Claims
- 1. A persistent free radical compound of formula (I)
- C(Ar.sup.1).sub.3 (I)
- where each group Ar.sup.1, which may be the same or different, is an optionally substituted aromatic group, and at least one of said Ar.sup.1 groups is a group Ar.sup.3 selected from the group consisting of: ##STR77## wherein R.sup.7 is hydrogen or optionally hydroxylated alkyl and R.sup.1 is a hydrogen atom or a group of formula --M, --XM, --X--Ar.sup.2 or --Ar.sup.2, where M is a water solubilizing group, X is an oxygen or sulphur atom or a group CO or S(O).sub.n, where n is 1 to 3, and Ar.sup.2 is a 5 to 10 membered aromatic ring optionally substituted by a water solubilizing group M.
- 2. A compound as claimed in claim 1 wherein R.sup.1 is selected from the group consisting of: ##STR78## where R.sup.2 is hydrogen or optionally hydroxylated alkyl.
- 3. A compound as claimed in claim 1 of formula Ia, Ib, Ic or Id: ##STR79## where R.sup.11 and R.sup.12 are as defined for R.sup.1 in claim 1, or a salt thereof.
- 4. A compound as claimed in claim 3 where R.sup.11 and where present R.sup.12 is selected from the group consisting of hydrogen, SCH.sub.3, SCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3, SCH.sub.2 COOH, SO.sub.2 N(CH.sub.3)CH.sub.2 (CHOH).sub.4 CH.sub.2 OH, SO.sub.2 NH.sub.2, SO.sub.2 NCH.sub.2 CH.sub.2 OH, and SO.sub.2 NCH.sub.2 CHOHCH.sub.2 OH.
- 5. A magnetic resonance imaging contrast medium composition comprising a physiologically tolerable radical as defined in claim 1 together with at least one pharmacologically acceptable carrier or excipient.
- 6. An ESR imaging contrast medium composition comprising a physiologically tolerable radical as defined in claim 1 together with at least one pharmacologically acceptable carrier or excipient.
- 7. A compound as claimed in claim 1 which is tris(8-carboxy-2,2,6,6-tetrahydroxymethylbenzo�1,2-d:4,5-d'!bis(1,3)dithiole-4-yl)-methyl or a salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
93-07027.4 |
Apr 1993 |
GBX |
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CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of application Ser. No. 08/220,522, filed Mar. 31, 1994 now U.S. Pat. No. 5,530,140.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5312617 |
Unger et al. |
May 1994 |
|
5530140 |
Andersson et al. |
Jun 1996 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
9112024 |
Aug 1991 |
WOX |
9302710 |
Feb 1993 |
WOX |
9302711 |
Feb 1993 |
WOX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
220522 |
Mar 1994 |
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