Full spectrum LED illuminator having a mechanical enclosure and heatsink

Information

  • Patent Grant
  • 9814378
  • Patent Number
    9,814,378
  • Date Filed
    Thursday, August 25, 2016
    8 years ago
  • Date Issued
    Tuesday, November 14, 2017
    7 years ago
Abstract
An apparatus for providing a light output to an optical guide for illumination of an imaged object including a plurality of solid state light-emitting sources each of which are independently powered and independently controlled, each light-emitting source emitting light at a wavelength which is different from the wavelength emitted by the other light-emitting sources. The apparatus also includes a heat sink configured to thermally couple the plurality of solid state light-emitting sources and provide conduction of heat generated by the plurality of solid state light-emitting sources. The apparatus further includes an optical elements to collect, collimate, and combine the emissions from the plurality of solid state light-emitting sources into a combined beam of light to be optically coupled to the light guide.
Description
BACKGROUND OF THE INVENTION

The present disclosure relates to an illumination system, in particular for endoscopy, and more particularly a full spectrum illumination system using light-emitting diodes (LED) and/or semiconductor lasers.


Illumination systems for endoscopy, microscopy and similar optical imaging applications have for many years utilized arc lamp or halogen technology as the light source of choice. More recently, various forms of solid state light sources such as light emitting diodes or diode lasers have been introduced for use in some of these imaging applications. Due to the output brightness or output spectrum limitations of these solid state light sources, the use of LEDs and/or laser diodes has, until recently, been limited to optical imaging applications where low light levels are sufficient or where narrow spectrum illumination is required/desired.


Achieving sufficiently bright, full visible spectrum illumination with solid state light sources has remained challenging for a number of reasons.


a) Firstly, LED technology has been improving, but started far behind that of lamp technology in terms of total light output. Increasingly higher light outputs are now available, but light from a single phosphor-coated (“white”) LED, for example, is still orders of magnitude below that of an arc lamp.


b) Alternatively light from multiple, different colored (e.g. red, green and blue) LEDs can be combined using dichroic mirrors to “source” emitting over a wide spectral range. The imaging applications mentioned above, however, generally require coupling light into liquid, fiberoptic, or rod lens light guides. Such optical light guides typically have both a small physical aperture with dimensions of a few mm across and a constrained/limited numerical aperture (NA). Moreover, etendue considerations rapidly constrain the practical implementation of such combined source illumination systems.


c) Should the etendue considerations with a multiple different colored LED arrangement be overcome by a suitable arrangement of sources and dichroics with optical path lengths that are carefully equalized, then other implementation issues arise with respect to effective cooling and cost.


Finally, although output brightness of red and blue LEDs has reached levels at which they can produce light with a brightness substantially equivalent to that of the red and blue portions of an arc lamp or a halogen lamp spectrum, the output of green LEDs tends to be substantially less than the green light produced by lamps.


It would therefore be desirable and advantageous to address this problem and to obviate other prior art shortcomings by providing a cost-effective and reliable illuminator utilizing solid state light sources to produce a bright, color balanced, broad spectrum visible light output that may be effectively coupled to an optical light guide. It would also be desirable to include in such illuminator and in the resulting light emission, other light sources for UV or NIR illumination (e.g. for fluorescence excitation of tissue).


SUMMARY OF THE INVENTION

According to one aspect of the present disclosure, an illuminator is disclosed which utilizes solid state light sources to produce a bright, color balanced, broad-spectrum, visible light output.


According to one advantageous feature of the disclosure, the illuminator may contain multiple high power LED light sources that span the visible spectrum (e.g. from 400-700 nm). These LED light sources are separately powered and controlled. The light produced by these LEDs is combined into a single beam using either mirrors or dichroic filters appropriately wavelength matched to the LED light output. The combined light may then be coupled into an optical light guide using an appropriate optical element such as a high (e.g. >0.5) NA lens.


According to one advantageous feature of the disclosure, the illuminator may include LED light sources housed in discrete high thermal conductivity packages. The LED dies may be edge-emitting or surface emitting and they may be packaged in single or multi-die configurations.


According to one advantageous feature of the disclosure, the illuminator may contain a combination of red, green and blue LED light sources. Alternatively or in addition, one or more of these LED light sources may have other hues of the visible spectrum, including violet, yellow, amber/orange LEDs, as required or desirable for the application (e.g. in the endoscope). Alternatively, or in addition, a single LED package may contain any combination of these color dies.


According to one advantageous feature of the disclosure, to increase the green component of the emitted light and provide a more color balanced output, the illuminator may contain in addition to red and blue LED light sources at least two green LED light sources, such as a long wavelength green and a short wavelength green. The peak wavelengths and bandwidth of the two green LEDs is carefully selected to ensure that the combining optics produce maximum net green light output. In one embodiment the long wavelength green may have a peak wavelength at ˜530 nm and an approximate FWHM bandwidth of +/−40 nm and the short wavelength green may have a peak wavelength at ˜515 nm and an approximate FWHM bandwidth of +/−37 nm.


According to one advantageous feature of the disclosure, the LED light sources may be mounted on a heat sink in good thermal contact with a single heat spreader plate. The spreader plate may be a metal having high thermal conductivity, such as copper, aluminum, iron, diamond, gold or silver and the like. The spreader plate may be mounted on or integral with a passive cooling system, such as a finned heat sink or a heat pipe, or an active cooling system, such as a thermoelectric cooler (TEC) or liquid cooler. Thermal contact between the LEDs and the plate may be provided by, for example, soldering or with the application of a thermally conductive compound, such as Type 120 Silicon Thermal Joint Compound (Wakefield Thermal Solutions, New Hampshire). This mounting arrangement and cooling structure optimizes both cost/complexity of the assembly and cooling efficiency and therefore also the lifetime/reliability of the solid state source.


According to one advantageous feature of the disclosure, the LED light sources may be mounted on a plane which is common to the planar surface of the heat sink on the single heat spreader plate, with the optical path length increasing with wavelength, e.g. the red LED has longest optical path, the blue LED has shortest optical path. LED light source is positioned at or near the focal point of a compound collector group consisting of an aspheric lens (e.g., Newport KPA040-C, Irvine, Calif.), which collects the light from each LED light source. The collection efficiency of the aspheric lens may be enhanced by a field lens mounted between the LED and the aspheric lens. The aspheric lens projects a nearly collimated light beam from the LED onto a mirror or a dichroic filter (e.g. Semrock FF670-SDi01-25×36, Rochester, N.Y.) positioned to reflect light at a right angle relative to the light projected by the aspheric lens into the combined light beam path. The dichroic filter is designed to reflect substantially all light at or above the wavelength of the LED emission and transmits the light of all shorter wavelengths. The power and position of each aspheric lens and the power and position of any field lens is adjusted as required for each LED to accommodate the differences in optical path lengths. In this way, the etendue constraints with a linear arrangement of light sources can be managed and the capacity of the high NA lens in coupling the combined beam of light into an optical light guide can be maximized.


According to one advantageous feature of the disclosure, all optical elements not directly attached to the LED light sources (including all remaining collector lenses, reflective and dichroic mirrors, and collimating/condensing lenses) may be mounted in a mating mechanical enclosure. The enclosure may be fabricated from a single block of material such as aluminum, or similar material and may be machined or may be cast and machined as a single element. The mechanical enclosure may also be composed of multiple elements individually fabricated (e.g. machined) and assembled. The enclosure has a linear array of input ports matching the linear pattern of LED sources on the heat spreader plate—e.g., one input port for each LED light source and a single output port. Once all optical components are mounted in the enclosure, the plate with the LED light sources is assembled to the enclosure input ports and a shutter that seals the exit aperture in the absence of a light guide is mounted placed on the output port. The enclosure is consequently fully sealed and the optical elements are protected against the ingress of dust and other contaminants.


According to one advantageous feature of the disclosure, the illuminator may utilize a design without lenses and have instead polished reflective surfaces that propagate the light emitted by the LEDs. The light can then, as before, be combined using dichroic filters, with the combined light being coupled into the optical light guide, by means of reflective surfaces.


According to one advantageous feature of the disclosure, the illuminator may also contain other light sources, such as one or more diode lasers, that are coupled into the combined optical path. In one embodiment, the diode lasers may be fiber coupled NIR lasers that emit in the 800-820 nm wavelength range suitable for fluorescence excitation of, for example, indocyanine green (ICG) or other NIR excited fluorescence agent. Alternatively or in addition, one or more of the fiber coupled diode lasers may produce 830 nm NIR light for purposes of mimicking the fluorescence of ICG. The NIR light emitted by the lasers may be coupled into the optical path by introducing an additional dichroic mirror that reflects NIR but transmits shorter wavelengths into the LED optical path. Alternatively, or in addition, the illuminator may contain one or more UV diode lasers for tissue autofluorescence excitation. These lasers may be coupled into the blue LED channel or directly coupled into the combined beam channel before the blue LED dichroic filter. The illuminator may also contain high powered NIR or UV LEDs instead of diode lasers.


The system also provides for imaging a conjugate plane from the collector group onto the light guide (i.e. fit a round cone to the light guide).





BRIEF DESCRIPTION OF THE DRAWINGS

Other features and advantages of the present invention will be more readily apparent upon reading the following description of currently preferred exemplified embodiments of the invention with reference to the accompanying drawing, in which:



FIG. 1 shows an LED package with a highly thermally conductive substrate;



FIG. 2 shows in a cut-away view an illuminator with a linear array of LEDs arranged on a heat spreader, with collection, combining and condensing optics;



FIG. 3 shows in a cut-away view an illuminator with a linear array of LEDs arranged on a heat spreader, with heat exchanger and fans; and



FIG. 4 shows an exemplary air flow pattern of the illuminator in an enclosure.





DETAILED DESCRIPTION OF THE EMBODIMENTS

Throughout all the figures, same or corresponding elements may generally be indicated by same reference numerals. These depicted embodiments are to be understood as illustrative of the invention and not as limiting in any way. It should also be understood that the figures are not necessarily to scale and that the embodiments are sometimes illustrated by graphic symbols, phantom lines, diagrammatic representations and fragmentary views. In certain instances, details which are not necessary for an understanding of the present invention or which render other details difficult to perceive may have been omitted.


Turning now to the drawing, and in particular to FIG. 1, there is shown an LED package 100 including a substrate 102 with high thermal conductivity having mounting holes 104 for attachment to a heat spreader 212 shown in FIG. 2. The LED package also includes electrical terminals 106 for supplying electric power to the LEDs.



FIG. 2 shows in a cut-away view an illuminator 210 with a linear array of LEDs 232, 234, 236, 238 arranged on the heat spreader 212, with collector optics 222, combining optics 242, 244, 246, 248, and condensing optics 226. The LEDS 212 are arranged with increasing optical path lengths from a combined light output port 230. Collector optics 222, such as an aspheric lens and optionally a field lens, may be placed in front of each LED. The light from the red LED 232 is reflected at a 90° angle by a mirror 242. Additional dichroic mirrors 244, 246, 248 are placed in the combined beam path between this mirror 242 and the combined light output port 230. These dichroic mirrors 244, 246, 248 are designed to reflect, in the listed order, at a 90° angle light emitted by the exemplary long wavelength green LED 234 (peak wavelength at ˜530 nm and approximate FWHM bandwidth of +/−40 nm), the exemplary short wavelength green LED 236 (peak wavelength at ˜515 nm and approximate FWHM bandwidth of +/−37 nm), and the exemplary blue LED 238 (peak wavelength at ˜460 nm and approximate FWHM bandwidth of +/−25 nm), while transmitting the wavelengths already present in the propagating combined beam, i.e., red, red+long green, red+long green+short green.


According to some exemplary embodiments, optical elements not directly attached to the LED light sources, for example, collector lenses, reflective and dichroic mirrors, and collimating/condensing lenses, may be mounted in a mating mechanical enclosure 224. The enclosure may be fabricated from a single block of material such as aluminum, or similar material, and may be machined or may be cast and machined as a single element. The mechanical enclosure may also be composed of multiple elements individually fabricated (e.g. machined) and assembled. The enclosure 224 has a linear array of input ports matching the linear pattern of LED sources 232, 234, 236, 238 on the heat spreader plate 212 e.g., one input port for each LED light source—and a single output port. Once all optical components are mounted in the enclosure 224, the heat spreader plate 212 with the LED light sources 232, 234, 236, 238 is assembled to the enclosure input ports.


The illuminator 210 may contain one or more other light sources, such as a diode laser 250, that are coupled into the combined optical path. The diode laser 250 may be a fiber-coupled NIR laser that emits in the 800-820 nm wavelength range suitable for fluorescence excitation of, for example, indocyanine green (ICG) or other NIR-excited fluorescence agent. Alternatively or additionally, a fiber-coupled diode laser may produce 830 nm NIR light for purposes of mimicking the fluorescence of ICG. As shown in FIG. 2, the NIR light emitted by the laser 250 may be coupled into the optical path by introducing an additional dichroic mirror 252 that reflects NIR but transmits shorter wavelengths into the LED optical path. Alternatively or additionally, the illuminator 210 may contain one or more UV diode lasers for tissue autofluorescence excitation. The aforementioned lasers may be coupled into the channel of the blue LED 238 or directly coupled into the combined beam channel before the blue LED dichroic filter 248. The illuminator 210 may also contain high powered NIR or UV LEDs instead of diode lasers.



FIG. 3 shows schematically the illuminator in a cut-away view with the linear array of LEDs 232, 234, 236 on heat spreader 212, the LED-Laser heat exchanger (heat sink) 352, and the LED-Laser heat exchanger fans 354.



FIG. 4 shows schematically an exemplary air flow pattern around the illuminator 210 in the enclosure 460. FIG. 4 is a perspective view that differs from the view of FIG. 3, as shown by the X-Y-Z axis.


While the invention has been illustrated and described in connection with currently preferred embodiments shown and described in detail, it is not intended to be limited to the details shown since various modifications and structural changes may be made without departing in any way from the spirit and scope of the present invention. The embodiments were chosen and described in order to explain the principles of the invention and practical application to thereby enable a person skilled in the art to best utilize the invention and various embodiments with various modifications as are suited to the particular use contemplated.

Claims
  • 1. An apparatus for providing a light output to an optical guide for illumination of an object to be imaged, the apparatus comprising: a plurality of solid state light-emitting sources each of which are independently powered and independently controlled, each light-emitting source emitting light at a wavelength that is different from a wavelength emitted by the other light-emitting sources;a heat sink configured to thermally couple the plurality of solid state light-emitting sources and provide conduction of heat generated by the plurality of solid state light-emitting sources, wherein the heat sink comprises a heat spreader plate having a planar surface and each of the solid-state light-emitting sources is mounted to the planar surface to orient each of the solid-state light-emitting sources along a common optical plane;optical elements configured to collect, collimate, and combine the emissions from the plurality of solid state light-emitting sources into a combined beam of light to be optically coupled to a light guide at an output of the apparatus; anda mechanical enclosure comprising a linear array of input ports matching a linear pattern of the light-emitting sources on the planar surface, wherein at least some of the optical elements are not directly attached to the light-emitting sources and the at least some of the optical elements not directly attached to the light-emitting sources are mounted in the mechanical enclosure and the heat spreader plate is configured to be assembled to the enclosure so as to seal the enclosure,wherein light emitted from each of the light-emitting sources travels an optical path length from the respective light-emitting source to the output, the optical path lengths from the light-emitting sources to the output varying based on the wavelength of the light emitted from the respective light-emitting source.
  • 2. The apparatus of claim 1, wherein the heat sink comprises a passive cooling system.
  • 3. The apparatus of claim 2, wherein the passive cooling system is a finned heat sink or a heat pipe.
  • 4. The apparatus of claim 1, wherein the heat sink comprises an active cooling system.
  • 5. The apparatus of claim 4, wherein the active cooling system is a thermoelectric cooler or a liquid cooler.
  • 6. The apparatus of claim 1, wherein the solid state light-emitting sources comprise light emitting diodes and diode lasers.
  • 7. The apparatus of claim 1, wherein the optical elements comprise a field lens and an aspheric lens configured to collect and collimate the emission from each of the plurality of solid state light-emitting sources.
  • 8. The apparatus of claim 1, further comprising a dichroic filter configured to couple the collimated emission from each of the plurality of solid state light-emitting sources into the combined beam of light directed along a common path to an output port.
  • 9. The apparatus of claim 1, wherein the optical elements are arranged such that the optical path length of each of the plurality of solid state light-emitting sources increases as the wavelength increases.
  • 10. The apparatus of claim 1, wherein the optical elements are arranged such that the optical path length of each of the plurality of solid state light-emitting sources increases as the wavelength decreases.
  • 11. The apparatus of claim 1, wherein the common optical plane comprises focal points of a compound collector group.
  • 12. The apparatus of claim 1, wherein the heat spreader plate comprises copper, aluminum, iron, diamond, gold or silver.
  • 13. The apparatus of claim 1, wherein the heat sink comprises a passive cooling system or an active cooling system and the passive or active cooling system is arranged on a side of the heat spreader plate opposite the planar surface.
REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 14/658,869, filed Mar. 16, 2015, which is a continuation of U.S. patent application Ser. No. 13/415,561, filed Mar. 8, 2012, now U.S. Pat. No. 8,979,301, which claims the benefit of provisional Application No. 61/450,360, filed Mar. 8, 2011, the entire contents of which are incorporated herein by reference.

US Referenced Citations (326)
Number Name Date Kind
1290744 Hollander Jan 1919 A
2453336 Orser Nov 1948 A
2857523 Corso Oct 1958 A
3215029 Woodcock Nov 1965 A
3582178 Boughton et al. Jun 1971 A
3671098 Rotter Jun 1972 A
3749494 Hodges Jul 1973 A
3790248 Kellow Feb 1974 A
3931593 Marshall Jan 1976 A
3970373 Pledger Jul 1976 A
3971068 Gerhardt et al. Jul 1976 A
4037866 Price Jul 1977 A
4066330 Jones Jan 1978 A
4115812 Akatsu Sep 1978 A
4149190 Wessler et al. Apr 1979 A
4158504 de Ponteves et al. Jun 1979 A
4200801 Schuresko Apr 1980 A
4260217 Traeger et al. Apr 1981 A
4318395 Tawara Mar 1982 A
4355325 Nakamura et al. Oct 1982 A
4378571 Handy Mar 1983 A
4449535 Renault May 1984 A
4471766 Terayama Sep 1984 A
4532918 Wheeler Aug 1985 A
4556057 Hiruma et al. Dec 1985 A
4575632 Lange Mar 1986 A
4597630 Brandstetter et al. Jul 1986 A
4611888 Prenovitz et al. Sep 1986 A
4638365 Kato Jan 1987 A
4660982 Okada Apr 1987 A
4688905 Okamura Aug 1987 A
4717952 Kohayakawa et al. Jan 1988 A
4742388 Cooper et al. May 1988 A
4768513 Suzuki Sep 1988 A
4786813 Svanberg et al. Nov 1988 A
4799104 Hosoya et al. Jan 1989 A
4806005 Schneider et al. Feb 1989 A
4821117 Sekiguchi Apr 1989 A
4837625 Douziech et al. Jun 1989 A
4852985 Fujihara et al. Aug 1989 A
4856495 Tohjoh et al. Aug 1989 A
4885634 Yabe Dec 1989 A
4895145 Joffe et al. Jan 1990 A
4930516 Alfano et al. Jun 1990 A
4930883 Salzman Jun 1990 A
4951135 Sasagawa et al. Aug 1990 A
4953539 Nakamura et al. Sep 1990 A
4954897 Ejima et al. Sep 1990 A
4974936 Ams et al. Dec 1990 A
5001556 Nakamura et al. Mar 1991 A
5007408 Ieoka Apr 1991 A
5028128 Onuki Jul 1991 A
5034888 Uehara et al. Jul 1991 A
5041852 Misawa et al. Aug 1991 A
5115308 Onuki May 1992 A
5121220 Nakamoto Jun 1992 A
5128803 Sprafke Jul 1992 A
5132837 Kitajima Jul 1992 A
5134662 Bacus et al. Jul 1992 A
5165079 Schulz-Hennig Nov 1992 A
5205280 Dennison, Jr. et al. Apr 1993 A
5208651 Buican May 1993 A
5214503 Chiu et al. May 1993 A
5225883 Carter et al. Jul 1993 A
5255087 Nakamura et al. Oct 1993 A
5278642 Danna et al. Jan 1994 A
5282082 Espie et al. Jan 1994 A
5295017 Brown Mar 1994 A
RE34622 Ledley May 1994 E
5365057 Morley et al. Nov 1994 A
5371355 Wodecki Dec 1994 A
5377686 O'Rourke et al. Jan 1995 A
5379756 Pileski et al. Jan 1995 A
5408263 Kikuchi et al. Apr 1995 A
5410363 Capen et al. Apr 1995 A
5419323 Kittrell et al. May 1995 A
5420628 Poulsen et al. May 1995 A
5421337 Richards-Kortum et al. Jun 1995 A
5424841 Van Gelder et al. Jun 1995 A
5426530 Copenhaver et al. Jun 1995 A
5430476 Häfele et al. Jul 1995 A
5481401 Kita et al. Jan 1996 A
5485203 Nakamura et al. Jan 1996 A
5490015 Umeyama et al. Feb 1996 A
5507287 Palcic et al. Apr 1996 A
5515449 Tsuruoka et al. May 1996 A
5535052 Jörgens Jul 1996 A
5536236 Yabe et al. Jul 1996 A
5557451 Copenhaver et al. Sep 1996 A
5585846 Kim Dec 1996 A
5590660 MacAulay et al. Jan 1997 A
5596654 Tanaka Jan 1997 A
5646680 Yajima Jul 1997 A
5647368 Zeng et al. Jul 1997 A
5647840 D'Amelio et al. Jul 1997 A
5667472 Finn et al. Sep 1997 A
5677724 Takizawa et al. Oct 1997 A
5682567 Spruck et al. Oct 1997 A
5689354 Orino Nov 1997 A
5695049 Bauman Dec 1997 A
5697373 Richards-Kortum et al. Dec 1997 A
5713364 DeBaryshe et al. Feb 1998 A
5729382 Morita et al. Mar 1998 A
5749830 Kaneko et al. May 1998 A
5769792 Palcic et al. Jun 1998 A
5772355 Ross et al. Jun 1998 A
5772580 Utsui et al. Jun 1998 A
5827190 Palcic et al. Oct 1998 A
5833617 Hayashi Nov 1998 A
5838001 Minakuchi et al. Nov 1998 A
5840017 Furusawba et al. Nov 1998 A
5852498 Youvan et al. Dec 1998 A
5891016 Utsui et al. Apr 1999 A
5897269 Ross et al. Apr 1999 A
5971918 Zanger Oct 1999 A
5973315 Saldana et al. Oct 1999 A
5984861 Crowley Nov 1999 A
5986271 Lazarev et al. Nov 1999 A
5986642 Ueda et al. Nov 1999 A
5990996 Sharp Nov 1999 A
5999240 Sharp et al. Dec 1999 A
6002137 Hayashi Dec 1999 A
6004263 Nakaichi et al. Dec 1999 A
6008889 Zeng et al. Dec 1999 A
6021344 Lui et al. Feb 2000 A
6028622 Suzuki Feb 2000 A
6030339 Tatsuno et al. Feb 2000 A
6059719 Yamamoto et al. May 2000 A
6059720 Furusawa et al. May 2000 A
6061591 Freitag et al. May 2000 A
6069689 Zeng et al. May 2000 A
6070096 Hayashi May 2000 A
6095982 Richards-Kortum et al. Aug 2000 A
6099466 Sano et al. Aug 2000 A
6110106 MacKinnon et al. Aug 2000 A
6120435 Eino Sep 2000 A
6147705 Krauter et al. Nov 2000 A
6148227 Wagnières et al. Nov 2000 A
6161035 Furusawa Dec 2000 A
6181414 Raz et al. Jan 2001 B1
6192267 Scherninski et al. Feb 2001 B1
6212425 Irion et al. Apr 2001 B1
6226126 Conemac May 2001 B1
6258576 Richards-Kortum et al. Jul 2001 B1
6280378 Kazuhiro et al. Aug 2001 B1
6293911 Imaizumi et al. Sep 2001 B1
6315712 Rovegno Nov 2001 B1
6332092 Deckert et al. Dec 2001 B1
6364829 Fulghum Apr 2002 B1
6364831 Crowley Apr 2002 B1
6419628 Rudischhauser et al. Jul 2002 B1
6422994 Kaneko et al. Jul 2002 B1
6462770 Cline et al. Oct 2002 B1
6510338 Irion et al. Jan 2003 B1
6526213 Ilenda et al. Feb 2003 B1
6529239 Dyck et al. Mar 2003 B1
6529768 Hakamata Mar 2003 B1
6537211 Wang et al. Mar 2003 B1
6544102 Schäfer et al. Apr 2003 B2
6571119 Hayashi May 2003 B2
6596996 Stone et al. Jul 2003 B1
6603552 Cline et al. Aug 2003 B1
6639664 Haan et al. Oct 2003 B2
6652452 Seifert et al. Nov 2003 B1
6750971 Overbeck et al. Jun 2004 B2
6772003 Kaneko et al. Aug 2004 B2
6773392 Kikuchi et al. Aug 2004 B2
6786865 Dhindsa Sep 2004 B2
6821245 Cline et al. Nov 2004 B2
6826424 Zeng et al. Nov 2004 B1
6898458 Zeng et al. May 2005 B2
6899675 Cline et al. May 2005 B2
6922583 Perelman et al. Jul 2005 B1
6960165 Ueno et al. Nov 2005 B2
7043291 Sendai May 2006 B2
7150552 Weidel Dec 2006 B2
7179222 Imaizumi et al. Feb 2007 B2
7235045 Wang et al. Jun 2007 B2
7236815 Richards-Kortum et al. Jun 2007 B2
7253894 Zeng et al. Aug 2007 B2
7324674 Ozawa et al. Jan 2008 B2
7333270 Pochapsky et al. Feb 2008 B1
7341557 Cline et al. Mar 2008 B2
7385772 Forkey et al. Jun 2008 B2
7420151 Fengler et al. Sep 2008 B2
7479990 Imaizumi et al. Jan 2009 B2
7697975 Zeng Apr 2010 B2
7704206 Suzuki et al. Apr 2010 B2
7722534 Cline et al. May 2010 B2
7798955 Ishihara et al. Sep 2010 B2
7811229 Sugimoto Oct 2010 B2
8140147 Maynard et al. Mar 2012 B2
8285015 Demos Oct 2012 B2
8337400 Mizuyoshi Dec 2012 B2
8361775 Flower Jan 2013 B2
8408269 Fengler et al. Apr 2013 B2
8408772 Li Apr 2013 B2
8448867 Liu et al. May 2013 B2
8498695 Westwick et al. Jul 2013 B2
8630698 Fengler et al. Jan 2014 B2
8759243 Coffy et al. Jun 2014 B2
8773756 Tesar et al. Jul 2014 B2
8790253 Sunagawa et al. Jul 2014 B2
8961403 Cline et al. Feb 2015 B2
8979301 Moore Mar 2015 B2
9143746 Westwick et al. Sep 2015 B2
9173554 Fengler et al. Nov 2015 B2
9295392 Douplik et al. Mar 2016 B2
9386909 Fengler et al. Jul 2016 B2
9435496 Moore Sep 2016 B2
9642532 Fengler et al. May 2017 B2
20010016679 Futatsugi et al. Aug 2001 A1
20010028458 Xiao Oct 2001 A1
20010049473 Hayashi Dec 2001 A1
20020013937 Ostanevich et al. Jan 2002 A1
20020016533 Marchitto et al. Feb 2002 A1
20020021355 Utsui et al. Feb 2002 A1
20020035330 Cline et al. Mar 2002 A1
20020076480 Hsieh et al. Jun 2002 A1
20020138008 Tsujita et al. Sep 2002 A1
20020143243 Georgakoudi et al. Oct 2002 A1
20020155619 Kurihara et al. Oct 2002 A1
20020161282 Fulghum Oct 2002 A1
20020161283 Sendai Oct 2002 A1
20020161284 Tanaka Oct 2002 A1
20020175993 Ueno et al. Nov 2002 A1
20020177778 Averback et al. Nov 2002 A1
20020186478 Watanabe et al. Dec 2002 A1
20020196335 Ozawa Dec 2002 A1
20030002036 Haan et al. Jan 2003 A1
20030042493 Kazakevich Mar 2003 A1
20030117491 Avni et al. Jun 2003 A1
20030135092 Cline et al. Jul 2003 A1
20030153811 Muckner Aug 2003 A1
20030191368 Wang et al. Oct 2003 A1
20030229270 Suzuki et al. Dec 2003 A1
20040006276 Demos et al. Jan 2004 A1
20040010183 Dhindsa Jan 2004 A1
20040021859 Cunningham Feb 2004 A1
20040037454 Ozawa et al. Feb 2004 A1
20040044275 Hakamata Mar 2004 A1
20040046865 Ueno et al. Mar 2004 A1
20040133073 Berci et al. Jul 2004 A1
20040143162 Krattiger et al. Jul 2004 A1
20040148141 Tsujita et al. Jul 2004 A1
20040149998 Henson et al. Aug 2004 A1
20040156124 Okada Aug 2004 A1
20040186351 Imaizumi et al. Sep 2004 A1
20040218115 Kawana et al. Nov 2004 A1
20040225222 Zeng et al. Nov 2004 A1
20040245350 Zeng Dec 2004 A1
20040263643 Imaizumi et al. Dec 2004 A1
20050027166 Matsumoto et al. Feb 2005 A1
20050096505 Imaizumi et al. May 2005 A1
20050140270 Henson et al. Jun 2005 A1
20050143627 Cline et al. Jun 2005 A1
20050154319 Cline et al. Jul 2005 A1
20050171440 Maki et al. Aug 2005 A1
20050182291 Hirata Aug 2005 A1
20050182321 Frangioni Aug 2005 A1
20050203421 Zeng et al. Sep 2005 A1
20050256373 Bar-Or et al. Nov 2005 A1
20050273011 Hattery et al. Dec 2005 A1
20050280783 Yamasaki et al. Dec 2005 A1
20050288593 Georgakoudi et al. Dec 2005 A1
20060002141 Ouderkirk et al. Jan 2006 A1
20060004292 Beylin Jan 2006 A1
20060017913 Kawamata et al. Jan 2006 A1
20060089554 Ishihara et al. Apr 2006 A1
20060146322 Komachi et al. Jul 2006 A1
20060149133 Sugimoto et al. Jul 2006 A1
20060155166 Takahashi et al. Jul 2006 A1
20060211915 Takeuchi et al. Sep 2006 A1
20060215406 Thrailkill Sep 2006 A1
20060217594 Ferguson Sep 2006 A1
20060241496 Fengler et al. Oct 2006 A1
20060258910 Stefanchik et al. Nov 2006 A1
20070041195 Chen Feb 2007 A1
20070091634 Sakurada Apr 2007 A1
20070177152 Tearney et al. Aug 2007 A1
20070213593 Nakaoka Sep 2007 A1
20070229309 Tomita et al. Oct 2007 A1
20080021274 Bayer et al. Jan 2008 A1
20080027280 Fengler et al. Jan 2008 A1
20080039697 Morishita Feb 2008 A1
20080074752 Chaves et al. Mar 2008 A1
20080177140 Cline et al. Jul 2008 A1
20080208006 Farr Aug 2008 A1
20080246920 Buczek et al. Oct 2008 A1
20090012361 MacKinnon et al. Jan 2009 A1
20090021739 Tsujita et al. Jan 2009 A1
20090040754 Brukilacchio et al. Feb 2009 A1
20090052185 Toriyama et al. Feb 2009 A1
20090114799 Maeda May 2009 A1
20090114803 Yamaguchi May 2009 A1
20090122135 Matsui May 2009 A1
20090122152 Yamaguchi et al. May 2009 A1
20090124854 Yamaguchi et al. May 2009 A1
20090153797 Allon et al. Jun 2009 A1
20090181339 Liang et al. Jul 2009 A1
20090201577 LaPlante et al. Aug 2009 A1
20090290149 Roth Nov 2009 A1
20100087741 Douplik et al. Apr 2010 A1
20100094136 Nakaoka et al. Apr 2010 A1
20100110168 Avni et al. May 2010 A1
20100110393 Chen et al. May 2010 A1
20100121146 Sugimoto May 2010 A1
20100125164 LaBombard May 2010 A1
20100157039 Sugai Jun 2010 A1
20100168588 Matsumoto et al. Jul 2010 A1
20100198010 Cline et al. Aug 2010 A1
20100208487 Li Aug 2010 A1
20100277817 Durell Nov 2010 A1
20110270092 Kang et al. Nov 2011 A1
20120044462 Kaji Feb 2012 A1
20130237762 Fengler et al. Sep 2013 A1
20140071328 Miesak Mar 2014 A1
20140078378 Demers et al. Mar 2014 A1
20140194687 Fengler et al. Jul 2014 A1
20150184811 Moore Jul 2015 A1
20150230698 Cline et al. Aug 2015 A1
20160100763 Fengler et al. Apr 2016 A1
20160249019 Westwick et al. Aug 2016 A1
20170064257 Westwick et al. Mar 2017 A1
20170064258 Westwick et al. Mar 2017 A1
20170142314 Moore et al. May 2017 A1
Foreign Referenced Citations (114)
Number Date Country
101726980 Jun 2010 CN
101828139 Sep 2010 CN
201974160 Sep 2011 CN
19535114 Mar 1996 DE
19608027 Sep 1996 DE
0512965 Nov 1992 EP
0672379 Sep 1995 EP
0774865 May 1997 EP
0792618 Sep 1997 EP
1374755 Jan 2004 EP
1883337 Feb 2008 EP
2051603 Apr 2009 EP
2671405 Jul 1992 FR
S-60-246733 Dec 1985 JP
S-61-159936 Jul 1986 JP
H-01-135349 May 1989 JP
03-97439 Apr 1991 JP
03-97441 Apr 1991 JP
03-97442 Apr 1991 JP
05-115435 May 1993 JP
06-125911 May 1994 JP
H-07-155285 Jun 1995 JP
H-07-155286 Jun 1995 JP
H-07-155290 Jun 1995 JP
H-07-155291 Jun 1995 JP
H-07-155292 Jun 1995 JP
H-07-204156 Aug 1995 JP
H-07-222712 Aug 1995 JP
H-07-250804 Oct 1995 JP
H-07-250812 Oct 1995 JP
H-07-327913 Dec 1995 JP
H-08-126605 May 1996 JP
08-140928 Jun 1996 JP
08-140929 Jun 1996 JP
H-08-224208 Sep 1996 JP
H-08-224209 Sep 1996 JP
H-08-224210 Sep 1996 JP
H-08-224240 Sep 1996 JP
H-08-252218 Oct 1996 JP
H-09-19408 Jan 1997 JP
09-066023 Mar 1997 JP
09-070384 Mar 1997 JP
H-10-127563 May 1998 JP
H-10-151104 Jun 1998 JP
10-201707 Aug 1998 JP
10-225427 Aug 1998 JP
H-10-201700 Aug 1998 JP
H-10-225426 Aug 1998 JP
H-10-243915 Sep 1998 JP
H-10-243920 Sep 1998 JP
H-10-308114 Nov 1998 JP
H-10-309281 Nov 1998 JP
H-10-309282 Nov 1998 JP
H10-321005 Dec 1998 JP
H-10-328129 Dec 1998 JP
H-11-47079 Feb 1999 JP
11-089789 Apr 1999 JP
11-104059 Apr 1999 JP
11-104060 Apr 1999 JP
11-104061 Apr 1999 JP
H-11-104070 Apr 1999 JP
H-11-113839 Apr 1999 JP
H-11-155812 Jun 1999 JP
H-11-244220 Sep 1999 JP
H-11-332819 Dec 1999 JP
2000-504968 Apr 2000 JP
2000-245693 Sep 2000 JP
2000-354583 Dec 2000 JP
2001-078205 Mar 2001 JP
2002-000560 Jan 2002 JP
2002-049302 Feb 2002 JP
2002-244122 Aug 2002 JP
2003-045210 Feb 2003 JP
2004-024611 Jan 2004 JP
2004-094043 Mar 2004 JP
2004-163902 Jun 2004 JP
2004-520105 Jul 2004 JP
2004-247156 Sep 2004 JP
2004-289545 Oct 2004 JP
2004-292722 Oct 2004 JP
2005-010315 Jan 2005 JP
2005-058618 Mar 2005 JP
2005-058619 Mar 2005 JP
2005-058620 Mar 2005 JP
2005-080819 Mar 2005 JP
2005-081079 Mar 2005 JP
2005-292404 Oct 2005 JP
2006087764 Apr 2006 JP
2006-525494 Nov 2006 JP
2007-029453 Feb 2007 JP
2007072392 Mar 2007 JP
2007-089840 Apr 2007 JP
2010-117442 May 2010 JP
2011-500921 Jan 2011 JP
2011-528918 Dec 2011 JP
5231625 Jul 2013 JP
5859578 Feb 2016 JP
99592 Nov 2010 RU
WO-9304648 Mar 1993 WO
WO-9413191 Jun 1994 WO
WO-9526673 Oct 1995 WO
WO-9824360 Jun 1998 WO
WO-9901749 Jan 1999 WO
WO-9953832 Oct 1999 WO
WO-0042910 Jul 2000 WO
WO-0054652 Sep 2000 WO
WO-0207587 Jan 2002 WO
WO-0250518 Jun 2002 WO
WO-03059159 Jul 2003 WO
WO-03059159 Jul 2003 WO
WO-2006116847 Nov 2006 WO
WO-2008011722 Jan 2008 WO
WO-2009033021 Mar 2009 WO
WO-2016055837 Apr 2016 WO
Non-Patent Literature Citations (111)
Entry
US 6,692,429, 02/2004, Imaizumi et al. (withdrawn)
Alfano, R.R. et al. (Oct. 1987). “Fluorescence Spectra From Cancerous and Normal Human Breast and Lung Tissues,” IEEE Journal of Quantum Electronics QE-23(10):1806-1811.
Andersson-Engels, S. et al. (Mar. 1989). “Tissue Diagnostics Using Laser Induced Fluorescence,” Ber. Bunsenges Physical Chemistry 93(3):335-342.
Bhunchet, E. et al. (Apr. 2002). “Fluorescein Electronic Endoscopy: A Novel Method for Detection of Early Stage Gastric Cancer Not Evident to Routine Endoscopy,” Gastrointestinal Endoscopy 55(4):562-571.
Dawson, J.B. et al. (Jul. 1980). “A Theoretical and Experimental Study of Light Absorption and Scattering by In Vivo Skin,” Phys. Med. Biol. 25(4):695-709.
Georgakoudi, I et al. (2003). “Quantitative Characterization of Biological Tissue Using Optical Spectroscopy,” in Chapter 31 of Biomedical Photonics Handbook, Tuan Vo-Dinh (ed.), CRC Press, New York, thirty three pages.
Georgakoudi, I et al. (Apr. 2005). “Characterization of Dysplastic Tissue Morphology and Biochemistry in Barrett's Esophagus using Diffuse Reflectance and Light Scattering Spectroscopy,” Techniques in Gastrointestinal Endoscopy 7(2):100-105.
Hung, J. et al. (1991). “Autofluorescence of Normal and Malignant Bronchial Tissue,” Lasers in Surgery and Medicine 11(2):99-105.
Török, B. et al. (May 1996). “Simultane digitale Indocyaningrün- und Fluoreszeinangiographie (Simultaneous Digital ICG and Fluorescein Angiography),” Klin Monatsbl Augenheilkd 208(5):333-336, (with English Translation of the Introduction only).
Chinese Office action dated Jul. 29, 2016 for application No. 2012800222843 filed on Mar. 8, 2012, eight pages.
Chinese Office action dated Nov. 24, 2015 for application No. 2012800222843 filed on Mar. 8, 2012, sixteen pages.
European Extended Search Report dated Jul. 17, 2014, for EP Application No. 09721252.6 filed on Mar. 18, 2009; eleven pages.
European Extended Search Report dated Sep. 20, 2013, for EP Application No. 08706262.6 filed on Jan. 23, 2008, five pages.
European Office Action dated Dec. 3, 2015, for EP Application No. 08706262.6 filed on Jan. 23, 2008; fifteen pages.
European Office Action dated Nov. 19, 2015, for EP Application No. 07 785 001.4, filed on Jul. 30, 2007, four pages.
European Office Action dated Nov. 3, 2015 for EP Patent Application No. 12754208.2 filed Oct. 4, 2013, four pages.
European Office Action dated Sep. 29, 2015, for EP Application No. 09721252.6 filed on Mar. 18, 2009; five pages.
European Supplemental Search Report dated Oct. 1, 2014 for EP Application No. 12754208.2 filed on Mar. 8, 2012, five pages.
European Supplemental Search Report dated Oct. 9, 2013, for European Patent Application No. 06721854.5, filed on May 4, 2005, six pages.
Extended European Search Report dated Jan. 24, 2012 for EP Application No. 07 785 001.4, filed on Jul. 30, 2007, seven pages.
Final Office Action dated Apr. 24, 2015 for U.S. Appl. No. 12/933,512, filed Nov. 24, 2010, nineteen pages.
Final Office Action dated Jul. 23, 2008, for U.S. Appl. No. 11/122,267, six pages.
Final Office Action dated Jun. 18, 2015, for U.S. Appl. No. 14/154,177, eight pages.
Final Office Action dated Jun. 5, 2014, for U.S. Appl. No. 12/761,462, fourteen pages.
Final Office Action dated May 11, 2011, for U.S. Appl. No. 11/412,715, eight pages.
Final Office Action dated May 21, 2012, for U.S. Appl. No. 11/964,330; twelve pages.
Final Office Action dated Nov. 24, 2009, for U.S. Appl. No. 11/009,965, fourteen pages.
Final Office Action dated Mar. 22, 2016 for U.S. Appl. No. 14/873,842, filed Oct. 2, 2015, eighteen pages.
International Preliminary Report on Patentability dated Feb. 3, 2009, for International Application No. PCT/CA2007/001335 filed on Jul. 30, 2007, five pages.
International Preliminary Report on Patentability dated Nov. 6, 2007, for International Application No. PCT/CA2006/000669, filed on Apr. 27, 2006, nine pages.
International Preliminary Report on Patentability dated Sep. 21, 2010, for International Application No. PCT/US2009/037506, filed on Mar. 18, 2009, seven pages.
International Search Report dated Aug. 3, 2006, for International Application No. PCT/CA2006/000669, filed on Apr. 27, 2006, three pages.
International Search Report dated Aug. 3, 2012, for International Application No. PCT/IB2012/000601, filed on Mar. 8, 2012, three pages.
International Search Report dated Dec. 7, 2007, for International Application No. PCT/CA2007/001335, filed on Jul. 30, 2007, two pages.
International Search Report dated Jan. 21, 2002, for International Application No. PCT/US2001/022198, filed on Jul. 13, 2001, three pages.
International Search Report dated Jul. 22, 2009, for International Application No. PCT/US09/37506, filed on Mar. 18, 2009, two pages.
International Search Report dated May 13, 2008 for Intentional Application No. PCT/CA2008/00015, filed on Jan. 8, 2008, one page.
Invitation to Pay additional Fees and, where Applicable, Protest Fee, dated Dec. 22, 2016 for International Application No. PCT/CA2016/051315, filed on Nov. 10, 2016, two pages.
Japanese Final Office Action dated Aug. 2, 2013, for Japanese Patent Application No. 2008-509275, filed on Apr. 27, 2006, four pages.
Japanese Notice of Allowance dated Nov. 28, 2016 for Japanese Patent Application No. 2015-245598, filed on Mar. 8, 2012, six pages.
Japanese Office Action dated Apr. 20, 2012, issued in counterpart Japanese Application No. 2011-500921, filed Mar. 18, 2009, four pages.
Japanese Office Action dated Apr. 3, 2015 in Japanese Application No. 2013-058356, filed Mar. 18, 2009, four pages.
Japanese Office Action dated Feb. 17, 2012, for Japanese Patent Application No. 2008-509275, filed on Apr. 27, 2006, six pages.
Japanese Office Action dated Jul. 22, 2014 for Japanese Patent Application No. 2013-557187 filed Mar. 8, 2012, seven pages.
Japanese Office Action dated Mar. 9, 2015 for Japanese Patent Application No. 2013-557187, filed Mar. 8, 2012, five pages.
Japanese Office Action dated Nov. 11, 2011, for Japanese Patent Application No. 2009-521077, filed on Jul. 30, 2007, four pages.
Japanese Office Action dated Sep. 14, 2012, for Japanese Patent Application No. 2008-509275, filed on Apr. 27, 2006, seven pages.
Japanese Office Action dated Sep. 19, 2014, for Japanese Patent Application No. 2013-246636, filed on Apr. 27, 2006, six pages.
Japanese Office dated Dec. 26, 2012 for Japanese Patent Application No. 2011-500921, filed on Mar. 18, 2009, two pages.
Japanese Office Action dated May 26, 2014 in Japanese Patent Application No. 2013-058356, filed on Mar. 18, 2009, w/Concise Explanation of the Relevance, three pages.
Korean Decision of Refusal Action dated Aug. 30, 2016 for patent application No. 10-2015-7033310 filed on Mar. 8, 2012, seven pages.
Korean Office Action dated Aug. 20, 2015 for patent application No. 20137026479 filed on Mar. 8, 2012.
Korean Office Action dated Dec. 8, 2015 for patent application No. 20157033310 filed on Mar. 8, 2012, seven pages.
Korean Notice of Allowance dated Jan. 2, 2017 for Korean Application No. 10-2015-7033310, filed on Nov. 20, 2015, three pages.
Non Final Office Action dated Apr. 2, 2009, for U.S. Appl. No. 11/009,965, thirteen pages.
Non Final Office Action dated Aug. 16, 2013, for U.S. Appl. No. 12/761,462, ten pages.
Non Final Office Action dated Aug. 16, 2013, for U.S. Appl. No. 12/761,523, nine pages.
Non Final Office Action dated Dec. 10, 2010, for U.S. Appl. No. 11/412,715, ten pages.
Non Final Office Action dated Dec. 14, 2011, for U.S. Appl. No. 11/412,715, eight pages.
Non Final Office Action dated Feb. 3, 2010, for U.S. Appl. No. 11/626,308; eleven pages.
Non Final Office Action dated Jan. 2, 2008, for U.S. Appl. No. 11/122,267, five pages.
Non Final Office Action dated Jan. 20, 2016, for U.S. Appl. No. 14/629,473, fifteen pages.
Non Final Office Action dated Jul. 17, 2003, for U.S. Appl. No. 09/905,642, six pages.
Non Final Office Action dated Jul. 2, 2013 for U.S. Appl. No. 12/933,512, filed Nov. 24, 2010, twelve pages.
Non Final Office Action dated Jun. 1, 2007, for U.S. Appl. No. 10/899,648, seven pages.
Non Final Office Action dated Jun. 20, 2008, for U.S. Appl. No. 11/009,398, fifteen pages.
Non Final Office Action dated Jun. 23, 2010, for U.S. Appl. No. 11/009,965, fifteen pages.
Non Final Office Action dated Jun. 27, 2014 for U.S. Appl. No. 13/415,561, filed Mar. 3, 2012, fourteen pages.
Non Final Office Action dated Jun. 9, 2011, for U.S. Appl. No. 11/830,323, five pages.
Non Final Office Action dated May 18, 2004, for U.S. Appl. No. 10/050,601, eight pages.
Non Final Office Action dated Nov. 23, 2009, for U.S. Appl. No. 11/969,974, seven pages.
Non Final Office Action dated Nov. 5, 2014, for U.S. Appl. No. 13/930,225; six pages.
Non Final Office Action dated Oct. 23, 2013 for U.S. Appl. No. 13/415,561, filed Mar. 8, 2012, ten pages.
Non Final Office Action dated Oct. 7, 2011, for U.S. Appl. No. 11/964,330; ten pages.
Non Final Office Action dated Sep. 12, 2014, for U.S. Appl. No. 14/154,177, four pages.
Non Final Office Action dated Sep. 6, 2016 for U.S. Appl. No. 14/873,842, filed Oct. 2, 2015, seven pages.
Non Final Office Action with Restriction Requirement dated Mar. 4, 2011, for U.S. Appl. No. 11/830,323, nine pages.
U.S. Appl. No. 15/348,664, titled “Systems and Methods for Illumination and Imaging of a Target.”
Design U.S. Appl. No. 29/562,795, filed Apr. 28, 2016, titled “Device for Illumination and Imaging of a Target.”
Notice of Allowance dated Dec. 30, 2016, for U.S. Appl. No. 14/873,842, filed Oct. 2, 2015, eleven pages.
Notice of Allowance dated Apr. 7, 2004, for U.S. Appl. No. 09/905,642, six pages.
Notice of Allowance dated Aug. 26, 2004, for U.S. Appl. No. 10/050,601, eight pages.
Notice of Allowance dated Aug. 6, 2015, for U.S. Appl. No. 13/853,656, seven pages.
Notice of Allowance dated Dec. 10, 2012, for U.S. Appl. No. 11/964,330; seven pages.
Notice of Allowance dated Feb. 25, 2010, for U.S. Appl. No. 11/969,974, four pages.
Notice of Allowance dated Jan. 2, 2008, for U.S. Appl. No. 10/899,648, three pages.
Notice of Allowance dated Jun. 25, 2015, for U.S. Appl. No. 12/933,512, filed Nov. 24, 2010 fourteen pages.
Notice of Allowance dated Mar. 22, 2013, for U.S. Appl. No. 11/964,330; eight pages.
Notice of Allowance dated Mar. 28, 2016, for U.S. Appl. No. 13/853,656 eight pages.
Notice of Allowance dated May 18, 2015, for U.S. Appl. No. 13/930,225; nine pages.
Notice of Allowance dated Nov. 23, 2015, for U.S. Appl. No. 13/853,656, seven pages.
Notice of Allowance dated Oct. 10, 2014, for U.S. Appl. No. 12/761,462, ten pages.
Notice of Allowance dated Oct. 5, 2007, for U.S. Appl. No. 10/899,648, six pages.
Notice of Allowance dated Sep. 10, 2013, for U.S. Appl. No. 11/412,715, eight pages.
Notice of Allowance dated Sep. 14, 2012, for U.S. Appl. No. 11/830,323, eight pages.
Russian Office Action—Decision to Grant dated Aug. 19, 2016 for Russian Patent Application No. 2013144845/07, filed on Mar. 8, 2012, thirteen pages.
Supplemental Notice of Allowability dated Mar. 10, 2005, for U.S. Appl. No. 10/050,601, five pages.
Written Opinion of the International Searching Authority dated Aug. 3, 2006, for International Application No. PCT/CA2006/000669, filed on Apr. 27, 2006, eight pages.
Written Opinion of the International Searching Authority dated Dec. 7, 2007, for International Application No. PCT/CA2007/001335, filed on Jul. 30, 2007, four pages.
Japanese Notice of Allowance dated Jan. 5, 2017 in Japanese Patent Application No. 2015-238784, filed on Dec. 7, 2015, six pages.
Canadian Examiner's Report for Registration of an Industrial Design dated Feb. 1, 2017 for Canadian Application No. 171282, filed on Oct. 27, 2016, two pages.
Chinese Third Office Action dated Mar. 14, 2017 for Chinese Patent Application No. 201280022284.3, filed on Nov. 7, 2013, seven pages.
European Communication pursuant to Rules 70(2) and 70a(2) EPC and Reference to Rule 39(1) EPC dated Jan. 23, 2017 for European Application No. 16186321.2 filed on Aug. 30, 2016, two pages.
European Communication under Rule 71(3) EPC dated Nov. 25, 2016 for EP Application No. 08706262.6 filed on Aug. 21, 2009, eight pages.
European Search Report and Written Opinion dated Dec. 21, 2016 for European Application No. 16186321.2 filed on Aug. 30, 2016, nine pages.
International Search Report and Written Opinion dated Apr. 24, 2017, for International Application No. PCT/CA2017/050083, filed on Jan. 26, 2017, seven pages.
International Search Report and Written Opinion of the International Searching Authority dated Feb. 10, 2017, for International Application No. PCT/CA2016/051315 filed on Nov. 10, 2016, thirteen pages.
U.S. Non Final Office Action dated Feb. 1, 2017, for U.S. Appl. No. 14/860,687, filed Sep. 21, 2015, sixteen pages.
U.S. Non Final Office Action dated Jan. 26, 2017, for U.S. Appl. No. 15/343,034, filed Nov. 3, 2016, seventeen pages.
U.S. Non Final Office Action dated Jan. 27, 2017, for U.S. Appl. No. 15/343,038, filed Nov. 3, 2016, fifteen pages.
U.S. Appl. No. 15/584,405 titled “Imaging System for Combine Full-Color Reflectance and Near-Infrared Imaging,” filed May 2, 2017.
Related Publications (1)
Number Date Country
20160360956 A1 Dec 2016 US
Provisional Applications (1)
Number Date Country
61450360 Mar 2011 US
Continuations (2)
Number Date Country
Parent 14658869 Mar 2015 US
Child 15247419 US
Parent 13415561 Mar 2012 US
Child 14658869 US