Claims
- 1. A method for the production of 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco-heptitol comprising catalytically hydrogenating 6-azido-7-O-tert-butyldimethylsilyl-1,6-dideoxy-3,4-O-isopropylidene-L-gulo-heptulo -2-ose with platinum (IV) oxide at about room temperature followed by hydrolytic removal of the silyl and isopropylidene protecting groups.
- 2. The method of claim 1 in which the catalytic hydrogenation is conducted in ethyl acetate solvent in the presence of platinum (IV) oxide catalyst.
Parent Case Info
This is a continuation of application Ser. No. 07/600,950, filed on Oct. 22, 1990, now abandoned, which is a division of application Ser. No. 07/372,415, filed Jun. 27, 1989, now U.S. Pat. No. 4,849,430.
Non-Patent Literature Citations (7)
Entry |
Fleet et al., FEBS Lett. 237, 128-132 (1988). |
Karpas et al., Proc. Natl. Acad. Sci. USA 85, 9229-9233 (1988). |
Liu et al., J. Org. Chem. 52, 4717-4721 (1987). |
Rhinehart et al., J. Pharmacol. Exptl. Therap. 241, 915-920 (1987). |
Kite et al., Tetrahedron Lett. 29, 6483-6486 (1988). |
Fleet et al., J. Chem. Soc. Chem. Commun. 1985, 841-842, 1988, 483-485. |
Fleet et al., J. Chem. Sco. Perkins Trans. 1, 665-666 (1989). |
Divisions (1)
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Date |
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Parent |
372415 |
Jun 1989 |
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Continuations (1)
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Date |
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600950 |
Oct 1990 |
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