantially non-odorous fragrance modulator and excessive levels of low volatile fragrance materials for any one of Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 on fragrance profile longevity and fidelity. Two outcomes are observed: (i) either the fragrance profile longevity is unaffected by the addition of the substantially non-odorous fragrance modulator or (ii) the fragrance profile appears to be suppressed with a loss of strength (data not shown).


Without wishing to be bound by theory, it is believed that the substantially non-odorous fragrance modulator acts to maintain the continued evaporation over time of the fragrance materials, particular the volatile fragrance materials. The effects of the improved fragrance profile longevity of the present invention are noticeable at, any one of, 1, 3 and 6 hours post application.


(c) Effects of the Substantially Non-Odorous Fragrance Modulators on the Fragrance Profile Fidelity of Compositions Having Diamond Fragrance Materials (Between 10 Wt % to 30 wt % Relative to the Total Weight of the Fragrance Component) Vs. Compositions Having Traditional Levels of Low Volatile Fragrance Materials (Greater than 30 wt % Relative to the Total Weight of the Fragrance Component) and No Substantially Non-Odorous Fragrance Modulator


Panelists are also asked to score the composition for the fragrance profile fidelity. In particular, the panelists are asked to score the dominance of the floral character attributable to the volatile fragrance materials on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panel test are then averaged. The results show the effect of the substantially non-odorous fragrance modulator and diamond fragrance materials for the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on the floral character dominance versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, the results show the effect of the substantially non-odorous fragrance modulator and diamond fragrance materials for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile fidelity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly floral character attributable to the volatile fragrance materials, are maintained by the substantially non-odorous fragrance modulator over time for up to 6 hours in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator.



FIG. 10 provides the fragrance fidelity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C4 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 to Composition B4 comprising Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).



FIG. 11 provides the fragrance fidelity profile of Composition A4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator PPG-20 Methyl Glucose Ether (i.e., Glucam™ P-20) and the Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C4 comprising the Traditional Muguesia Magnifica Fragrance Example 5a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Glucam™ P-20 to Composition B4 comprising Traditional Muguesia Magnifica Fragrance Example 5a does not result in improved fidelity of the floral character (data not shown).



FIG. 12 provides the fragrance fidelity profile of Composition D4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator Caprylyl/Capryl Glucoside (i.e., Plantacare® 810 UP) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Plantacare® 810 UP maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition F4 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Plantacare® 810 UP to Composition E4 comprising Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).



FIG. 13 provides the fragrance fidelity profile of Composition G4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator Undecyl Glucoside (i.e., Simulsol® SL 11W) and the Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Simulsol® SL 11W maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition I4 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Simulsol® SL 11W to Composition H4 comprising Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).



FIG. 14 provides the fragrance fidelity profile of Composition J4 (as disclosed in Table 18(d)), which comprises the substantially non-odorous fragrance modulator Isocetyl Aclohol (i.e., Ceraphyl® ICA) and the Diamond Floral Mangifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Ceraphyl® ICA maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition L4 comprising the Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Ceraphyl® ICA to Composition K4 comprising the Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).



FIG. 15 provides the fragrance fidelity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate to Composition B2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).



FIG. 16 provides the fragrance fidelity profile of Composition A2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator Diisobutyl Adipate and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition C2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator Diisobutyl Adipate to Composition B2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a does not result in improved fidelity of the floral character (data not shown).



FIG. 17 provides the fragrance fidelity profile of Composition J2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator PPG-11 Stearyl Ether and 7 wt % Diamond Floral Magnifica Fragrance Example 4b. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition L2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether to Composition K2 comprising 7 wt % Traditional Floral Magnifica Fragrance Example 4a does not result in improved fidelity of the floral character (data not shown).



FIG. 18 provides the fragrance fidelity profile of Composition J2 (as disclosed in Table 18(b)), which comprises 15 wt % substantially non-odorous fragrance modulator PPG-11 Stearyl Ether and 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether maintains the overwhelmingly dominate floral character for up to 6 hours. It is observed for Composition L2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a and no modulator, the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator PPG-11 Stearyl Ether to Composition K2 comprising 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a does not result in improved fidelity of the floral character (data not shown).


Panelists are also asked to score the Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 for the dominance of the floral character. The results show the effect of the substantially non-odorous fragrance modulator and excessive levels of low volatile fragrance materials for any one of Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 on fidelity of the floral character attributable to the volatile fragrance materials. It is observed that the floral character is perceived initially but then drops quickly over time. Addition of the substantially non-odorous fragrance modulator does not result in improved fidelity of the floral character as seen in any one of Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 (data not shown).


Panelists are further asked to score the compositions on a scale of 1 to 5, wherein 1 represents the fragrance profile remains unchanged and 5 represents a total change in the fragrance profile versus a control. The results of the panel test are averaged and plotted together with the confidence intervals. The results show the effect of the substantially non-odorous fragrance modulator and diamond fragrance materials for Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2. The presence of the substantially non-odorous fragrance modulator and diamond fragrance materials result in noticeable fidelity in fragrance characters. Particularly, noticeable fidelity in the floral aromas attributable to the volatile fragrance materials (data not shown).


Example 6—Analytical Evaporation Test Results

Using the analytical evaporation Test Method 3, it is possible to measure the amount of each component of a perfume mixture that remains as the fragrance mixture evaporates. Test compositions (MOD1 to MOD3) comprising a mixture of 10 volatile perfume materials, as disclosed in Table 11 (Fragrance Example 6), and a substantially non-odorous fragrance modulators, as disclosed in Tables 4(a) and 4(b), are introduced in the aluminum containers at the set temperature for pre-determined periods of time in accordance with the protocol described in Test Method 3. Indole is one of the components of the 10 PRMs mixture of Table 11. Control compositions containing the full 10 PRMs mixture as disclosed in Table 11 without the substantially non-odorous fragrance modulator are run alongside the test compositions. The average profile for the control composition is plotted against the individual profile for the indole component from the test composition containing the 10 PRMs mixture of Table 11 with the substantially non-odorous fragrance modulators. The error associated with the method is determined by running replicate evaporation experiments on the control composition. An average evaporation profile of the control composition as well as the 95% confidence interval at each time point are calculated from the replicates.


It is useful to consider the difference (Δ) in the % of remaining fragrance material between each of the test composition (MOD) and their respective control composition (REF) at each experimental time points (e.g., 30 mins, 60 mins and 180 mins) to determine the effect of the substantially non-odorous fragrance modulator on the volatile PRMs in a mixture. The difference (Δ) in the % of remaining of a given fragrance material is calculated as follows:

Δ=% remaining of given fragrance material in test composition (MOD)−% remaining of same fragrance material in control composition (REF)

The difference (Δ) can then be plotted (data not shown) for each of the perfume materials in the mixture at each of the time points. For ease of reference, the applicant has summarize the effect of the substantially non-odorous fragrance modulator on only one volatile fragrance component (e.g., indole) of the mixture, to serve as a representative of all of the volatile fragrance materials.


(a) Effect of PPG-3 Myristyl Ether on Compositions Having Volatile Fragrance Materials



FIG. 19 shows the effect of the substantially non-odorous fragrance modulator PPG-3 Myristyl Ether (i.e., available as Tegosoft® APM/Modulator 7 from Table 4(a)) on the evaporation profile for a representative component (i.e., indole) of the test composition (MOD1). With reference to FIG. 19, PPG-3 Myristyl Ether has a difference (Δ) of 12% after 30 mins, 22% after 60 mins, and 60% after 3 hours. Addition of the PPG-3 Myristyl Ether in the test composition (MOD1) maintains the concentration of the volatile fragrance material indole from 0 hour up to 3 hours whilst the control composition (REF), in the absence of PPG-3 Myristyl Ether, drops in fragrance concentration over the 3 hours. Thus, PPG-3 Myristyl Ether acts to maintain the continued evaporation of the volatile fragrance material over time. Similar results are observed for the other volatile fragrance materials in the mixture (data not shown).


(b) Effect of Neopentyl Glycol Diethylhexanoate on Compositions Having Volatile Fragrance Materials



FIG. 20 shows the effect of the substantially non-odorous fragrance modulator Neopentyl Glycol Diethylhexanoate (i.e., available as Schercemol™ NGDO/Modulator 8 from Table 4(a)) on the evaporation profile for a representative component (i.e., indole) of the test composition (MOD2). With reference to FIG. 20, Neopentyl Glycol Diethylhexanoate has a difference (Δ) of 11% after 30 mins, 21% after 60 mins, and 53% after 3 hours. Addition of the Neopentyl Glycol Diethylhexanoate in the test composition (MOD2) maintains the concentration of the volatile fragrance material indole from 0 hour up to 3 hours whilst the control composition (REF), in the absence of Neopentyl Glycol Diethylhexanoate, drops in fragrance concentration over the 3 hours. Thus, Neopentyl Glycol Diethylhexanoate acts to maintain the continued evaporation of the volatile fragrance material over time. Similar results are observed for the other volatile fragrance materials in the mixture (data not shown).


(c) Effect of Kolliphor® EL on Compositions Having Volatile Fragrance Materials



FIG. 21 shows the effect of the substantially non-odorous fragrance modulator Kolliphor® EL (disclosed as modulator 99 from Table 4(a)) on the evaporation profile for a representative component (i.e., indole) of the test composition (MOD3). With reference to FIG. 21, indole has a difference (Δ) of 15% after 30 mins, 28% after 60 mins, and 80% after 3 hours. Addition of the Kolliphor® EL in the test composition (MOD3) maintains the concentration of the volatile fragrance material indole from 0 hour up to 3 hours whilst the control composition (REF), in the absence of Kolliphor® EL, drops in fragrance concentration over the 3 hours. Thus, Kolliphor® EL acts to maintain the continued evaporation of the volatile fragrance material over time. Similar results are observed for the other volatile fragrance materials in the mixture (data not shown).


Example 7—Analytical Headspace Test Results

Using the analytical headspace Test Method 4, it is possible to demonstrate the character retention over time of a perfume mixture of a fragrance composition of the present invention vs. a control. Compositions disclosed in Tables 18(a)-18(e) are added to sealed vials in accordance with the protocol described in the Method Section, and the fragrance profile in the headspace are measured at specific time points through the use of headspace gas chromatography.


(a) Effects of the Substantially Non-Odorous Fragrance Modulators on Character Retention of Compositions Having Diamond Constructions Vs. Compositions Having Traditional Levels of Fragrance Materials


The test demonstrates the character retention over time of a fragrance composition. The results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile versus control Compositions C1, C2, C3, C4, C5, F1, F2, F4, I1, I2, I4, L1, L2, L4, O1, and O2 in the absence of the substantially non-odorous fragrance modulator. Alternatively, results show the effect of the substantially non-odorous fragrance modulator and fragrance materials in a diamond construction for any one of the inventive Compositions A1, A2, A3, A4, A5, D1, D2, D4, G1, G2, G4, J1, J2, J4, M1, and M2 on fragrance profile longevity versus traditional Compositions B1, B2, B3, B4, B5, E1, E2, E4, H1, H2, H4, K1, K2, K4, N1, and N2 in the presence of the substantially non-odorous fragrance modulator. Fragrance profile fidelity, particularly of floral characters attributable to the volatile fragrance materials are maintained for up to at least 1 hour in the presence of the substantially non-odorous fragrance modulator whilst it drops in the absence of the substantially non-odorous fragrance modulator.



FIG. 22(a)(i) provides the headspace chromatogram for control Composition L2 after 10 mins of evaporation, wherein Composition L2 comprises 7 wt % Traditional Muguesia Magnifica Fragrance Example 5a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxycitronellal; and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the high and moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 22(a)(ii), only one substantial moderate volatile fragrance material peak remains, for example Helional. In contrast, the low volatile fragrance materials remain with substantial peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.



FIG. 22(b)(i) provides the headspace chromatogram for inventive Composition J2 after 10 mins of evaporation, wherein Composition J2 comprises 7 wt % Diamond Muguesia Magnifica Fragrance Example 5b and 15 wt % PPG-11 Stearyl Ether substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxy citronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition L2, particularly the peaks due to the moderately volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 22(b)(ii), most of the moderate volatile fragrance materials peaks remain. This includes Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxy citronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition L2. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition J2 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Consumers will experience this as a fragrance with a prolonged intensity, particularly of the characters attributable to the volatile fragrance materials, most particularly of the floral characters.



FIG. 23(a)(i) provides the headspace chromatogram for control Composition C4 after 10 mins of evaporation, wherein Composition C4 comprises the Traditional Muguesia Magnifica Fragrance Example 5a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Phenethyl alcohol, Cymal or Jasmal, and hydroxy citronellal and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 23(a)(ii), only two small moderate volatile fragrance material peaks remain, Helional and Cyclogalbante or Majantol. In contrast, the low volatile fragrance materials remain with many peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.



FIG. 23(b)(i) provides the headspace chromatogram for inventive Composition A4 after 10 mins of evaporation, wherein Composition A4 comprises the Diamond Muguesia Magnifica Fragrance Example 5b and PPG-20 Methyl Glucose Ether (i.e., GLUCAM™ P-20) substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Phenethyl alcohol, Cymal or Jasmal, and hydroxycitronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition C4, particularly the peaks due to the moderate volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 23(b)(ii), most of the moderate volatile fragrance materials peaks remain. This includes Cyclogalbanate or Majantol®, Phenethyl alcohol, Cymal or Jasmal, and hydroxycitronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition C4. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition A4 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Olfactively this is perceived as a fragrance with a prolonged intensity, particularly of the characters attributable to the moderate volatile fragrance materials, most particularly of the floral characters.



FIG. 24(a)(i) provides the headspace chromatogram for control Composition L4 after 10 mins of evaporation, wherein Composition L4 comprises the Traditional Floral Magnifica Fragrance Example 4a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Pyranol (Florol), Cyclogalbanate or Majantol®, Cymal or Jasmal, and hydroxycitronellal and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 24(a)(ii), only a few small moderate volatile fragrance material peaks remain, Cymal or Jasmal and Helional. In contrast, the low volatile fragrance materials remain with many peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.



FIG. 24(b)(i) provides the headspace chromatogram for inventive Composition J4 after 10 mins of evaporation, wherein Composition J4 comprises the Diamond Floral Magnifica Fragrance Example 4b and Isocetyl Alcohol (i.e., Ceraphyl® ICA) substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Pyranol (Florol), Cyclogalbanate or Majantol®, Cymal or Jasmal, and hydroxy citronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition C4, particularly the peaks due to the moderate volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 24(b)(ii), most of the moderate volatile fragrance materials peaks remain. This includes Pyranol (Florlol), Cyclogalbanate or Majantol®, Cymal or Jasmal, and hydroxy citronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition C4. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition A4 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Olfactively this is perceived as a fragrance with a prolonged intensity, particularly of the characters attributable to the moderate volatile fragrance materials, most particularly of the floral characters.



FIG. 25(a)(i) provides the headspace chromatogram for control Composition I4 after 10 mins of evaporation, wherein Composition I4 comprises the Traditional Muguesia Magnifica Fragrance Example 5a and no modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal, and hydroxy citronellal and (2) low volatile fragrance materials having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example: Hedione® HC and Iso-E Super®. As the fragrance evaporates, the height of the peaks reduces significantly, particularly the peaks due to the high and moderate volatile fragrance materials. After 60 mins of evaporation, as shown in FIG. 25(a)(ii), only one substantial moderate volatile fragrance material peak remains, Helional. In contrast, the low volatile fragrance materials remain with substantial peaks for many perfume materials, for example Hedione® HC and Iso-E Super®. These chromatograms illustrate the loss of fragrance materials during evaporation, particularly the loss of the moderate volatile fragrance materials. Olfactively this is perceived as a loss in intensity and perception of these particular fragrance materials, particularly those that provide the floral characters.



FIG. 25(b)(i) provides the headspace chromatogram for inventive Composition G4 after 10 mins of evaporation, wherein Composition G4 comprises the Diamond Muguesia Magnifica Fragrance Example 5b and Undecyl Glucoside (i.e., Simulsol® SL 11W) substantially non-odorous fragrance modulator. The headspace is a complex fragrance and many perfume materials can be observed spanning a range of volatility and characters. This includes: (1) moderate volatile fragrance materials having a vapor pressure in the range of 0.1 Torr to 0.001 Torr (0.0133 kPa to 0.000133 kPa) at 25° C., for example: Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxy citronellal; and (2) low volatile fragrance material having a vapor pressure less than 0.001 Torr (0.000133 kPa) at 25° C., for example Hedione® HC and Iso-E Super®. As the fragrance evaporates the height of the peaks reduces but not as much as compared to the control Composition I4, particularly the peaks due to the moderately volatile fragrance materials are maintained. After 60 mins of evaporation, as shown in FIG. 25(b)(ii), most of the moderate volatile fragrance materials peaks remain. This includes Cyclogalbanate or Majantol®, Helional, Cymal or Jasmal and hydroxycitronellal. The low volatile fragrance materials, Hedione® HC and Iso-E Super®, remain in the headspace but are not dominant when compared to Composition I4. These chromatograms illustrate the prolonged presence of the volatile fragrance materials in Composition G4 and the dominance of the headspace after 60 mins by the moderate volatile fragrance materials at the expense of the low volatile fragrance materials. Olfactively this is perceived as a fragrance with a prolonged intensity, particularly of the characters attributable to the moderate volatile fragrance materials, most particularly of the floral characters.


It should be understood that every maximum numerical limitation given throughout this specification includes every lower numerical limitation, as if such lower numerical limitations were expressly written herein. Every minimum numerical limitation given throughout this specification will include every higher numerical limitation, as if such higher numerical limitations were expressly written herein. Every numerical range given throughout this specification will include every narrower numerical range that falls within such broader numerical range, as if such narrower numerical.


The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as “40 mm” is intended to mean “about 40 mm.”


Every document cited herein, including any cross referenced or related patent or application and any patent application or patent to which this application claims priority or benefit thereof, is hereby incorporated herein by reference in its entirety unless expressly excluded or otherwise limited. The citation of any document is not an admission that it is prior art with respect to any invention disclosed or claimed herein or that it alone, or in any combination with any other reference or references, teaches, suggests or discloses any such invention. Further, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall govern.


While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims
  • 1. A composition comprising: (i) a fragrance component present in an amount of from about 0.04 wt % to about 30 wt %, relative to the total weight of the composition, and wherein the fragrance component comprises: (a) methyl jasmonate present in an amount of from about 10 wt % to about 30 wt %, relative to the total weight of the fragrance component;(b) ethyl phenyl acetate present in an amount of from about 40 wt % to about 80 wt %, relative to the total weight of the fragrance component; and(c) ethyl butyrate present in an amount of from about 1 wt % to about 30 wt %, relative to the total weight of the fragrance component;(ii) undecyl glucoside present in the amount of from about 0.1 wt % to about 20 wt %, relative to the total weight of the composition;(iii) a volatile solvent present in an amount of from about 50 wt % to about 80 wt %, relative to the total weight of the composition; and(iv) optionally water.
  • 2. The composition of claim 1, wherein the volatile solvent is a branch or unbranched C1 to C10 alkyl, alkenyl or alkynyl group having at least one alcohol moiety.
  • 3. The composition of claim 1, wherein the composition is a fine fragrance composition in the form of a perfume concentrate, a perfume, a perfume, an eau de toilette, an eau de perfume, or a cologne.
  • 4. The composition of claim 1, wherein the composition is in the form of a body splash or a body spray.
  • 5. A method for imparting, intensifying, or modifying an odour on human skin or human hair, comprising applying to human skin and/or human hair the composition according to claim 1.
  • 6. The method of claim 5, wherein the method is preferably for imparting, intensifying or modifying the longevity of a floral character on human skin or human hair, wherein the perceived intensity of the floral character at 1 hr, 2 hrs, 3 hrs or 6 hrs after application is greater than a control composition that does not include the substantially non-odorous fragrance modulator as determined by the panel method as disclosed herein, and wherein the floral character is selected from the group consisting of lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia-type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note, a patchouli-type note and the like.
  • 7. A perfuming consumer product or article comprising a composition of claim 1, wherein the perfuming consumer product is selected from the group consisting of a fabric care product, an air care product or a home care product.
Priority Claims (1)
Number Date Country Kind
15171783 Jun 2015 EP regional
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Related Publications (1)
Number Date Country
20160362630 A1 Dec 2016 US